{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:21:07Z","timestamp":1790335267752,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.exer.2011.08.003","type":"journal-article","created":{"date-parts":[[2011,8,16]],"date-time":"2011-08-16T15:30:06Z","timestamp":1313508606000},"page":"35-39","source":"Crossref","is-referenced-by-count":85,"title":["Endothelial mesenchymal transformation mediated by IL-1\u03b2-induced FGF-2 in corneal endothelial cells"],"prefix":"10.1016","volume":"95","author":[{"given":"Jeong Goo","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MinHee K.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EunDuck P.","family":"Kay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2011.08.003_bib1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1128\/MCB.19.1.505","article-title":"A\u00a0new 34-kilodalton isoform of human fibroblast growth factor 2 is cap dependently synthesized by using a non-AUG start codon and behaves as a survival factor","volume":"19","author":"Arnaud","year":"1999","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.exer.2011.08.003_bib2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/ICU.0b013e3283360b95","article-title":"Descemet\u2019s stripping with automated endothelial keratoplasty and glaucoma","volume":"21","author":"Banitt","year":"2010","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.exer.2011.08.003_bib3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1210\/er.18.1.26","article-title":"Biological roles of fibroblast growth factor-2","volume":"18","author":"Bikfalvi","year":"1997","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.exer.2011.08.003_bib4","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1093\/emboj\/cdf343","article-title":"A\u00a0growth factor-dependent nuclear kinase phosphorylates p27Kip1 and regulates cell cycle progression","volume":"21","author":"Boehm","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.exer.2011.08.003_bib5","doi-asserted-by":"crossref","first-page":"13755","DOI":"10.1074\/jbc.M310064200","article-title":"Suppression of WEE1 and stimulation of CDC25A correlates with endothelin-dependent proliferation of rat aortic smooth muscle cells","volume":"279","author":"Chen","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2011.08.003_bib6","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1016\/S0002-9440(10)65516-2","article-title":"Basic fibroblast growth factor synthesis by human peritoneal mesothelial cells: induction by interleukin-1","volume":"155","author":"Cronauer","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2011.08.003_bib7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cytogfr.2005.01.007","article-title":"Mechanisms underlying differential responses to FGF signaling","volume":"16","author":"Dailey","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.exer.2011.08.003_bib8","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family","volume":"27","author":"Dinarello","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.exer.2011.08.003_bib9","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nature01148","article-title":"Rho GTPases in cell biology","volume":"420","author":"Etienne-Manneville","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.exer.2011.08.003_bib10","doi-asserted-by":"crossref","first-page":"28706","DOI":"10.1074\/jbc.M203668200","article-title":"Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization","volume":"277","author":"Fujita","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2011.08.003_bib11","doi-asserted-by":"crossref","first-page":"5199","DOI":"10.1158\/0008-5472.CAN-10-0918","article-title":"Potential for targeting the fibroblast growth factor receptors in breast cancer","volume":"70","author":"Hynes","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.exer.2011.08.003_bib12","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ajo.2010.03.011","article-title":"Retrocorneal membranes: a comparative immunohistochemical analysis of keratocytic, endothelial, and epithelial origins","volume":"150","author":"Jakobiec","year":"2010","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2011.08.003_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-230X(08)60821-0","article-title":"Structural and functional diversity in the FGF receptor multigene family","volume":"60","author":"Johnson","year":"1993","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.exer.2011.08.003_bib14","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1350-9462(02)00065-4","article-title":"Proliferative capacity of the corneal endothelium","volume":"22","author":"Joyce","year":"2003","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2011.08.003_bib15","first-page":"200","article-title":"Type I collagen and fibronectin synthesis by retrocorneal fibrous membrane","volume":"22","author":"Kay","year":"1982","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.08.003_bib16","first-page":"495","article-title":"Stability of collagen phenotype in morphologically modulated rabbit corneal endothelial cells","volume":"25","author":"Kay","year":"1984","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.08.003_bib17","first-page":"502","article-title":"Modulation of endothelial cell morphology and collagen synthesis by polymorphonuclear leukocytes","volume":"25","author":"Kay","year":"1984","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.08.003_bib18","first-page":"663","article-title":"Corneal endothelial modulation: a factor released by leukocytes induces basic fibroblast growth factor that\u00a0modulates cell shape and collagen","volume":"34","author":"Kay","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.08.003_bib19","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1167\/iovs.08-2606","article-title":"Interleukin-1\u03b2-induced disruption of barrier function in cultured human corneal epithelial cells","volume":"50","author":"Kimura","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.08.003_bib20","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1006\/excr.2000.5155","article-title":"Subcellular localization of procollagen I and prolyl 4-hydroxylase in corneal endothelial cells","volume":"264","author":"Ko","year":"2001","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.exer.2011.08.003_bib21","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1167\/iovs.05-0818","article-title":"Regulatory role of FGF-2 on type I collagen expression during endothelial mesenchymal transformation","volume":"46","author":"Ko","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.08.003_bib22","first-page":"624","article-title":"FGF-2 induced reorganization and disruption of actin cytoskeleton through PI 3-kinase, Rho, and Cdc42 in corneal endothelial cells","volume":"9","author":"Lee","year":"2003","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2011.08.003_bib23","doi-asserted-by":"crossref","first-page":"32325","DOI":"10.1074\/jbc.M405208200","article-title":"FGF-2 induced by interleukin-1\u03b2 through the action of phosphatidylinositol 3-kinase mediates endothelial mesenchymal transformation in corneal endothelial cells","volume":"279","author":"Lee","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2011.08.003_bib24","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1167\/iovs.05-1490","article-title":"Cross-talk among Rho GTPases acting downstream of PI 3-kinase induces mesenchymal transformation of corneal endothelial cells mediated by FGF-2","volume":"47","author":"Lee","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.08.003_bib25","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1167\/iovs.05-1223","article-title":"FGF-2-induced wound healing in corneal endothelial cells requires Cdc42 activation and Rho inactivation through the phosphatidylinositol 3-kinase pathway","volume":"47","author":"Lee","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.08.003_bib27","doi-asserted-by":"crossref","first-page":"6444","DOI":"10.1074\/jbc.M607808200","article-title":"Two populations of p27 use differential kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-kinase in response to fibroblast growth factor-2 stimulation","volume":"282","author":"Lee","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2011.08.003_bib28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1167\/iovs.07-0855","article-title":"Involvement of two distinct ubiquitin E3 ligase systems for p27 degradation in corneal endothelial cells","volume":"49","author":"Lee","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.08.003_bib29","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1167\/iovs.08-3135","article-title":"Common and distinct pathways for cellular activities in FGF-2 signaling induced by IL-1\u03b2 in corneal endothelial cells","volume":"50","author":"Lee","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.08.003_bib30","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1167\/iovs.10-6140","article-title":"PI 3-kinase\/Rac1 and ERK1\/2 regulate FGF-2-mediated cell proliferation through phosphorylation of p27 at Ser10 by KIS andThr187 by Cdc25A\/Cdk2","volume":"52","author":"Lee","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.08.003_bib31","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/nm761","article-title":"PKB\/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest","volume":"8","author":"Liang","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.exer.2011.08.003_bib32","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1128\/MCB.00329-08","article-title":"USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1","volume":"29","author":"Lu","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.exer.2011.08.003_bib33","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1242\/jcs.011080","article-title":"Unconventional secretion: an extracellular trap for export of fibroblast growth factor 2","volume":"120","author":"Nickel","year":"2007","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.exer.2011.08.003_bib34","doi-asserted-by":"crossref","first-page":"3005.1","DOI":"10.1186\/gb-2001-2-3-reviews3005","article-title":"Fibroblast growth factors","volume":"2","author":"Ornitz","year":"2001","journal-title":"Genome Biol."},{"key":"10.1016\/j.exer.2011.08.003_bib35","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1126\/science.7624798","article-title":"Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27","volume":"269","author":"Pagano","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.exer.2011.08.003_bib36","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1073\/pnas.86.6.1836","article-title":"High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons","volume":"86","author":"Prats","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2011.08.003_bib37","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/ICU.0b013e3281a4775b","article-title":"Descemet\u2019s stripping endothelial keratoplasty","volume":"18","author":"Price","year":"2007","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.exer.2011.08.003_bib38","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1101\/gad.13.12.1501","article-title":"CDK inhibitors: positive and negative regulators of G1-phase progression","volume":"13","author":"Sherr","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.exer.2011.08.003_bib39","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1167\/iovs.09-4240","article-title":"Induction of FGF-2 synthesis by IL-1\u03b2 in aqueous humor through PI 3-kinase p38 in rabbit corneal endothelium","volume":"51","author":"Song","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.08.003_bib40","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nrc2780","article-title":"Fibroblast growth factor signalling: from development to cancer","volume":"10","author":"Turner","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.exer.2011.08.003_bib41","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1001\/archopht.1982.01030030124015","article-title":"Posterior collagenous layer of the cornea. Ultrastructural classification of abnormal collagenous tissue posterior to Descemet\u2019s membrane in 30 cases","volume":"100","author":"Waring","year":"1982","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2011.08.003_bib42","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1442-9071.2009.02050.x","article-title":"Case of post Descemet stripping endothelial keratoplasty retrocorneal fibrous membrane","volume":"37","author":"Young","year":"2009","journal-title":"Clin. Experiment. Ophthalmol."},{"key":"10.1016\/j.exer.2011.08.003_bib43","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1167\/iovs.03-1238","article-title":"Involvement of p27Kip1 in the proliferation of the developing corneal endothelium","volume":"45","author":"Yoshida","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483511002326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483511002326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T18:50:44Z","timestamp":1543603844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483511002326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0014483511002326"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2011.08.003","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}