{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:35:29Z","timestamp":1778754929073,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"Engineering Research Center","doi-asserted-by":"publisher","award":["2011\u20130030075"],"award-info":[{"award-number":["2011\u20130030075"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean government","award":["2011-0019633"],"award-info":[{"award-number":["2011-0019633"]}]},{"DOI":"10.13039\/501100003645","name":"National Cancer Center Korea","doi-asserted-by":"crossref","award":["1320220"],"award-info":[{"award-number":["1320220"]}],"id":[{"id":"10.13039\/501100003645","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center, Korea","doi-asserted-by":"crossref","award":["2014-7202"],"award-info":[{"award-number":["2014-7202"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.exer.2015.01.013","type":"journal-article","created":{"date-parts":[[2015,1,17]],"date-time":"2015-01-17T02:04:19Z","timestamp":1421460259000},"page":"101-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Comparison of confocal microscopy and two-photon microscopy in mouse cornea in\u00a0vivo"],"prefix":"10.1016","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0481-3151","authenticated-orcid":false,"given":"Jun Ho","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seunghun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Song","family":"Gho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Seok","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hungwon","family":"Tchah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myoung Joon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Hean","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2015.01.013_bib1","first-page":"935","article-title":"Two-photon imaging of the trabecular meshwork","volume":"16","author":"Ammar","year":"2010","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2015.01.013_bib2","first-page":"583","article-title":"Trans-scleral imaging of the human trabecular meshwork by two-photon microscopy","volume":"17","author":"Ammar","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2015.01.013_bib3","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1167\/iovs.09-4586","article-title":"Multimodal nonlinear imaging of the human cornea","volume":"51","author":"Aptel","year":"2010","journal-title":"Investigative Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.013_bib4","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1167\/iovs.06-0570","article-title":"Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis","volume":"48","author":"Bock","year":"2007","journal-title":"Investigative Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.013_bib5","first-page":"e50148","article-title":"In\u00a0vivo two-photon imaging of experience-dependent molecular changes in cortical neurons","volume":"71","author":"Cao","year":"2013","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.exer.2015.01.013_bib6","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1167\/iovs.10-7105","article-title":"Quantitative assessment of UVA-riboflavin corneal cross-linking using nonlinear optical microscopy","volume":"52","author":"Chai","year":"2011","journal-title":"Investigative Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.013_bib7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/jemt.20528","article-title":"Combination of multiphoton and reflective confocal imaging of cornea","volume":"71","author":"Chen","year":"2008","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.exer.2015.01.013_bib8","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nprot.2012.009","article-title":"Second harmonic generation microscopy for quantitative analysis of collagen fibrillar structure","volume":"7","author":"Chen","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.exer.2015.01.013_bib9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1126\/science.2321027","article-title":"Two-photon laser scanning fluorescence microscopy","volume":"248","author":"Denk","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.exer.2015.01.013_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/870879","article-title":"Multiphoton microscopy for ophthalmic imaging","author":"Gibson","year":"2011","journal-title":"J.\u00a0Ophthalmol."},{"key":"10.1016\/j.exer.2015.01.013_bib11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1442-9071.2009.02016.x","article-title":"In\u00a0vivo confocal microscopy, an inner vision of the cornea \u2013 a major review","volume":"37","author":"Guthoff","year":"2009","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2015.01.013_bib12","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.1364\/OPEX.13.005791","article-title":"Second harmonic generation imaging of collagen fibrils in cornea and sclera","volume":"13","author":"Han","year":"2005","journal-title":"Opt. Express"},{"key":"10.1016\/j.exer.2015.01.013_bib13","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.1167\/iovs.10-7115","article-title":"Two-photon imaging of the mouse eye","volume":"52","author":"Johnson","year":"2011","journal-title":"Investigative Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.013_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1046\/j.1365-2818.2000.00738.x","article-title":"Multiphoton microscopy in life sciences","volume":"200","author":"Konig","year":"2000","journal-title":"J.\u00a0Microsc."},{"key":"10.1016\/j.exer.2015.01.013_bib15","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1167\/iovs.10-7112","article-title":"Combined nonlinear and femtosecond confocal laser-scanning microscopy of rabbit corneas after photochemical cross-linking","volume":"52","author":"Kr\u00fcger","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.013_bib16","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/jemt.20373","article-title":"Intact corneal stroma visualization of GFP mouse revealed by multiphoton imaging","volume":"69","author":"Lo","year":"2006","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.exer.2015.01.013_bib17","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1167\/iovs.06-1177","article-title":"Second-harmonic imaging microscopy of normal human and keratoconus cornea","volume":"48","author":"Morishige","year":"2007","journal-title":"Investigative Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.013_bib18","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1167\/iovs.12-10214","article-title":"Abnormalities of stromal structure in the bullous keratopathy cornea identified by second harmonic generation imaging microscopy","volume":"53","author":"Morishige","year":"2012","journal-title":"Investigative Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.013_bib19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.preteyeres.2009.11.001","article-title":"Clinical in\u00a0vivo confocal microscopy of the human cornea in health and disease","volume":"29","author":"Niederer","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2015.01.013_bib20","doi-asserted-by":"crossref","DOI":"10.1117\/1.3655587","article-title":"In\u00a0vivo spectral imaging of different cell types in the small intestine by two-photon excited autofluorescence","volume":"16","author":"Orzekowsky-Schroeder","year":"2011","journal-title":"J.\u00a0Biomed. Opt."},{"key":"10.1016\/j.exer.2015.01.013_bib21","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1167\/iovs.09-4407","article-title":"Cellular-level characterization of lymph vessels in live, unlabeled corneas by in\u00a0vivo confocal microscopy","volume":"51","author":"Peebo","year":"2010","journal-title":"Investigative Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.013_bib22","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1365-2818.1995.tb03576.x","article-title":"Three-dimensionally resolved NAD(P)H cellular metabolic redox imaging of the in situ cornea with two-photon excitation laser scanning microscopy","volume":"178","author":"Piston","year":"1995","journal-title":"J.\u00a0Microsc."},{"key":"10.1016\/j.exer.2015.01.013_bib23","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1364\/BOE.4.001285","article-title":"In\u00a0vivo two-photon imaging of the mouse retina","volume":"4","author":"Sharma","year":"2013","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.exer.2015.01.013_bib24","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.bioeng.2.1.399","article-title":"Two-photon excitation fluorescence microscopy","volume":"2","author":"So","year":"2000","journal-title":"Annu Rev. Biomed. Eng."},{"key":"10.1016\/j.exer.2015.01.013_bib25","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/nprot.2008.118","article-title":"Noninvasive high-resolution in\u00a0vivo imaging of cell biology in the anterior chamber of the mouse eye","volume":"3","author":"Speier","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.exer.2015.01.013_bib26","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/11698","article-title":"Long-term two-photon fluorescence imaging of mammalian embryos without compromising viability","volume":"17","author":"Squirrell","year":"1999","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.exer.2015.01.013_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026253","article-title":"Intravital two-photon microscopy of immune cell dynamics in corneal lymphatic vessels","volume":"6","author":"Steven","year":"2011","journal-title":"Plos One"},{"key":"10.1016\/j.exer.2015.01.013_bib28","doi-asserted-by":"crossref","DOI":"10.1117\/1.3275475","article-title":"Comparison of cornea module and dermainspect for noninvasive imaging of ocular surface pathologies","volume":"14","author":"Steven","year":"2009","journal-title":"J.\u00a0Biomed. Opt."},{"key":"10.1016\/j.exer.2015.01.013_bib29","doi-asserted-by":"crossref","first-page":"5251","DOI":"10.1167\/iovs.06-0386","article-title":"Multiphoton fluorescence and second harmonic generation imaging of the structural alterations in keratoconus ex\u00a0vivo","volume":"47","author":"Tan","year":"2006","journal-title":"Investigative Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.013_bib30","doi-asserted-by":"crossref","DOI":"10.1117\/1.2717133","article-title":"Multiphoton fluorescence and second harmonic generation microscopy for imaging infectious keratitis","volume":"12","author":"Tan","year":"2007","journal-title":"J.\u00a0Biomed. Opt."},{"key":"10.1016\/j.exer.2015.01.013_bib31","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1167\/iovs.04-1520","article-title":"Multiphoton autofluorescence and second-harmonic generation imaging of the ex\u00a0vivo porcine eye","volume":"47","author":"Teng","year":"2006","journal-title":"Investigative Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.01.013_bib32","doi-asserted-by":"crossref","first-page":"7075","DOI":"10.1073\/pnas.0832308100","article-title":"Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation","volume":"100","author":"Zipfel","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2015.01.013_bib33","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1038\/nbt899","article-title":"Nonlinear magic: multiphoton microscopy in the biosciences","volume":"21","author":"Zipfel","year":"2003","journal-title":"Nat. Biotechnol."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483515000202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483515000202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T03:29:23Z","timestamp":1537932563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483515000202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":33,"alternative-id":["S0014483515000202"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2015.01.013","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of confocal microscopy and two-photon microscopy in mouse cornea in\u00a0vivo","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2015.01.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}