{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:18:51Z","timestamp":1789773531168,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["HL086901"],"award-info":[{"award-number":["HL086901"]}]},{"name":"First String Research, Inc"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.exer.2013.07.001","type":"journal-article","created":{"date-parts":[[2013,7,20]],"date-time":"2013-07-20T01:00:24Z","timestamp":1374282024000},"page":"178-188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["A synthetic connexin 43 mimetic peptide augments corneal wound healing"],"prefix":"10.1016","volume":"115","author":[{"given":"Keith","family":"Moore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary J.","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Ghatnekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udai P.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Gourdie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay D.","family":"Potts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.exer.2013.07.001_bib1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1167\/iovs.11-8222","article-title":"Slug is upregulated during wound healing and regulates cellular phenotypes in corneal epithelial cells","volume":"53","author":"Aomatsu","year":"2012","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"10.1016\/j.exer.2013.07.001_bib2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1161\/hh0302.104471","article-title":"Increased association of ZO-1 with connexin43 during remodeling of cardiac gap junctions","volume":"90","author":"Barker","year":"2002","journal-title":"Circulation Research"},{"key":"10.1016\/j.exer.2013.07.001_bib3","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.addr.2009.07.013","article-title":"Electrohydrodynamics: a facile technique to fabricate drug delivery systems","volume":"61","author":"Chakraborty","year":"2009","journal-title":"Advanced Drug Delivery Reviews"},{"issue":"2","key":"10.1016\/j.exer.2013.07.001_bib4","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/brain\/awr338","article-title":"Connexin43 mimetic peptide reduces vascular leak and retinal ganglion cell death following retinal ischaemia","volume":"135","author":"Danesh-Meyer","year":"2012","journal-title":"Brain\u2013A Journal of Neurology"},{"key":"10.1016\/j.exer.2013.07.001_bib5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1442-9071.2010.02229.x","article-title":"Contemporary limbal stem cell transplantation\u2013a review","volume":"38","author":"Dua","year":"2010","journal-title":"Clinical Experimental Ophthalmology"},{"key":"10.1016\/j.exer.2013.07.001_bib6","first-page":"243","article-title":"Formation of the gap junction nexus: binding partners for connexins","volume":"96","author":"Duffy","year":"2002","journal-title":"Journal of Physiology"},{"key":"10.1016\/j.exer.2013.07.001_bib7","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.colsurfa.2010.11.038","article-title":"Electrohydrodynamic preparation of particles, capsules, and bubbles for biomedical engineering applications","volume":"382","author":"Enayati","year":"2011","journal-title":"Colloids and Surfaces A: Physiochemical and Engineering Aspects"},{"key":"10.1016\/j.exer.2013.07.001_bib8","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2147\/OPTH.S30935","article-title":"Quantitative evaluation of corneal epithelial injury caused by n-heptanol using a corneal resistance measuring device in vivo","volume":"6","author":"Fukuda","year":"2012","journal-title":"Clinical Ophthalmology"},{"issue":"2","key":"10.1016\/j.exer.2013.07.001_bib9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2217\/17460751.4.2.205","article-title":"Connexin43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding","volume":"4","author":"Ghatnekar","year":"2009","journal-title":"Regenerative Medicine"},{"issue":"3","key":"10.1016\/j.exer.2013.07.001_bib10","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1167\/iovs.11-8711","article-title":"Improved Corneal Wound Healing through Modulation of Gap Junction Communication Using Connexin43-Specific Antisense Oligodeoxynucleotides","volume":"53","author":"Grupcheva","year":"2012","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"10.1016\/j.exer.2013.07.001_bib11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbamem.2003.10.022","article-title":"Diversity in protein-protein interactions of connexins: emerging roles","volume":"1662","author":"Herve","year":"2004","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.exer.2013.07.001_bib12","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.1091\/mbc.E05-08-0737","article-title":"Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion","volume":"16","author":"Hunter","year":"2005","journal-title":"Molecular Biology of the Cell"},{"issue":"8","key":"10.1016\/j.exer.2013.07.001_bib17","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/term.429","article-title":"Transforming growth factor beta 3 regulates assembly of a nonfibrotic matrix in a 3D corneal model","volume":"5","author":"Karamichos","year":"2011","journal-title":"Journal of Tissue Engineering and Regenerative Medicine"},{"key":"10.1016\/j.exer.2013.07.001_bib14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/jcp.24126","article-title":"Activation of Smad-Mediated TGF-b Signaling Triggers Epithelial\u2013Mesenchymal Transitions in Murine Cloned Corneal Progenitor Cells","volume":"228","author":"Kawakita","year":"2012","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.exer.2013.07.001_bib15","doi-asserted-by":"crossref","first-page":"5146","DOI":"10.1038\/onc.2010.258","article-title":"AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-\u03b2-mediated ERK signaling","volume":"29","author":"Kong","year":"2010","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.exer.2013.07.001_bib52","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1083\/jcb.200601018","article-title":"The epithelial-mesenchymal transition: new insights in signaling, development and disease","volume":"172","author":"Lee","year":"2006","journal-title":"The Journal of Cell Biology"},{"key":"10.1016\/j.exer.2013.07.001_bib53","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.exer.2011.08.003","article-title":"Endothelial mesenchymal transformation mediated by IL-1b-induced FGF-2 in corneal endothelial cells","volume":"95","author":"Lee","year":"2012","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.exer.2013.07.001_bib18","first-page":"403","article-title":"Notch signaling promotes the corneal epithelium wound healing","volume":"18","author":"Lu","year":"2012","journal-title":"Molecular Vision"},{"key":"10.1016\/j.exer.2013.07.001_bib19","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1524-475X.2010.00648.x","article-title":"A role for notch signaling in corneal wound healing","volume":"19","author":"Ma","year":"2010","journal-title":"Wound Repair and Regeneration"},{"issue":"1","key":"10.1016\/j.exer.2013.07.001_bib20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1017\/S143192761201389X","article-title":"Characterization of polymeric microcapsules containing a low molecular weight peptide for controlled release","volume":"19","author":"Moore","year":"2013","journal-title":"Microscopy and Microanalysis"},{"issue":"5","key":"10.1016\/j.exer.2013.07.001_bib21","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/01.ico.0000151544.23360.17","article-title":"Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy","volume":"24","author":"Netto","year":"2005","journal-title":"Cornea"},{"issue":"1-2","key":"10.1016\/j.exer.2013.07.001_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/15419060802014164","article-title":"Connexin43 Mimetic Peptides Reduce Swelling, Astrogliosis, and Neuronal Cell Death after Spinal Cord Injury","volume":"15","author":"O'Carroll","year":"2008","journal-title":"Cell Communication and Adhesion"},{"key":"10.1016\/j.exer.2013.07.001_bib23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11030-005-1296-8","article-title":"Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3","volume":"9","author":"Ondeykal","year":"2005","journal-title":"Molecular Diversity"},{"key":"10.1016\/j.exer.2013.07.001_bib24","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1161\/CIRCRESAHA.110.235747","article-title":"A peptide mimetic of the connexin43 carboxyl terminus reduces gap junction remodeling and induced arrhythmia following ventricular injury","volume":"108","author":"O'Quinn","year":"2011","journal-title":"Circulation Research"},{"key":"10.1016\/j.exer.2013.07.001_bib25","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbamem.2003.10.021","article-title":"Gap junctions and connexin-mediated communication in the immune system","volume":"1662","author":"Oviedo-Orta","year":"2004","journal-title":"Biochimica et Biophysica Acta"},{"issue":"19","key":"10.1016\/j.exer.2013.07.001_bib26","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1242\/jcs.02552","article-title":"Epithelial-mesenchymal transition","volume":"118","author":"Radisky","year":"2005","journal-title":"Journal of Cell Science"},{"issue":"4","key":"10.1016\/j.exer.2013.07.001_bib27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.tibtech.2007.12.007","article-title":"Novel therapies for scar reduction and regenerative healing of skin wounds","volume":"26","author":"Rhett","year":"2008","journal-title":"Trends in Biotechnology"},{"key":"10.1016\/j.exer.2013.07.001_bib28","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1091\/mbc.E10-06-0548","article-title":"Connexin 43 connnexon to gap junction transition is regulated by zonula occludins-1","volume":"22","author":"Rhett","year":"2011","journal-title":"Molecular Biology of the Cell"},{"issue":"2","key":"10.1016\/j.exer.2013.07.001_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0032128","article-title":"Activation of JNK Signaling Mediates Connective Tissue Growth Factor Expression and Scar Formation in Corneal Wound Healing","volume":"7","author":"Shi","year":"2012","journal-title":"PLoS one"},{"key":"10.1016\/j.exer.2013.07.001_bib30","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1136\/bjo.2004.050591","article-title":"Transplantation of corneal endothelium with Descemet\u2019s membrane using a hyroxyethyl methacrylate polymer as a carrier","volume":"89","author":"Shimmura","year":"2005","journal-title":"British Journal of Ophthalmology"},{"key":"10.1016\/j.exer.2013.07.001_bib31","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.4049\/jimmunol.171.3.1401","article-title":"Inhibition of IFN-\u03b3-Inducible Protein-10 Abrogates Colitis in IL-10-\/- Mice","volume":"171","author":"Singh","year":"2003","journal-title":"Journal of Immunology"},{"issue":"5","key":"10.1016\/j.exer.2013.07.001_bib32","first-page":"1440","article-title":"The connexin43 carboxyl-terminal peptide ACT1 modulates the biological response to silicone implants","volume":"123","author":"Soder","year":"2009","journal-title":"Journal of the American Society of Plastic Surgeons"},{"key":"10.1016\/j.exer.2013.07.001_bib33","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0168-3659(97)00254-X","article-title":"Biological response to a synthetic cornea","volume":"53","author":"Trinkaus-Randall","year":"1998","journal-title":"Journal of Controlled Release"},{"key":"10.1016\/j.exer.2013.07.001_bib34","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.biomaterials.2008.10.044","article-title":"A three-dimensional model of vasculogenesis","volume":"30","author":"Valarmathi","year":"2009","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.exer.2013.07.001_bib35","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/j.bbamem.2011.06.011","article-title":"Non-channel functions of connexins in cell growth and cell death","volume":"1818","author":"Vinkin","year":"2011","journal-title":"Biochimica et Biophysica Acta"},{"issue":"5","key":"10.1016\/j.exer.2013.07.001_bib36","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1350-9462(01)00008-8","article-title":"The Corneal Wound Healing Response: Cytokine-mediated Interaction of the Epithelium, Stroma, and Inflammatory Cells","volume":"20","author":"Wilson","year":"2001","journal-title":"Progress in Retinal and Eye Research"},{"issue":"2","key":"10.1016\/j.exer.2013.07.001_bib37","doi-asserted-by":"crossref","first-page":"e30842","DOI":"10.1371\/journal.pone.0030842","article-title":"Role of Mesenchymal Stem Cells on Cornea Wound Healing Induced by Acute Alkali Burn","volume":"7","author":"Yao","year":"2012","journal-title":"PLoS one"},{"key":"10.1016\/j.exer.2013.07.001_bib38","first-page":"2894","article-title":"Differential expression of MT1-MMP (MMP-14) and collagenase III (MMP-13) genes in normal and wounded rat corneas","volume":"41","author":"Ye","year":"2000","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"10.1016\/j.exer.2013.07.001_bib39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/exer.2000.0926","article-title":"Kinetics of keratocyte proliferation in response to epithelial debridement","volume":"72","author":"Zieske","year":"2001","journal-title":"Experimental Eye Research"},{"issue":"6","key":"10.1016\/j.exer.2013.07.001_bib40","doi-asserted-by":"crossref","first-page":"R105","DOI":"10.1186\/bcr2210","article-title":"Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5\/Erk5-mediated epithelial-mesenchymal transition phenotype","volume":"10","author":"Zhou","year":"2008","journal-title":"Breast Cancer Research"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483513001917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483513001917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T12:51:50Z","timestamp":1539521510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483513001917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":40,"alternative-id":["S0014483513001917"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2013.07.001","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A synthetic connexin 43 mimetic peptide augments corneal wound healing","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2013.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}