{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:36:21Z","timestamp":1770482181412,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.exer.2012.09.003","type":"journal-article","created":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T15:01:48Z","timestamp":1349708508000},"page":"43-52","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Everolimus improves experimental autoimmune uveoretinitis"],"prefix":"10.1016","volume":"105","author":[{"given":"M.","family":"Hennig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Wasmuth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Busch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Walscheid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Thanos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Heiligenhaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2012.09.003_bib1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jaut.2007.02.002","article-title":"Balancing autoaggressive and protective T cell responses","volume":"28","author":"Abbas","year":"2007","journal-title":"Journal of Autoimmunity"},{"key":"10.1016\/j.exer.2012.09.003_bib2","first-page":"395","article-title":"Rodent models of experimental autoimmune uveitis","volume":"102","author":"Agarwal","year":"2004","journal-title":"Methods in Molecular Medicine"},{"key":"10.1016\/j.exer.2012.09.003_bib3","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.4049\/jimmunol.162.5.2648","article-title":"Pregnancy ameliorates induction and expression of experimental autoimmune uveitis","volume":"162","author":"Agarwal","year":"1999","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.exer.2012.09.003_bib4","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nm1585","article-title":"T(H)17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27\/STAT1","volume":"13","author":"Amadi-Obi","year":"2007","journal-title":"Nature Medicine"},{"key":"10.1016\/j.exer.2012.09.003_bib5","first-page":"1264","article-title":"Inhibition of autoimmune uveitis by anti-CD4 antibody","volume":"31","author":"Atalla","year":"1990","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2012.09.003_bib6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2337\/diabetes.55.01.06.db05-0613","article-title":"Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance","volume":"55","author":"Battaglia","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.exer.2012.09.003_bib7","doi-asserted-by":"crossref","first-page":"8338","DOI":"10.4049\/jimmunol.177.12.8338","article-title":"Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients","volume":"177","author":"Battaglia","year":"2006","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.exer.2012.09.003_bib8","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1182\/blood-2004-10-3932","article-title":"Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells","volume":"105","author":"Battaglia","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.exer.2012.09.003_bib9","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1136\/ard.2006.068320","article-title":"Imbalance in distribution of functional autologous regulatory T cells in rheumatoid arthritis","volume":"66","author":"Behrens","year":"2007","journal-title":"Annals of the Rheumatic Diseases"},{"key":"10.1016\/j.exer.2012.09.003_bib10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0165-5728(93)90028-W","article-title":"Recruitment of antigen-nonspecific cells plays a pivotal role in the pathogenesis of a T cell-mediated organ-specific autoimmune disease, experimental autoimmune uveoretinitis","volume":"47","author":"Caspi","year":"1993","journal-title":"Journal of Neuroimmunology"},{"issue":"Suppl.","key":"10.1016\/j.exer.2012.09.003_bib11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3109\/02713689008999438","article-title":"The mouse as a model of experimental autoimmune uveoretinitis (EAU)","volume":"9","author":"Caspi","year":"1990","journal-title":"Current Eye Research"},{"key":"10.1016\/j.exer.2012.09.003_bib12","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.4049\/jimmunol.140.5.1490","article-title":"A\u00a0new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens","volume":"140","author":"Caspi","year":"1988","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.exer.2012.09.003_bib13","doi-asserted-by":"crossref","first-page":"928","DOI":"10.4049\/jimmunol.136.3.928","article-title":"T\u00a0cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat","volume":"136","author":"Caspi","year":"1986","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.exer.2012.09.003_bib14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0896-8411(90)90144-H","article-title":"Pathology of experimental autoimmune uveoretinitis in mice","volume":"3","author":"Chan","year":"1990","journal-title":"Journal of Autoimmunity"},{"key":"10.1016\/j.exer.2012.09.003_bib15","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.4049\/jimmunol.182.3.1247","article-title":"Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression","volume":"182","author":"Chauhan","year":"2009","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.exer.2012.09.003_bib16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S1083-8791(00)70062-0","article-title":"Graft-versus-host disease prevention by rapamycin: cellular mechanisms","volume":"6","author":"Chen","year":"2000","journal-title":"Biology of Blood and Marrow Transplantation"},{"issue":"8","key":"10.1016\/j.exer.2012.09.003_bib17","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1167\/iovs.08-1793","article-title":"Decreased frequency and diminished function of CD4+CD25 high regulatory T cells are associated with active uveitis in patients with Vogt-Koyanagi-Harada syndrome","volume":"49","author":"Chen","year":"2008","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2012.09.003_bib18","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1182\/blood-2005-07-3032","article-title":"Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells","volume":"107","author":"Coenen","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.exer.2012.09.003_bib19","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/sj.bmt.1705628","article-title":"Rapamycin, not cyclosporine, permits thymic generation and peripheral preservation of CD4+ CD25+ FoxP3+ T cells","volume":"39","author":"Coenen","year":"2007","journal-title":"Bone Marrow Transplantation"},{"key":"10.1016\/j.exer.2012.09.003_bib20","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1016\/S0041-1345(98)00590-9","article-title":"Effect of SDZ RAD on transplant arteriosclerosis in the rat aortic model","volume":"30","author":"Cole","year":"1998","journal-title":"Transplantation Proceedings"},{"issue":"Suppl.","key":"10.1016\/j.exer.2012.09.003_bib21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3109\/02713689008999424","article-title":"Comparison of clinical and experimental uveitis","volume":"9","author":"Forrester","year":"1990","journal-title":"Current Eye Research"},{"key":"10.1016\/j.exer.2012.09.003_bib22","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/S0041-1345(02)02763-X","article-title":"Influence of a novel rapamycin analogon SDZ RAD on endothelial tissue factor and adhesion molecule expression","volume":"34","author":"Haubitz","year":"2002","journal-title":"Transplantation Proceedings"},{"key":"10.1016\/j.exer.2012.09.003_bib23","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/00007890-200002270-00005","volume":"69","author":"Hausen","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.exer.2012.09.003_bib24","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/00007890-200001150-00015","article-title":"Combined immunosuppression with cyclosporine (neoral) and SDZ RAD in non-human primate lung transplantation: systematic pharmacokinetic-based trials to improve efficacy and tolerability","volume":"69","author":"Hausen","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.exer.2012.09.003_bib25","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1084\/jem.20071477","article-title":"The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells","volume":"205","author":"Haxhinasto","year":"2008","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/j.exer.2012.09.003_bib26","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0002-9394(00)00659-0","article-title":"Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel","volume":"130","author":"Jabs","year":"2000","journal-title":"American Journal of Ophthalmology"},{"key":"10.1016\/j.exer.2012.09.003_bib27","first-page":"3177","article-title":"Macrophages and dendritic cells in IRBP-induced experimental autoimmune uveoretinitis in B10RIII mice","volume":"40","author":"Jiang","year":"1999","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2012.09.003_bib28","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1189\/jlb.1207851","article-title":"De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in\u00a0vivo following systemic antigen administration accompanied by blockade of mTOR","volume":"83","author":"Kang","year":"2008","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.exer.2012.09.003_bib29","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1189\/jlb.0204114","article-title":"Inducible immune regulation following autoimmune disease in the immune-privileged eye","volume":"77","author":"Kitaichi","year":"2005","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.exer.2012.09.003_bib30","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1084\/jem.20071258","article-title":"Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category","volume":"205","author":"Luger","year":"2008","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/j.exer.2012.09.003_bib31","doi-asserted-by":"crossref","first-page":"14292","DOI":"10.1073\/pnas.1009234107","article-title":"Proinflammatory T helper type 17 cells are effective B-cell helpers","volume":"107","author":"Mitsdoerffer","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.exer.2012.09.003_bib32","first-page":"1","article-title":"Adoptive transfer of experimental autoimmune uveoretinitis in rats. Immunopathogenic mechanisms and histologic features","volume":"26","author":"Mochizuki","year":"1985","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"2","key":"10.1016\/j.exer.2012.09.003_bib33","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/bmt.2009.140","article-title":"Novel mechanism of rapamycin in GVHD: increase in interstitial regulatory T cells","volume":"45","author":"Palmer","year":"2010","journal-title":"Bone Marrow Transplantation"},{"key":"10.1016\/j.exer.2012.09.003_bib34","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev.iy.11.040193.001555","article-title":"T\u00a0cell-dependent B cell activation","volume":"11","author":"Parker","year":"1993","journal-title":"Annual Review of Immunology"},{"key":"10.1016\/j.exer.2012.09.003_bib35","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/02713689308999487","article-title":"Treatment of autoimmune uveoretinitis in the rat with rapamycin, an inhibitor of lymphocyte growth factor signal transduction","volume":"12","author":"Roberge","year":"1993","journal-title":"Current Eye Research"},{"key":"10.1016\/j.exer.2012.09.003_bib36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1432-2277.2009.00940.x","article-title":"Reduction of cyclosporine following the introduction of everolimus in maintenance heart transplant recipients: a pilot study","volume":"23","author":"Ross","year":"2010","journal-title":"Transplant International"},{"key":"10.1016\/j.exer.2012.09.003_bib37","doi-asserted-by":"crossref","first-page":"7797","DOI":"10.1073\/pnas.0800928105","article-title":"T\u00a0cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR","volume":"105","author":"Sauer","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.exer.2012.09.003_bib38","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/00007890-199707150-00008","article-title":"SDZ RAD, a new rapamycin derivative: pharmacological properties in\u00a0vitro and in\u00a0vivo","volume":"64","author":"Schuler","year":"1997","journal-title":"Transplantation"},{"key":"10.1016\/j.exer.2012.09.003_bib39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/00007890-199707150-00007","article-title":"SDZ RAD, a new rapamycin derivative: synergism with cyclosporine","volume":"64","author":"Schuurman","year":"1997","journal-title":"Transplantation"},{"key":"10.1016\/j.exer.2012.09.003_bib40","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1097\/00007890-200003150-00011","article-title":"Oral efficacy of the macrolide immunosuppressant SDZ RAD and of cyclosporine microemulsion in cynomolgus monkey kidney allotransplantation","volume":"69","author":"Schuurman","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.exer.2012.09.003_bib41","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1016\/S0041-1345(98)00589-2","article-title":"The macrolide SDZ RAD is efficacious in a nonhuman primate model of allotransplantation","volume":"30","author":"Schuurman","year":"1998","journal-title":"Transplantation Proceedings"},{"key":"10.1016\/j.exer.2012.09.003_bib42","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1167\/iovs.09-3514","article-title":"Contribution of CD4+CD25+ T cells to the regression phase of experimental autoimmune uveoretinitis","volume":"51","author":"Sun","year":"2010","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2012.09.003_bib43","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3109\/09273940903414525","article-title":"Increased regulatory T cells in spleen during experimental autoimmune uveoretinitis","volume":"18","author":"Sun","year":"2010","journal-title":"Ocular Immunology and Inflammation"},{"key":"10.1016\/j.exer.2012.09.003_bib44","doi-asserted-by":"crossref","first-page":"944","DOI":"10.4049\/jimmunol.177.2.944","article-title":"Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ T cells","volume":"177","author":"Valmori","year":"2006","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.exer.2012.09.003_bib45","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/02713688208998375","article-title":"Antibody determination by ELISA in rats with retinal S antigen-induced uveoretinitis","volume":"2","author":"Van Tuyen","year":"1982","journal-title":"Current Eye Research"},{"key":"10.1016\/j.exer.2012.09.003_bib46","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1084\/jem.20031579","article-title":"Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis","volume":"199","author":"Viglietta","year":"2004","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/j.exer.2012.09.003_bib47","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1097\/01.tp.0000246312.89689.17","article-title":"A\u00a0potential side effect of cyclosporin A: inhibition of CD4(+)CD25(+) regulatory T cells in mice","volume":"82","author":"Wang","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.exer.2012.09.003_bib48","doi-asserted-by":"crossref","first-page":"5228","DOI":"10.1167\/iovs.03-0312","article-title":"Topical treatment with antisense oligonucleotides targeting tumor necrosis factor-alpha in herpetic stromal keratitis","volume":"44","author":"Wasmuth","year":"2003","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2012.09.003_bib49","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/intimm\/dxm017","article-title":"PI3K\/AKT\/mTOR hypersignaling in autoimmune lymphoproliferative disease engendered by the epistatic interplay of Sle1b and FASlpr","volume":"19","author":"Xie","year":"2007","journal-title":"International Immunology"},{"key":"10.1016\/j.exer.2012.09.003_bib50","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/1521-4141(200001)30:1<272::AID-IMMU272>3.0.CO;2-X","article-title":"Transgenic expression of an immunologically privileged retinal antigen extraocularly enhances self tolerance and abrogates susceptibility to autoimmune uveitis","volume":"30","author":"Xu","year":"2000","journal-title":"European Journal of Immunology"},{"key":"10.1016\/j.exer.2012.09.003_bib51","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1182\/blood-2007-06-094482","article-title":"Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells","volume":"111","author":"Zeiser","year":"2008","journal-title":"Blood"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483512002746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483512002746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:21:21Z","timestamp":1687738881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483512002746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":51,"alternative-id":["S0014483512002746"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2012.09.003","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}