{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T03:49:13Z","timestamp":1788666553677,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000967","name":"The American Health Assistance Foundation","doi-asserted-by":"crossref","award":["G2008-010"],"award-info":[{"award-number":["G2008-010"]}],"id":[{"id":"10.13039\/100000967","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Joseph Alexander Foundation"},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["LSHM-CT-2005-018637"],"award-info":[{"award-number":["LSHM-CT-2005-018637"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.exer.2013.06.018","type":"journal-article","created":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T13:33:16Z","timestamp":1372426396000},"page":"47-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Functional and structural evaluation of lamotrigine treatment in rat models of acute and chronic ocular hypertension"],"prefix":"10.1016","volume":"115","author":[{"given":"Shai","family":"Sandalon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birte","family":"K\u00f6nnecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"Levkovitch-Verbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Simons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Hein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel B.","family":"S\u00e4ttler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"B\u00e4hr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Ofri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2013.06.018_bib1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cell.2004.11.049","article-title":"Cleavage of the plasma membrane Na+\/Ca2+ exchanger in excitotoxicity","volume":"120","author":"Bano","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.exer.2013.06.018_bib2","first-page":"1542","article-title":"Axonal protection achieved in a model of multiple sclerosis using lamotrigine","volume":"253","author":"Bechtold","year":"2006","journal-title":"J.\u00a0Neurol."},{"key":"10.1016\/j.exer.2013.06.018_bib3","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1002\/glia.20830","article-title":"Sodium channel activity modulates multiple functions in microglia","volume":"57","author":"Black","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.exer.2013.06.018_bib4","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/brain\/awq003","article-title":"Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1.5","volume":"133","author":"Black","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.exer.2013.06.018_bib5","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1167\/iovs.04-0731","article-title":"Effect of glatiramer acetate on primary and secondary degeneration of retinal ganglion cells in the rat","volume":"46","author":"Blair","year":"2005","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.06.018_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0896-6273(01)00265-3","article-title":"Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon","author":"Boiko","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.exer.2013.06.018_bib7","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1523\/JNEUROSCI.23-06-02306.2003","article-title":"Functional specialization of the axon initial segment by isoform-specific sodium channel targeting","author":"Boiko","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.exer.2013.06.018_bib8","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0014-4886(03)00117-1","article-title":"Lamotrigine and remacemide protect striatal neurons against in\u00a0vitro ischemia: an electrophysiological study","volume":"182","author":"Calabresi","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.exer.2013.06.018_bib9","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/glia.20112","article-title":"Sodium channels contribute to microglia\/macrophage activation and function in EAE and MS","volume":"49","author":"Craner","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.exer.2013.06.018_bib10","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1093\/brain\/awg153","article-title":"Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination","volume":"126","author":"Craner","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.exer.2013.06.018_bib11","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1161\/01.STR.28.11.2230","article-title":"Lamotrigine protects hippocampal CA1 neurons from ischemic damage after cardiac arrest","volume":"28","author":"Crumrine","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.exer.2013.06.018_bib12","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1017\/S0952523808080851","article-title":"Two types of cone bipolar cells express voltage-gated Na+ channels in the rat retina","author":"Cui","year":"2008","journal-title":"Vis. Neurosci."},{"key":"10.1016\/j.exer.2013.06.018_bib13","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3923\/ijp.2005.369.375","article-title":"Neuroprotection in acute ischemia and ischemia\/reperfusion in rat retina","volume":"1","author":"Guizzo","year":"2005","journal-title":"Int. J. Pharmacol."},{"key":"10.1016\/j.exer.2013.06.018_bib14","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1097\/IAE.0b013e31815ec2da","article-title":"Neuroprotective effects of oral lamotrigine administration on rabbit retinas after pars plana vitrectomy and silicone oil injection","volume":"28","author":"Guizzo","year":"2008","journal-title":"Retina"},{"key":"10.1016\/j.exer.2013.06.018_bib15","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1167\/iovs.05-0618","article-title":"Neuroprotection by sodium channel blockade with phenytoin in an experimental model of glaucoma","author":"Hains","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.06.018_bib16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0168-0102(98)00037-6","article-title":"Ca2+ regulation by the Na(+)\u2013Ca2+ exchanger in retinal horizontal cells depolarized by L-glutamate","volume":"31","author":"Hayashida","year":"1998","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.exer.2013.06.018_bib17","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/jnr.21906","article-title":"A\u00a0Na+\/Ca2+ exchanger isoform, NCX1, is involved in retinal cell death after N-methyl-D-aspartate injection and ischemia-reperfusion","volume":"87","author":"Inokuchi","year":"2009","journal-title":"J.\u00a0Neurosci. Res."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.exer.2013.06.018_bib18","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1463-5224.2007.00529.x","article-title":"Endothelin-1, nitric oxide, and glutamate in the normal and glaucomatous dog eye","volume":"10","author":"K\u00e4llberg","year":"2007","journal-title":"Vet. Ophthalmol."},{"key":"10.1016\/j.exer.2013.06.018_bib19","first-page":"1063","article-title":"Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia","volume":"39","author":"Lagr\u00e8ze","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.06.018_bib20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1203\/PDR.0b013e31806790d7","article-title":"Lamotrigine is neuroprotective in the energy deficiency model of MPTP intoxicated mice","volume":"62","author":"Lagrue","year":"2007","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.exer.2013.06.018_bib21","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/00061198-200210000-00005","article-title":"Measurement of amino acid levels in the vitreous humor of rats after chronic intraocular pressure elevation or optic nerve transection","volume":"11","author":"Levkovitch-Verbin","year":"2002","journal-title":"J.\u00a0Glaucoma"},{"key":"10.1016\/j.exer.2013.06.018_bib22","first-page":"402","article-title":"Translimbal laser photocoagulation to the trabecular meshwork as a model of glaucoma in rats","volume":"43","author":"Levkovitch-Verbin","year":"2002","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.06.018_bib23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neuroscience.2011.04.058","article-title":"Activation of voltage-gated Na+ and Ca2+ channels is required for glutamate release from retinal glial cells implicated in cell volume regulation","volume":"188","author":"Linnertz","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.exer.2013.06.018_bib24","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1167\/iovs.12-10109","article-title":"Morphology of astrocytes in a glaucomatous optic nerve","volume":"54","author":"Lye-Barthel","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.06.018_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exer.2012.09.002","article-title":"Lamotrigine monotherapy does not provide protection against the loss of optic nerve axons in a rat model of ocular hypertension","volume":"104","author":"Marina","year":"2012","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2013.06.018_bib26","first-page":"2163","article-title":"Voltage-gated sodium channel alpha-subunits Na(v)1.1, Na(v)1.2, and Na(v)1.6 in the distal mammalian retina","volume":"13","author":"Mojumder","year":"2007","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2013.06.018_bib27","doi-asserted-by":"crossref","first-page":"9960","DOI":"10.1523\/JNEUROSCI.2003-05.2005","article-title":"Na+-dependent sources of intra-axonal Ca2+ release in rat optic nerve during in\u00a0vitro chemical ischemia","volume":"25","author":"Nikolaeva","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.exer.2013.06.018_bib28","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1017\/S1461145707008012","article-title":"Neuroprotection by lamotrigine in a rat model of neonatal hypoxic-ischaemic encephalopathy","volume":"11","author":"Papazisis","year":"2008","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.exer.2013.06.018_bib29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00221-009-1896-0","article-title":"Differential expression of two glutamate transporters, GLAST and GLT-1, in an experimental rat model of glaucoma","volume":"197","author":"Park","year":"2009","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.exer.2013.06.018_bib30","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/exnr.2001.7681","article-title":"Neuroprotective effects of lamotrigine and remacemide on excitotoxicity induced by glutamate agonists in isolated chick retina","volume":"170","author":"Pisani","year":"2001","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.exer.2013.06.018_bib31","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/jnr.22314","article-title":"Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model","volume":"88","author":"Rosenbaum","year":"2010","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.exer.2013.06.018_bib32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10633-008-9141-x","article-title":"The effect of topical anesthesia on the rat electroretinogram","volume":"118","author":"Sandalon","year":"2009","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.exer.2013.06.018_bib33","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0006-8993(95)01048-1","article-title":"Neuroprotective effects of lamotrigine in global ischemia in gerbils. A histological, in\u00a0vivo microdialysis and behavioral study","author":"Shuaib","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.exer.2013.06.018_bib34","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1097\/00001756-200207020-00019","article-title":"Lamotrigine derivatives and riluzole inhibit INa, P in cortical neurons","volume":"13","author":"Spadoni","year":"2002","journal-title":"Neuroreport"},{"key":"10.1016\/j.exer.2013.06.018_bib35","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1136\/bjo.72.2.88","article-title":"Experimental posterior uveitis. II. Electroretinographic studies","volume":"72","author":"Stanford","year":"1988","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2013.06.018_bib36","first-page":"30","article-title":"Passive administration of antibody against retinal S-antigen induces electroretinographic supernormality","volume":"33","author":"Stanford","year":"1992","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.06.018_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jns.2005.03.031","article-title":"General mechanisms of axonal damage and its prevention","volume":"233","author":"Stys","year":"2005","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.exer.2013.06.018_bib38","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/sj.jcbfm.9600455","article-title":"Excitotoxic mechanisms of ischemic injury in myelinated white matter","volume":"27","author":"Tekk\u00f6k","year":"2007","journal-title":"J.\u00a0Cereb. Blood Flow Metab."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448351300167X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448351300167X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:58:43Z","timestamp":1715587123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448351300167X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":38,"alternative-id":["S001448351300167X"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2013.06.018","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional and structural evaluation of lamotrigine treatment in rat models of acute and chronic ocular hypertension","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2013.06.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}