{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:29:07Z","timestamp":1790760547705,"version":"4.1.0"},"reference-count":154,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.exer.2013.07.014","type":"journal-article","created":{"date-parts":[[2013,7,20]],"date-time":"2013-07-20T15:32:45Z","timestamp":1374334365000},"page":"53-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":266,"special_numbering":"C","title":["Antimicrobial compounds in tears"],"prefix":"10.1016","volume":"117","author":[{"given":"Alison M.","family":"McDermott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2013.07.014_bib1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","article-title":"The definition and classification of dry eye disease: report of the definition and classification Subcommittee of the International Dry Eye WorkShop (2007)","volume":"5","author":"Anon","year":"2007","journal-title":"The Ocular Surface"},{"key":"10.1016\/j.exer.2013.07.014_bib2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1542-0124(12)70082-4","article-title":"The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007)","volume":"5","author":"Anon","year":"2007","journal-title":"The Ocular Surface"},{"key":"10.1016\/j.exer.2013.07.014_bib3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1477-7525-9-111","article-title":"Development and validation of the impact of dry eye on everyday life (IDEEL) questionnaire, a patient-reported outcomes (PRO) measure for the assessment of the burden of dry eye on patients","volume":"9","author":"Abetz","year":"2011","journal-title":"Health and Quality of Life Outcomes"},{"key":"10.1016\/j.exer.2013.07.014_bib4","first-page":"1826","article-title":"Synthesis of group II phospholipase A2 and lysozyme in lacrimal glands","volume":"37","author":"Aho","year":"1996","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib5","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1076\/ceyr.24.3.224.8299","article-title":"Group IIA phospholipase A2 content of basal, nonstimulated and reflex tears","volume":"24","author":"Aho","year":"2002","journal-title":"Current Eye Research"},{"key":"10.1016\/j.exer.2013.07.014_bib6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00417-002-0607-3","article-title":"Diurnal variation in group IIa phospholipase A2 content in tears of contact lens wearers and normal controls","volume":"241","author":"Aho","year":"2003","journal-title":"Graefe's archive for clinical and experimental ophthalmology\u00a0=\u00a0Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie"},{"key":"10.1016\/j.exer.2013.07.014_bib7","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1167\/iovs.10-6125","article-title":"Factors impacting corneal epithelial barrier function against Pseudomonas aeruginosa traversal","volume":"52","author":"Alarcon","year":"2011","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib8","series-title":"Albert & Jakobiec's Principles and Practice of Ophthalmology","author":"Albert","year":"2008"},{"key":"10.1016\/j.exer.2013.07.014_bib9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1139\/o2012-013","article-title":"Lactoferrin: an alternative view of its role in human biological fluids","volume":"90","author":"Alexander","year":"2012","journal-title":"Biochemistry and cell biology\u00a0=\u00a0Biochimie et biologie cellulaire"},{"key":"10.1016\/j.exer.2013.07.014_bib10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2174\/157489110791233559","article-title":"Surfactant protein (SP)-A and SP-D as antimicrobial and immunotherapeutic agents","volume":"5","author":"Awasthi","year":"2010","journal-title":"Recent Patents on Anti-infective Drug Discovery"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.exer.2013.07.014_bib11","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/j.clae.2010.06.011","article-title":"Comparative evaluation of multi-purpose solutions in the stabilization of tear lysozyme","volume":"33","author":"Barniak","year":"2010","journal-title":"Contact Lens & Anterior Eye: The Journal of the British Contact Lens Association"},{"key":"10.1016\/j.exer.2013.07.014_bib12","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1097\/ICO.0b013e3182254009","article-title":"Contact lens materials, mucin fragmentation and relation to symptoms","volume":"31","author":"Berry","year":"2012","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2013.07.014_bib13","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1167\/iovs.07-1081","article-title":"Release of membrane-associated mucins from ocular surface epithelia","volume":"49","author":"Blalock","year":"2008","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib14","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1097\/OPX.0b013e3181bbc1b3","article-title":"Ex\u00a0vivo protein deposition on bi-weekly silicone hydrogel contact lenses","volume":"86","author":"Boone","year":"2009","journal-title":"Optometry and Vision Science: Official Publication of the American Academy of Optometry"},{"key":"10.1016\/j.exer.2013.07.014_bib15","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1167\/iovs.07-0201","article-title":"Detection of surfactant proteins A and D in human tear fluid and the human lacrimal system","volume":"48","author":"Brauer","year":"2007","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S1388-1981(00)00018-4","article-title":"Bacterial cell membrane hydrolysis by secreted phospholipases A(2): a major physiological role of human group IIa sPLA(2) involving both bacterial cell wall penetration and interfacial catalysis","volume":"1484","author":"Buckland","year":"2000","journal-title":"Biochimica et biophysica acta"},{"key":"10.1016\/j.exer.2013.07.014_bib17","first-page":"3","article-title":"The role of the thrombocytic cationic protein (beta-lysin) in anti-infectious protection","author":"Bukharin","year":"1997","journal-title":"Zhurnal mikrobiologii, epidemiologii, i immunobiologii"},{"key":"10.1016\/j.exer.2013.07.014_bib18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/ICL.0b013e31823bad0e","article-title":"The impact of cellular debris on Pseudomonas aeruginosa adherence to silicone hydrogel contact lenses and contact lens storage cases","volume":"38","author":"Burnham","year":"2012","journal-title":"Eye & Contact Lens"},{"key":"10.1016\/j.exer.2013.07.014_bib19","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1139\/w04-057","article-title":"Human IgA inhibits adherence of Acanthamoeba polyphaga to epithelial cells and contact lenses","volume":"50","author":"Campos-Rodriguez","year":"2004","journal-title":"Canadian Journal of Microbiology"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.exer.2013.07.014_bib20","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1111\/j.1442-9071.1997.tb01752.x","article-title":"Effect of hydrogel lens wear on the major tear proteins during extended wear","volume":"25","author":"Carney","year":"1997","journal-title":"Australian and New Zealand Journal of Ophthalmology"},{"key":"10.1016\/j.exer.2013.07.014_bib21","first-page":"2081","article-title":"Immunoglobulin A antibodies against Pseudomonas aeruginosa in the tear fluid of contact lens wearers","volume":"37","author":"Cheng","year":"1996","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib22","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1159\/000336630","article-title":"Cationic host defence peptides: multifaceted role in immune modulation and inflammation","volume":"4","author":"Choi","year":"2012","journal-title":"Journal of Innate Immunity"},{"key":"10.1016\/j.exer.2013.07.014_bib23","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1046\/j.1365-2249.2001.01408.x","article-title":"Tears contain the complement regulator CD59 as well as decay-accelerating factor (DAF)","volume":"123","author":"Cocuzzi","year":"2001","journal-title":"Clinical and Experimental Immunology"},{"key":"10.1016\/j.exer.2013.07.014_bib24","doi-asserted-by":"crossref","first-page":"623","DOI":"10.4049\/jimmunol.167.2.623","article-title":"Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity","volume":"167","author":"Cole","year":"2001","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.exer.2013.07.014_bib25","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/OPX.0b013e3181b4f02e","article-title":"Conjunctival mucin mRNA expression in contact lens wear","volume":"86","author":"Corrales","year":"2009","journal-title":"Optometry and Vision Science: Official Publication of the American Academy of Optometry"},{"key":"10.1016\/j.exer.2013.07.014_bib26","first-page":"119","article-title":"Antimicrobial peptides in the oral environment: expression and function in health and disease","volume":"7","author":"Dale","year":"2005","journal-title":"Current Issues in Molecular Biology"},{"key":"10.1016\/j.exer.2013.07.014_bib27","first-page":"4080","article-title":"C57BL\/6 mice lacking Muc1 show no ocular surface phenotype","volume":"41","author":"Danjo","year":"2000","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib28","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S1542-0124(11)70022-2","article-title":"Tear lipocalin: structure and function","volume":"9","author":"Dartt","year":"2011","journal-title":"The Ocular Surface"},{"key":"10.1016\/j.exer.2013.07.014_bib29","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1128\/MMBR.41.2.501-513.1977","article-title":"beta-Lysin of platelet origin","volume":"41","author":"Donaldson","year":"1977","journal-title":"Bacteriological Reviews"},{"key":"10.1016\/j.exer.2013.07.014_bib30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1128\/CMR.15.2.167-193.2002","article-title":"Biofilms: survival mechanisms of clinically relevant microorganisms","volume":"15","author":"Donlan","year":"2002","journal-title":"Clinical Microbiology Reviews"},{"key":"10.1016\/j.exer.2013.07.014_bib31","first-page":"14","article-title":"Factors influencing bacterial adhesion to contact lenses","volume":"18","author":"Dutta","year":"2012","journal-title":"Molecular Vision"},{"key":"10.1016\/j.exer.2013.07.014_bib32","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1172\/JCI115407","article-title":"Killing of gram-negative bacteria by lactoferrin and lysozyme","volume":"88","author":"Ellison","year":"1991","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.exer.2013.07.014_bib33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/ICL.0b013e318275b473","article-title":"Microbial keratitis: could contact lens material affect disease pathogenesis?","volume":"39","author":"Evans","year":"2013","journal-title":"Eye & Contact Lens"},{"key":"10.1016\/j.exer.2013.07.014_bib34","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0161-5890(03)00152-4","article-title":"Lactoferrin \u2013 a multifunctional protein with antimicrobial properties","volume":"40","author":"Farnaud","year":"2003","journal-title":"Molecular Immunology"},{"key":"10.1016\/j.exer.2013.07.014_bib35","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.survophthal.2012.01.005","article-title":"Herpes simplex epithelial and stromal keratitis: an epidemiologic update","volume":"57","author":"Farooq","year":"2012","journal-title":"Survey of Ophthalmology"},{"key":"10.1016\/j.exer.2013.07.014_bib36","first-page":"501","article-title":"Tear analysis in contact lens wearers","volume":"83","author":"Farris","year":"1985","journal-title":"Transactions of the American Ophthalmological Society"},{"key":"10.1016\/j.exer.2013.07.014_bib37","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.1128\/IAI.71.7.3866-3874.2003","article-title":"Modification of Pseudomonas aeruginosa interactions with corneal epithelial cells by human tear fluid","volume":"71","author":"Fleiszig","year":"2003","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.exer.2013.07.014_bib38","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1128\/IAI.62.5.1799-1804.1994","article-title":"Modulation of Pseudomonas aeruginosa adherence to the corneal surface by mucus","volume":"62","author":"Fleiszig","year":"1994","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.exer.2013.07.014_bib39","first-page":"463","article-title":"On a remarkable bacteriolytic element found in tissues and secretions","volume":"21","author":"Fleming","year":"1922","journal-title":"Proceedings of the Royal Society B"},{"key":"10.1016\/j.exer.2013.07.014_bib40","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1128\/AAC.48.9.3367-3372.2004","article-title":"Human tear lipocalin exhibits antimicrobial activity by scavenging microbial siderophores","volume":"48","author":"Fluckinger","year":"2004","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.exer.2013.07.014_bib41","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0002-9394(76)90188-4","article-title":"Identification of a nonlysozymal bactericidal factor (beta lysin) in human tears and aqueous humor","volume":"81","author":"Ford","year":"1976","journal-title":"American Journal of Ophthalmology"},{"key":"10.1016\/j.exer.2013.07.014_bib42","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1177\/37.4.2926127","article-title":"Tissue distribution of antileukoprotease and lysozyme in humans","volume":"37","author":"Franken","year":"1989","journal-title":"The Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society"},{"key":"10.1016\/j.exer.2013.07.014_bib43","first-page":"181","article-title":"Conjunctival-associated lymphoid tissue: evidence for a role in the secretory immune system","volume":"25","author":"Franklin","year":"1984","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib44","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/ICU.0b013e32833a8c15","article-title":"Impact of dry eye disease and treatment on quality of life","volume":"21","author":"Friedman","year":"2010","journal-title":"Current Opinion in Ophthalmology"},{"key":"10.1016\/j.exer.2013.07.014_bib45","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1167\/iovs.10-5928","article-title":"Topical flagellin-mediated innate defense against Candida albicans keratitis","volume":"52","author":"Gao","year":"2011","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib46","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1136\/bjo.82.1.88","article-title":"CA 19-9 ELISA test: a new method for studying mucus changes in tears","volume":"82","author":"Garcher","year":"1998","journal-title":"The British Journal of Ophthalmology"},{"key":"10.1016\/j.exer.2013.07.014_bib47","doi-asserted-by":"crossref","first-page":"4914","DOI":"10.1167\/iovs.10-6598","article-title":"Expression and regulation of antimicrobial peptide psoriasin (S100A7) at the ocular surface and in the lacrimal apparatus","volume":"52","author":"Garreis","year":"2011","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib48","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00418-010-0713-y","article-title":"Roles of human beta-defensins in innate immune defense at the ocular surface: arming and alarming corneal and conjunctival epithelial cells","volume":"134","author":"Garreis","year":"2010","journal-title":"Histochemistry and Cell Biology"},{"key":"10.1016\/j.exer.2013.07.014_bib49","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1006\/bbrc.1999.1668","article-title":"Interaction of tear lipocalin with lysozyme and lactoferrin","volume":"265","author":"Gasymov","year":"1999","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.exer.2013.07.014_bib50","doi-asserted-by":"crossref","first-page":"9188","DOI":"10.1167\/iovs.11-7658","article-title":"A\u00a0novel mechanism of increased infections in contact lens wearers","volume":"52","author":"Gordon","year":"2011","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib51","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.exer.2010.02.014","article-title":"Membrane-tethered mucins have multiple functions on the ocular surface","volume":"90","author":"Govindarajan","year":"2010","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.exer.2013.07.014_bib52","first-page":"291","article-title":"Mass spectrometry-based proteomic analyses of contact lens deposition","volume":"14","author":"Green-Church","year":"2008","journal-title":"Molecular Vision"},{"key":"10.1016\/j.exer.2013.07.014_bib53","first-page":"456","article-title":"Investigation of the human tear film proteome using multiple proteomic approaches","volume":"14","author":"Green-Church","year":"2008","journal-title":"Molecular Vision"},{"key":"10.1016\/j.exer.2013.07.014_bib54","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0009-8981(74)90398-2","article-title":"Lysozyme in human body fluids","volume":"57","author":"Hankiewicz","year":"1974","journal-title":"Clinica Chimica Acta; International Journal of Clinical Chemistry"},{"key":"10.1016\/j.exer.2013.07.014_bib55","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1365-2249.1992.tb06986.x","article-title":"Soluble forms of membrane cofactor protein (CD46, MCP) are present in plasma, tears, and seminal fluid in normal subjects","volume":"89","author":"Hara","year":"1992","journal-title":"Clinical and Experimental Immunology"},{"key":"10.1016\/j.exer.2013.07.014_bib56","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1136\/bjo.83.6.737","article-title":"Antimicrobial defensin peptides of the human ocular surface","volume":"83","author":"Haynes","year":"1999","journal-title":"The British Journal of Ophthalmology"},{"key":"10.1016\/j.exer.2013.07.014_bib57","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1042\/BST0391045","article-title":"The bactericidal\/permeability-increasing protein (BPI) in the innate defence of the lower airways","volume":"39","author":"Holweg","year":"2011","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.exer.2013.07.014_bib58","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/01.ico.0000177838.38873.2f","article-title":"Mucins and contact lens wear","volume":"25","author":"Hori","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2013.07.014_bib59","article-title":"Lacritin, a novel tear glycoprotein, is an effective topical antimicrobial agent in an animal model","volume":"53","author":"Hosseini","year":"2012","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib60","doi-asserted-by":"crossref","first-page":"6326","DOI":"10.1002\/pmic.200600284","article-title":"Human body fluid proteome analysis","volume":"6","author":"Hu","year":"2006","journal-title":"Proteomics"},{"key":"10.1016\/j.exer.2013.07.014_bib61","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1080\/02713680701446653","article-title":"Ocular surface expression and in\u00a0vitro activity of antimicrobial peptides","volume":"32","author":"Huang","year":"2007","journal-title":"Current Eye Research"},{"key":"10.1016\/j.exer.2013.07.014_bib62","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1128\/AAC.01317-06","article-title":"In\u00a0vitro activity of human beta-defensin 2 against Pseudomonas aeruginosa in the presence of tear fluid","volume":"51","author":"Huang","year":"2007","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.exer.2013.07.014_bib63","doi-asserted-by":"crossref","first-page":"4498","DOI":"10.1167\/iovs.07-0274","article-title":"Cathelicidin-deficient (Cnlp\u00a0\u2212\/\u2212) mice show increased susceptibility to Pseudomonas aeruginosa keratitis","volume":"48","author":"Huang","year":"2007","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib64","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1167\/iovs.05-1649","article-title":"Multifunctional roles of human cathelicidin (LL-37) at the ocular surface","volume":"47","author":"Huang","year":"2006","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib65","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1440-1711.2005.01326.x","article-title":"A\u00a0Staphylococcus aureus mouse keratitis topical infection model: cytokine balance in different strains of mice","volume":"83","author":"Hume","year":"2005","journal-title":"Immunology and Cell Biology"},{"key":"10.1016\/j.exer.2013.07.014_bib66","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1167\/iovs.03-1242","article-title":"Secretory phospholipase A2 deposition on contact lenses and its effect on bacterial adhesion","volume":"45","author":"Hume","year":"2004","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib67","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/01.ICL.0000062461.24391.7F","article-title":"Evasion of cellular ocular defenses by contact lens isolates of Serratia marcescens","volume":"29","author":"Hume","year":"2003","journal-title":"Eye & Contact Lens"},{"key":"10.1016\/j.exer.2013.07.014_bib68","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/ICL.0b013e3181faa43e","article-title":"Effects of multipurpose contact lens care solutions and their ingredients on membrane-associated mucins of human corneal epithelial cells","volume":"36","author":"Imayasu","year":"2010","journal-title":"Eye & Contact Lens"},{"key":"10.1016\/j.exer.2013.07.014_bib69","first-page":"1156","article-title":"Nonlysozyme antibacterial factor in human tears. Fact or fiction?","volume":"25","author":"Janssen","year":"1984","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib70","first-page":"623","article-title":"Origin and biosynthesis of human tear fluid proteins","volume":"24","author":"Janssen","year":"1983","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib71","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3181\/00379727-131-33951","article-title":"Enhancement of lysozyme activity by anodal tear protein","volume":"131","author":"Josephson","year":"1969","journal-title":"Proceedings of the Society for Experimental Biology and Medicine"},{"key":"10.1016\/j.exer.2013.07.014_bib72","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3109\/02713683.2010.533810","article-title":"Ocular fungal infections","volume":"36","author":"Kalkanci","year":"2011","journal-title":"Current Eye Research"},{"key":"10.1016\/j.exer.2013.07.014_bib73","first-page":"1328","article-title":"Bacterial conjunctivitis in Muc1 null mice","volume":"40","author":"Kardon","year":"1999","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib74","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2174\/1874364101206010110","article-title":"Diversity of microbial species implicated in keratitis: a review","volume":"6","author":"Karsten","year":"2012","journal-title":"The Open Ophthalmology Journal"},{"key":"10.1016\/j.exer.2013.07.014_bib75","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.exer.2007.09.013","article-title":"Lactoferrin Glu561Asp polymorphism is associated with susceptibility to herpes simplex keratitis","volume":"86","author":"Keijser","year":"2008","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.exer.2013.07.014_bib76","doi-asserted-by":"crossref","first-page":"22378","DOI":"10.1074\/jbc.270.38.22378","article-title":"A\u00a0natural disruption of the secretory group II phospholipase A2 gene in inbred mouse strains","volume":"270","author":"Kennedy","year":"1995","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.exer.2013.07.014_bib77","first-page":"193","article-title":"The role of lactoferrin in the nonspecific immune response on the ocular surface","volume":"3","author":"Kijlstra","year":"1990","journal-title":"Regional Immunology"},{"key":"10.1016\/j.exer.2013.07.014_bib78","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3109\/02713689209000062","article-title":"Transient decrease of secretory IgA in tears during rigid gas permeable contact lens wear","volume":"11","author":"Kijlstra","year":"1992","journal-title":"Current Eye Research"},{"key":"10.1016\/j.exer.2013.07.014_bib79","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1469-7580.2005.00394.x","article-title":"The role of eye-associated lymphoid tissue in corneal immune protection","volume":"206","author":"Knop","year":"2005","journal-title":"Journal of Anatomy"},{"key":"10.1016\/j.exer.2013.07.014_bib80","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1007\/s00018-011-0713-7","article-title":"Role of host-defence peptides in eye diseases","volume":"68","author":"Kolar","year":"2011","journal-title":"Cellular and Molecular Life Sciences: CMLS"},{"key":"10.1016\/j.exer.2013.07.014_bib81","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00417-010-1456-0","article-title":"Effect of contact lenses on the protein composition in tear film: a ProteinChip study","volume":"249","author":"Kramann","year":"2011","journal-title":"Graefe's archive for clinical and experimental ophthalmology\u00a0=\u00a0Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie"},{"key":"10.1016\/j.exer.2013.07.014_bib82","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1128\/IAI.01404-06","article-title":"Human tear fluid protects against Pseudomonas aeruginosa keratitis in a murine experimental model","volume":"75","author":"Kwong","year":"2007","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.exer.2013.07.014_bib83","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/01.ICL.0000140224.70483.2F","article-title":"What does overnight lens wear do to the corneal epithelium?: is corneal refractive therapy different?","volume":"30","author":"Ladage","year":"2004","journal-title":"Eye & Contact Lens"},{"key":"10.1016\/j.exer.2013.07.014_bib84","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1046\/j.1440-1606.1999.00208.x","article-title":"Effect of tear-specific immunoglobulin A on the adhesion of Pseudomonas aeruginosa I to contact lenses","volume":"27","author":"Lan","year":"1999","journal-title":"Australian and New Zealand Journal of Ophthalmology"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.exer.2013.07.014_bib85","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1111\/j.1442-9071.1998.tb01367.x","article-title":"Effect of tear secretory IgA on chemotaxis of polymorphonuclear leucocytes","volume":"26","author":"Lan","year":"1998","journal-title":"Australian and New Zealand Journal of Ophthalmology"},{"key":"10.1016\/j.exer.2013.07.014_bib86","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1073\/pnas.96.6.2678","article-title":"Lysozyme and RNases as anti-HIV components in beta-core preparations of human chorionic gonadotropin","volume":"96","author":"Lee-Huang","year":"1999","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.exer.2013.07.014_bib87","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1099\/00222615-47-9-837","article-title":"Synergic antistaphylococcal properties of lactoferrin and lysozyme","volume":"47","author":"Leitch","year":"1998","journal-title":"Journal of Medical Microbiology"},{"key":"10.1016\/j.exer.2013.07.014_bib88","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1076\/ceyr.19.1.12.5342","article-title":"Lactoferrin increases the susceptibility of S. epidermidis biofilms to lysozyme and vancomycin","volume":"19","author":"Leitch","year":"1999","journal-title":"Current Eye Research"},{"key":"10.1016\/j.exer.2013.07.014_bib89","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.pt.2013.01.006","article-title":"Acanthamoeba keratitis: an emerging disease gathering importance worldwide?","volume":"29","author":"Lorenzo-Morales","year":"2013","journal-title":"Trends in Parasitology"},{"key":"10.1016\/j.exer.2013.07.014_bib90","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.clae.2011.12.005","article-title":"Protein deposition on contact lenses: the past, the present, and the future","volume":"35","author":"Luensmann","year":"2012","journal-title":"Contact Lens & Anterior Eye: The Journal of the British Contact Lens Association"},{"key":"10.1016\/j.exer.2013.07.014_bib91","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.exer.2007.01.025","article-title":"Focus on molecules: lacritin","volume":"86","author":"Ma","year":"2008","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.exer.2013.07.014_bib92","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.exer.2007.04.001","article-title":"Exposure of human corneal epithelial cells to contact lenses in\u00a0vitro suppresses the upregulation of human beta-defensin-2 in response to antigens of Pseudomonas aeruginosa","volume":"85","author":"Maltseva","year":"2007","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.exer.2013.07.014_bib93","doi-asserted-by":"crossref","first-page":"734","DOI":"10.3109\/02713688509017675","article-title":"Conformational state of lacrimal proteins adsorbed on contact lenses","volume":"4","author":"Mannucci","year":"1985","journal-title":"Current Eye Research"},{"key":"10.1016\/j.exer.2013.07.014_bib94","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/ACI.0b013e32830e6b04","article-title":"Functions of ocular surface mucins in health and disease","volume":"8","author":"Mantelli","year":"2008","journal-title":"Current Opinion in Allergy and Clinical Immunology"},{"key":"10.1016\/j.exer.2013.07.014_bib95","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/mi.2011.41","article-title":"Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut","volume":"4","author":"Mantis","year":"2011","journal-title":"Mucosal Immunology"},{"key":"10.1016\/j.exer.2013.07.014_bib96","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1080\/09273940701486423","article-title":"Surfactant protein D in Pseudomonas aeruginosa keratitis","volume":"15","author":"McCormick","year":"2007","journal-title":"Ocular Immunology and Inflammation"},{"key":"10.1016\/j.exer.2013.07.014_bib97","article-title":"Antimicrobial activity in recombinant variants of prosecretory mitogen lacritin","volume":"49","author":"McKown","year":"2008","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib98","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1080\/02713680590969456","article-title":"Interaction of Pseudomonas aeruginosa with human tear fluid components","volume":"30","author":"McNamara","year":"2005","journal-title":"Current Eye Research"},{"key":"10.1016\/j.exer.2013.07.014_bib99","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/ICL.0b013e3180676d5d","article-title":"Deposition of lipid, protein, and secretory phospholipase A2 on hydrophilic contact lenses","volume":"34","author":"Mochizuki","year":"2008","journal-title":"Eye & Contact Lens"},{"key":"10.1016\/j.exer.2013.07.014_bib100","doi-asserted-by":"crossref","first-page":"e57850","DOI":"10.1371\/journal.pone.0057850","article-title":"MicroRNA-762 is upregulated in human corneal epithelial cells in response to tear fluid and Pseudomonas aeruginosa antigens and negatively regulates the expression of host defense genes encoding RNase7 and ST2","volume":"8","author":"Mun","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.exer.2013.07.014_bib101","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/srep00008","article-title":"Modulation of epithelial immunity by mucosal fluid","volume":"1","author":"Mun","year":"2011","journal-title":"Scientific Reports"},{"key":"10.1016\/j.exer.2013.07.014_bib102","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1128\/IAI.00173-09","article-title":"Clearance of Pseudomonas aeruginosa from a healthy ocular surface involves surfactant protein D and is compromised by bacterial elastase in a murine null-infection model","volume":"77","author":"Mun","year":"2009","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.exer.2013.07.014_bib103","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jtos.2012.12.002","article-title":"Dry eye disease and microbial keratitis: is there a connection?","volume":"11","author":"Narayanan","year":"2013","journal-title":"The Ocular Surface"},{"key":"10.1016\/j.exer.2013.07.014_bib104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbalip.2007.12.001","article-title":"Antibacterial actions of secreted phospholipases A2. Review","volume":"1781","author":"Nevalainen","year":"2008","journal-title":"Biochimica et biophysica acta"},{"key":"10.1016\/j.exer.2013.07.014_bib105","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1128\/IAI.73.4.2147-2156.2005","article-title":"Surfactant protein D is present in human tear fluid and the cornea and inhibits epithelial cell invasion by Pseudomonas aeruginosa","volume":"73","author":"Ni","year":"2005","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.exer.2013.07.014_bib106","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/09629359990559","article-title":"Inhibitors of complement activity in human breast-milk: a proposed hypothesis of their physiological significance","volume":"8","author":"Ogundele","year":"1999","journal-title":"Mediators of Inflammation"},{"key":"10.1016\/j.exer.2013.07.014_bib107","first-page":"390","article-title":"Quantification of individual proteins in silicone hydrogel contact lens deposits","volume":"19","author":"Omali","year":"2013","journal-title":"Molecular Vision"},{"key":"10.1016\/j.exer.2013.07.014_bib108","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/ICU.0b013e3283045e74","article-title":"Contact lens-related microbial keratitis: recent outbreaks","volume":"19","author":"Patel","year":"2008","journal-title":"Current Opinion in Ophthalmology"},{"key":"10.1016\/j.exer.2013.07.014_bib109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.proghi.2006.03.001","article-title":"Mucins and TFF peptides of the tear film and lacrimal apparatus","volume":"41","author":"Paulsen","year":"2006","journal-title":"Progress in Histochemistry and Cytochemistry"},{"key":"10.1016\/j.exer.2013.07.014_bib110","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1046\/j.1440-1606.1999.00206.x","article-title":"Secretory IgA epitopes in basal tears of extended-wear soft contact lens wearers and in non-lens wearers","volume":"27","author":"Pearce","year":"1999","journal-title":"Australian and New Zealand Journal of Ophthalmology"},{"key":"10.1016\/j.exer.2013.07.014_bib111","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00417-005-0062-z","article-title":"Bactericidal\/permeability-increasing protein in lacrimal gland and in tears of healthy subjects","volume":"244","author":"Peuravuori","year":"2006","journal-title":"Graefe's archive for clinical and experimental ophthalmology\u00a0=\u00a0Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie"},{"key":"10.1016\/j.exer.2013.07.014_bib112","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.ajo.2011.11.030","article-title":"Impact of ocular surface symptoms on quality of life in a United States veterans affairs population","volume":"153","author":"Pouyeh","year":"2012","journal-title":"American Journal of Ophthalmology"},{"key":"10.1016\/j.exer.2013.07.014_bib113","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.clae.2012.12.005","article-title":"Comparison of IgA, TNF-alpha and surface tension of the tear film in two different times of the day","volume":"36","author":"Puinhas","year":"2013","journal-title":"Contact Lens & Anterior Eye: The Journal of the British Contact Lens Association"},{"key":"10.1016\/j.exer.2013.07.014_bib114","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1128\/IAI.66.6.2791-2797.1998","article-title":"Secretory phospholipase A2 is the principal bactericide for staphylococci and other gram-positive bacteria in human tears","volume":"66","author":"Qu","year":"1998","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.exer.2013.07.014_bib115","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/OPX.0b013e3181819f25","article-title":"Mucins in contact lens wear and dry eye conditions","volume":"85","author":"Ramamoorthy","year":"2008","journal-title":"Optometry and Vision Science: Official Publication of the American Academy of Optometry"},{"key":"10.1016\/j.exer.2013.07.014_bib116","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0167-4838(00)00142-4","article-title":"Human tear lipocalin","volume":"1482","author":"Redl","year":"2000","journal-title":"Biochimica et biophysica acta"},{"key":"10.1016\/j.exer.2013.07.014_bib117","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/ICL.0b013e31827c5b73","article-title":"The effects of silicone hydrogel lens wear on the corneal epithelium and risk for microbial keratitis","volume":"39","author":"Robertson","year":"2013","journal-title":"Eye & Contact Lens"},{"key":"10.1016\/j.exer.2013.07.014_bib118","first-page":"318","article-title":"Group II PLA(2) content of tears in normal subjects","volume":"42","author":"Saari","year":"2001","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib119","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1023\/A:1017943826684","article-title":"Host-defense mechanism of the ocular surfaces","volume":"21","author":"Sack","year":"2001","journal-title":"Bioscience Reports"},{"key":"10.1016\/j.exer.2013.07.014_bib120","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1165\/rcmb.2010-0095RT","article-title":"Secretory leukocyte protease inhibitor and elafin\/trappin-2: versatile mucosal antimicrobials and regulators of immunity","volume":"42","author":"Sallenave","year":"2010","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"10.1016\/j.exer.2013.07.014_bib121","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.chroma.2007.05.108","article-title":"Variations in electrophoretic tear protein pattern due to contact lens wear","volume":"1161","author":"Sariri","year":"2007","journal-title":"Journal of Chromatography. A"},{"key":"10.1016\/j.exer.2013.07.014_bib122","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1080\/02713689808951215","article-title":"Identification, origins and the diurnal role of the principal serine protease inhibitors in human tear fluid","volume":"17","author":"Sathe","year":"1998","journal-title":"Current Eye Research"},{"key":"10.1016\/j.exer.2013.07.014_bib123","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0014-4835(82)90079-3","article-title":"Isolation and purification of bactericides from human tears","volume":"34","author":"Selsted","year":"1982","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.exer.2013.07.014_bib124","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1076\/ceyr.28.5.297.28682","article-title":"Corneal epithelial cells and stromal keratocytes efficiently produce CC chemokine-ligand 20 (CCL20) and attract cells expressing its receptor CCR6 in mouse herpetic stromal keratitis","volume":"28","author":"Shirane","year":"2004","journal-title":"Current Eye Research"},{"key":"10.1016\/j.exer.2013.07.014_bib125","doi-asserted-by":"crossref","first-page":"L799","DOI":"10.1152\/ajplung.2000.279.5.L799","article-title":"Synergistic and additive killing by antimicrobial factors found in human airway surface liquid","volume":"279","author":"Singh","year":"2000","journal-title":"American journal of physiology. Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.exer.2013.07.014_bib126","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.exer.2007.01.018","article-title":"Assay of mucins in human tear fluid","volume":"84","author":"Spurr-Michaud","year":"2007","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.exer.2013.07.014_bib127","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1177\/002215540205000506","article-title":"Immunolocalization of surfactant protein-D (SP-D) in human fetal, newborn, and adult tissues","volume":"50","author":"Stahlman","year":"2002","journal-title":"The Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society"},{"key":"10.1016\/j.exer.2013.07.014_bib128","article-title":"Detection of histatin 5 in normal human Schirmer strip samples by mass spectroscopy","volume":"43","author":"Steele","year":"2002","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib129","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/S0161-6420(81)34938-0","article-title":"Basal and reflex human tear analysis. II. Chemical analysis: lactoferrin and lysozyme","volume":"88","author":"Stuchell","year":"1981","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2013.07.014_bib130","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1097\/OPX.0b013e31821ffccb","article-title":"Influence of protein deposition on bacterial adhesion to contact lenses","volume":"88","author":"Subbaraman","year":"2011","journal-title":"Optometry and Vision Science: Official Publication of the American Academy of Optometry"},{"key":"10.1016\/j.exer.2013.07.014_bib131","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1097\/00006324-200011000-00008","article-title":"Decay-accelerating factor in tears of contact lens wearers and patients with contact lens-associated complications","volume":"77","author":"Szczotka","year":"2000","journal-title":"Optometry and Vision Science: Official Publication of the American Academy of Optometry"},{"key":"10.1016\/j.exer.2013.07.014_bib132","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1172\/JCI64416","article-title":"Cytokeratins mediate epithelial innate defense through their antimicrobial properties","volume":"122","author":"Tam","year":"2012","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.exer.2013.07.014_bib133","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/ICL.0b013e31822c36c2","article-title":"Assessment of effects of multipurpose contact lens care solutions on human corneal epithelial cells","volume":"37","author":"Tchedre","year":"2011","journal-title":"Eye & Contact Lens"},{"key":"10.1016\/j.exer.2013.07.014_bib134","first-page":"191","article-title":"Tear lysozyme levels in contact lens wearers","volume":"23","author":"Temel","year":"1991","journal-title":"Annals of Ophthalmology"},{"key":"10.1016\/j.exer.2013.07.014_bib135","first-page":"69","article-title":"The effect of contact lens wear on tear immunoglobulins","volume":"17","author":"Temel","year":"1991","journal-title":"The CLAO Journal: Official Publication of the Contact Lens Association of Ophthalmologists, Inc."},{"key":"10.1016\/j.exer.2013.07.014_bib136","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1167\/iovs.06-0998","article-title":"Comparative analysis of human conjunctival and corneal epithelial gene expression with oligonucleotide microarrays","volume":"48","author":"Turner","year":"2007","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib137","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1074\/jbc.272.3.1837","article-title":"The salivary lipocalin von Ebner's gland protein is a cysteine proteinase inhibitor","volume":"272","author":"van't Hof","year":"1997","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.exer.2013.07.014_bib138","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/OPX.0b013e318264f4dc","article-title":"Bacterial adhesion to unworn and worn silicone hydrogel lenses","volume":"89","author":"Vijay","year":"2012","journal-title":"Optometry and Vision Science: Official Publication of the American Academy of Optometry"},{"key":"10.1016\/j.exer.2013.07.014_bib139","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1755-3768.1987.tb08485.x","article-title":"The concentration of lysozyme and secretory IgA in tears from healthy persons with and without contact lens use","volume":"65","author":"Vinding","year":"1987","journal-title":"Acta Ophthalmologica"},{"key":"10.1016\/j.exer.2013.07.014_bib140","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1167\/iovs.11-8684","article-title":"Isoforms of secretory group two phospholipase A (sPLA2) in mouse ocular surface epithelia and lacrimal glands","volume":"53","author":"Wei","year":"2012","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib141","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0161-6420(88)33228-8","article-title":"The immunoarchitecture of the normal human lacrimal gland. Relevancy for understanding pathologic conditions","volume":"95","author":"Wieczorek","year":"1988","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2013.07.014_bib142","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/ICL.0b013e318275e284","article-title":"Microbial adhesion to silicone hydrogel lenses: a review","volume":"39","author":"Willcox","year":"2013","journal-title":"Eye & Contact Lens"},{"key":"10.1016\/j.exer.2013.07.014_bib143","first-page":"1","article-title":"Complement and complement regulatory proteins in human tears","volume":"38","author":"Willcox","year":"1997","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.exer.2013.07.014_bib144","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/ICL.0b013e31823fdb2a","article-title":"Preservation of human tear protein structure and function by a novel contact lens multipurpose solution containing protein-stabilizing agents","volume":"38","author":"Wright","year":"2012","journal-title":"Eye & Contact Lens"},{"key":"10.1016\/j.exer.2013.07.014_bib145","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1172\/JCI16889","article-title":"Surfactant proteins A and D inhibit the growth of gram-negative bacteria by increasing membrane permeability","volume":"111","author":"Wu","year":"2003","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.exer.2013.07.014_bib146","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.4049\/jimmunol.182.3.1609","article-title":"Beta-defensin-2 promotes resistance against infection with P. aeruginosa","volume":"182","author":"Wu","year":"2009","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.exer.2013.07.014_bib147","doi-asserted-by":"crossref","first-page":"8054","DOI":"10.4049\/jimmunol.0902140","article-title":"Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis","volume":"183","author":"Wu","year":"2009","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.exer.2013.07.014_bib148","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1097\/01.ico.0000247217.16510.f2","article-title":"Phospholipids and their degrading enzyme in the tears of soft contact lens wearers","volume":"25","author":"Yamada","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2013.07.014_bib149","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1189\/jlb.0103024","article-title":"Many chemokines including CCL20\/MIP-3alpha display antimicrobial activity","volume":"74","author":"Yang","year":"2003","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.exer.2013.07.014_bib150","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jpba.2005.02.039","article-title":"Decreased mucin concentrations in tear fluids of contact lens wearers","volume":"39","author":"Yasueda","year":"2005","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"10.1016\/j.exer.2013.07.014_bib151","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/09286586.2012.681336","article-title":"Acanthamoeba keratitis: the persistence of cases following a multistate outbreak","volume":"19","author":"Yoder","year":"2012","journal-title":"Ophthalmic Epidemiology"},{"key":"10.1016\/j.exer.2013.07.014_bib152","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1002\/elps.200900755","article-title":"Post-translation modification of proteins in tears","volume":"31","author":"You","year":"2010","journal-title":"Electrophoresis"},{"key":"10.1016\/j.exer.2013.07.014_bib153","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1002\/pmic.200700137","article-title":"Proteomic analysis of rabbit tear fluid: defensin levels after an experimental corneal wound are correlated to wound closure","volume":"7","author":"Zhou","year":"2007","journal-title":"Proteomics"},{"key":"10.1016\/j.exer.2013.07.014_bib154","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1021\/pr034065n","article-title":"Proteomic analysis of human tears: defensin expression after ocular surface surgery","volume":"3","author":"Zhou","year":"2004","journal-title":"Journal of Proteome Research"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483513002121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483513002121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T10:22:10Z","timestamp":1688379730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483513002121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":154,"alternative-id":["S0014483513002121"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2013.07.014","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antimicrobial compounds in tears","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2013.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}