{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:25:32Z","timestamp":1788870332875,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["No. 30973252"],"award-info":[{"award-number":["No. 30973252"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.exer.2013.01.006","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T10:28:45Z","timestamp":1361269725000},"page":"22-30","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Retinoic acid suppresses the adhesion and migration of human retinal pigment epithelial cells"],"prefix":"10.1016","volume":"109","author":[{"given":"Ying-Hua","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Hirooka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Qin","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Bin","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Xue","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2013.01.006_bib1","first-page":"3239","article-title":"A\u00a0rapid in\u00a0vitro assay for quantitating the invasive potential of tumour cells","volume":"47","author":"Albini","year":"1987","journal-title":"Cancer Res."},{"key":"10.1016\/j.exer.2013.01.006_bib2","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0008-6363(00)00312-6","article-title":"All-trans retinoic acid regulates proliferation, migration, differentiation, and extracellular matrix turnover of human arterial smooth muscle cells","volume":"49","author":"Axel","year":"2001","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.exer.2013.01.006_bib3","first-page":"853","article-title":"TGF-b increases retinal endothelial cell permeability by increasing MMP-9: possible role of glial cells in endothelial barrier function","volume":"42","author":"Behzadian","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"22","key":"10.1016\/j.exer.2013.01.006_bib4","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1038\/emboj.2008.223","article-title":"Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration","volume":"27","author":"Blake","year":"2008","journal-title":"EMBO J."},{"issue":"6","key":"10.1016\/j.exer.2013.01.006_bib5","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0092-8674(00)81203-9","article-title":"Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease","volume":"93","author":"Casari","year":"1998","journal-title":"Cell."},{"key":"10.1016\/j.exer.2013.01.006_bib6","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.exer.2008.11.028","article-title":"All-trans retinoic acid remodels ECM and suppresses laminin-enhanced contractility of cultured human retinal pigment epithelial cells","volume":"88","author":"Chang","year":"2009","journal-title":"Exp. Eye Res."},{"issue":"48","key":"10.1016\/j.exer.2013.01.006_bib7","doi-asserted-by":"crossref","first-page":"29012","DOI":"10.1074\/jbc.270.48.29012","article-title":"Binding of tenascin-C to soluble fibronectin and matrix fibril","volume":"270","author":"Chung","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2013.01.006_bib8","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1001\/archopht.117.4.498","article-title":"Retinal neovascularization is suppressed with a MMP inhibitor","volume":"117","author":"Das","year":"1999","journal-title":"Arch. Ophthalmol."},{"issue":"7","key":"10.1016\/j.exer.2013.01.006_bib9","first-page":"1256","article-title":"Matrix metalloproteinases and their inhibitors in human vitreous","volume":"39","author":"De La Paz","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.01.006_bib10","first-page":"480","article-title":"Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment","volume":"6","author":"Denko","year":"2000","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.exer.2013.01.006_bib11","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/00006982-200602000-00015","article-title":"Prevention of experimental proliferative vitreoretinopathy with a biodegradable intravitreal drug delivery system of all-trans retinoic acid","volume":"26","author":"Dong","year":"2006","journal-title":"Retina"},{"key":"10.1016\/j.exer.2013.01.006_bib12","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3109\/02713689209000749","article-title":"Factors modulating the effect of retinoids on cultured retinal pigment epithelial cell proliferation","volume":"11","author":"Doyle","year":"1992","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2013.01.006_bib13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1023\/A:1012213604731","article-title":"Membrane-type matrix metalloproteinases (MT-MMPs): expression and function during glioma invasion","volume":"53","author":"Fillmore","year":"2001","journal-title":"J.\u00a0Neurooncol."},{"key":"10.1016\/j.exer.2013.01.006_bib14","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/labinvest.3700251","article-title":"Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood-retinal barrier","volume":"85","author":"Giebel","year":"2005","journal-title":"Lab. Invest."},{"key":"10.1016\/j.exer.2013.01.006_bib15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF00318703","article-title":"Local production of fibronectin by ectopic human retinal cells","volume":"267","author":"Hiscott","year":"1992","journal-title":"Cell. Tissue Res."},{"key":"10.1016\/j.exer.2013.01.006_bib16","first-page":"2210","article-title":"Studies of human uveal melanocytes in\u00a0vitro: isolation, purification and cultivation of human uveal melanocytes","volume":"34","author":"Hu","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.exer.2013.01.006_bib17","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell."},{"key":"10.1016\/j.exer.2013.01.006_bib18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.283.5398.83","article-title":"The transcriptional program in the response of human fibroblasts to serum","volume":"283","author":"Iyer","year":"1999","journal-title":"Science (Wash. DC)"},{"issue":"13","key":"10.1016\/j.exer.2013.01.006_bib19","first-page":"4324","article-title":"Promotion of adhesion and migration of RPE cells to provisional extracellular matrices by TNF-alpha","volume":"41","author":"Jin","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"15","key":"10.1016\/j.exer.2013.01.006_bib20","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1016\/j.biomaterials.2012.02.002","article-title":"The potential of laminin-2-biomimetic short peptide to promote cell adhesion, spreading and migration by inducing membrane recruitment and phosphorylation of PKC\u03b4","volume":"33","author":"Jung","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.exer.2013.01.006_bib21","first-page":"4225","article-title":"Correlation between expression of the matrix metalloproteinase-1 gene in ovarian cancers and an insertion\/deletion polymorphism in its promoter region","volume":"59","author":"Kanamori","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.exer.2013.01.006_bib22","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1076\/ceyr.17.5.483.5192","article-title":"Effects of retinoic acid and TGF-beta 1 on the proliferation and melanin synthesis in chick retinal pigment epithelial cells in\u00a0vitro","volume":"7","author":"Kishi","year":"1998","journal-title":"Curr. Eye Res."},{"issue":"28","key":"10.1016\/j.exer.2013.01.006_bib23","doi-asserted-by":"crossref","first-page":"25527","DOI":"10.1074\/jbc.M202494200","article-title":"Alternative splicing and promoter usage generates an intracellular stromelysin 3 isoform directly translated as an active matrix metalloproteinase","volume":"277","author":"Luo","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"issue":"5","key":"10.1016\/j.exer.2013.01.006_bib24","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.ceb.2011.08.005","article-title":"Mechanisms of integrin activation and trafficking","volume":"23","author":"Margadant","year":"2011","journal-title":"Curr. Opin. Cell. Biol."},{"key":"10.1016\/j.exer.2013.01.006_bib25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3835(99)00098-1","article-title":"Anti-metastatic activity of curcumin and catechin","volume":"14","author":"Menon","year":"1999","journal-title":"Cancer Lett."},{"key":"10.1016\/j.exer.2013.01.006_bib26","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/1097-0215(20000801)87:3<336::AID-IJC5>3.0.CO;2-3","article-title":"The a 3 b 1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity","volume":"87","author":"Morini","year":"2000","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.exer.2013.01.006_bib27","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1136\/bjo.74.7.393","article-title":"Variation in epiretinal membrane components with clinical duration of the proliferative tissue","volume":"74","author":"Morino","year":"1990","journal-title":"Br. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2013.01.006_bib28","first-page":"417","article-title":"Expression of the metalloproteinase matrilysin in DU-145 cells increases their invasive potential in severe combined immunodeficient mice","volume":"53","author":"Powell","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/j.exer.2013.01.006_bib29","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/73432","article-title":"Systematic variation in gene expression patterns in human cancer cell lines","volume":"24","author":"Ross","year":"2000","journal-title":"Nat. Genet."},{"issue":"10","key":"10.1016\/j.exer.2013.01.006_bib30","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1136\/bjo.84.10.1091","article-title":"Matrix metalloproteinases and their natural inhibitors in fibrovascular membranes of proliferative diabetic retinopathy","volume":"84","author":"Salzmann","year":"2000","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2013.01.006_bib31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0014-5793(98)01542-7","article-title":"A\u00a0matrix which prevents fibroblast-2 mediated collagen lattice contraction","volume":"441","author":"Scott","year":"1998","journal-title":"FEBS Lett."},{"issue":"4","key":"10.1016\/j.exer.2013.01.006_bib32","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/S0002-9440(10)62540-0","article-title":"Matrix metalloproteinases: a role in the contraction of vitreo-retinal scar tissue","volume":"159","author":"Sheridan","year":"2001","journal-title":"Am. J. Pathol."},{"issue":"8","key":"10.1016\/j.exer.2013.01.006_bib33","doi-asserted-by":"crossref","first-page":"s874","DOI":"10.2741\/1168","article-title":"CD36: a critical anti-angiogenic receptor","volume":"1","author":"Simantov","year":"2003","journal-title":"Front. Biosci."},{"issue":"2","key":"10.1016\/j.exer.2013.01.006_bib34","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1074\/jbc.M406968200","article-title":"Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2","volume":"280","author":"Solovjov","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2013.01.006_bib35","first-page":"4942","article-title":"Expression of matrix metalloproteinase genes in transformed rate cell lines of high and low metastatic potential","volume":"52","author":"Sreenath","year":"1992","journal-title":"Cancer Res."},{"issue":"1\u20132","key":"10.1016\/j.exer.2013.01.006_bib36","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1023\/A:1007141912654","article-title":"Expression of rennin\u2013angiotensin system and extracellular matrix genes in cardiovascular cells and its regulation through AT1 receptor","volume":"212","author":"Tamura","year":"2000","journal-title":"Mol. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.exer.2013.01.006_bib37","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3727\/105221611X13176664479322","article-title":"Role of TGF-\u03b2 and the tumor microenvironment during mammary tumorigenesis","volume":"15","author":"Taylor","year":"2011","journal-title":"Gene Expr."},{"key":"10.1016\/j.exer.2013.01.006_bib38","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0092-8674(91)90143-M","article-title":"Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role","volume":"66","author":"Uleminckx","year":"1991","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.exer.2013.01.006_bib39","doi-asserted-by":"crossref","first-page":"e23893","DOI":"10.1371\/journal.pone.0023893","article-title":"PS integrins and laminins: key regulators of cell migration during Drosophila embryogenesis","volume":"6","author":"Urbano","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.exer.2013.01.006_bib40","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ymeth.2005.08.001","article-title":"Cell migration and invasion assays","volume":"37","author":"Valster","year":"2005","journal-title":"Methods (San Diego, Calif.)"},{"issue":"12","key":"10.1016\/j.exer.2013.01.006_bib41","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.tcb.2011.09.006","article-title":"Extracellular matrix determinants of proteolytic and non-proteolytic cell migration","volume":"21","author":"Wolf","year":"2011","journal-title":"Trends Cell. Biol."},{"issue":"6","key":"10.1016\/j.exer.2013.01.006_bib42","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1083\/jcb.200212033","article-title":"Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin","volume":"161","author":"Wong","year":"2003","journal-title":"J.\u00a0Cell. Biol."},{"key":"10.1016\/j.exer.2013.01.006_bib43","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1089\/jop.2005.21.44","article-title":"Effects of retinoic acid on retinal pigment epithelium from excised membranes from proliferative vitreoretinopathy","volume":"21","author":"Wu","year":"2005","journal-title":"J.\u00a0Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.exer.2013.01.006_bib44","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1562\/2004-09-03-RA-302.1","article-title":"Phototoxicity of indocyanine green on human retinal pigment epithelium in\u00a0vitro and its reduction by lutein","volume":"81","author":"Wu","year":"2005","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.exer.2013.01.006_bib45","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1007\/s00417-009-1135-1","article-title":"Mechanical force enhances MMP-2 activation via p38 signaling pathway in human retinal pigment epithelial cells","volume":"247","author":"Xu","year":"2009","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"issue":"22","key":"10.1016\/j.exer.2013.01.006_bib46","doi-asserted-by":"crossref","first-page":"13055","DOI":"10.1074\/jbc.271.22.13055","article-title":"Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression","volume":"271","author":"Ye","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"issue":"2","key":"10.1016\/j.exer.2013.01.006_bib47","doi-asserted-by":"crossref","first-page":"e31802","DOI":"10.1371\/journal.pone.0031802","article-title":"Reelin is involved in transforming growth factor-\u03b21-induced cell migration in esophageal carcinoma cells","volume":"7","author":"Yuan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2013.01.006_bib48","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.exer.2006.07.020","article-title":"Antisense oligonucleotide targeting c-fos mRNA limits retinal pigment epithelial cell proliferation; a key step in the progression of proliferative vitreoretinopathy","volume":"83","author":"Zhang","year":"2006","journal-title":"Exp. Eye Res."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483513000146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483513000146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T11:21:44Z","timestamp":1539861704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483513000146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":48,"alternative-id":["S0014483513000146"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2013.01.006","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}