{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:14:22Z","timestamp":1789953262492,"version":"4.0.1"},"reference-count":142,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.exer.2013.07.027","type":"journal-article","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T00:04:20Z","timestamp":1376438660000},"page":"62-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":190,"special_numbering":"C","title":["Tear film mucins: Front line defenders of the ocular surface; comparison with airway and gastrointestinal tract mucins"],"prefix":"10.1016","volume":"117","author":[{"given":"Robin R.","family":"Hodges","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darlene A.","family":"Dartt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2013.07.027_bib1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.exer.2009.12.009","article-title":"Effect of pro-inflammatory mediators on membrane-associated mucins expressed by human ocular surface epithelial cells","volume":"90","author":"Albertsmeyer","year":"2010","journal-title":"Exp. Eye Res."},{"issue":"Pt 1","key":"10.1016\/j.exer.2013.07.027_bib2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/eye.1996.12","article-title":"Impression cytology of the conjunctival epithelium in patients with vernal conjunctivitis","volume":"10","author":"Aragona","year":"1996","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.exer.2013.07.027_bib3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s10384-012-0228-2","article-title":"Glycobiology of the ocular surface: mucins and lectins","volume":"57","author":"Argueso","year":"2013","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.exer.2013.07.027_bib4","first-page":"1004","article-title":"Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjogren syndrome","volume":"43","author":"Argueso","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib5","doi-asserted-by":"crossref","first-page":"23037","DOI":"10.1074\/jbc.M109.033332","article-title":"Association of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrier","volume":"284","author":"Argueso","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2013.07.027_bib6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jams.2012.07.022","article-title":"Inhibitory effects of isoflavonoids on rat prostate testosterone 5alpha-reductase","volume":"5","author":"Bae","year":"2012","journal-title":"J.\u00a0Acupunct Meridian Stud."},{"key":"10.1016\/j.exer.2013.07.027_bib7","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1038\/onc.2010.87","article-title":"Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells","volume":"29","author":"Bafna","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.exer.2013.07.027_bib8","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1165\/ajrcmb.20.4.3442","article-title":"Mucin gene expression during differentiation of human airway epithelia in\u00a0vitro. Muc4 and muc5b are strongly induced","volume":"20","author":"Bernacki","year":"1999","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.exer.2013.07.027_bib9","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1023\/A:1018587031814","article-title":"MUC7 gene expression and genetic polymorphism","volume":"14","author":"Biesbrock","year":"1997","journal-title":"Glycoconj J."},{"key":"10.1016\/j.exer.2013.07.027_bib10","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1167\/iovs.07-1081","article-title":"Release of membrane-associated mucins from ocular surface epithelia","volume":"49","author":"Blalock","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib11","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1167\/iovs.07-0430","article-title":"Functions of MUC16 in corneal epithelial cells","volume":"48","author":"Blalock","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1023\/A:1008841013622","article-title":"Tissue-specific expression of human salivary mucin gene, MUC7, in transgenic mice","volume":"7","author":"Bobek","year":"1998","journal-title":"Transgenic Res."},{"issue":"Pt 2","key":"10.1016\/j.exer.2013.07.027_bib13","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1042\/bj2990579","article-title":"Role of calcium in carbachol- and neurotensin-induced mucin exocytosis in a human colonic goblet cell line and cross-talk with the cyclic AMP pathway","volume":"299","author":"Bou-Hanna","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/j.exer.2013.07.027_bib14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1242\/jcs.86.1.249","article-title":"Electron-microscopic studies of the CA antigen, epitectin","volume":"86","author":"Bramwell","year":"1986","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib15","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1477-7827-2-4","article-title":"MUC1: a multifunctional cell surface component of reproductive tissue epithelia","volume":"2","author":"Brayman","year":"2004","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.exer.2013.07.027_bib16","first-page":"1720","article-title":"MUC1 expression in Sjogren's syndrome, KCS, and control subjects","volume":"16","author":"Caffery","year":"2010","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2013.07.027_bib17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0079-6603(02)71043-X","article-title":"Muc4\/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive","volume":"71","author":"Carraway","year":"2002","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"key":"10.1016\/j.exer.2013.07.027_bib18","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.cca.2012.06.015","article-title":"Mucin genes in gallstone disease","volume":"413","author":"Chuang","year":"2012","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.exer.2013.07.027_bib19","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1097\/00003226-200310000-00010","article-title":"Human epithelium from conjunctival impression cytology expresses MUC7 mucin gene","volume":"22","author":"Corrales","year":"2003","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2013.07.027_bib20","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.1167\/iovs.11-7655","article-title":"Ocular mucin gene expression levels as biomarkers for the diagnosis of dry eye syndrome","volume":"52","author":"Corrales","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib21","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.sbi.2011.08.007","article-title":"Post-translational regulation of signaling mucins","volume":"21","author":"Cullen","year":"2011","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.exer.2013.07.027_bib22","first-page":"4080","article-title":"C57BL\/6 mice lacking Muc1 show no ocular surface phenotype","volume":"41","author":"Danjo","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib23","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1350-9462(02)00038-1","article-title":"Regulation of mucin and fluid secretion by conjunctival epithelial cells","volume":"21","author":"Dartt","year":"2002","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.exer.2003.10.005","article-title":"Control of mucin production by ocular surface epithelial cells","volume":"78","author":"Dartt","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib25","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0014-4835(03)00202-1","article-title":"Interaction of EGF family growth factors and neurotransmitters in regulating lacrimal gland secretion","volume":"78","author":"Dartt","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib26","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.4049\/jimmunol.1000833","article-title":"Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation","volume":"186","author":"Dartt","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.exer.2013.07.027_bib27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/exer.1996.0088","article-title":"Vasoactive intestinal peptide-stimulated glycoconjugate secretion from conjunctival goblet cells","volume":"63","author":"Dartt","year":"1996","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib28","doi-asserted-by":"crossref","first-page":"993","DOI":"10.3109\/02713689508998520","article-title":"Localization of nerves adjacent to goblet cells in rat conjunctiva","volume":"14","author":"Dartt","year":"1995","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib29","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1006\/exer.2000.0915","article-title":"Regulation of conjunctival goblet cell secretion by Ca(2+) and protein kinase C","volume":"71","author":"Dartt","year":"2000","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib30","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.physiol.70.113006.100638","article-title":"Regulated airway goblet cell mucin secretion","volume":"70","author":"Davis","year":"2008","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.exer.2013.07.027_bib31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000163037","article-title":"Role of intestinal mucins in innate host defense mechanisms against pathogens","volume":"1","author":"Dharmani","year":"2009","journal-title":"J.\u00a0Innate Immun."},{"key":"10.1016\/j.exer.2013.07.027_bib32","first-page":"2270","article-title":"Presence of nerves and their receptors in mouse and human conjunctival goblet cells","volume":"42","author":"Diebold","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib33","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1111\/j.1398-9995.2008.01781.x","article-title":"Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis","volume":"63","author":"Dogru","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.exer.2013.07.027_bib34","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1167\/iovs.11-8269","article-title":"Effect of biopsy location and size on proliferative capacity of ex\u00a0vivo expanded conjunctival tissue","volume":"53","author":"Eidet","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib35","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/MCP.0b013e32831da8d3","article-title":"Mucus hypersecretion in asthma: causes and effects","volume":"15","author":"Evans","year":"2009","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.exer.2013.07.027_bib36","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.pharmthera.2008.11.001","article-title":"Airway mucus: the good, the bad, the sticky","volume":"121","author":"Evans","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.exer.2013.07.027_bib37","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2174\/1874306401004010063","article-title":"Regulation of human MUC7 mucin gene expression by cigarette smoke extract or cigarette smoke and Pseudomonas aeruginosa lipopolysaccharide in human airway epithelial cells and in MUC7 transgenic mice","volume":"4","author":"Fan","year":"2010","journal-title":"Open Respir. Med. J."},{"key":"10.1016\/j.exer.2013.07.027_bib38","doi-asserted-by":"crossref","first-page":"e50704","DOI":"10.1371\/journal.pone.0050704","article-title":"Mucin deficiency causes functional and structural changes of the ocular surface","volume":"7","author":"Floyd","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2013.07.027_bib39","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1089\/10807680260218524","article-title":"INS365 suppresses loss of corneal epithelial integrity by secretion of mucin-like glycoprotein in a rabbit short-term dry eye model","volume":"18","author":"Fujihara","year":"2002","journal-title":"J.\u00a0Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.exer.2013.07.027_bib40","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0014-4835(03)00204-5","article-title":"Distribution of mucins at the ocular surface","volume":"78","author":"Gipson","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7696(03)31001-0","article-title":"Role of mucins in the function of the corneal and conjunctival epithelia","volume":"231","author":"Gipson","year":"2003","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.exer.2013.07.027_bib42","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1097\/ICO.0b013e31820d852a","article-title":"Comparison of mucin levels at the ocular surface of postmenopausal women with and without a history of dry eye","volume":"30","author":"Gipson","year":"2011","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2013.07.027_bib43","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2334\/josnusd.53.445","article-title":"Genetic polymorphism of MUC7 in individuals with aggressive or chronic periodontitis","volume":"53","author":"Gomes","year":"2011","journal-title":"J.\u00a0Oral Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib44","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.exer.2007.11.004","article-title":"Presence of EGF growth factor ligands and their effects on cultured rat conjunctival goblet cell proliferation","volume":"86","author":"Gu","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib45","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1167\/iovs.10-7068","article-title":"Mouse conjunctival forniceal gene expression during postnatal development and its regulation by Kruppel-like factor 4","volume":"52","author":"Gupta","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib46","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1023\/A:1006978818555","article-title":"Structural features of the human salivary mucin, MUC7","volume":"15","author":"Gururaja","year":"1998","journal-title":"Glycoconj J."},{"key":"10.1016\/j.exer.2013.07.027_bib47","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S1542-0124(12)70213-6","article-title":"Structure and biological roles of mucin-type O-glycans at the ocular surface","volume":"8","author":"Guzman-Aranguez","year":"2010","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2013.07.027_bib48","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mib.2011.11.002","article-title":"Role of mucus layers in gut infection and inflammation","volume":"15","author":"Hansson","year":"2012","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.exer.2013.07.027_bib49","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1146\/annurev.physiol.70.113006.100659","article-title":"Structure and function of the cell surface (tethered) mucins","volume":"70","author":"Hattrup","year":"2008","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.exer.2013.07.027_bib50","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1167\/iovs.11-8748","article-title":"Role of histamine and its receptor subtypes in stimulation of conjunctival goblet cell secretion","volume":"53","author":"Hayashi","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib51","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.exer.2012.08.010","article-title":"Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion","volume":"103","author":"Hodges","year":"2012","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib52","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.exer.2007.08.019","article-title":"Effect of protein kinase C and Ca(2+) on p42\/p44 MAPK, Pyk2, and Src activation in rat conjunctival goblet cells","volume":"85","author":"Hodges","year":"2007","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib53","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1167\/iovs.03-0903","article-title":"Differential regulation of membrane-associated mucins in the human ocular surface epithelium","volume":"45","author":"Hori","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib54","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1167\/iovs.05-0627","article-title":"Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16","volume":"46","author":"Hori","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib55","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1167\/iovs.02-1117","article-title":"Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells","volume":"44","author":"Horikawa","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib56","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.exer.2006.01.031","article-title":"MUC1 splice variants in human ocular surface tissues: possible differences between dry eye patients and normal controls","volume":"83","author":"Imbert","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib57","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1006\/bbrc.1997.7051","article-title":"Cloning of rat Muc5AC mucin gene: comparison of its structure and tissue distribution to that of human and mouse homologues","volume":"236","author":"Inatomi","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2013.07.027_bib58","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.exer.2011.06.014","article-title":"An NGF mimetic, MIM-D3, stimulates conjunctival cell glycoconjugate secretion and demonstrates therapeutic efficacy in a rat model of dry eye","volume":"93","author":"Jain","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib59","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1007\/s00018-011-0822-3","article-title":"Composition and functional role of the mucus layers in the intestine","volume":"68","author":"Johansson","year":"2011","journal-title":"Cell Mol. Life Sci. CMLS"},{"key":"10.1016\/j.exer.2013.07.027_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biochi.2009.09.018","article-title":"The membrane-bound mucins: from cell signalling to transcriptional regulation and expression in epithelial cancers","volume":"92","author":"Jonckheere","year":"2010","journal-title":"Biochimie"},{"key":"10.1016\/j.exer.2013.07.027_bib61","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1006\/exer.1998.0520","article-title":"Regulation of ocular mucin secretion by P2Y2 nucleotide receptors in rabbit and human conjunctiva","volume":"67","author":"Jumblatt","year":"1998","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib62","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00003226-200301000-00010","article-title":"MUC7 expression in the human lacrimal gland and conjunctiva","volume":"22","author":"Jumblatt","year":"2003","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2013.07.027_bib63","doi-asserted-by":"crossref","first-page":"C988","DOI":"10.1152\/ajpcell.00582.2001","article-title":"Cholinergic agonists transactivate EGFR and stimulate MAPK to induce goblet cell secretion","volume":"284","author":"Kanno","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.exer.2013.07.027_bib64","first-page":"1328","article-title":"Bacterial conjunctivitis in Muc1 null mice","volume":"40","author":"Kardon","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib65","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.4049\/jimmunol.1102405","article-title":"Membrane-tethered MUC1 mucin is phosphorylated by epidermal growth factor receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88","volume":"188","author":"Kato","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.exer.2013.07.027_bib66","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ydbio.2011.05.005","article-title":"Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells","volume":"356","author":"Kenchegowda","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.exer.2013.07.027_bib67","doi-asserted-by":"crossref","first-page":"L15","DOI":"10.1152\/ajplung.00194.2009","article-title":"Unpacking a gel-forming mucin: a view of MUC5B organization after granular release. American journal of physiology","volume":"298","author":"Kesimer","year":"2010","journal-title":"Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.exer.2013.07.027_bib68","article-title":"Mucous gland system of the conjunctiva. A quantitative normal anatomical study","author":"Kessing","year":"1968","journal-title":"Acta Ophthalmol. (Copenh), Suppl.\u00a095"},{"key":"10.1016\/j.exer.2013.07.027_bib69","doi-asserted-by":"crossref","first-page":"985","DOI":"10.3109\/02713689508998519","article-title":"Stimulation of goblet cell mucous secretion by activation of nerves in rat conjunctiva","volume":"14","author":"Kessler","year":"1995","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib70","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s11894-010-0131-2","article-title":"Intestinal goblet cells and mucins in health and disease: recent insights and progress","volume":"12","author":"Kim","year":"2010","journal-title":"Curr. Gastroenterol. Rep."},{"key":"10.1016\/j.exer.2013.07.027_bib71","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1442-2042.2004.00739.x","article-title":"Detection of circulating MUC7-positive cells by reverse transcription-polymerase chain reaction in bladder cancer patients","volume":"11","author":"Kinjo","year":"2004","journal-title":"Int. J. Urol."},{"key":"10.1016\/j.exer.2013.07.027_bib72","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/sj.ejhg.5200642","article-title":"Genetic polymorphism of MUC7: allele frequencies and association with asthma","volume":"9","author":"Kirkbride","year":"2001","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.exer.2013.07.027_bib73","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1167\/iovs.10-6997c","article-title":"The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland","volume":"52","author":"Knop","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib74","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000315017","article-title":"Regulation of the inflammatory component in chronic dry eye disease by the eye-associated lymphoid tissue (EALT)","volume":"45","author":"Knop","year":"2010","journal-title":"Dev. Ophthalmol."},{"key":"10.1016\/j.exer.2013.07.027_bib75","doi-asserted-by":"crossref","first-page":"33245","DOI":"10.1074\/jbc.272.52.33245","article-title":"Reversible disruption of cell-matrix and cell-cell interactions by overexpression of sialomucin complex","volume":"272","author":"Komatsu","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2013.07.027_bib76","first-page":"2483","article-title":"Alteration in goblet cell numbers and mucin gene expression in a mouse model of allergic conjunctivitis","volume":"42","author":"Kunert","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib77","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1167\/iovs.08-2716","article-title":"In\u00a0vitro evidence of nerve growth factor effects on human conjunctival epithelial cell differentiation and mucin gene expression","volume":"50","author":"Lambiase","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib78","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0014-4835(03)00064-2","article-title":"Mucin gene expression is not regulated by estrogen and\/or progesterone in the ocular surface epithelia of mice","volume":"77","author":"Lange","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib79","series-title":"The Dry Eye: a Comprehensive Guide","first-page":"101","article-title":"Basic principles and classifications of dry eye disorders","author":"Lemp","year":"1992"},{"key":"10.1016\/j.exer.2013.07.027_bib80","doi-asserted-by":"crossref","DOI":"10.1038\/mi.2013.7","article-title":"Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion","author":"Li","year":"2013","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.exer.2013.07.027_bib81","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1167\/iovs.12-11264","article-title":"Effect of VIP on intracellular [Ca2+], extracellular regulated kinase 1\/2, and secretion in cultured rat conjunctival goblet cells","volume":"54","author":"Li","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib82","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1165\/rcmb.2006-0110OC","article-title":"Functional analysis of human MUC7 mucin gene 5'-flanking region in lung epithelial cells","volume":"35","author":"Li","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.exer.2013.07.027_bib83","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.cellimm.2010.07.014","article-title":"Neutralization of interleukin (IL)-10 released by monocytes\/macrophages enhances the up-regulatory effect of monocyte\/macrophage-derived IL-6 on expressions of IL-6 and MUC1, and migration in HT-29 colon cancer cells","volume":"265","author":"Li","year":"2010","journal-title":"Cell Immunol."},{"key":"10.1016\/j.exer.2013.07.027_bib84","first-page":"2789","article-title":"Fibroblast growth factor 10 upregulates the expression of mucins in rat conjunctival epithelial cells","volume":"17","author":"Ma","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2013.07.027_bib85","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s00417-006-0452-x","article-title":"Conjunctival mucin deficiency in complete androgen insensitivity syndrome (CAIS)","volume":"245","author":"Mantelli","year":"2007","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2013.07.027_bib86","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1167\/iovs.08-2734","article-title":"Glycogene expression in conjunctiva of patients with dry eye: downregulation of Notch signaling","volume":"50","author":"Mantelli","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib87","first-page":"939","article-title":"Progesterone stimulates production and secretion of MUC1 epithelial mucin in steroid-responsive breast cancer cell lines","volume":"12","author":"McGuckin","year":"1998","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.exer.2013.07.027_bib88","first-page":"703","article-title":"Quantification of MUC2 and MUC5AC transcripts in human conjunctiva","volume":"41","author":"McKenzie","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib89","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3109\/02713689509003760","article-title":"Experimental model of allergic conjunctivitis to ragweed in guinea pig","volume":"14","author":"Merayo-Lloves","year":"1995","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib90","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.neo.7900194","article-title":"Androgen-dependent regulation of human MUC1 mucin expression","volume":"4","author":"Mitchell","year":"2002","journal-title":"Neoplasia"},{"key":"10.1016\/j.exer.2013.07.027_bib91","doi-asserted-by":"crossref","first-page":"6174","DOI":"10.1167\/iovs.10-7022","article-title":"Effect of tear hyperosmolarity and signs of clinical ocular surface pathology upon conjunctival goblet cell function in the human ocular surface","volume":"52","author":"Moore","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib92","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1089\/108076803322279390","article-title":"P2Y(2) receptor elicits PAS-positive glycoprotein secretion from rabbit conjunctival goblet cells in\u00a0vivo","volume":"19","author":"Murakami","year":"2003","journal-title":"J.\u00a0Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.exer.2013.07.027_bib93","first-page":"G380","article-title":"Regulation of intestinal goblet cell secretion. II. A survey of potential secretagogues","volume":"242","author":"Neutra","year":"1982","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.exer.2013.07.027_bib94","first-page":"20","article-title":"Regulation of intestinal goblet cells in situ, in mucosal explants and in the isolated epithelium","volume":"109","author":"Neutra","year":"1984","journal-title":"Ciba Found Symp."},{"key":"10.1016\/j.exer.2013.07.027_bib95","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1159\/000341423","article-title":"Secreted and membrane-bound mucins and idiopathic peptic ulcer disease","volume":"86","author":"Niv","year":"2012","journal-title":"Digestion"},{"key":"10.1016\/j.exer.2013.07.027_bib96","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000131068","article-title":"Functional anatomy and immunological interactions of ocular surface and adnexa","volume":"41","author":"Paulsen","year":"2008","journal-title":"Dev. Ophthalmol."},{"key":"10.1016\/j.exer.2013.07.027_bib97","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.aanat.2007.05.001","article-title":"Regulation of MUC16 by inflammatory mediators in ocular surface epithelial cell lines","volume":"190","author":"Paulsen","year":"2008","journal-title":"Ann. Anat."},{"key":"10.1016\/j.exer.2013.07.027_bib98","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00441-004-0877-7","article-title":"Human lacrimal gland mucins","volume":"316","author":"Paulsen","year":"2004","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.exer.2013.07.027_bib99","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1083\/jcb.145.4.769","article-title":"Location and clonal analysis of stem cells and their differentiated progeny in the human ocular surface","volume":"145","author":"Pellegrini","year":"1999","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.exer.2013.07.027_bib100","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1074\/jbc.M510520200","article-title":"Mucin granule intraluminal organization in living mucous\/goblet cells. Roles of protein post-translational modifications and secretion","volume":"281","author":"Perez-Vilar","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2013.07.027_bib101","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.exer.2007.12.008","article-title":"Focus on Molecules: human mucin MUC16","volume":"87","author":"Perez","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib102","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1076\/ceyr.19.3.201.5309","article-title":"Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca","volume":"19","author":"Pflugfelder","year":"1999","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib103","first-page":"1316","article-title":"Detection of sialomucin complex (MUC4) in human ocular surface epithelium and tear fluid","volume":"41","author":"Pflugfelder","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib104","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.4161\/cbt.7.12.6956","article-title":"MUC1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathway","volume":"7","author":"Raina","year":"2008","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.exer.2013.07.027_bib105","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.eururo.2003.10.011","article-title":"Detection of occult tumor cells in lymph nodes from bladder cancer patients by MUC7 nested RT-PCR","volume":"45","author":"Retz","year":"2004","journal-title":"Eur. Urol."},{"key":"10.1016\/j.exer.2013.07.027_bib106","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1128\/IAI.00708-08","article-title":"Cell surface O-glycans limit Staphylococcus aureus adherence to corneal epithelial cells","volume":"76","author":"Ricciuto","year":"2008","journal-title":"Infect Immun."},{"key":"10.1016\/j.exer.2013.07.027_bib107","first-page":"2127","article-title":"Development of conjunctival goblet cells and their neuroreceptor subtype expression","volume":"41","author":"Rios","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib108","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1167\/iovs.06-1226","article-title":"Role of neurotrophins and neurotrophin receptors in rat conjunctival goblet cell secretion and proliferation","volume":"48","author":"Rios","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib109","first-page":"1102","article-title":"Immunolocalization of muscarinic and VIP receptor subtypes and their role in stimulating goblet cell secretion","volume":"40","author":"Rios","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib110","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0002-9394(14)71404-7","article-title":"Conjunctival epithelial cell hypermitosis and goblet cell hyperplasia in atopic keratoconjunctivitis","volume":"116","author":"Roat","year":"1993","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2013.07.027_bib111","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00010.2005","article-title":"Respiratory tract mucin genes and mucin glycoproteins in health and disease","volume":"86","author":"Rose","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exer.2013.07.027_bib112","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1469-1809.2006.00250.x","article-title":"MUC7 haplotype analysis: results from a longitudinal birth cohort support protective effect of the MUC7*5 allele on respiratory function","volume":"70","author":"Rousseau","year":"2006","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.exer.2013.07.027_bib113","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/ICO.0b013e31804f5a09","article-title":"Regulation of membrane-associated mucins in the human corneal epithelial cells by dexamethasone","volume":"26","author":"Seo","year":"2007","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2013.07.027_bib114","doi-asserted-by":"crossref","first-page":"5922","DOI":"10.1021\/cr100396c","article-title":"Resolvins and protectins in inflammation resolution","volume":"111","author":"Serhan","year":"2011","journal-title":"Chem. Rev."},{"key":"10.1016\/j.exer.2013.07.027_bib115","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1167\/iovs.08-1677","article-title":"ERK\/p44p42 mitogen-activated protein kinase mediates EGF-stimulated proliferation of conjunctival goblet cells in culture","volume":"49","author":"Shatos","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib116","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1167\/iovs.08-2930","article-title":"Stimulatory role of PKCalpha in extracellular regulated kinase 1\/2 pathway in conjunctival goblet cell proliferation","volume":"50","author":"Shatos","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib117","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1167\/iovs.08-2467","article-title":"Role of cPKCalpha and nPKCepsilon in EGF-stimulated goblet cell proliferation","volume":"50","author":"Shatos","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib118","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1167\/iovs.02-0550","article-title":"Isolation and characterization of cultured human conjunctival goblet cells","volume":"44","author":"Shatos","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib119","first-page":"1455","article-title":"Isolation, characterization, and propagation of rat conjunctival goblet cells in\u00a0vitro","volume":"42","author":"Shatos","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib120","doi-asserted-by":"crossref","first-page":"15698","DOI":"10.1074\/jbc.M313241200","article-title":"Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin","volume":"279","author":"Sheehan","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2013.07.027_bib121","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1440-1746.2011.06909.x","article-title":"Mucins in inflammatory bowel diseases and colorectal cancer","volume":"27","author":"Sheng","year":"2012","journal-title":"J.\u00a0Gastroenterol. Hepatol."},{"key":"10.1016\/j.exer.2013.07.027_bib122","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.archoralbio.2008.08.003","article-title":"Higher levels of salivary MUC5B and MUC7 in individuals with gastric diseases who harbor Helicobacter pylori","volume":"54","author":"Silva","year":"2009","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.exer.2013.07.027_bib123","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/glycob\/11.6.459","article-title":"In\u00a0vivo glycosylation of mucin tandem repeats","volume":"11","author":"Silverman","year":"2001","journal-title":"Glycobiology"},{"key":"10.1016\/j.exer.2013.07.027_bib124","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.tcb.2006.07.006","article-title":"Cell surface-associated mucins in signal transduction","volume":"16","author":"Singh","year":"2006","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.exer.2013.07.027_bib125","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1128\/AAC.44.6.1485-1493.2000","article-title":"In\u00a0vitro assessment of antifungal therapeutic potential of salivary histatin-5, two variants of histatin-5, and salivary mucin (MUC7) domain 1","volume":"44","author":"Situ","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.exer.2013.07.027_bib126","first-page":"2283","article-title":"Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease","volume":"42","author":"Solomon","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib127","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.exer.2007.01.018","article-title":"Assay of mucins in human tear fluid","volume":"84","author":"Spurr-Michaud","year":"2007","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib128","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2500\/ajra.2010.24.3504","article-title":"Aberrant mucin glycoprotein patterns of chronic rhinosinusitis patients with bacterial biofilms","volume":"24","author":"Tan","year":"2010","journal-title":"Am. J. Rhinol Allergy"},{"key":"10.1016\/j.exer.2013.07.027_bib129","first-page":"1944","article-title":"Developmental expression of mucin genes ASGP (rMuc4) and rMuc5ac by the rat ocular surface epithelium","volume":"40","author":"Tei","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib130","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.physiol.70.113006.100441","article-title":"Regulation of airway mucin gene expression","volume":"70","author":"Thai","year":"2008","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.exer.2013.07.027_bib131","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/jcb.21539","article-title":"Molecular signaling in the regulation of mucins","volume":"102","author":"Theodoropoulos","year":"2007","journal-title":"J.\u00a0Cell Biochem."},{"key":"10.1016\/j.exer.2013.07.027_bib132","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1016\/S0161-6420(98)91236-2","article-title":"Elevated tear interleukin-6 levels in patients with Sjogren syndrome","volume":"105","author":"Tishler","year":"1998","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2013.07.027_bib133","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0161-6420(95)31024-X","article-title":"Dry eye with only decreased tear break-up time is sometimes associated with allergic conjunctivitis","volume":"102","author":"Toda","year":"1995","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2013.07.027_bib134","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1182\/blood.V93.4.1287","article-title":"Muc-1 core protein is expressed on multiple myeloma cells and is induced by dexamethasone","volume":"93","author":"Treon","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.exer.2013.07.027_bib135","first-page":"108","article-title":"Alteration of ocular surface mucins in MUC5AC-DTA transgenic mice","volume":"15","author":"Wang","year":"2009","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2013.07.027_bib136","doi-asserted-by":"crossref","first-page":"882","DOI":"10.2310\/JIM.0b013e3181c0466d","article-title":"MUC7 polymorphisms are associated with a decreased risk of a diagnosis of asthma in an African American population","volume":"57","author":"Watson","year":"2009","journal-title":"J.\u00a0Invest. Med."},{"key":"10.1016\/j.exer.2013.07.027_bib137","first-page":"236","article-title":"Label-retaining cells are preferentially located in fornical epithelium: implications on conjunctival epithelial homeostasis","volume":"36","author":"Wei","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib138","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/archoto.2010.71","article-title":"Expression of membrane-bound mucins in human nasal mucosa: different patterns for MUC4 and MUC16","volume":"136","author":"Woo","year":"2010","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.exer.2013.07.027_bib139","doi-asserted-by":"crossref","first-page":"5641","DOI":"10.1167\/iovs.11-7196","article-title":"Notch signaling modulates MUC16 biosynthesis in an in\u00a0vitro model of human corneal and conjunctival epithelial cell differentiation","volume":"52","author":"Xiong","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2013.07.027_bib140","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1177\/000348940010900612","article-title":"Secretory differentiation of serially passaged normal human nasal epithelial cells by retinoic acid: expression of mucin and lysozyme","volume":"109","author":"Yoon","year":"2000","journal-title":"Ann. Otol Rhinol Laryngol."},{"key":"10.1016\/j.exer.2013.07.027_bib141","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.exer.2007.11.013","article-title":"MUC19 expression in human ocular surface and lacrimal gland and its alteration in Sjogren syndrome patients","volume":"86","author":"Yu","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2013.07.027_bib142","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1242\/dev.082842","article-title":"Mastermind-like transcriptional co-activator-mediated notch signaling is indispensable for maintaining conjunctival epithelial identity","volume":"140","author":"Zhang","year":"2013","journal-title":"Development"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483513002376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483513002376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T13:34:15Z","timestamp":1646314455000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483513002376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":142,"alternative-id":["S0014483513002376"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2013.07.027","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tear film mucins: Front line defenders of the ocular surface; comparison with airway and gastrointestinal tract mucins","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2013.07.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}