{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:43:48Z","timestamp":1791517428259,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.exer.2011.09.024","type":"journal-article","created":{"date-parts":[[2011,10,14]],"date-time":"2011-10-14T20:57:21Z","timestamp":1318625841000},"page":"873-879","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Periocular injection of in situ hydrogels containing Leu\u2013Ile, an inducer for neurotrophic factors, promotes retinal ganglion cell survival after optic nerve injury"],"prefix":"10.1016","volume":"93","author":[{"given":"Masayoshi","family":"Nakatani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Shinohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Takii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisato","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuharu","family":"Asai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Furukawa-Hibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsumi","family":"Nitta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2011.09.024_bib1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bbr.2010.02.028","article-title":"Oral supplementation with Leu\u2013Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase","volume":"210","author":"Alkam","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.exer.2011.09.024_bib2","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1167\/iovs.09-3903","article-title":"Valproic acid-mediated neuroprotection and regeneration in injured retinal ganglion cells","volume":"51","author":"Biermann","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.09.024_bib3","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1523\/JNEUROSCI.5010-05.2006","article-title":"An analog of a dipeptide-like structure of FK506 increases glial cell line-derived neurotrophic factor expression through cAMP response element-binding protein activated by heat shock protein 90\/Akt signaling pathway","volume":"26","author":"Cen","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.exer.2011.09.024_bib4","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1167\/iovs.01-0886","article-title":"Activation of MAPK and CREB by GM1 induces survival of RGCs in the retina with axotomized nerve","volume":"44","author":"Choi","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.09.024_bib5","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.drudis.2010.02.007","article-title":"Strategies for optic nerve rescue and regeneration in glaucoma and other optic neuropathies","volume":"15","author":"Dahlmann-Noor","year":"2010","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.exer.2011.09.024_bib6","first-page":"2952","article-title":"Constitutive and inducible heat shock protein 70 immunoreactivity in the normal rat eye","volume":"40","author":"Dean","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.09.024_bib7","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1007\/s11095-006-9104-4","article-title":"A\u00a0review of poloxamer 407 pharmaceutical and pharmacological characteristics","volume":"23","author":"Dumortier","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.exer.2011.09.024_bib8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00401-008-0440-9","article-title":"Axonal protection by brain-derived neurotrophic factor associated with CREB phosphorylation in tumor necrosis factor-alpha-induced optic nerve degeneration","volume":"117","author":"Fujino","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.exer.2011.09.024_bib9","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbr.2011.02.003","article-title":"The hydrophobic dipeptide Leu\u2013Ile inhibits immobility induced by repeated forced swimming via the induction of BDNF","volume":"220","author":"Furukawa-Hibi","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.exer.2011.09.024_bib10","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1128\/MCB.26.7.2746-2757.2006","article-title":"GDNF family ligands trigger indirect neuroprotective signaling in retinal glial cells","volume":"26","author":"Hauck","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.exer.2011.09.024_bib11","first-page":"1783","article-title":"Intravitreal injections of GDNF-loaded biodegradable microspheres are neuroprotective in a rat model of glaucoma","volume":"13","author":"Jiang","year":"2007","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2011.09.024_bib12","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/IJG.0b013e3181752c6f","article-title":"Neuroprotective effect of nipradilol [3,4-dihydro-8-(2-hydroxy-3-isopropylamino)-propoxy-3-nitroxy-2H-1-benzopyran] in a rat model of optic nerve degeneration","volume":"18","author":"Karim","year":"2009","journal-title":"J.\u00a0Glaucoma"},{"key":"10.1016\/j.exer.2011.09.024_bib13","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/S0042-6989(97)00364-7","article-title":"Effects of GDNF on retinal ganglion cell survival following axotomy","volume":"38","author":"Koeberle","year":"1998","journal-title":"Vision Res."},{"key":"10.1016\/j.exer.2011.09.024_bib14","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0306-4522(01)00557-7","article-title":"Neurturin enhances the survival of axotomized retinal ganglion cells in\u00a0vivo: combined effects with glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor","volume":"110","author":"Koeberle","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.exer.2011.09.024_bib15","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.exer.2009.08.014","article-title":"Delayed administration of glial cell line-derived neurotrophic factor (GDNF) protects retinal ganglion\u00a0cells in a pig model of acute retinal ischemia","volume":"89","author":"Kyhn","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2011.09.024_bib16","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1021\/bm0496965","article-title":"In situ gelling of alginate\/pluronic solutions for ophthalmic delivery of pilocarpine","volume":"5","author":"Lin","year":"2004","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.exer.2011.09.024_bib17","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1167\/iovs.03-0365","article-title":"A\u00a0novel neuroprotectant against retinal ganglion cell damage in a glaucoma model and an optic nerve crush model in the rat","volume":"45","author":"Maeda","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.09.024_bib18","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1167\/iovs.02-1332","article-title":"Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model","volume":"44","author":"Martin","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.09.024_bib19","first-page":"3319","article-title":"Brain-derived neurotrophic factor prevents axotomized retinal ganglion cell death through MAPK and PI3K signaling pathways","volume":"43","author":"Nakazawa","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.09.024_bib20","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/jnr.20258","article-title":"Hydrophobic dipeptide Leu\u2013Ile protects against neuronal death by inducing brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis","volume":"78","author":"Nitta","year":"2004","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.exer.2011.09.024_bib21","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.biopsych.2006.06.016","article-title":"An inducer for glial cell line-derived neurotrophic factor and tumor necrosis factor-alpha protects against methamphetamine-induced rewarding effects and sensitization","volume":"61","author":"Niwa","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.exer.2011.09.024_bib22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.exer.2009.02.015","article-title":"Effects of different neurotrophic factors on the survival of retinal ganglion cells after a complete intraorbital nerve crush injury: a quantitative in\u00a0vivo study","volume":"15","author":"Parrilla-Reverter","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2011.09.024_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1089\/jop.2009.0059","article-title":"Sustained subconjunctival protein delivery using a thermosetting gel delivery system","volume":"26","author":"Rieke","year":"2010","journal-title":"J.\u00a0Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.exer.2011.09.024_bib24","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1046\/j.1460-9568.2002.01893.x","article-title":"Dose-dependent rescue of axotomized rat retinal ganglion cells by adenovirus-mediated expression of glial cell-line derived neurotrophic factor in\u00a0vivo","volume":"15","author":"Schmeer","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.exer.2011.09.024_bib25","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1096\/fj.05-4024fje","article-title":"Mechanisms of cell death and neuroprotection by poloxamer 188 after mechanical trauma","volume":"20","author":"Serbest","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.exer.2011.09.024_bib26","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.exer.2008.06.004","article-title":"Neuroprotective effects of recombinant human granulocyte colony-stimulating factor (G-CSF) in neurodegeneration after optic nerve crush in rats","volume":"87","author":"Tsai","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2011.09.024_bib27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1600-0420.2007.01001.x","article-title":"Peribulbar poloxamer for ocular drug delivery","volume":"86","author":"Vehanen","year":"2007","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.exer.2011.09.024_bib28","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1167\/iovs.09-3740","article-title":"Combined application of BDNF to the eye and brain enhances ganglion cell survival and function in the cat after optic nerve injury","volume":"51","author":"Weber","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.09.024_bib29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0168-3659(02)00271-7","article-title":"Pluronic F127 gel formulations of deslorelin and GnRH reduce drug degradation and sustain drug release and effect in cattle","volume":"85","author":"Wenzel","year":"2002","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.exer.2011.09.024_bib30","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/(SICI)1097-4695(19990215)38:3<382::AID-NEU7>3.0.CO;2-5","article-title":"Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of axotomized retinal ganglion cells in adult rats: comparison to and combination with brain-derived neurotrophic factor (BDNF)","volume":"38","author":"Yan","year":"1999","journal-title":"J.\u00a0Neurobiol."},{"key":"10.1016\/j.exer.2011.09.024_bib31","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.bbrc.2006.03.231","article-title":"Effects of bone marrow stromal cell injection in an experimental glaucoma model","volume":"344","author":"Yu","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483511002867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483511002867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:54:38Z","timestamp":1757998478000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483511002867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0014483511002867"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2011.09.024","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Periocular injection of in situ hydrogels containing Leu\u2013Ile, an inducer for neurotrophic factors, promotes retinal ganglion cell survival after optic nerve injury","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2011.09.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}