{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:15:08Z","timestamp":1773281708255,"version":"3.50.1"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["IIS-0808772"],"award-info":[{"award-number":["IIS-0808772"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["ITR-0331697"],"award-info":[{"award-number":["ITR-0331697"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007044","name":"Macula Vision Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007044","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Santa Barbara Cottage Hospital Research Grant"},{"DOI":"10.13039\/100001694","name":"International Retinal Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY-019968"],"award-info":[{"award-number":["EY-019968"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.exer.2016.03.027","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T12:25:49Z","timestamp":1460118349000},"page":"4-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Astrocyte structural reactivity and plasticity in models of retinal detachment"],"prefix":"10.1016","volume":"150","author":[{"given":"Gabriel","family":"Luna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick W.","family":"Keeley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin E.","family":"Reese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth A.","family":"Linberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey P.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven K.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2016.03.027_bib1","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1073\/pnas.92.9.4002","article-title":"Spatial organization of retinal information about the direction of image motion","volume":"92","author":"Amthor","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2016.03.027_bib2","doi-asserted-by":"crossref","first-page":"e1000074","DOI":"10.1371\/journal.pbio.1000074","article-title":"A\u00a0computational framework for ultrastructural mapping of neural circuitry","volume":"7","author":"Anderson","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1016\/j.exer.2016.03.027_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2818.2010.03402.x","article-title":"The viking viewer for connectomics: scalable multi-user annotation and summarization of large volume data sets","volume":"241","author":"Anderson","year":"2011","journal-title":"J.\u00a0Microsc."},{"key":"10.1016\/j.exer.2016.03.027_bib4","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.brainres.2008.09.044","article-title":"Elevated pressure induced astrocyte damage in the optic nerve","volume":"1244","author":"Balaratnasingam","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.exer.2016.03.027_bib5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bcp.2009.09.014","article-title":"Astrocytes in the damaged brain: molecular and cellular insights into their reactive response and healing potential","volume":"79","author":"Buffo","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.exer.2016.03.027_bib6","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0896-6273(00)80781-3","article-title":"Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice","volume":"23","author":"Bush","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.exer.2016.03.027_bib7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ijdevneu.2003.12.008","article-title":"Maturation of astrocyte morphology and the establishment of astrocyte domains during postnatal hippocampal development","volume":"22","author":"Bushong","year":"2004","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.exer.2016.03.027_bib8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1523\/JNEUROSCI.22-01-00183.2002","article-title":"Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains","volume":"22","author":"Bushong","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.exer.2016.03.027_bib9","first-page":"2148","article-title":"Degeneration of astrocytes in feline retinopathy of prematurity causes failure of the blood-retinal barrier","volume":"33","author":"Chan-Ling","year":"1992","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"13","key":"10.1016\/j.exer.2016.03.027_bib10","article-title":"A\u00a0new mouse model of a retinal detachment with secondary angle closure glaucoma","volume":"49","author":"Chang","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.03.027_bib11","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/sj.eye.6700194","article-title":"Proliferative vitreoretinopathy-developments in adjunctive treatment and retinal pathology","volume":"16","author":"Charteris","year":"2002","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.exer.2016.03.027_bib12","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1365-2818.2006.01577.x","article-title":"Automated microscopy system for mosaic acquisition and processing","volume":"222","author":"Chow","year":"2006","journal-title":"J.\u00a0Microsc."},{"key":"10.1016\/j.exer.2016.03.027_bib13","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nature12776","article-title":"Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways","volume":"504","author":"Chung","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.exer.2016.03.027_bib14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0014-4835(02)00305-6","article-title":"Evidence that ganglion cells react to retinal detachment","volume":"76","author":"Coblentz","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.03.027_bib15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.exer.2015.11.016","article-title":"Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA\/2J mouse model of glaucoma","volume":"150","author":"Cooper","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.03.027_bib16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/glia.21242","article-title":"Structural basis of glaucoma: the fortified astrocytes of the optic nerve head are the target of raised intraocular pressure","volume":"60","author":"Dai","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.exer.2016.03.027_bib17","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1167\/iovs.06-0591","article-title":"The effect of alkylphosphocholines on intraretinal proliferation initiated by experimental retinal detachment","volume":"48","author":"Eibl","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.03.027_bib18","first-page":"927","article-title":"Retinal detachment in the cat: the outer nuclear and outer plexiform layers","volume":"24","author":"Erickson","year":"1983","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.03.027_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0014-4835(87)80023-4","article-title":"Glial fibrillary acidic protein increases in M\u00fcller cells after retinal detachment","volume":"44","author":"Erickson","year":"1987","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.03.027_bib20","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0002-9394(99)00401-8","article-title":"Abnormalities in rod photoreceptors, amacrine cells, and horizontal cells in human retinas with retinitis pigmentosa","volume":"129","author":"Fariss","year":"2000","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2016.03.027_bib21","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3389\/fncel.2015.00484","article-title":"Astrocytes and M\u00fcller cell alterations during retinal degeneration in a transgenic rat model of retinitis pigmentosa","volume":"9","author":"Fern\u00e1ndez-S\u00e1nchez","year":"2015","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.exer.2016.03.027_bib22","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1177\/1073858413504465","article-title":"Glial biology in learning and cognition","volume":"20","author":"Fields","year":"2014","journal-title":"Neuroscientist"},{"key":"10.1016\/j.exer.2016.03.027_bib23","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0042-6989(02)00680-6","article-title":"M\u00fcller cell and neuronal remodeling in retinal detachment and reattachment and their potential consequences for visual recovery: a review and reconsideration of recent data","volume":"43","author":"Fisher","year":"2003","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2016.03.027_bib24","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.preteyeres.2004.10.004","article-title":"Cellular remodeling in mammalian retina: results from studies of experimental retinal detachment","volume":"24","author":"Fisher","year":"2005","journal-title":"Prog. Retin Eye Res."},{"key":"10.1016\/j.exer.2016.03.027_bib25","first-page":"737","article-title":"Use of the MIB-1 antibody for detecting proliferating cells in the retina","volume":"36","author":"Geller","year":"1995","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.03.027_bib26","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0736-5748(83)90023-0","article-title":"Immunohistochemical and biochemical approaches to the development of neuroglia in the CNS, with special reference to cerebellum","volume":"1","author":"Ghandour","year":"1983","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.exer.2016.03.027_bib27","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/00006982-199414050-00005","article-title":"Clinical risk factors for proliferative vitreoretinopathy after retinal detachment surgery","volume":"14","author":"Girard","year":"1994","journal-title":"Retina (Philadelphia, Pa.)"},{"key":"10.1016\/j.exer.2016.03.027_bib28","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1126\/science.1190721","article-title":"Astrocytes control breathing through pH-dependent release of ATP","volume":"329","author":"Gourine","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.exer.2016.03.027_bib29","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0074-7696(08)62339-6","article-title":"Geometrical models for cells in tissues","volume":"81","author":"Honda","year":"1983","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.exer.2016.03.027_bib30","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/ana.24428","article-title":"Aberrant astrocytes impair vascular reactivity in Huntington disease","volume":"78","author":"Hsiao","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.exer.2016.03.027_bib31","first-page":"143","article-title":"Morphometric analysis of the extramacular retina from postmortem eyes with retinitis pigmentosa","volume":"40","author":"Humayun","year":"1999","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.03.027_bib32","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1167\/iovs.08-1723","article-title":"M\u00fcller cell response to blue light injury of the rat retina","volume":"49","author":"Iandiev","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.03.027_bib33","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1093\/bioinformatics\/btv097","article-title":"Characterizing spatial distributions of astrocytes in the mammalian retina","volume":"31","author":"Jammalamadaka","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.exer.2016.03.027_bib34","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1136\/bjo.2005.088856","article-title":"PVR as a complication of rhegmatogeneous retinal detachment: a solved problem?","volume":"90","author":"Joeres","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2016.03.027_bib35","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/glia.22781","article-title":"Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes","volume":"63","author":"Ju","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.exer.2016.03.027_bib36","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/cne.902490410","article-title":"Immunocytochemical studies on astroglia of the cat retina under normal and pathological conditions","volume":"249","author":"Karschin","year":"1986","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.exer.2016.03.027_bib37","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1002\/cne.22270","article-title":"Morphology of dopaminergic amacrine cells in the mouse retina: independence from homotypic interactions","volume":"518","author":"Keeley","year":"2010","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.exer.2016.03.027_bib38","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.tins.2008.09.003","article-title":"Neuroglia: the 150 years after","volume":"31","author":"Kettenmann","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.exer.2016.03.027_bib39","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nn1088","article-title":"Robust neural integration from retinal transplants in mice deficient in GFAP and vimentin","volume":"6","author":"Kinouchi","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.exer.2016.03.027_bib40","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1159\/000438972","article-title":"Retinal detachment and proliferative vitreoretinopathy","volume":"55","author":"Kwon","year":"2016","journal-title":"Dev. Ophthalmol."},{"key":"10.1016\/j.exer.2016.03.027_bib41","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1136\/bjo.2007.132332","article-title":"Ganglion cell neurites in human idiopathic epiretinal membranes","volume":"92","author":"Lesnik Oberstein","year":"2008","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2016.03.027_bib42","series-title":"Plasticity in the Visual System, Retinal Plasticity and Interactive Cellular Remodeling in Retinal Detachment and Reattachment","first-page":"55","article-title":"Retinal plasticity and interactive cellular remodeling in retinal detachment and reattachment","author":"Lewis","year":"2006"},{"key":"10.1016\/j.exer.2016.03.027_bib43","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0074-7696(03)30005-1","article-title":"Up-regulation of glial fibrillary acidic protein in response to retinal injury: its potential role in glial remodeling and a comparison to vimentin expression","volume":"230","author":"Lewis","year":"2003","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.exer.2016.03.027_bib44","first-page":"424","article-title":"Neurite outgrowth from bipolar and horizontal cells after experimental retinal detachment","volume":"39","author":"Lewis","year":"1998","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.03.027_bib45","first-page":"1530","article-title":"Effects of the neurotrophin brain-derived neurotrophic factor in an experimental model of retinal detachment","volume":"40","author":"Lewis","year":"1999","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.03.027_bib46","first-page":"2404","article-title":"Changes in the organization and expression of cytoskeletal proteins during retinal degeneration induced by retinal detachment","volume":"36","author":"Lewis","year":"1995","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.03.027_bib47","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1017\/S095252380219506X","article-title":"Experimental retinal detachment in the cone-dominant ground squirrel retina: morphology and basic immunocytochemistry","volume":"19","author":"Linberg","year":"2002","journal-title":"Vis. Neurosci."},{"key":"10.1016\/j.exer.2016.03.027_bib48","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature06293","article-title":"Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system","volume":"450","author":"Livet","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.exer.2016.03.027_bib49","first-page":"2511","article-title":"Expression profiles of nestin and synemin in reactive astrocytes and M\u00fcller cells following retinal injury: a comparison with glial fibrillar acidic protein and vimentin","volume":"16","author":"Luna","year":"2010","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2016.03.027_bib50","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1167\/iovs.12-10109","article-title":"Morphology of astrocytes in a glaucomatous optic nerve","volume":"54","author":"Lye-Barthel","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.03.027_bib51","first-page":"1694","article-title":"Amino acid signatures in the detached cat retina","volume":"39","author":"Marc","year":"1998","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.03.027_bib52","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jsb.2007.10.003","article-title":"The cell centered database project: an update on building community resources for managing and sharing 3D imaging data","volume":"161","author":"Martone","year":"2008","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.exer.2016.03.027_bib53","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1167\/iovs.06-1398","article-title":"Attenuated glial reactions and photoreceptor degeneration after retinal detachment in mice deficient in glial fibrillary acidic protein and vimentin","volume":"48","author":"Nakazawa","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.03.027_bib54","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1073\/pnas.1013965108","article-title":"Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma","volume":"108","author":"Nguyen","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2016.03.027_bib55","first-page":"1794","article-title":"Cell proliferation in human epiretinal membranes: characterization of cell types and correlation with disease condition and duration","volume":"17","author":"Oberstein","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2016.03.027_bib56","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0306-4522(02)00041-6","article-title":"Structural and quantitative analysis of astrocytes in the mouse hippocampus","volume":"113","author":"Ogata","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.exer.2016.03.027_bib57","first-page":"63","article-title":"Role of glia in stress-induced enhancement and impairment of memory","volume":"9","author":"Pearson-Leary","year":"2015","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.exer.2016.03.027_bib58","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1152\/physrev.00041.2013","article-title":"Astrocyte reactivity and reactive astrogliosis: costs and benefits","volume":"94","author":"Pekny","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exer.2016.03.027_bib59","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.ajo.2005.10.045","article-title":"An evolutionary perspective on the photoreceptor damage response","volume":"141","author":"Rattner","year":"2006","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2016.03.027_bib60","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1523\/JNEUROSCI.0492-05.2005","article-title":"The genomic response to retinal disease and injury: evidence for endothelin signaling from photoreceptors to glia","volume":"25","author":"Rattner","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.exer.2016.03.027_bib61","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/brv.12139","article-title":"Design principles and developmental mechanisms underlying retinal mosaics","volume":"90","author":"Reese","year":"2014","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.exer.2016.03.027_bib62","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/glia.22477","article-title":"New functions of M\u00fcller cells","volume":"61","author":"Reichenbach","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.exer.2016.03.027_bib63","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1167\/iovs.02-0633","article-title":"Cone photoreceptor recovery after experimental detachment and reattachment: an immunocytochemical, morphological, and electrophysiological study","volume":"44","author":"Sakai","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.03.027_bib64","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1093\/cercor\/1.4.348","article-title":"Mouse barrel cortex viewed as Dirichlet domains","volume":"1","author":"Senft","year":"1991","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.exer.2016.03.027_bib65","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1167\/iovs.03-0518","article-title":"Glial remodeling and neural plasticity in human retinal detachment with proliferative vitreoretinopathy","volume":"46","author":"Sethi","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.03.027_bib66","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1006\/exer.1996.0249","article-title":"Glial fibrillary acidic protein (GFAP) is synthesized in the early stages of the photoreceptor cell degeneration of the mivit\/mivit (vitiligo) mouse","volume":"64","author":"Smith","year":"1997","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.03.027_bib67","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.tins.2009.08.002","article-title":"Molecular dissection of reactive astrogliosis and glial scar formation","volume":"32","author":"Sofroniew","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.exer.2016.03.027_bib68","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/glia.440010103","article-title":"Nervenkitt: notes on the history of the concept of neuroglia","volume":"1","author":"Somjen","year":"1988","journal-title":"Glia"},{"key":"10.1016\/j.exer.2016.03.027_bib69","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/glia.20962","article-title":"Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss","volume":"58","author":"Son","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.exer.2016.03.027_bib70","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/978-1-61779-452-0_33","article-title":"Assessment of glial function in the in\u00a0vivo retina","volume":"814","author":"Srienc","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.exer.2016.03.027_bib71","series-title":"The Whole Mount Handbook: a Guide to the Preparation and Analysis of Retinal Whole Mounts","author":"Stone","year":"1981"},{"key":"10.1016\/j.exer.2016.03.027_bib72","doi-asserted-by":"crossref","first-page":"11020","DOI":"10.1073\/pnas.190291097","article-title":"Modifications of retinal neurons in a mouse model of retinitis pigmentosa","volume":"97","author":"Strettoi","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2016.03.027_bib73","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1523\/JNEUROSCI.22-13-05492.2002","article-title":"Morphological and functional abnormalities in the inner retina of the rd\/rd mouse","volume":"22","author":"Strettoi","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.exer.2016.03.027_bib74","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1177\/1073858411423441","article-title":"Structural remodeling of astrocytes in the injured CNS","volume":"18","author":"Sun","year":"2012","journal-title":"Neuroscientist"},{"key":"10.1016\/j.exer.2016.03.027_bib75","doi-asserted-by":"crossref","first-page":"14008","DOI":"10.1523\/JNEUROSCI.3605-10.2010","article-title":"Structural remodeling of fibrous astrocytes after axonal injury","volume":"30","author":"Sun","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.exer.2016.03.027_bib76","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.mcn.2011.03.006","article-title":"Reactive gliosis of astrocytes and M\u00fcller glial cells in retina of POMGnT1-deficient mice","volume":"47","author":"Takahashi","year":"2011","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.exer.2016.03.027_bib77","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1167\/iovs.07-1474","article-title":"Abnormal reactivity of muller cells after retinal detachment in mice deficient in GFAP and vimentin","volume":"49","author":"Verardo","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.03.027_bib78","doi-asserted-by":"crossref","first-page":"e61631","DOI":"10.1371\/journal.pone.0061631","article-title":"M\u00fcller cell reactivity in response to photoreceptor degeneration in rats with defective polycystin-2","volume":"8","author":"Vogler","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2016.03.027_bib79","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1098\/rspb.1981.0032","article-title":"Morphology and topography of on- and off-alpha cells in the cat retina","volume":"212","author":"W\u00e4ssle","year":"1981","journal-title":"Proc. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.exer.2016.03.027_bib80","doi-asserted-by":"crossref","first-page":"17513","DOI":"10.1073\/pnas.0602841103","article-title":"Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury","volume":"103","author":"Wilhelmsson","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2016.03.027_bib81","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/1096-9861(20000108)429:2<253::AID-CNE6>3.0.CO;2-S","article-title":"Confocal microscopic study of glial-vascular relationships in the retinas of pigmented rats","volume":"429","author":"Zahs","year":"2001","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.exer.2016.03.027_bib82","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.conb.2010.06.005","article-title":"Astrocyte heterogeneity: an underappreciated topic in neurobiology","volume":"20","author":"Zhang","year":"2010","journal-title":"Curr. Opin. Neurobiol."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483516300641?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483516300641?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:57:34Z","timestamp":1757998654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483516300641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":82,"alternative-id":["S0014483516300641"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2016.03.027","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Astrocyte structural reactivity and plasticity in models of retinal detachment","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2016.03.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}