{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:38:01Z","timestamp":1790080681911,"version":"4.0.1"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.exer.2014.01.021","type":"journal-article","created":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T16:47:13Z","timestamp":1392050833000},"page":"26-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"special_numbering":"C","title":["Valproic acid suppresses Nrf2\/Keap1 dependent antioxidant protection through induction of endoplasmic reticulum stress and Keap1 promoter DNA demethylation in human lens epithelial cells"],"prefix":"10.1016","volume":"121","author":[{"given":"Periyasamy","family":"Palsamy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshore R.","family":"Bidasee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-9039","authenticated-orcid":false,"given":"Toshimichi","family":"Shinohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.exer.2014.01.021_bib1","first-page":"36","article-title":"Image processing with ImageJ","volume":"11","author":"Abramoff","year":"2004","journal-title":"Biophot. Int."},{"key":"10.1016\/j.exer.2014.01.021_bib2","doi-asserted-by":"crossref","first-page":"10309","DOI":"10.1073\/pnas.0504248102","article-title":"Valproate activates bovine leukemia virus gene expression, triggers apoptosis, and induces leukemia\/lymphoma regression in\u00a0vivo","volume":"102","author":"Achachi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2014.01.021_bib3","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1006\/exer.1996.0234","article-title":"Activation of calpain in lens: a review and proposed mechanism","volume":"64","author":"Azuma","year":"1997","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2014.01.021_bib4","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1001\/archopht.1983.01040010422016","article-title":"Presenile cataracts in phenytoin-treated epileptic patients","volume":"101","author":"Bar","year":"1983","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2014.01.021_bib5","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.biopsych.2005.10.018","article-title":"Regulation of editing and expression of glutamate alpha-amino-propionic-acid (AMPA)\/kainate receptors by antidepressant drugs","volume":"59","author":"Barbon","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.exer.2014.01.021_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diabetes.48.1.1","article-title":"Role of oxidative stress in diabetic complications: a new perspective on an old paradigm","volume":"48","author":"Baynes","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.exer.2014.01.021_bib7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.exer.2008.05.018","article-title":"Mitochondrial function and redox control in the aging eye: role of MsrA and other repair systems in cataract and macular degenerations","volume":"88","author":"Brennan","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2014.01.021_bib8","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1046\/j.1471-4159.2000.0751557.x","article-title":"Gliotoxic action of glutamate on cultured astrocytes","volume":"75","author":"Chen","year":"2000","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.exer.2014.01.021_bib9","first-page":"F96","article-title":"Calcium binding chaperones of the endoplasmic reticulum","volume":"28","author":"Coe","year":"2009","journal-title":"Gen. Physiol. Biophys."},{"key":"10.1016\/j.exer.2014.01.021_bib10","doi-asserted-by":"crossref","first-page":"20108","DOI":"10.1074\/jbc.M314219200","article-title":"PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress","volume":"279","author":"Cullinan","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2014.01.021_bib11","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.biocel.2005.09.018","article-title":"Coordination of ER and oxidative stress signaling: the PERK\/Nrf2 signaling pathway","volume":"38","author":"Cullinan","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.exer.2014.01.021_bib12","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1124\/mol.105.017855","article-title":"Valproic acid increases conservative homologous recombination frequency and reactive oxygen species formation: a potential mechanism for valproic acid-induced neural tube defects","volume":"69","author":"Defoort","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.exer.2014.01.021_bib13","doi-asserted-by":"crossref","first-page":"27586","DOI":"10.1074\/jbc.M303740200","article-title":"Valproate induces replication-independent active DNA demethylation","volume":"278","author":"Detich","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2014.01.021_bib14","doi-asserted-by":"crossref","first-page":"730","DOI":"10.4161\/epi.5.8.13053","article-title":"Valproate induces DNA demethylation in nuclear extracts from adult mouse brain","volume":"5","author":"Dong","year":"2010","journal-title":"Epigenetics"},{"key":"10.1016\/j.exer.2014.01.021_bib15","doi-asserted-by":"crossref","first-page":"13614","DOI":"10.1073\/pnas.0805493105","article-title":"Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation","volume":"105","author":"Dong","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2014.01.021_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2012.08.017","article-title":"Age-related cataracts: homocysteine coupled endoplasmic reticulum stress and suppression of Nrf2-dependent antioxidant protection","volume":"200","author":"Elanchezhian","year":"2012","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.exer.2014.01.021_bib17","doi-asserted-by":"crossref","first-page":"e301","DOI":"10.1038\/cddis.2012.40","article-title":"Low glucose under hypoxic conditions induces unfolded protein response and produces reactive oxygen species in lens epithelial cells","volume":"3","author":"Elanchezhian","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2014.01.021_bib18","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.bbrc.2012.01.009","article-title":"GluA2 AMPA glutamate receptor subunit exhibits codon 607 Q\/R RNA editing in the lens","volume":"418","author":"Farooq","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2014.01.021_bib19","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S0161-6420(02)00959-4","article-title":"Ophthalmic findings in fetal anticonvulsant syndrome(s)","volume":"109","author":"Glover","year":"2002","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2014.01.021_bib20","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1158\/0008-5472.CAN-03-0799","article-title":"Histone deacetylase is a target of valproic acid-mediated cellular differentiation","volume":"64","author":"Gurvich","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.exer.2014.01.021_bib21","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3109\/02713681003664915","article-title":"Prevalence of epilepsy among cataract patients","volume":"35","author":"Hanhart","year":"2010","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2014.01.021_bib22","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S1097-2765(00)00108-8","article-title":"Regulated translation initiation controls stress-induced gene expression in mammalian cells","volume":"6","author":"Harding","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.exer.2014.01.021_bib23","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrd3976","article-title":"Targeting the unfolded protein response in disease","volume":"12","author":"Hetz","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.exer.2014.01.021_bib24","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.exer.2006.01.033","article-title":"Role of the unfolded protein response (UPR) in cataract formation","volume":"83","author":"Ikesugi","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2014.01.021_bib25","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1001\/archopht.1991.01080020102053","article-title":"Exposure to phenothiazine drugs and risk of cataract","volume":"109","author":"Isaac","year":"1991","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2014.01.021_bib26","first-page":"295","article-title":"Breeding of cataract rat strain (ICRF\/Kmu\/\/Yg)","volume":"39","author":"Kato","year":"1990","journal-title":"Jikken Dobutsu"},{"key":"10.1016\/j.exer.2014.01.021_bib27","doi-asserted-by":"crossref","first-page":"6563","DOI":"10.1158\/0008-5472.CAN-06-0814","article-title":"Valproic acid-induced gene expression through production of reactive oxygen species","volume":"66","author":"Kawai","year":"2006","journal-title":"Cancer Res."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.exer.2014.01.021_bib28","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/epi.12103","article-title":"Treatment of behavioral problems in intellectually disabled adult patients with epilepsy","volume":"54","author":"Kerr","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.exer.2014.01.021_bib29","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1111\/j.1471-4159.2004.02783.x","article-title":"Two different Ca2+-dependent inhibitory mechanisms of spontaneous firing by glutamate in dopamine neurons","volume":"91","author":"Kim","year":"2004","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.exer.2014.01.021_bib30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s10384-003-0017-z","article-title":"Bilateral drug-induced cataract in a patient receiving anticonvulsant therapy","volume":"48","author":"Kinoshita","year":"2004","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.exer.2014.01.021_bib31","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/j.bbamcr.2013.01.026","article-title":"Regulation of inositol 1,4,5-trisphosphate receptors during endoplasmic reticulum stress","volume":"1833","author":"Kiviluoto","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2014.01.021_bib32","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.2169\/internalmedicine.48.2008","article-title":"Epileptic seizure, cataract, and tongue atrophy during the 8 years after electrical brain injury","volume":"48","author":"Kuwabara","year":"2009","journal-title":"Intern. Med."},{"key":"10.1016\/j.exer.2014.01.021_bib33","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S1350-9462(03)00050-8","article-title":"Redox regulation in the lens","volume":"22","author":"Lou","year":"2003","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2014.01.021_bib34","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1158\/0008-5472.CAN-04-2478","article-title":"Valproic acid alters chromatin structure by regulation of chromatin modulation proteins","volume":"65","author":"Marchion","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.exer.2014.01.021_bib35","first-page":"291","article-title":"Development of presenile cataracts in association with high serum levels of phenytoin","volume":"19","author":"Mathers","year":"1987","journal-title":"Ann. Ophthalmol."},{"key":"10.1016\/j.exer.2014.01.021_bib36","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/carcin\/bgl167","article-title":"Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes","volume":"28","author":"Milutinovic","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.exer.2014.01.021_bib37","doi-asserted-by":"crossref","first-page":"34287","DOI":"10.1074\/jbc.M204973200","article-title":"An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12","volume":"277","author":"Morishima","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2014.01.021_bib38","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/bdra.10030","article-title":"Anticonvulsant valproic acid inhibits cardiomyocyte differentiation of embryonic stem cells by increasing intracellular levels of reactive oxygen species","volume":"67","author":"Na","year":"2003","journal-title":"Birth Defects Res. Part A Clin. Mol. Teratol."},{"key":"10.1016\/j.exer.2014.01.021_bib39","doi-asserted-by":"crossref","first-page":"e51111","DOI":"10.1371\/journal.pone.0051111","article-title":"Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SH-SY5Y cells","volume":"7","author":"Narasimhan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2014.01.021_bib40","doi-asserted-by":"crossref","first-page":"23685","DOI":"10.1074\/jbc.M003061200","article-title":"Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response","volume":"275","author":"Pagani","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2014.01.021_bib41","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.bbrc.2012.05.164","article-title":"Promoter demethylation of Keap1 gene in human diabetic cataractous lenses","volume":"423","author":"Palsamy","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2014.01.021_bib42","doi-asserted-by":"crossref","first-page":"a007666","DOI":"10.1101\/cshperspect.a007666","article-title":"Endoplasmic reticulum stress, pancreatic beta-cell degeneration, and diabetes","volume":"2","author":"Papa","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.exer.2014.01.021_bib43","doi-asserted-by":"crossref","first-page":"2401S","DOI":"10.1093\/jn\/132.8.2401S","article-title":"Role of DNA methylation in the regulation of cell function: autoimmunity, aging and cancer","volume":"132","author":"Richardson","year":"2002","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.exer.2014.01.021_bib44","doi-asserted-by":"crossref","first-page":"56","DOI":"10.5698\/1535-7511-11.2.56","article-title":"Revisiting AMPA receptors as an antiepileptic drug target","volume":"11","author":"Rogawski","year":"2011","journal-title":"Epilepsy Curr."},{"key":"10.1016\/j.exer.2014.01.021_bib45","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/1471-2105-11-230","article-title":"BISMA\u2013fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences","volume":"11","author":"Rohde","year":"2010","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.exer.2014.01.021_bib46","doi-asserted-by":"crossref","first-page":"11632","DOI":"10.1016\/S0021-9258(18)99004-6","article-title":"The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity","volume":"266","author":"Rushmore","year":"1991","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2014.01.021_bib47","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0893-133X(99)00072-X","article-title":"Changes in tyrosine hydroxylase mRNA expression in the rat locus coeruleus following acute or chronic treatment with valproic acid","volume":"22","author":"Sands","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.exer.2014.01.021_bib48","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.neures.2009.03.009","article-title":"Effects of antidepressants on GluR2 Q\/R site-RNA editing in modified HeLa cell line","volume":"64","author":"Sawada","year":"2009","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.exer.2014.01.021_bib49","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1126\/science.1081208","article-title":"BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis","volume":"300","author":"Scorrano","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.exer.2014.01.021_bib50","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.18632\/oncotarget.1181","article-title":"Understanding the role of NRF2-regulated miRNAs in human malignancies","volume":"4","author":"Shah","year":"2013","journal-title":"Oncotarget"},{"key":"10.1016\/j.exer.2014.01.021_bib51","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1152\/japplphysiol.91280.2008","article-title":"Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation","volume":"106","author":"Shao","year":"2009","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.exer.2014.01.021_bib52","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1076\/ceyr.22.6.458.5483","article-title":"Proteolysis by m-calpain enhances in\u00a0vitro light scattering by crystallins from human and bovine lenses","volume":"22","author":"Shih","year":"2001","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2014.01.021_bib53","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1093\/carcin\/bgt026","article-title":"MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis","volume":"34","author":"Singh","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.exer.2014.01.021_bib54","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1600-0404.2011.01607.x","article-title":"Cancer risk in people with epilepsy using valproate-sodium","volume":"125","author":"Singh","year":"2012","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.exer.2014.01.021_bib55","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/brain\/awh363","article-title":"Cancer risk in people with epilepsy: the role of antiepileptic drugs","volume":"128","author":"Singh","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.exer.2014.01.021_bib56","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2165\/11584860-000000000-00000","article-title":"Pharmacotherapy of epilepsy: newly approved and developmental agents","volume":"25","author":"Stephen","year":"2011","journal-title":"CNS Drugs"},{"key":"10.1016\/j.exer.2014.01.021_bib57","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S1097-2765(02)00696-2","article-title":"The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum","volume":"10","author":"Tu","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.exer.2014.01.021_bib58","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1083\/jcb.200311055","article-title":"Oxidative protein folding in eukaryotes: mechanisms and consequences","volume":"164","author":"Tu","year":"2004","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.exer.2014.01.021_bib59","first-page":"347","article-title":"Actions of sodium valproate on the central nervous system","volume":"50","author":"Tunnicliff","year":"1999","journal-title":"J.\u00a0Physiol. Pharmacol."},{"key":"10.1016\/j.exer.2014.01.021_bib60","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/nature04431","article-title":"The Polycomb group protein EZH2 directly controls DNA methylation","volume":"439","author":"Vire","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.exer.2014.01.021_bib61","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1002\/ajmg.a.35438","article-title":"Antiepileptic drugs and pregnancy outcomes","volume":"158A","author":"Wlodarczyk","year":"2012","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.exer.2014.01.021_bib62","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s10549-011-1604-1","article-title":"MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism","volume":"129","author":"Yang","year":"2011","journal-title":"Breast Cancer Res. Treat."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483514000360?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483514000360?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T05:29:06Z","timestamp":1648272546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483514000360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":62,"alternative-id":["S0014483514000360"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2014.01.021","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Valproic acid suppresses Nrf2\/Keap1 dependent antioxidant protection through induction of endoplasmic reticulum stress and Keap1 promoter DNA demethylation in human lens epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2014.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}