{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T07:42:22Z","timestamp":1784706142610,"version":"3.55.0"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea","award":["A121487"],"award-info":[{"award-number":["A121487"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.exer.2015.01.010","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T14:47:27Z","timestamp":1449758847000},"page":"32-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Fibroblast biology in pterygia"],"prefix":"10.1016","volume":"142","author":[{"given":"Kyoung Woo","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9601-3559","authenticated-orcid":false,"given":"Soo Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Chan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2015.01.010_bib1","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1038\/jid.2010.120","article-title":"Epithelial cells promote fibroblast activation via IL-1 alpha in systemic sclerosis","volume":"130","author":"Aden","year":"2010","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.exer.2015.01.010_bib2","first-page":"69","article-title":"Comparing techniques for pterygium surgery","volume":"3","author":"Alpay","year":"2009","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.exer.2015.01.010_bib3","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1136\/bjo.2009.177857","article-title":"Mycophenolic acid suppresses human pterygium and normal tenon fibroblast proliferation in\u00a0vitro","volume":"94","author":"Amer","year":"2010","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2015.01.010_bib4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1076\/ceyr.17.1.79.5261","article-title":"Chemotaxis of human keratocytes is increased by platelet-derived growth factor-BB, epidermal growth factor, transforming growth factor-alpha, acidic fibroblast growth factor, insulin-like growth factor-I, and transforming growth factor-beta","volume":"17","author":"Andresen","year":"1998","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2015.01.010_bib5","first-page":"836","article-title":"Primary pterygium recurrence time","volume":"3","author":"Avisar","year":"2001","journal-title":"Isr. Med. Assoc. J."},{"key":"10.1016\/j.exer.2015.01.010_bib6","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/labinvest.3700654","article-title":"The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses","volume":"87","author":"Bellini","year":"2007","journal-title":"Lab. Invest."},{"key":"10.1016\/j.exer.2015.01.010_bib7","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1136\/bjo.2008.151852","article-title":"The science of pterygia","volume":"94","author":"Bradley","year":"2010","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2015.01.010_bib8","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1167\/iovs.12-10469","article-title":"Ultraviolet-A irradiation upregulated urokinase-type plasminogen activator in pterygium fibroblasts through ERK and JNK pathways","volume":"54","author":"Chao","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF02632046","article-title":"Fibroblasts isolated from human pterygia exhibit transformed cell characteristics","volume":"30A","author":"Chen","year":"1994","journal-title":"In\u00a0Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.exer.2015.01.010_bib10","doi-asserted-by":"crossref","first-page":"4842","DOI":"10.1167\/iovs.14-14441","article-title":"Isolation and characterization of mesenchymal progenitor cells from human orbital adipose tissue","volume":"55","author":"Chen","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jtos.2012.12.001","article-title":"Correlation of microRNA-145 levels and clinical severity of pterygia","volume":"11","author":"Chien","year":"2013","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2015.01.010_bib12","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0161-6420(00)00651-5","article-title":"Proliferative activity and p53 expression in primary and recurrent pterygia","volume":"108","author":"Chowers","year":"2001","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2015.01.010_bib13","first-page":"3199","article-title":"IL-8 gene expression in cultures of human corneal epithelial cells and keratocytes","volume":"34","author":"Cubitt","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib14","first-page":"330","article-title":"Differences in interleukin-6 gene expression between cultured human corneal epithelial cells and keratocytes","volume":"36","author":"Cubitt","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib15","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/j.1442-9071.2011.02531.x","article-title":"Downregulation of c-Myc in pterygium and cultured pterygial cells","volume":"39","author":"Cui","year":"2011","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2015.01.010_bib16","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1136\/bjo.82.11.1324","article-title":"Evaluation of loss of heterozygosity and microsatellite instability in human pterygium: clinical correlations","volume":"82","author":"Detorakis","year":"1998","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2015.01.010_bib17","first-page":"671","article-title":"Expression of MMPs and TIMPs in human pterygia and cultured pterygium epithelial cells","volume":"41","author":"Di Girolamo","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib18","first-page":"3430","article-title":"UVB-mediated induction of interleukin-6 and -8 in pterygia and cultured human pterygium epithelial cells","volume":"43","author":"Di Girolamo","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.preteyeres.2004.02.002","article-title":"Pathogenesis of pterygia: role of cytokines, growth factors, and matrix metalloproteinases","volume":"23","author":"Di Girolamo","year":"2004","journal-title":"Prog. Retin Eye Res."},{"key":"10.1016\/j.exer.2015.01.010_bib20","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0002-9440(10)62992-6","article-title":"Epidermal growth factor receptor signaling is partially responsible for the increased matrix metalloproteinase-1 expression in ocular epithelial cells after UVB radiation","volume":"167","author":"Di Girolamo","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2015.01.010_bib21","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/art.23451","article-title":"Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with scleroderma","volume":"58","author":"Duan","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.exer.2015.01.010_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/bjo.2007.119842","article-title":"The prevalence, severity and risk factors for pterygium in central Myanmar: the Meiktila Eye Study","volume":"92","author":"Durkin","year":"2008","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2015.01.010_bib23","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.exer.2013.07.003","article-title":"miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium","volume":"115","author":"Engelsvold","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2015.01.010_bib24","doi-asserted-by":"crossref","first-page":"5480","DOI":"10.1021\/bi00341a030","article-title":"Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells","volume":"24","author":"Fett","year":"1985","journal-title":"Biochemistry"},{"key":"10.1016\/j.exer.2015.01.010_bib25","first-page":"115","article-title":"Refractive change following pterygium surgery","volume":"24","author":"Fong","year":"1998","journal-title":"CLAO J."},{"key":"10.1016\/j.exer.2015.01.010_bib26","doi-asserted-by":"crossref","first-page":"e23185","DOI":"10.1371\/journal.pone.0023185","article-title":"IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis","volume":"6","author":"Gasse","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2015.01.010_bib27","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1755-3768.1994.tb04688.x","article-title":"Limbal-conjunctival autograft transplantation in cases with recurrent pterygium","volume":"72","author":"Guler","year":"1994","journal-title":"Acta Ophthalmol. Copenh."},{"key":"10.1016\/j.exer.2015.01.010_bib28","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/nm.3282","article-title":"Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs","volume":"19","author":"Henderson","year":"2013","journal-title":"Nat. Med."},{"issue":"Pt 2","key":"10.1016\/j.exer.2015.01.010_bib29","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/eye.1989.31","article-title":"Pathogenesis of pterygium","volume":"3","author":"Hill","year":"1989","journal-title":"Eye Lond."},{"key":"10.1016\/j.exer.2015.01.010_bib30","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2353\/ajpath.2007.070112","article-title":"The myofibroblast: one function, multiple origins","volume":"170","author":"Hinz","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2015.01.010_bib31","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.ajpath.2012.02.004","article-title":"Recent developments in myofibroblast biology: paradigms for connective tissue remodeling","volume":"180","author":"Hinz","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2015.01.010_bib32","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1038\/nm.3421","article-title":"It has to be the alphav: myofibroblast integrins activate latent TGF-beta1","volume":"19","author":"Hinz","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.exer.2015.01.010_bib33","first-page":"637","article-title":"Platelet-derived growth factor: receptor expression in corneas and effects on corneal cells","volume":"34","author":"Hoppenreijs","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib34","doi-asserted-by":"crossref","first-page":"e97402","DOI":"10.1371\/journal.pone.0097402","article-title":"Evaluation of global differential gene and protein expression in primary pterygium: S100A8 and S100A9 as possible drivers of a signaling network","volume":"9","author":"Hou","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2015.01.010_bib35","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.ophtha.2013.01.001","article-title":"Ocular demodicosis as a risk factor of pterygium recurrence","volume":"120","author":"Huang","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2015.01.010_bib36","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00003226-200307000-00015","article-title":"Decreased pigment epithelium-derived factor and increased vascular endothelial growth factor levels in pterygia","volume":"22","author":"Jin","year":"2003","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2015.01.010_bib37","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000090329","article-title":"Frequency of chromosome 17 aneuploidy in primary and recurrent pterygium by interphase-fluorescence in situ hybridization","volume":"38","author":"Kamis","year":"2006","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.exer.2015.01.010_bib38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jtos.2012.07.002","article-title":"Wakayama symposium: challenges of future research in ocular surface cell biology","volume":"11","author":"Kao","year":"2013","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2015.01.010_bib39","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4103\/0301-4738.39663","article-title":"Cyclooxygenase-2 expression in primary and recurrent pterygium","volume":"56","author":"Karahan","year":"2008","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.exer.2015.01.010_bib40","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1167\/iovs.06-1060","article-title":"Beta-catenin activation and epithelial-mesenchymal transition in the pathogenesis of pterygium","volume":"48","author":"Kato","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib41","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ophtha.2012.06.066","article-title":"Options and adjuvants in surgery for pterygium: a report by the American Academy of Ophthalmology","volume":"120","author":"Kaufman","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2015.01.010_bib42","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0002-9440(10)62983-5","article-title":"Intrastromal invasion by limbal epithelial cells is mediated by epithelial-mesenchymal transition activated by air exposure","volume":"167","author":"Kawakita","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2015.01.010_bib43","first-page":"2483","article-title":"Ultraviolet irradiation induces the production of multiple cytokines by human corneal cells","volume":"38","author":"Kennedy","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib44","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bbrc.2006.11.047","article-title":"Angiogenin-induced protein kinase B\/Akt activation is necessary for angiogenesis but is independent of nuclear translocation of angiogenin in HUVE cells","volume":"352","author":"Kim","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2015.01.010_bib45","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.1167\/iovs.13-12141","article-title":"Overexpression of angiogenin in pterygium body fibroblasts and its association with proliferative potency","volume":"54","author":"Kim","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib46","doi-asserted-by":"crossref","first-page":"7198","DOI":"10.1167\/iovs.13-13044","article-title":"Upregulated stromal cell-derived factor 1 (SDF-1) expression and its interaction with CXCR4 contribute to the pathogenesis of severe pterygia","volume":"54","author":"Kim","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib47","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1136\/bjophthalmol-2012-302784","article-title":"Management of complicated multirecurrent pterygia using multimicroporous expanded polytetrafluoroethylene","volume":"97","author":"Kim","year":"2013","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2015.01.010_bib48","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S1350-9462(01)00007-6","article-title":"Characteristics of the human ocular surface epithelium","volume":"20","author":"Kinoshita","year":"2001","journal-title":"Prog. Retin Eye Res."},{"key":"10.1016\/j.exer.2015.01.010_bib49","doi-asserted-by":"crossref","first-page":"20009","DOI":"10.1073\/pnas.1013805107","article-title":"Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts","volume":"107","author":"Kojima","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2015.01.010_bib50","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0065-1281(96)80038-9","article-title":"Immunohistochemical localization of basic fibroblast growth factor, platelet derived growth factor, transforming growth factor-beta and tumor necrosis factor-alpha in the pterygium","volume":"98","author":"Kria","year":"1996","journal-title":"Acta Histochem."},{"key":"10.1016\/j.exer.2015.01.010_bib51","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1007\/s004170050144","article-title":"Growth factors in cultured pterygium fibroblasts: immunohistochemical and ELISA analysis","volume":"236","author":"Kria","year":"1998","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2015.01.010_bib52","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1167\/iovs.09-4022","article-title":"Role of periostin and interleukin-4 in recurrence of pterygia","volume":"51","author":"Kuo","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib53","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/00003226-199405000-00005","article-title":"A\u00a0model for pterygium formation","volume":"13","author":"Kwok","year":"1994","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2015.01.010_bib54","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.exer.2003.09.008","article-title":"Corneal epithelial stem cells at the limbus: looking at some old problems from a new angle","volume":"78","author":"Lavker","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2015.01.010_bib55","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-beta signaling and the fibrotic response","volume":"18","author":"Leask","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.exer.2015.01.010_bib56","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1038\/sj.eye.6702433","article-title":"Endothelial progenitor cells in pterygium pathogenesis","volume":"21","author":"Lee","year":"2007","journal-title":"Eye Lond."},{"key":"10.1016\/j.exer.2015.01.010_bib57","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.cyto.2009.11.008","article-title":"The change of cytokines in tear and blood after different pterygium operation","volume":"49","author":"Lee","year":"2010","journal-title":"Cytokine"},{"key":"10.1016\/j.exer.2015.01.010_bib58","doi-asserted-by":"crossref","first-page":"680","DOI":"10.3109\/02713683.2013.867063","article-title":"Antifibrotic effect of pirfenidone on human pterygium fibroblasts","volume":"39","author":"Lee","year":"2014","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2015.01.010_bib59","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1076\/0271-3683(200004)2041-5FT325","article-title":"Suppression of TGF-beta signaling in both normal conjunctival fibroblasts and pterygial body fibroblasts by amniotic membrane","volume":"20","author":"Lee","year":"2000","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2015.01.010_bib60","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1038\/eye.2012.194","article-title":"Comparative evaluation of lymphatic vessels in primary versus recurrent pterygium","volume":"26","author":"Ling","year":"2012","journal-title":"Eye Lond."},{"key":"10.1016\/j.exer.2015.01.010_bib61","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1001\/archophthalmol.2011.328","article-title":"New grading system to improve the surgical outcome of multirecurrent pterygia","volume":"130","author":"Liu","year":"2012","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2015.01.010_bib62","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1006\/exer.2001.1116","article-title":"Pterygial derived fibroblasts express functionally active histamine and epidermal growth factor receptors","volume":"74","author":"Maini","year":"2002","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2015.01.010_bib63","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/bjo.80.4.288","article-title":"Long term results of intraoperative mitomycin C in the treatment of recurrent pterygium","volume":"80","author":"Mastropasqua","year":"1996","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2015.01.010_bib64","first-page":"3289","article-title":"Immunohistochemical localization of transforming growth factor-beta 1, -beta 2, and -beta 3 latency-associated peptide in human cornea","volume":"35","author":"Nishida","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcp.1041530102","article-title":"Interleukin 6 promotes epithelial migration by a fibronectin-dependent mechanism","volume":"153","author":"Nishida","year":"1992","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.exer.2015.01.010_bib66","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1001\/archopht.1992.01080210110036","article-title":"Interleukin 6 facilitates corneal epithelial wound closure in\u00a0vivo","volume":"110","author":"Nishida","year":"1992","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2015.01.010_bib67","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1167\/iovs.03-0046","article-title":"Proliferative effects of heparin-binding epidermal growth factor-like growth factor on pterygium epithelial cells and fibroblasts","volume":"45","author":"Nolan","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib68","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1167\/iovs.06-1054","article-title":"Modulation of cholesterol homeostasis by antiproliferative drugs in human pterygium fibroblasts","volume":"48","author":"Peiretti","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib69","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.canlet.2003.10.026","article-title":"Loss of heterozygosity and p53 expression in pterygium","volume":"206","author":"Reisman","year":"2004","journal-title":"Cancer Lett."},{"key":"10.1016\/j.exer.2015.01.010_bib70","doi-asserted-by":"crossref","first-page":"e14687","DOI":"10.1371\/journal.pone.0014687","article-title":"Aberrant DNA methylation of matrix remodeling and cell adhesion related genes in pterygium","volume":"6","author":"Riau","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2015.01.010_bib71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/08977199309029129","article-title":"Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta)","volume":"8","author":"Roberts","year":"1993","journal-title":"Growth Factors"},{"key":"10.1016\/j.exer.2015.01.010_bib72","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1165\/rcmb.2007-0322OC","article-title":"Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis","volume":"39","author":"Sanders","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.exer.2015.01.010_bib73","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1076\/opep.6.3.219.1504","article-title":"Pterygium: prevalence, demography and risk factors","volume":"6","author":"Saw","year":"1999","journal-title":"Ophthalmic Epidemiol."},{"key":"10.1016\/j.exer.2015.01.010_bib74","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1167\/iovs.11-7941","article-title":"Involvement of SPARC and MMP-3 in the pathogenesis of human pterygium","volume":"53","author":"Seet","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib75","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3109\/02713683.2014.900806","article-title":"Inhibition of alpha-smooth muscle actin expression and migration of pterygium fibroblasts by coculture with amniotic mesenchymal stem cells","volume":"39","author":"Sha","year":"2014","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2015.01.010_bib76","first-page":"1364","article-title":"Telomerase activity and p53 expression in pterygia","volume":"41","author":"Shimmura","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib77","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1167\/iovs.10-5735","article-title":"The nuclear-factor kappaB pathway is activated in pterygium","volume":"52","author":"Siak","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib78","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0002-9440(10)65624-6","article-title":"Transfer of tumor necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts","volume":"153","author":"Sime","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2015.01.010_bib79","first-page":"2154","article-title":"Regulation of collagenase, stromelysin, and urokinase-type plasminogen activator in primary pterygium body fibroblasts by inflammatory cytokines","volume":"41","author":"Solomon","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib80","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0161-6420(00)00567-4","article-title":"Amniotic membrane transplantation after extensive removal of primary and recurrent pterygia","volume":"108","author":"Solomon","year":"2001","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2015.01.010_bib81","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1167\/iovs.01-1185","article-title":"Overexpression of insulin-like growth factor-binding protein-2 in pterygium body fibroblasts","volume":"44","author":"Solomon","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.010_bib82","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3349\/ymj.2005.46.5.687","article-title":"The involvement of adult stem cells originated from bone marrow in the pathogenesis of pterygia","volume":"46","author":"Song","year":"2005","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.exer.2015.01.010_bib83","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0002-9394(14)70141-2","article-title":"Abnormal expression of the p53 tumor suppressor gene in the conjunctiva of patients with pterygium","volume":"123","author":"Tan","year":"1997","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2015.01.010_bib84","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1001\/archopht.1997.01100160405001","article-title":"Effect of pterygium morphology on pterygium recurrence in a controlled trial comparing conjunctival autografting with bare sclera excision","volume":"115","author":"Tan","year":"1997","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2015.01.010_bib85","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1136\/bjo.2004.050633","article-title":"Characterisation of myofibroblasts in fibrovascular tissues of primary and recurrent pterygia","volume":"89","author":"Touhami","year":"2005","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2015.01.010_bib86","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.3748\/wjg.v13.i22.3056","article-title":"Transforming growth factor-beta and fibrosis","volume":"13","author":"Verrecchia","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.exer.2015.01.010_bib87","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20092121","article-title":"Bleomycin and IL-1 beta-mediated pulmonary fibrosis is IL-17A dependent","volume":"207","author":"Wilson","year":"2010","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.exer.2015.01.010_bib88","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.ophtha.2011.01.052","article-title":"Diplopia and quality of life","volume":"118","author":"Wu-Chen","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2015.01.010_bib89","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.exer.2015.01.010_bib90","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/sj.eye.6701346","article-title":"Involvement of bone marrow-derived stem and progenitor cells in the pathogenesis of pterygium","volume":"18","author":"Ye","year":"2004","journal-title":"Eye Lond."},{"key":"10.1016\/j.exer.2015.01.010_bib91","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1128\/MCB.17.7.4015","article-title":"Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis","volume":"17","author":"Yoshida","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.exer.2015.01.010_bib92","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1097\/ICO.0b013e31823cbecb","article-title":"Comparison of pterygium recurrence rates after limbal conjunctival autograft transplantation and other techniques: meta-analysis","volume":"31","author":"Zheng","year":"2012","journal-title":"Cornea"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483515000111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483515000111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T05:54:45Z","timestamp":1567403685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483515000111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":92,"alternative-id":["S0014483515000111"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2015.01.010","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fibroblast biology in pterygia","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2015.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}