{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T06:17:26Z","timestamp":1785219446370,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NEI","award":["EY017006"],"award-info":[{"award-number":["EY017006"]}]},{"name":"NEI","award":["EY0020490"],"award-info":[{"award-number":["EY0020490"]}]},{"name":"Core Grant","award":["P30 EY016665"],"award-info":[{"award-number":["P30 EY016665"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.exer.2014.11.009","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T07:51:56Z","timestamp":1416297116000},"page":"9-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["NFATc1 activity regulates the expression of myocilin induced by dexamethasone"],"prefix":"10.1016","volume":"130","author":[{"given":"Jennifer A.","family":"Faralli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross W.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Filla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2014.11.009_bib1","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1093\/hmg\/6.12.2091","article-title":"Recurrent mutations in a single exon encoding the evolutionarily conserved olfactomedin-homology domain of TIGR in familial open-angle glaucoma","volume":"6","author":"Adam","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2014.11.009_bib2","first-page":"464","article-title":"Human trabecular meshwork cells II. Growth pattern and ultrastructural characteristics","volume":"23","author":"Alvarado","year":"1982","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2014.11.009_bib3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/32100","article-title":"Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA","volume":"392","author":"Chen","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.exer.2014.11.009_bib4","first-page":"1769","article-title":"Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues","volume":"42","author":"Clark","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2014.11.009_bib5","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1074\/mcp.M112.019745","article-title":"Comparative genomic and proteomic analysis of cytoskeletal changes in dexamethasone-treated trabecular meshwork cells","volume":"12","author":"Clark","year":"2013","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.exer.2014.11.009_bib6","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/357695a0","article-title":"Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation","volume":"357","author":"Clipstone","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.exer.2014.11.009_bib7","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1126\/science.2595372","article-title":"Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation","volume":"246","author":"Emmel","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.exer.2014.11.009_bib8","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1172\/JCI43085","article-title":"Glaucoma: genes, phenotypes, and new directions for therapy","volume":"120","author":"Fan","year":"2010","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.exer.2014.11.009_bib9","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1016\/j.bbamcr.2013.09.020","article-title":"Dexamethasone increases \u03b1v\u03b23 integrin expression and affinity through a calcineurin\/NFAT pathway","volume":"1833","author":"Faralli","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2014.11.009_bib10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.exer.2004.02.010","article-title":"Distribution of syndecans 1-4 within the anterior segment of the human eye: expression of a variant syndecan-3 and matrix-associated syndecan-2","volume":"79","author":"Filla","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2014.11.009_bib11","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/hmg\/8.5.899","article-title":"Analysis of myocilin mutations in 1703 glaucoma patients from five different populations","volume":"8","author":"Fingert","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2014.11.009_bib12","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0039-6257(02)00353-3","article-title":"Myocilin glaucoma","volume":"47","author":"Fingert","year":"2002","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2014.11.009_bib13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00418-008-0518-4","article-title":"Myocilin promotes substrate adhesion, spreading and formation of focal contacts in podocytes and mesangial cells","volume":"131","author":"Goldwich","year":"2009","journal-title":"Histochem. Cell. Biol."},{"key":"10.1016\/j.exer.2014.11.009_bib14","doi-asserted-by":"crossref","first-page":"13216","DOI":"10.1074\/jbc.M111.224063","article-title":"Myocilin interacts with syntrophins and is member of dystrophin-associated protein complex","volume":"287","author":"Joe","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2014.11.009_bib15","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.bbrc.2003.10.162","article-title":"Accumulation of mutant myocilins in ER leads to ER stress and potential cytotoxicity in human trabecular meshwork cells","volume":"312","author":"Joe","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2014.11.009_bib16","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.visres.2011.02.014","article-title":"Analysis of glucocorticoid-induced MYOC expression in human trabecular meshwork cells","volume":"51","author":"Joe","year":"2011","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2014.11.009_bib17","doi-asserted-by":"crossref","first-page":"7707","DOI":"10.1128\/MCB.21.22.7707-7713.2001","article-title":"Targeted disruption of the myocilin gene (MYOC) suggests that human glaucoma-causing mutations are gain of function","volume":"21","author":"Kim","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.exer.2014.11.009_bib18","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1046\/j.1365-2443.2000.00355.x","article-title":"Regulation of human myocilin\/TIGR gene transcription in trabecular meshwork cells and astrocytes: role of upstream stimulatory factor","volume":"5","author":"Kirstein","year":"2000","journal-title":"Genes. Cells"},{"key":"10.1016\/j.exer.2014.11.009_bib19","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1006\/geno.1997.4682","article-title":"A\u00a0novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: molecular cloning, tissue expression, and chromosomal mapping","volume":"41","author":"Kubota","year":"1997","journal-title":"Genomics"},{"key":"10.1016\/j.exer.2014.11.009_bib20","doi-asserted-by":"crossref","first-page":"26357","DOI":"10.1074\/jbc.M112.446138","article-title":"Myocilin mediates myelination in the peripheral nervous system through ErbB2\/3 signaling","volume":"288","author":"Kwon","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2014.11.009_bib21","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1002\/jcp.22701","article-title":"Myocilin, a glaucoma-associated protein, promotes cell migration through activation of integrin-focal adhesion kinase-serine\/threonine kinase signaling pathway","volume":"226","author":"Kwon","year":"2011","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.exer.2014.11.009_bib22","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1056\/NEJMra0804630","article-title":"Primary open-angle glaucoma","volume":"360","author":"Kwon","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.exer.2014.11.009_bib23","first-page":"1386","article-title":"Truncations in the TIGR gene in individuals with and without primary open-angle glaucoma","volume":"41","author":"Lam","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2014.11.009_bib24","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0092-8674(91)90124-H","article-title":"Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes","volume":"66","author":"Liu","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.exer.2014.11.009_bib25","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.1074\/jbc.273.11.6341","article-title":"Gene structure and properties of TIGR, a olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells","volume":"273","author":"Nguyen","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2014.11.009_bib26","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0014-5793(97)00934-4","article-title":"Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin","volume":"413","author":"Ortego","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.exer.2014.11.009_bib27","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/j.1365-2443.2007.01102.x","article-title":"Interaction between two glaucoma genes, optineurin and myocilin","volume":"12","author":"Park","year":"2007","journal-title":"Genes. Cells"},{"key":"10.1016\/j.exer.2014.11.009_bib28","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.yexcr.2004.09.026","article-title":"Myocilin binding to Hep II domain of fibronectin inhibits cell spreading and incorporation of paxillin into focal adhesions","volume":"303","author":"Peters","year":"2005","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/j.exer.2014.11.009_bib29","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1093\/nar\/29.9.e45","article-title":"A\u00a0new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2014.11.009_bib30","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000310780","article-title":"Cellular pharmacology and molecular biology of the trabecular meshwork inducible glucocorticoid response gene product","volume":"211","author":"Polansky","year":"1997","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.exer.2014.11.009_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0092845","article-title":"Cellular processing of myocilin","volume":"9","author":"Qiu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2014.11.009_bib32","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/bjo.80.5.389","article-title":"Number of people with glaucoma worldwide","volume":"80","author":"Quigley","year":"1996","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2014.11.009_bib33","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/j.cellsig.2008.06.003","article-title":"Regulation of calcineurin activity in insulin-secreting cells: stimulation by Hsp90 during glucocorticoid-induced apoptosis","volume":"20","author":"Ranta","year":"2008","journal-title":"Cell. Signal"},{"key":"10.1016\/j.exer.2014.11.009_bib34","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1006\/exer.2001.1063","article-title":"Expression of myocilin\/TIGR in normal and glaucomatous primate optic nerves","volume":"73","author":"Ricard","year":"2001","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2014.11.009_bib35","doi-asserted-by":"crossref","first-page":"7554","DOI":"10.1073\/pnas.0401835101","article-title":"Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules","volume":"101","author":"Roehrl","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2014.11.009_bib36","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/jcp.21147","article-title":"Mitochondrial association of myocilin, product of a glaucoma gene, in human trabecular meshwork cells","volume":"213","author":"Sakai","year":"2007","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.exer.2014.11.009_bib37","first-page":"3173","article-title":"Delayed secondary glucocorticoid responsiveness of MYOC in human trabecular meshwork cells","volume":"42","author":"Shepard","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2014.11.009_bib38","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.275.5300.668","article-title":"Identification of a gene that causes primary open angle glaucoma","volume":"275","author":"Stone","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.exer.2014.11.009_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10384-013-0286-0","article-title":"Genetics of primary open angle glaucoma","volume":"58","author":"Takamoto","year":"2014","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.exer.2014.11.009_bib40","first-page":"2577","article-title":"Modulation of myocilin\/TIGR expression in human trabecular meshwork","volume":"40","author":"Tamm","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2014.11.009_bib41","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1172\/JCI119278","article-title":"Aldosterone and dexamethasone stimulate calcineurin activity through a transcription-independent mechanism involving steroid receptor-associated heat shock proteins","volume":"99","author":"Tumlin","year":"1997","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.exer.2014.11.009_bib42","first-page":"618","article-title":"Pro370Leu mutant myocilin disturbs the endoplasm reticulum stress response and mitochondrial membrane potential in human trabecaulr meshwork cells","volume":"13","author":"Wang","year":"2007","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2014.11.009_bib43","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1172\/JCI58183","article-title":"Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma","volume":"121","author":"Zode","year":"2011","journal-title":"J.\u00a0Clin. Invest"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483514003054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483514003054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T13:55:36Z","timestamp":1538056536000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483514003054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":43,"alternative-id":["S0014483514003054"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2014.11.009","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NFATc1 activity regulates the expression of myocilin induced by dexamethasone","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2014.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}