{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:07:36Z","timestamp":1787317656668,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.exer.2015.05.006","type":"journal-article","created":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T23:22:03Z","timestamp":1431732123000},"page":"93-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Pharmacokinetics of topically applied recombinant human keratinocyte growth factor-2 in alkali-burned and intact rabbit eye"],"prefix":"10.1016","volume":"136","author":[{"given":"Jianqiu","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifang","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuechao","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2015.05.006_bib1","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1167\/iovs.05-0635","article-title":"Differential regulation of key stages in early corneal wound healing by TGF-beta isoforms and their inhibitors","volume":"47","author":"Carrington","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.05.006_bib2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1517\/17425255.2012.673585","article-title":"Pharmacokinetics of recombinant bifunctional fusion proteins","volume":"8","author":"Chen","year":"2012","journal-title":"Expert. Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.exer.2015.05.006_bib3","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1586\/ecp.10.59","article-title":"Potential clinical application of KGF-2 (FGF-10) for acute lung injury\/acute respiratory distress syndrome","volume":"3","author":"Fang","year":"2010","journal-title":"Expert. Rev. Clin. Pharmacol."},{"key":"10.1016\/j.exer.2015.05.006_bib4","doi-asserted-by":"crossref","first-page":"8318","DOI":"10.1158\/1078-0432.CCR-04-1118","article-title":"Phase I\/II randomized trial evaluating the safety and clinical effects of repifermin administered to reduce mucositis in patients undergoing autologous hematopoietic stem cell transplantation","volume":"10","author":"Freytes","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.exer.2015.05.006_bib5","doi-asserted-by":"crossref","first-page":"G1011","DOI":"10.1152\/ajpgi.2000.279.5.G1011","article-title":"Keratinocyte growth factor-2 (FGF-10) promotes healing of experimental small intestinal ulceration in rats","volume":"279","author":"Han","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.exer.2015.05.006_bib6","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jbiotec.2009.05.004","article-title":"Chemical modification of recombinant human keratinocyte growth factor 2 with polyethylene glycol improves biostability and reduces animal immunogenicity","volume":"142","author":"Huang","year":"2009","journal-title":"J.\u00a0Biotechnol."},{"key":"10.1016\/j.exer.2015.05.006_bib7","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00003226-199703000-00010","article-title":"Inhibition of corneal fibrosis by topical application of blocking antibodies to TGF beta in the rabbit","volume":"16","author":"Jester","year":"1997","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2015.05.006_bib8","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1006\/jsre.1998.5501","article-title":"Keratinocyte growth factor-2 accelerates wound healing in incisional wounds","volume":"81","author":"Jimenez","year":"1999","journal-title":"J.\u00a0Surg. Res."},{"key":"10.1016\/j.exer.2015.05.006_bib9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2174\/1389200033489488","article-title":"Pharmacokinetics of topical ocular drug delivery: potential uses for the treatment of diseases of the posterior segment and beyond","volume":"4","author":"Koevary","year":"2003","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.exer.2015.05.006_bib10","first-page":"1963","article-title":"Growth factors modulate clonal growth and differentiation of cultured rabbit limbal and corneal epithelium","volume":"34","author":"Kruse","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.05.006_bib11","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.1167\/iovs.05-0301","article-title":"Pharmacokinetics of conjunctivally applied nerve growth factor in the retina and optic nerve of adult rats","volume":"46","author":"Lambiase","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.05.006_bib12","first-page":"107","article-title":"Keratinocyte growth factor-2 on the proliferation of corneal epithelial stem cells in rabbit alkali burned cornea","volume":"23","author":"Liu","year":"2007","journal-title":"Yan Ke Xue Bao"},{"key":"10.1016\/j.exer.2015.05.006_bib13","first-page":"2789","article-title":"Fibroblast growth factor 10 upregulates the expression of mucins in rat conjunctival epithelial cells","volume":"17","author":"Ma","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2015.05.006_bib14","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1046\/j.0022-202x.2001.01280.x","article-title":"Fibroblast growth factor 10 induces proliferation and differentiation of human primary cultured keratinocytes","volume":"116","author":"Marchese","year":"2001","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.exer.2015.05.006_bib15","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1186\/1472-6882-13-337","article-title":"Topical Brazilian propolis improves corneal wound healing and inflammation in rats following alkali burns","volume":"13","author":"Martin","year":"2013","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.exer.2015.05.006_bib16","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0022-3565(24)34921-3","article-title":"Efficacy of keratinocyte growth factor-2 in dextran sulfate sodium-induced murine colitis","volume":"290","author":"Miceli","year":"1999","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.exer.2015.05.006_bib17","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1076\/ceyr.17.7.736.5163","article-title":"Neutralizing antibody to TGFbeta modulates stromal fibrosis but not regression of photoablative effect following PRK","volume":"17","author":"M\u00f8ller-Pedersen","year":"1998","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2015.05.006_bib18","first-page":"265","article-title":"In search of markers for the stem cells of the corneal epithelium","volume":"97","author":"Pajoohesh-Ganji","year":"2005","journal-title":"Biol. Cell. Auspices Eur. Cell. Biol. Organ."},{"key":"10.1016\/j.exer.2015.05.006_bib19","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/BCR.0b013e318240540a","article-title":"Sugar-coating wound repair: a review of FGF-10 and dermatan sulfate in wound healing and their potential application in burn wounds","volume":"33","author":"Plichta","year":"2012","journal-title":"J.\u00a0Burn. Care Res."},{"key":"10.1016\/j.exer.2015.05.006_bib20","doi-asserted-by":"crossref","first-page":"G615","DOI":"10.1152\/ajpgi.00445.2012","article-title":"Keratinocyte growth factor-2 stimulates P-glycoprotein expression and function in intestinal epithelial cells","volume":"304","author":"Saksena","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.exer.2015.05.006_bib21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v16.i1.20","article-title":"Enhancement of ocular drug penetration","volume":"16","author":"Sasaki","year":"1999","journal-title":"Crit. Rev. Ther. Drug Carr. Syst."},{"key":"10.1016\/j.exer.2015.05.006_bib22","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1111\/j.1582-4934.2012.01588.x","article-title":"KGF-2 targets alveolar epithelia and capillary endothelia to reduce high altitude pulmonary oedema in rats","volume":"16","author":"She","year":"2012","journal-title":"J.\u00a0Cell. Mol. Med."},{"key":"10.1016\/j.exer.2015.05.006_bib23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/00004630-200021010-00003","article-title":"Efficacy of growth factors in the accelerated closure of interstices in explanted meshed human skin grafts","volume":"21","author":"Smith","year":"2000","journal-title":"J.\u00a0Burn. Care Rehabil."},{"key":"10.1016\/j.exer.2015.05.006_bib24","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.1208\/ps040206","article-title":"Pharmacologic and pharmacokinetic profile of repifermin (KGF-2) in monkeys and comparative pharmacokinetics in humans","volume":"4","author":"Sung","year":"2002","journal-title":"AAPS Pharm. Sci."},{"issue":"4","key":"10.1016\/j.exer.2015.05.006_bib25","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0039-6257(96)00007-0","article-title":"Chemical injuries of the eye: current concepts in pathophysiology and therapy","volume":"41","author":"Wagoner","year":"1997","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2015.05.006_bib26","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s10529-009-9948-x","article-title":"Construction and characterization of a high activity mutant of human keratinocyte growth factor-2","volume":"31","author":"Wang","year":"2009","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.exer.2015.05.006_bib27","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1248\/bpb.33.971","article-title":"Effects of keratinocyte growth factor-2 on corneal epithelial wound healing in a rabbit model of carbon dioxide laser injury","volume":"33","author":"Wang","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.exer.2015.05.006_bib28","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00253-008-1782-x","article-title":"Large-scale production of biologically active human keratinocyte growth factor-2","volume":"82","author":"Wu","year":"2009","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.exer.2015.05.006_bib29","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/(SICI)1096-9896(199908)188:4<431::AID-PATH362>3.0.CO;2-B","article-title":"Effects of keratinocyte growth factor-2 (KGF-2) on wound healing in an ischaemia-impaired rabbit ear model and on scar formation","volume":"188","author":"Xia","year":"1999","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.exer.2015.05.006_bib30","first-page":"15","article-title":"Effect of keratinocyte growth factor on corneal epithelial wound healing","volume":"34","author":"Zhong","year":"1998","journal-title":"Zhonghua Yan Ke Za Zhi"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483515001542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483515001542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T20:33:09Z","timestamp":1748377989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483515001542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":30,"alternative-id":["S0014483515001542"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2015.05.006","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacokinetics of topically applied recombinant human keratinocyte growth factor-2 in alkali-burned and intact rabbit eye","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2015.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}