{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:19:04Z","timestamp":1791051544674,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30801265"],"award-info":[{"award-number":["30801265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2011CB510200"],"award-info":[{"award-number":["2011CB510200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.exer.2011.10.013","type":"journal-article","created":{"date-parts":[[2011,11,5]],"date-time":"2011-11-05T18:29:39Z","timestamp":1320517779000},"page":"921-926","source":"Crossref","is-referenced-by-count":27,"title":["Expression of pro- and anti-angiogenic isoforms of VEGF in the mouse model of oxygen-induced retinopathy"],"prefix":"10.1016","volume":"93","author":[{"given":"Min","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wankun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2011.10.013_bib1","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1095\/biolreprod.109.078097","article-title":"Neutralization of vascular endothelial growth factor antiangiogenic isoforms is more effective than treatment with proangiogenic isoforms in stimulating vascular development and follicle progression in the perinatal rat ovary","volume":"81","author":"Artac","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.exer.2011.10.013_bib2","first-page":"4123","article-title":"VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma","volume":"62","author":"Bates","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.exer.2011.10.013_bib3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35025220","article-title":"Angiogenesis in cancer and other diseases","volume":"407","author":"Carmeliet","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.exer.2011.10.013_bib4","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1007\/s00018-006-6254-9","article-title":"A\u00a0VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2","volume":"63","author":"Cebe Suarez","year":"2006","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.exer.2011.10.013_bib5","first-page":"1517","article-title":"Levels of vascular endothelial growth factor-A165b (VEGF-A165b) are elevated in experimental glaucoma","volume":"14","author":"Ergorul","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2011.10.013_bib6","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ajo.2011.01.040","article-title":"Levels of VEGF but not VEGF165b are increased in the vitreous of patients with retinal vein occlusion","volume":"152","author":"Ehlken","year":"2011","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2011.10.013_bib7","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nrc2505","article-title":"VEGF-A splicing: the key to anti-angiogenic therapeutics?","volume":"8","author":"Harper","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.exer.2011.10.013_bib8","first-page":"2115","article-title":"Constitutive expression of VEGF, VEGFR-1, and VEGFR-2 in normal eyes","volume":"40","author":"Kim","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.10.013_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1096\/fasebj.13.1.9","article-title":"Vascular endothelial growth factor (VEGF) and its receptors","volume":"13","author":"Neufeld","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.exer.2011.10.013_bib10","doi-asserted-by":"crossref","first-page":"5532","DOI":"10.1074\/jbc.M109.074930","article-title":"Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis","volume":"285","author":"Nowak","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2011.10.013_bib11","first-page":"182","article-title":"Hypoxia inducible factor-1alpha is increased in ischemic retina: temporal and spatial correlation with VEGF expression","volume":"40","author":"Ozaki","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.10.013_bib12","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1007\/s00125-005-1951-8","article-title":"Diabetic retinopathy is associated with a switch in splicing from anti- to pro-angiogenic isoforms of vascular endothelial growth factor","volume":"48","author":"Perrin","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.exer.2011.10.013_bib13","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1096\/fj.07-9718com","article-title":"Mammary alveolar development during lactation is inhibited by the endogenous anti-angiogenic growth factor isoform, VEGF165b","volume":"22","author":"Qiu","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.exer.2011.10.013_bib14","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1038\/sj.bjc.6604309","article-title":"The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice","volume":"98","author":"Rennel","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.exer.2011.10.013_bib15","first-page":"1","article-title":"Antiangiogenic isoforms of vascular endothelial growth factor predominate in subretinal fluid of patients with rhegmatogenous retinal detachment and proliferative vitreoretinopathy","author":"Ricker","year":"2011","journal-title":"Retina"},{"key":"10.1016\/j.exer.2011.10.013_bib16","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/359843a0","article-title":"Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis","volume":"359","author":"Shweiki","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.exer.2011.10.013_bib17","first-page":"101","article-title":"Oxygen-induced retinopathy in the mouse","volume":"35","author":"Smith","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2011.10.013_bib18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9394(42)92088-9","article-title":"Extreme prematurity and fibroblastic overgrowth of persistent vascular sheath behind each crystalline lens. I. Preliminary report","volume":"25","author":"Terry","year":"1942","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2011.10.013_bib19","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/sj.bjc.6604308","article-title":"VEGF165b, an anti-angiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and anti-angiogenic VEGF-A isoforms has implications for therapy","volume":"98","author":"Varey","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.exer.2011.10.013_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1350-9462(02)00043-5","article-title":"Vascular endothelial growth factors and angiogenesis in eye disease","volume":"22","author":"Witmer","year":"2003","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2011.10.013_bib21","doi-asserted-by":"crossref","first-page":"7822","DOI":"10.1158\/0008-5472.CAN-04-0934","article-title":"VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in\u00a0vivo effect on angiogenesis and endogenous protein expression","volume":"64","author":"Woolard","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.exer.2011.10.013_bib22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.gene.2011.06.024","article-title":"The evolution of alternative splicing exons in vascular endothelial growth factor A","volume":"487","author":"Xu","year":"2011","journal-title":"Gene"},{"key":"10.1016\/j.exer.2011.10.013_bib23","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/35025215","article-title":"Vascular-specific growth factors and blood vessel formation","volume":"407","author":"Yancopoulos","year":"2000","journal-title":"Nature"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483511003290?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483511003290?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:57:32Z","timestamp":1588813052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483511003290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0014483511003290"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2011.10.013","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}