{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:53:35Z","timestamp":1773867215950,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.exer.2012.03.008","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T23:47:39Z","timestamp":1332373659000},"page":"28-36","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Activation of neural progenitor cells in human eyes with proliferative vitreoretinopathy"],"prefix":"10.1016","volume":"98","author":[{"given":"Erik O.","family":"Johnsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca C.","family":"Fr\u00f8en","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9ka","family":"Albert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente K.","family":"Omdal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Sarang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Berta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f8rn","family":"Nicolaissen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goran","family":"Petrovski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten C.","family":"Moe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2012.03.008_bib1","doi-asserted-by":"crossref","first-page":"12846","DOI":"10.1073\/pnas.97.23.12846","article-title":"Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas","volume":"97","author":"Aboody","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.exer.2012.03.008_bib2","first-page":"1293","article-title":"Pax-6, Prox 1, and Chx10 homeobox gene expression correlates with phenotypic fate of retinal precursor cells","volume":"38","author":"Belecky-Adams","year":"1997","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2012.03.008_bib3","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.exer.2009.04.005","article-title":"Distribution of Muller stem cells within the neural retina: evidence for the existence of a ciliary margin-like zone in the adult human eye","volume":"89","author":"Bhatia","year":"2009","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.exer.2012.03.008_bib4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2174\/1874364101004010030","article-title":"Adult retinal stem cells revisited","volume":"4","author":"Bhatia","year":"2010","journal-title":"The Open Ophthalmology Journal"},{"key":"10.1016\/j.exer.2012.03.008_bib5","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.exer.2011.09.015","article-title":"Differences between the neurogenic and proliferative abilities of Muller glia with stem cell characteristics and the ciliary epithelium from the adult human eye","volume":"93","author":"Bhatia","year":"2011","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.exer.2012.03.008_bib6","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1006\/exer.2002.2031","article-title":"A\u00a0mouse model of proliferative vitreoretinopathy induced by dispase","volume":"75","author":"Canto Soler","year":"2002","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.exer.2012.03.008_bib7","doi-asserted-by":"crossref","first-page":"6685","DOI":"10.1073\/pnas.0901596106","article-title":"Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells","volume":"106","author":"Cicero","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.exer.2012.03.008_bib8","doi-asserted-by":"crossref","first-page":"15772","DOI":"10.1073\/pnas.0401596101","article-title":"Facile isolation and the characterization of human retinal stem cells","volume":"101","author":"Coles","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.exer.2012.03.008_bib9","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1126\/science.1136281","article-title":"Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension","volume":"315","author":"Curtis","year":"2007","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.exer.2012.03.008_bib10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ydbio.2006.07.029","article-title":"Neural stem cell properties of Muller glia in the mammalian retina: regulation by Notch and Wnt signaling","volume":"299","author":"Das","year":"2006","journal-title":"Developmental Biology"},{"key":"10.1016\/j.exer.2012.03.008_bib11","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ydbio.2009.06.023","article-title":"Pax6 dosage requirements in iris and ciliary body differentiation","volume":"333","author":"Davis","year":"2009","journal-title":"Developmental Biology"},{"key":"10.1016\/j.exer.2012.03.008_bib12","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.lfs.2010.02.012","article-title":"ABCG2: a potential marker of stem cells and novel target in stem cell and cancer therapy","volume":"86","author":"Ding","year":"2010","journal-title":"Life Sciences"},{"key":"10.1016\/j.exer.2012.03.008_bib13","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)80783-7","article-title":"Subventricular zone astrocytes are neural stem cells in the adult mammalian brain","volume":"97","author":"Doetsch","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.exer.2012.03.008_bib14","article-title":"Proliferation of the ciliary epithelium with retinal neuronal and photoreceptor cell differentiation in human eyes with retinal detachment and proliferative vitreoretinopathy","author":"Ducournau","year":"2011","journal-title":"Graefe's Archive for Clinical and Experimental Ophthalmology"},{"key":"10.1016\/j.exer.2012.03.008_bib15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1006\/dbio.2000.9640","article-title":"Identification of a proliferating marginal zone of retinal progenitors in postnatal chickens","volume":"220","author":"Fischer","year":"2000","journal-title":"Developmental Biology"},{"key":"10.1016\/j.exer.2012.03.008_bib16","first-page":"3256","article-title":"Immunocytochemical characterization of cysts in the peripheral retina and pars plana of the adult primate","volume":"42","author":"Fischer","year":"2001","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2012.03.008_bib17","first-page":"2157","article-title":"A\u00a0new model of proliferative vitreoretinopathy","volume":"39","author":"Frenzel","year":"1998","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2012.03.008_bib18","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1083\/jcb.131.2.453","article-title":"Rapid, widespread, and longlasting induction of nestin contributes to the generation of glial scar tissue after CNS injury","volume":"131","author":"Frisen","year":"1995","journal-title":"The Journal of Cell Biology"},{"key":"10.1016\/j.exer.2012.03.008_bib19","doi-asserted-by":"crossref","first-page":"e635","DOI":"10.1111\/j.1755-3768.2011.02198.x","article-title":"Pigment epithelial cells isolated from human peripheral iridectomies have limited properties of retinal stem cells","volume":"89","author":"Froen","year":"2011","journal-title":"Acta Ophthalmologica"},{"key":"10.1016\/j.exer.2012.03.008_bib20","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1126\/science.287.5457.1433","article-title":"Mammalian neural stem cells","volume":"287","author":"Gage","year":"2000","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.exer.2012.03.008_bib21","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/stem.579","article-title":"Adult human Muller glia cells are a highly efficient source of rod photoreceptors","volume":"29","author":"Giannelli","year":"2011","journal-title":"Stem Cells (Dayton, Ohio)"},{"key":"10.1016\/j.exer.2012.03.008_bib22","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1002\/stem.423","article-title":"Adult ciliary epithelial cells, previously identified as retinal stem cells with potential for retinal repair, fail to differentiate into new rod photoreceptors","volume":"28","author":"Gualdoni","year":"2010","journal-title":"Stem Cells (Dayton, Ohio)"},{"key":"10.1016\/j.exer.2012.03.008_bib23","doi-asserted-by":"crossref","first-page":"18117","DOI":"10.1073\/pnas.0408258102","article-title":"Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha\/CXC chemokine receptor 4 pathway","volume":"101","author":"Imitola","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.exer.2012.03.008_bib24","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/stem.279","article-title":"Maximizing functional photoreceptor differentiation from adult human retinal stem cells","volume":"28","author":"Inoue","year":"2010","journal-title":"Stem Cells (Dayton, Ohio)"},{"key":"10.1016\/j.exer.2012.03.008_bib25","doi-asserted-by":"crossref","first-page":"19508","DOI":"10.1073\/pnas.0807453105","article-title":"Stimulation of neural regeneration in the mouse retina","volume":"105","author":"Karl","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.exer.2012.03.008_bib26","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1167\/iovs.04-0511","article-title":"Multipotent retinal progenitors express developmental markers, differentiate into retinal neurons, and preserve light-mediated behavior","volume":"45","author":"Klassen","year":"2004","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2012.03.008_bib27","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.brainres.2006.03.093","article-title":"Sphere formation of ocular epithelial cells in the ciliary body is a reprogramming system for neural differentiation","volume":"1093","author":"Kohno","year":"2006","journal-title":"Brain Research"},{"key":"10.1016\/j.exer.2012.03.008_bib28","doi-asserted-by":"crossref","first-page":"e8763","DOI":"10.1371\/journal.pone.0008763","article-title":"Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells","volume":"5","author":"Lamba","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2012.03.008_bib29","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1634\/stemcells.2006-0724","article-title":"MIO-M1 cells and similar muller glial cell lines derived from adult human retina exhibit neural stem cell characteristics","volume":"25","author":"Lawrence","year":"2007","journal-title":"Stem Cells (Dayton, Ohio)"},{"key":"10.1016\/j.exer.2012.03.008_bib30","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0092-8674(90)90662-X","article-title":"CNS stem cells express a new class of intermediate filament protein","volume":"60","author":"Lendahl","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.exer.2012.03.008_bib31","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0896-6273(94)90354-9","article-title":"Developmental expression of a novel murine homeobox gene (Chx10): evidence for roles in determination of the neuroretina and inner nuclear layer","volume":"13","author":"Liu","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.exer.2012.03.008_bib32","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1634\/stemcells.2007-0867","article-title":"Enumeration of neural stem and progenitor cells in the neural colony-forming cell assay","volume":"26","author":"Louis","year":"2008","journal-title":"Stem Cells (Dayton, Ohio)"},{"key":"10.1016\/j.exer.2012.03.008_bib33","doi-asserted-by":"crossref","first-page":"21721","DOI":"10.1074\/jbc.M301708200","article-title":"OTX2 activates the molecular network underlying retina pigment epithelium differentiation","volume":"278","author":"Martinez-Morales","year":"2003","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.exer.2012.03.008_bib34","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/cne.21860","article-title":"Gradual morphogenesis of retinal neurons in the peripheral retinal margin of adult monkeys and humans","volume":"511","author":"Martinez-Navarrete","year":"2008","journal-title":"The Journal of Comparative Neurology"},{"key":"10.1016\/j.exer.2012.03.008_bib35","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1093\/brain\/awh574","article-title":"Multipotent progenitor cells from the adult human brain: neurophysiological differentiation to mature neurons","volume":"128","author":"Moe","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.exer.2012.03.008_bib36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.exer.2008.09.020","article-title":"A\u00a0comparison of epithelial and neural properties in progenitor cells derived from the adult human ciliary body and brain","volume":"88","author":"Moe","year":"2009","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.exer.2012.03.008_bib37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0925-4773(97)00188-3","article-title":"Mutations in microphthalmia, the mouse homolog of the human deafness gene MITF, affect neuroepithelial and neural crest-derived melanocytes differently","volume":"70","author":"Nakayama","year":"1998","journal-title":"Mechanisms of Development"},{"key":"10.1016\/j.exer.2012.03.008_bib38","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/nn1155","article-title":"Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development","volume":"6","author":"Nishida","year":"2003","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.exer.2012.03.008_bib39","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1167\/iovs.07-1008","article-title":"Identification of photoreceptor precursors in the pars plana during ocular development and after retinal injury","volume":"49","author":"Nishiguchi","year":"2008","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2012.03.008_bib40","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1001\/archopht.1967.00980020771010","article-title":"Peripheral cystoid degeneration of the retina. Incidence and distribution in 1,000 autopsy eyes","volume":"77","author":"O'Malley","year":"1967","journal-title":"Archives of Ophthalmology"},{"key":"10.1016\/j.exer.2012.03.008_bib41","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1227\/01.NEU.0000255461.91892.0D","article-title":"Transplantation of stem cells from the adult human brain to the adult rat brain","volume":"60","author":"Olstorn","year":"2007","journal-title":"Neurosurgery"},{"key":"10.1016\/j.exer.2012.03.008_bib42","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1227\/NEU.0b013e3181fd2c11","article-title":"Predifferentiated brain-derived adult human progenitor cells migrate toward ischemia after transplantation to the adult rat brain","volume":"68","author":"Olstorn","year":"2011","journal-title":"Neurosurgery"},{"key":"10.1016\/j.exer.2012.03.008_bib43","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/1521-1878(200008)22:8<685::AID-BIES1>3.0.CO;2-C","article-title":"Retinal stem cells in vertebrates","volume":"22","author":"Perron","year":"2000","journal-title":"Bioessays"},{"key":"10.1016\/j.exer.2012.03.008_bib44","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nn0502-392","article-title":"Neural stem cells: form and function","volume":"5","author":"Reh","year":"2002","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.exer.2012.03.008_bib45","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1126\/science.1553558","article-title":"Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system","volume":"255","author":"Reynolds","year":"1992","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.exer.2012.03.008_bib46","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ydbio.2004.03.039","article-title":"Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter","volume":"271","author":"Rowan","year":"2004","journal-title":"Developmental Biology"},{"key":"10.1016\/j.exer.2012.03.008_bib47","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9","article-title":"The Ki-67 protein: from the known and the unknown","volume":"182","author":"Scholzen","year":"2000","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.exer.2012.03.008_bib48","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nmeth926","article-title":"Defining the actual sensitivity and specificity of the neurosphere assay in stem cell biology","volume":"3","author":"Singec","year":"2006","journal-title":"Nature Methods"},{"key":"10.1016\/j.exer.2012.03.008_bib49","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1600-0420.2006.00840.x","article-title":"Regeneration of the epithelium in organ-cultured donor corneas with extended post-mortem time","volume":"85","author":"Slettedal","year":"2007","journal-title":"Acta Ophthalmologica Scandinavica"},{"key":"10.1016\/j.exer.2012.03.008_bib50","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1101\/gad.1407906","article-title":"SOX2 is a dose-dependent regulator of retinal neural progenitor competence","volume":"20","author":"Taranova","year":"2006","journal-title":"Genes and Development"},{"key":"10.1016\/j.exer.2012.03.008_bib51","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1126\/science.287.5460.2032","article-title":"Retinal stem cells in the adult mammalian eye","volume":"287","author":"Tropepe","year":"2000","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.exer.2012.03.008_bib52","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.febslet.2004.03.064","article-title":"Human limbal epithelium contains side population cells expressing the ATP-binding cassette transporter ABCG2","volume":"565","author":"Watanabe","year":"2004","journal-title":"FEBS Letters"},{"key":"10.1016\/j.exer.2012.03.008_bib53","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S0014-4827(03)00291-X","article-title":"Stem cells from the adult human brain develop into functional neurons in culture","volume":"289","author":"Westerlund","year":"2003","journal-title":"Experimental Cell Research"},{"key":"10.1016\/j.exer.2012.03.008_bib54","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1167\/iovs.06-1034","article-title":"Characteristics of progenitor cells derived from adult ciliary body in mouse, rat, and human eyes","volume":"48","author":"Xu","year":"2007","journal-title":"Investigative Ophthalmology & Visual Science"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483512000929?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483512000929?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T18:28:01Z","timestamp":1641407281000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483512000929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":54,"alternative-id":["S0014483512000929"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2012.03.008","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}