{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:21:49Z","timestamp":1790014909311,"version":"4.0.1"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100001641","name":"Glaucoma Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001641","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015112","name":"Melza M. and Frank Theodore Barr Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015112","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Utah Vision Core","award":["5P30EY014800"],"award-info":[{"award-number":["5P30EY014800"]}]},{"name":"US National Institute of Healthy","award":["R01EY020878"],"award-info":[{"award-number":["R01EY020878"]}]},{"name":"US National Institute of Healthy","award":["R01EY023621"],"award-info":[{"award-number":["R01EY023621"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.exer.2016.01.014","type":"journal-article","created":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T21:03:07Z","timestamp":1454533387000},"page":"34-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Glial coverage in the optic nerve expands in proportion to optic axon loss in chronic mouse glaucoma"],"prefix":"10.1016","volume":"150","author":[{"given":"Alejandra","family":"Bosco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin T.","family":"Breen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah R.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Steele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Calkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica L.","family":"Vetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2016.01.014_bib1","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.1073\/pnas.0407357102","article-title":"High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma","volume":"102","author":"Anderson","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2016.01.014_bib2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1242\/dmm.018788","article-title":"Neurodegeneration severity can be predicted from early microglia alterations monitored in\u00a0vivo in a mouse model of chronic glaucoma","volume":"8","author":"Bosco","year":"2015","journal-title":"Dis. Model Mech."},{"key":"10.1016\/j.exer.2016.01.014_bib3","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/cne.22516","article-title":"Early microglia activation in a mouse model of chronic glaucoma","volume":"519","author":"Bosco","year":"2011","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.exer.2016.01.014_bib4","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1523\/JNEUROSCI.4443-07.2008","article-title":"Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma","volume":"28","author":"Buckingham","year":"2008","journal-title":"J.\u00a0Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.exer.2016.01.014_bib5","doi-asserted-by":"crossref","first-page":"18183","DOI":"10.1073\/pnas.0506535102","article-title":"Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair","volume":"102","author":"Buffo","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2016.01.014_bib6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuron.2013.12.034","article-title":"Reactive gliosis and the multicellular response to CNS damage and disease","volume":"81","author":"Burda","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.exer.2016.01.014_bib7","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.preteyeres.2012.07.001","article-title":"Critical pathogenic events underlying progression of neurodegeneration in glaucoma","volume":"31","author":"Calkins","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2016.01.014_bib8","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/cne.20368","article-title":"Morphological identification of ganglion cells expressing the alpha subunit of type II calmodulin-dependent protein kinase in the macaque retina","volume":"481","author":"Calkins","year":"2005","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.exer.2016.01.014_bib9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.expneurol.2006.04.030","article-title":"Cytoplasmic translocation of Olig2 in adult glial progenitors marks the generation of reactive astrocytes following autoimmune inflammation","volume":"201","author":"Cassiani-Ingoni","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.exer.2016.01.014_bib10","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1442-9071.2012.02773.x","article-title":"Definition of glaucoma: clinical and experimental concepts","volume":"40","author":"Casson","year":"2012","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2016.01.014_bib11","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1167\/iovs.05-1206","article-title":"Semiquantitative optic nerve grading scheme for determining axonal loss in experimental optic neuropathy","volume":"47","author":"Chauhan","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.01.014_bib12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1167\/iovs.09-5115","article-title":"Optic neuropathy due to microbead-induced elevated intraocular pressure in the mouse","volume":"52","author":"Chen","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.01.014_bib13","doi-asserted-by":"crossref","first-page":"10983","DOI":"10.1523\/JNEUROSCI.3545-08.2008","article-title":"The basic helix-loop-helix transcription factor olig2 is critical for reactive astrocyte proliferation after cortical injury","volume":"28","author":"Chen","year":"2008","journal-title":"J.\u00a0Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.exer.2016.01.014_bib14","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00401-011-0807-1","article-title":"The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma","volume":"121","author":"Chidlow","year":"2011","journal-title":"Acta neuropathol."},{"key":"10.1016\/j.exer.2016.01.014_bib15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.exer.2015.11.016","article-title":"Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA\/2J mouse model of glaucoma","volume":"150","author":"Cooper","year":"2016","journal-title":"Exp Eye Res."},{"key":"10.1016\/j.exer.2016.01.014_bib16","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1073\/pnas.0913141107","article-title":"Distal axonopathy with structural persistence in glaucomatous neurodegeneration","volume":"107","author":"Crish","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2016.01.014_bib17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/glia.21242","article-title":"Structural basis of glaucoma: the fortified astrocytes of the optic nerve head are the target of raised intraocular pressure","volume":"60","author":"Dai","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.exer.2016.01.014_bib18","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.1167\/iovs.10-5284","article-title":"Microglial activation in the visual pathway in experimental glaucoma: spatiotemporal characterization and correlation with axonal injury","volume":"51","author":"Ebneter","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.01.014_bib19","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/j.1442-9071.2011.02741.x","article-title":"Estimation of axon counts in a rat model of glaucoma: comparison of fixed-pattern sampling with targeted sampling","volume":"40","author":"Ebneter","year":"2012","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2016.01.014_bib20","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1167\/iovs.05-0289","article-title":"Pathophysiologic changes in the optic nerves of eyes with primary open angle and pseudoexfoliation glaucoma","volume":"46","author":"Gottanka","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.01.014_bib21","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/srep00530","article-title":"The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA\/2J mice","volume":"2","author":"Harder","year":"2012","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2016.01.014_bib22","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1350-9462(99)00017-8","article-title":"The optic nerve head in glaucoma: role of astrocytes in tissue remodeling","volume":"19","author":"Hernandez","year":"2000","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2016.01.014_bib23","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1083\/jcb.200706181","article-title":"Axons of retinal ganglion cells are insulted in the optic nerve early in DBA\/2J glaucoma","volume":"179","author":"Howell","year":"2007","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.exer.2016.01.014_bib24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1471-2156-8-45","article-title":"Absence of glaucoma in DBA\/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1","volume":"8","author":"Howell","year":"2007","journal-title":"BMC Genet."},{"key":"10.1016\/j.exer.2016.01.014_bib25","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1172\/JCI44646","article-title":"Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma","volume":"121","author":"Howell","year":"2011","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.exer.2016.01.014_bib26","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1172\/JCI61135","article-title":"Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma","volume":"122","author":"Howell","year":"2012","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.exer.2016.01.014_bib27","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/glia.20516","article-title":"Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma","volume":"55","author":"Inman","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.exer.2016.01.014_bib71","series-title":"Glaucoma \u2013 Current Clinical Research Aspects","isbn-type":"print","article-title":"Manipulating glia to protect retinal ganglion cells in glaucoma","author":"Inman","year":"2011","ISBN":"https:\/\/id.crossref.org\/isbn\/9789533072630"},{"key":"10.1016\/j.exer.2016.01.014_bib28","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1167\/iovs.05-0925","article-title":"Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA\/2 mouse model of glaucoma","volume":"47","author":"Inman","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.01.014_bib29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jneumeth.2014.05.032","article-title":"Modification of commercially available image analysis software for semi-automated qualitative analysis of axon regeneration and myelination in the rat sciatic nerve","volume":"233","author":"Isaacs","year":"2014","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.exer.2016.01.014_bib30","first-page":"1380","article-title":"Patterns of intraocular pressure elevation after aqueous humor outflow obstruction in rats","volume":"41","author":"Jia","year":"2000","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.01.014_bib31","first-page":"951","article-title":"Essential iris atrophy, pigment dispersion, and glaucoma in DBA\/2J mice","volume":"39","author":"John","year":"1998","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.01.014_bib32","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1167\/iovs.06-1282","article-title":"Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model","volume":"48","author":"Johnson","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.01.014_bib33","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/BF00180945","article-title":"Optic nerve fiber count and diameter of the retrobulbar optic nerve in normal and glaucomatous eyes","volume":"233","author":"Jonas","year":"1995","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2016.01.014_bib34","doi-asserted-by":"crossref","first-page":"6431","DOI":"10.1167\/iovs.10-5212","article-title":"Morphometric changes in the rat optic nerve following short-term intermittent elevations in intraocular pressure","volume":"51","author":"Joos","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.01.014_bib35","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1017\/S0952523805225130","article-title":"Inherited glaucoma in DBA\/2J mice: pertinent disease features for studying the neurodegeneration","volume":"22","author":"Libby","year":"2005","journal-title":"Vis. Neurosci."},{"key":"10.1016\/j.exer.2016.01.014_bib36","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1371\/journal.pgen.0010004","article-title":"Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage","volume":"1","author":"Libby","year":"2005","journal-title":"PLoS Genet."},{"key":"10.1016\/j.exer.2016.01.014_bib37","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1167\/iovs.12-10109","article-title":"Morphology of astrocytes in a glaucomatous optic nerve","volume":"54","author":"Lye-Barthel","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.01.014_bib38","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1167\/iovs.03-0138","article-title":"Optic nerve damage in experimental mouse ocular hypertension","volume":"44","author":"Mabuchi","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.01.014_bib39","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1002\/jnr.21368","article-title":"Evidence that nucleocytoplasmic Olig2 translocation mediates brain-injury-induced differentiation of glial precursors to astrocytes","volume":"85","author":"Magnus","year":"2007","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.exer.2016.01.014_bib40","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1038\/nprot.2010.128","article-title":"A\u00a0semiautomated targeted sampling method to assess optic nerve axonal loss in a rat model of glaucoma","volume":"5","author":"Marina","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.exer.2016.01.014_bib41","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s00401-005-0011-2","article-title":"Optic nerve degeneration in the DBA\/2NNia mouse: is the lamina cribrosa important in the development of glaucomatous optic neuropathy?","volume":"111","author":"May","year":"2006","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.exer.2016.01.014_bib42","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/exer.1996.0184","article-title":"A\u00a0rat model of chronic pressure-induced optic nerve damage","volume":"64","author":"Morrison","year":"1997","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.01.014_bib43","doi-asserted-by":"crossref","first-page":"12633","DOI":"10.1523\/JNEUROSCI.2801-06.2006","article-title":"Tumor necrosis factor-alpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma","volume":"26","author":"Nakazawa","year":"2006","journal-title":"J.\u00a0Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.exer.2016.01.014_bib44","first-page":"2962","article-title":"Detection of early neuron degeneration and accompanying microglial responses in the retina of a rat model of glaucoma","volume":"43","author":"Naskar","year":"2002","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.01.014_bib45","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev.neuro.051508.135728","article-title":"Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy","volume":"35","author":"Nickells","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.exer.2016.01.014_bib46","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.exer.2015.06.006","article-title":"Assessment of retinal ganglion cell damage in glaucomatous optic neuropathy: axon transport, injury and soma loss","volume":"141","author":"Nuschke","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.01.014_bib47","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1167\/iovs.11-8872","article-title":"Silencing of Fem1cR3 gene expression in the DBA\/2J mouse precedes retinal ganglion cell death and is associated with histone deacetylase activity","volume":"53","author":"Pelzel","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.01.014_bib48","doi-asserted-by":"crossref","first-page":"e67094","DOI":"10.1371\/journal.pone.0067094","article-title":"The time course of gene expression during reactive gliosis in the optic nerve","volume":"8","author":"Qu","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.exer.2016.01.014_bib49","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0140-6736(10)61423-7","article-title":"Glaucoma","volume":"377","author":"Quigley","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.exer.2016.01.014_bib50","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1001\/archopht.1982.01030030137016","article-title":"Optic nerve damage in human glaucoma. III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischemic neuropathy, papilledema, and toxic neuropathy","volume":"100","author":"Quigley","year":"1982","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2016.01.014_bib51","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1001\/archopht.1984.01040031377031","article-title":"Laser-induced primate glaucoma. II. Histopathology","volume":"102","author":"Radius","year":"1984","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2016.01.014_bib52","series-title":"Automated Quantification of Optic Nerve Axons in Primate Glaucomatous and Normal Eyes\u2013method and Comparison to Semi-Automated Manual Quantification","author":"Reynaud","year":"2012"},{"key":"10.1016\/j.exer.2016.01.014_bib53","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.exer.2009.10.003","article-title":"Ocular hypertension impairs optic nerve axonal transport leading to progressive retinal ganglion cell degeneration","volume":"90","author":"Salinas-Navarro","year":"2010","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.01.014_bib54","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/cne.10162","article-title":"Effects of age on the glial cells in the rhesus monkey optic nerve","volume":"445","author":"Sandell","year":"2002","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.exer.2016.01.014_bib55","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1167\/iovs.09-3947","article-title":"The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice","volume":"51","author":"Sappington","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.01.014_bib56","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1167\/iovs.03-0039","article-title":"Optic nerve degeneration in a murine model of juvenile ceroid lipofuscinosis","volume":"44","author":"Sappington","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.01.014_bib57","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1471-2202-7-66","article-title":"Progressive ganglion cell loss and optic nerve degeneration in DBA\/2J mice is variable and asymmetric","volume":"7","author":"Schlamp","year":"2006","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.exer.2016.01.014_bib58","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1167\/iovs.07-0745","article-title":"Dependency of intraocular pressure elevation and glaucomatous changes in DBA\/2J and DBA\/2J-Rj mice","volume":"49","author":"Scholz","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.01.014_bib59","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s00401-003-0816-9","article-title":"Retinal neurodegeneration in the DBA\/2J mouse-a model for ocular hypertension","volume":"107","author":"Schuettauf","year":"2004","journal-title":"Acta neuropathol."},{"key":"10.1016\/j.exer.2016.01.014_bib72","series-title":"Systemic Evaluation of the Mouse Eye","first-page":"265","article-title":"General and specific histopathology","author":"Smith","year":"2002"},{"key":"10.1016\/j.exer.2016.01.014_bib60","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.tins.2009.08.002","article-title":"Molecular dissection of reactive astrogliosis and glial scar formation","volume":"32","author":"Sofroniew","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.exer.2016.01.014_bib61","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/glia.20962","article-title":"Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss","volume":"58","author":"Son","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.exer.2016.01.014_bib62","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1523\/JNEUROSCI.3714-07.2008","article-title":"Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model","volume":"28","author":"Soto","year":"2008","journal-title":"J.\u00a0Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.exer.2016.01.014_bib63","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1167\/iovs.10-5856","article-title":"Retinal ganglion cell loss in a rat ocular hypertension model is sectorial and involves early optic nerve axon loss","volume":"52","author":"Soto","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.01.014_bib64","first-page":"567","article-title":"Structural remodeling of astrocytes in the injured CNS","volume":"18","author":"Sun","year":"2012","journal-title":"Neurosci. Rev. J. Bring. Neurobiol. Neurol. Psychiatr."},{"key":"10.1016\/j.exer.2016.01.014_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.22058","article-title":"The morphology and spatial arrangement of astrocytes in the optic nerve head of the mouse","volume":"516","author":"Sun","year":"2009","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.exer.2016.01.014_bib66","first-page":"376","article-title":"Quantifying optic nerve axons in a cat glaucoma model by a semi-automated targeted counting method","volume":"20","author":"Teixeira","year":"2014","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2016.01.014_bib67","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.exer.2014.10.001","article-title":"ImagePAD, a novel counting application for the Apple iPad, used to quantify axons in the mouse optic nerve","volume":"128","author":"Templeton","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.01.014_bib68","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1042\/BST20140107","article-title":"Glia in the pathogenesis of neurodegenerative diseases","volume":"42","author":"Verkhratsky","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.exer.2016.01.014_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2011.08.001","article-title":"Understanding glaucomatous damage: anatomical and functional data from ocular hypertensive rodent retinas","volume":"31","author":"Vidal-Sanz","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2016.01.014_bib70","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1167\/iovs.12-9814","article-title":"Microbead-induced ocular hypertensive mouse model for screening and testing of aqueous production suppressants for glaucoma","volume":"53","author":"Yang","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483516300136?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483516300136?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T04:30:34Z","timestamp":1718339434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483516300136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":72,"alternative-id":["S0014483516300136"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2016.01.014","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glial coverage in the optic nerve expands in proportion to optic axon loss in chronic mouse glaucoma","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2016.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}