{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T22:13:44Z","timestamp":1778019224156,"version":"3.51.4"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1R21NS08542"],"award-info":[{"award-number":["1R21NS08542"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I21RX001553"],"award-info":[{"award-number":["I21RX001553"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["C3638R"],"award-info":[{"award-number":["C3638R"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I21RX001593"],"award-info":[{"award-number":["I21RX001593"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["C7506M"],"award-info":[{"award-number":["C7506M"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["B3756\u2013F"],"award-info":[{"award-number":["B3756\u2013F"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.exer.2015.12.010","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T21:15:28Z","timestamp":1451423728000},"page":"95-102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Rho GTPase signaling promotes constitutive expression and release of TGF-\u03b22 by human trabecular meshwork cells"],"prefix":"10.1016","volume":"146","author":[{"given":"Cynthia L.","family":"Pervan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Lautz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea L.","family":"Blitzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly A.","family":"Langert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Evan B.","family":"Stubbs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2015.12.010_bib1","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1167\/iovs.05-1393","article-title":"Ultrastructural and biochemical evaluation of the porcine anterior chamber perfusion model","volume":"47","author":"Bachmann","year":"2006","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1167\/iovs.08-2632","article-title":"Cochlin expression in anterior segment organ culture models after TGFbeta2 treatment","volume":"50","author":"Bhattacharya","year":"2009","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib3","first-page":"85","article-title":"Transforming growth factor-\u03b22 gene cloning and protein expression in human trabecular meshwork cells","volume":"23","author":"Cao","year":"2003","journal-title":"J.\u00a0Huazhong Univ. Sci. Technol. Med. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib4","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1101\/gad.915701","article-title":"Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA","volume":"15","author":"Charron","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.exer.2015.12.010_bib5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/sj.gt.3301865","article-title":"Novel antisense oligonucleotides targeting TGF-beta inhibit in\u00a0vivo scarring and improve surgical outcome","volume":"10","author":"Cordeiro","year":"2003","journal-title":"Gene Ther."},{"key":"10.1016\/j.exer.2015.12.010_bib6","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1167\/iovs.05-1060","article-title":"TGFbeta2-induced changes in human trabecular meshwork: implications for intraocular pressure","volume":"47","author":"Fleenor","year":"2006","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib7","doi-asserted-by":"crossref","first-page":"33347","DOI":"10.1074\/jbc.M113.484568","article-title":"miR-29 promotes murine osteoclastogenesis by regulating osteoclast commitment and migration","volume":"288","author":"Franceschetti","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2015.12.010_bib8","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1001\/archopht.122.4.532","article-title":"Prevalence of open-angle glaucoma among adults in the United States","volume":"122","author":"Friedman","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2015.12.010_bib9","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.exer.2009.01.002","article-title":"Gene expression profiling of TGFbeta2- and\/or BMP7-treated trabecular meshwork cells: identification of Smad7 as a critical inhibitor of TGF-beta2 signaling","volume":"88","author":"Fuchshofer","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2015.12.010_bib10","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0014-4835(03)00220-3","article-title":"The effect of TGF-beta2 on human trabecular meshwork extracellular proteolytic system","volume":"77","author":"Fuchshofer","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2015.12.010_bib11","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1167\/iovs.06-0226","article-title":"Bone morphogenetic protein-7 is an antagonist of transforming growth factor-beta2 in human trabecular meshwork cells","volume":"48","author":"Fuchshofer","year":"2007","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1167\/iovs.03-0796","article-title":"Effects of TGF-beta2 in perfused human eyes","volume":"45","author":"Gottanka","year":"2004","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib13","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1167\/iovs.10-6640","article-title":"Elasticity-dependent modulation of TGF-beta responses in human trabecular meshwork cells","volume":"52","author":"Han","year":"2011","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib14","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0092-8674(05)80020-0","article-title":"The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF","volume":"81","author":"Hill","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.exer.2015.12.010_bib15","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1167\/iovs.14-15622","article-title":"Decorin reduces intraocular pressure and retinal ganglion cell loss in rodents through fibrolysis of the scarred trabecular meshwork","volume":"56","author":"Hill","year":"2015","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s004170000241","article-title":"Transforming growth factor-beta 2 levels in aqueous humor of glaucomatous eyes","volume":"239","author":"Inatani","year":"2001","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2015.12.010_bib17","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.1167\/iovs.09-3673","article-title":"Differential effects of ADAMTS-1, -4, and -5 in the trabecular meshwork","volume":"50","author":"Keller","year":"2009","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib18","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.ophtha.2007.03.050","article-title":"A\u00a0phase III study of subconjunctival human anti-transforming growth factor beta(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy","volume":"114","author":"Khaw","year":"2007","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2015.12.010_bib19","doi-asserted-by":"crossref","first-page":"34020","DOI":"10.1074\/jbc.274.48.34020","article-title":"Transcriptional regulation of the transforming growth factor-beta2 promoter by cAMP-responsive element-binding protein (CREB) and activating transcription factor-1 (ATF-1) is modulated by protein kinases and the coactivators p300 and CREB-binding protein","volume":"274","author":"Kingsley-Kallesen","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2015.12.010_bib20","doi-asserted-by":"crossref","DOI":"10.4161\/sgtp.29260","article-title":"Novel role of Cdc42 and RalA GTPases in TNF-alpha mediated secretion of CCL2","volume":"5","author":"Langert","year":"2014","journal-title":"Small GTPases"},{"key":"10.1016\/j.exer.2015.12.010_bib21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/jns5.12032","article-title":"Cdc42 GTPases facilitate TNF-alpha-mediated secretion of CCL2 from peripheral nerve microvascular endoneurial endothelial cells","volume":"18","author":"Langert","year":"2013","journal-title":"J.\u00a0Peripher Nerv. Syst."},{"key":"10.1016\/j.exer.2015.12.010_bib22","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1167\/iovs.10-6448","article-title":"Cross-talk between miR-29 and transforming growth factor-betas in trabecular meshwork cells","volume":"52","author":"Luna","year":"2011","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib23","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1101\/gad.855801","article-title":"Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway","volume":"15","author":"Marinissen","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.exer.2015.12.010_bib24","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.exer.2013.10.017","article-title":"Smad3 is necessary for transforming growth factor-beta2 induced ocular hypertension in mice","volume":"116","author":"McDowell","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2015.12.010_bib25","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1167\/iovs.02-0978","article-title":"Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery","volume":"44","author":"Mead","year":"2003","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib26","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3341\/kjo.2006.20.3.162","article-title":"Transforming growth factor-beta levels in human aqueous humor of glaucomatous, diabetic and uveitic eyes","volume":"20","author":"Min","year":"2006","journal-title":"Korean J. Ophthalmol."},{"key":"10.1016\/j.exer.2015.12.010_bib27","doi-asserted-by":"crossref","first-page":"e0134003","DOI":"10.1371\/journal.pone.0134003","article-title":"All-trans retinoic acid induces TGF-beta2 in intestinal epithelial cells via RhoA- and p38alpha MAPK-mediated activation of the transcription factor ATF2","volume":"10","author":"Namachivayam","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2015.12.010_bib28","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0021-5155(01)00523-8","article-title":"Higher concentration of transforming growth factor-beta in aqueous humor of glaucomatous eyes and diabetic eyes","volume":"46","author":"Ochiai","year":"2002","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.exer.2015.12.010_bib29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1023\/B:INTE.0000018524.48581.79","article-title":"The aqueous levels of TGF-beta2 in patients with glaucoma","volume":"25","author":"Ozcan","year":"2004","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.exer.2015.12.010_bib30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nsmb.1533","article-title":"miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42","volume":"16","author":"Park","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.exer.2015.12.010_bib31","first-page":"23","article-title":"Immunolocalization of TGF-beta 1, TGF-beta 2, and TGF-beta 3 in the anterior segment of the human eye","volume":"34","author":"Pasquale","year":"1993","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib32","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/jcp.24524","article-title":"Regulation of plasticity and fibrogenic activity of trabecular meshwork cells by Rho GTPase signaling","volume":"229","author":"Pattabiraman","year":"2014","journal-title":"J.\u00a0Cell Physiol."},{"key":"10.1016\/j.exer.2015.12.010_bib33","doi-asserted-by":"crossref","first-page":"C749","DOI":"10.1152\/ajpcell.00317.2009","article-title":"Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells","volume":"298","author":"Pattabiraman","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.exer.2015.12.010_bib34","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s004170000252","article-title":"Transforming growth factor beta 2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb development","volume":"239","author":"Picht","year":"2001","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2015.12.010_bib35","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2015.12.010_bib36","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1167\/iovs.07-1639","article-title":"Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork","volume":"49","author":"Rao","year":"2008","journal-title":"Invest Ophthalmol. Vis. Sci."},{"issue":"7\u201315","key":"10.1016\/j.exer.2015.12.010_bib37","first-page":"15","article-title":"Multiple forms of TGF-beta: distinct promoters and differential expression","volume":"157","author":"Roberts","year":"1991","journal-title":"Ciba Found. Symp."},{"key":"10.1016\/j.exer.2015.12.010_bib38","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1167\/iovs.09-3380","article-title":"Ocular gene transfer of active TGF-beta induces changes in anterior segment morphology and elevated IOP in rats","volume":"51","author":"Robertson","year":"2010","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib39","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s004170050354","article-title":"Immunolocalization of TGF-beta1, -beta2, and -beta3, and TGF-beta receptors in human lens capsules with lens implants","volume":"238","author":"Saika","year":"2000","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2015.12.010_bib40","first-page":"1880","article-title":"Suppression of transforming growth factor-beta effects in rabbit subconjunctival fibroblasts by activin receptor-like kinase 5 inhibitor","volume":"16","author":"Sapitro","year":"2010","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2015.12.010_bib41","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1167\/iovs.09-4567","article-title":"Adenoviral gene transfer of active human transforming growth factor-{beta}2 elevates intraocular pressure and reduces outflow facility in rodent eyes","volume":"51","author":"Shepard","year":"2010","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib42","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jhep.2010.07.026","article-title":"TGF-beta1 mediated activation of Rho kinase induces TGF-beta2 and endothelin-1 expression in human hepatic stellate cells","volume":"54","author":"Shimada","year":"2011","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.exer.2015.12.010_bib43","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1167\/iovs.04-0776","article-title":"Effects of cholesterol-lowering statins on the aqueous humor outflow pathway","volume":"46","author":"Song","year":"2005","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib44","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12035-012-8249-x","article-title":"Prenylation of rho g-proteins: a novel mechanism regulating gene expression and protein stability in human trabecular meshwork cells","volume":"46","author":"Stubbs","year":"2012","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.exer.2015.12.010_bib45","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1167\/iovs.13-12463","article-title":"TGF-beta2-mediated ocular hypertension is attenuated in SPARC-null mice","volume":"55","author":"Swaminathan","year":"2014","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib46","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.exer.2011.06.011","article-title":"Transforming growth factor-beta2 utilizes the canonical smad-signaling pathway to regulate tissue transglutaminase expression in human trabecular meshwork cells","volume":"93","author":"Tovar-Vidales","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2015.12.010_bib47","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1006\/exer.1994.1046","article-title":"Trabecular cells express the TGF-beta 2 gene and secrete the cytokine","volume":"58","author":"Tripathi","year":"1994","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2015.12.010_bib48","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1006\/exer.1994.1158","article-title":"Aqueous humor in glaucomatous eyes contains an increased level of TGF-beta 2","volume":"59","author":"Tripathi","year":"1994","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2015.12.010_bib49","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1167\/iovs.13-12712","article-title":"Pharmacological regulation of SPARC by lovastatin in human trabecular meshwork cells","volume":"55","author":"Villarreal","year":"2014","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib50","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1167\/iovs.11-9289","article-title":"Transforming growth factor-beta2 induces synthesis and secretion of endothelin-1 in human trabecular meshwork cells","volume":"53","author":"Von Zee","year":"2012","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib51","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1167\/iovs.08-2466","article-title":"Increased RhoA and RhoB protein accumulation in cultured human trabecular meshwork cells by lovastatin","volume":"50","author":"Von Zee","year":"2009","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib52","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1167\/iovs.10-6171","article-title":"Geranylgeranylation facilitates proteasomal degradation of rho g-proteins in human trabecular meshwork cells","volume":"52","author":"Von Zee","year":"2011","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib53","first-page":"2229","article-title":"Induction of tissue transglutaminase in the trabecular meshwork by TGF-beta1 and TGF-beta2","volume":"41","author":"Welge-Lussen","year":"2000","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib54","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1167\/iovs.06-0296","article-title":"Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma","volume":"48","author":"Wordinger","year":"2007","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib55","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1167\/iovs.08-1675","article-title":"SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism","volume":"50","author":"Xiao","year":"2009","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2015.12.010_bib56","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000083019","article-title":"Concentration of transforming growth factor beta2 in aqueous humor","volume":"37","author":"Yamamoto","year":"2005","journal-title":"Ophthalmic Res."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483515300956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483515300956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:28:24Z","timestamp":1762147704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483515300956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":56,"alternative-id":["S0014483515300956"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2015.12.010","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rho GTPase signaling promotes constitutive expression and release of TGF-\u03b22 by human trabecular meshwork cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2015.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}