{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:24:28Z","timestamp":1792027468606,"version":"4.4.0"},"reference-count":167,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Institutes of Health research","award":["EY022737"],"award-info":[{"award-number":["EY022737"]}]},{"DOI":"10.13039\/100001607","name":"Eye and Ear Foundation of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.exer.2016.04.023","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T06:18:54Z","timestamp":1461997134000},"page":"73-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Gene transfer to the outflow tract"],"prefix":"10.1016","volume":"158","author":[{"given":"Yalong","family":"Dang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralitsa","family":"Loewen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7794-8332","authenticated-orcid":false,"given":"Hardik A.","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pritha","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-1213","authenticated-orcid":false,"given":"Nils A.","family":"Loewen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2016.04.023_bib1","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.1167\/iovs.14-14519","article-title":"Differential effects of caveolin-1 and -2 knockdown on aqueous outflow and altered extracellular matrix turnover in caveolin-silenced trabecular meshwork cells","volume":"55","author":"Aga","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib2","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.ajhg.2009.03.017","article-title":"Null mutations in LTBP2 cause primary congenital glaucoma","volume":"84","author":"Ali","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.exer.2016.04.023_bib3","doi-asserted-by":"crossref","first-page":"7100","DOI":"10.1167\/iovs.15-17660","article-title":"Profiling of cytokines secreted by conventional aqueous outflow pathway endothelial cells activated in\u00a0vitro and ex\u00a0vivo with laser irradiation","volume":"56","author":"Alvarado","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib4","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1128\/JVI.61.5.1647-1650.1987","article-title":"Effect of internal viral sequences on the utility of retroviral vectors","volume":"61","author":"Armentano","year":"1987","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.exer.2016.04.023_bib5","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1093\/hmg\/ddr140","article-title":"The sleeping beauty transposon system: a non-viral vector for gene therapy","volume":"20","author":"Aronovich","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2016.04.023_bib6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.peptides.2013.06.011","article-title":"Ghrelin in ocular pathophysiology: from the anterior to the posterior segment","volume":"47","author":"Azevedo-Pinto","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.exer.2016.04.023_bib7","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1056\/NEJMoa0802268","article-title":"Effect of gene therapy on visual function in Leber's congenital amaurosis","volume":"358","author":"Bainbridge","year":"2008","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.exer.2016.04.023_bib8","first-page":"4.21.1","article-title":"Production and titration of lentiviral vectors","volume":"Unit 4.21","author":"Barde","year":"2010","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.exer.2016.04.023_bib9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1089\/hum.2008.086","article-title":"Prolonged transgene expression with lentiviral vectors in the aqueous humor outflow pathway of nonhuman primates","volume":"20","author":"Barraza","year":"2009","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.exer.2016.04.023_bib10","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/mt.2009.278","article-title":"Prostaglandin pathway gene therapy for sustained reduction of intraocular pressure","volume":"18","author":"Barraza","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2016.04.023_bib11","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1038\/nprot.2007.471","article-title":"Preferential delivery of the sleeping beauty transposon system to livers of mice by hydrodynamic injection","volume":"2","author":"Bell","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.exer.2016.04.023_bib12","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1038\/nprot.2007.460","article-title":"Lung-directed gene therapy in mice using the nonviral sleeping beauty transposon system","volume":"2","author":"Belur","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.exer.2016.04.023_bib13","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1006\/viro.2000.0659","article-title":"Gene transfer systems derived from Visna virus: analysis of virus production and infectivity","volume":"279","author":"Berkowitz","year":"2001","journal-title":"Virology"},{"key":"10.1016\/j.exer.2016.04.023_bib14","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1128\/JVI.75.7.3371-3382.2001","article-title":"Construction and molecular analysis of gene transfer systems derived from bovine immunodeficiency virus","volume":"75","author":"Berkowitz","year":"2001","journal-title":"J.\u00a0Virol."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.exer.2016.04.023_bib15","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1038\/sj.gt.3302364","article-title":"Immune responses to gene therapy vectors: influence on vector function and effector mechanisms","volume":"11","author":"Bessis","year":"2004","journal-title":"Gene Ther."},{"key":"10.1016\/j.exer.2016.04.023_bib16","doi-asserted-by":"crossref","first-page":"e0128759","DOI":"10.1371\/journal.pone.0128759","article-title":"Capsid mutated adeno-associated virus delivered to the anterior chamber results in efficient transduction of trabecular meshwork in mouse and rat","volume":"10","author":"Bogner","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2016.04.023_bib17","first-page":"1503","article-title":"Gene transfer to the human trabecular meshwork by anterior segment perfusion","volume":"39","author":"Borr\u00e1s","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib18","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/sj.gt.3300860","article-title":"Adenoviral reporter gene transfer to the human trabecular meshwork does not alter aqueous humor outflow. Relevance for potential gene therapy of glaucoma","volume":"6","author":"Borr\u00e1s","year":"1999","journal-title":"Gene Ther."},{"key":"10.1016\/j.exer.2016.04.023_bib19","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/jgm.210","article-title":"Non-invasive observation of repeated adenoviral GFP gene delivery to the anterior segment of the monkey eye in\u00a0vivo","volume":"3","author":"Borr\u00e1s","year":"2001","journal-title":"J.\u00a0Gene Med."},{"key":"10.1016\/j.exer.2016.04.023_bib20","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/jgm.886","article-title":"Mechanisms of AAV transduction in glaucoma-associated human trabecular meshwork cells","volume":"8","author":"Borr\u00e1s","year":"2006","journal-title":"J.\u00a0Gene Med."},{"key":"10.1016\/j.exer.2016.04.023_bib21","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1001\/jamaophthalmol.2014.4747","article-title":"Prevention of nocturnal elevation of intraocular pressure by gene transfer of dominant-negative RhoA in rats","volume":"133","author":"Borr\u00e1s","year":"2015","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.exer.2016.04.023_bib22","first-page":"2211","article-title":"In\u00a0vivo gene transfer into murine corneal endothelial and trabecular meshwork cells","volume":"36","author":"Budenz","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib23","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1167\/iovs.09-3847","article-title":"Self-complementary AAV virus (scAAV) safe and long-term gene transfer in the trabecular meshwork of living rats and monkeys","volume":"51","author":"Buie","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib24","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1167\/iovs.13-11651","article-title":"Development of a model of elevated intraocular pressure in rats by gene transfer of bone morphogenetic protein 2","volume":"54","author":"Buie","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib25","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1136\/bjophthalmol-2013-304717","article-title":"Outcomes of ab interno trabeculectomy with the trabectome after failed trabeculectomy","volume":"99","author":"Bussel","year":"2014","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2016.04.023_bib26","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1136\/bjophthalmol-2014-305577","article-title":"Outcomes of ab interno trabeculectomy with the trabectome by degree of angle opening","volume":"99","author":"Bussel","year":"2015","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2016.04.023_bib27","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ajo.2011.05.029","article-title":"Intraocular pressure: modulation as treatment for glaucoma","volume":"152","author":"Caprioli","year":"2011","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2016.04.023_bib28","doi-asserted-by":"crossref","first-page":"5005","DOI":"10.1167\/iovs.14-14515","article-title":"Nitric oxide (NO): an emerging target for the treatment of glaucoma","volume":"55","author":"Cavet","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib29","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1167\/iovs.04-1252","article-title":"\u03c6C31 integrase confers genomic integration and long-term transgene expression in rat retina","volume":"46","author":"Chalberg","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib30","first-page":"425","article-title":"Lentiviral mediated gene delivery to the anterior chamber of rodent eyes","volume":"11","author":"Challa","year":"2005","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2016.04.023_bib31","doi-asserted-by":"crossref","first-page":"C205","DOI":"10.1152\/ajpcell.00347.2014","article-title":"Role of nitric oxide in murine conventional outflow physiology","volume":"309","author":"Chang","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.exer.2016.04.023_bib32","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ymthe.2005.04.009","article-title":"Long-term neuroprotection achieved with latency-associated promoter-driven herpes simplex virus gene transfer to the peripheral nervous system","volume":"12","author":"Chattopadhyay","year":"2005","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2016.04.023_bib33","series-title":"Retroviruses","author":"Coffin","year":"1997"},{"key":"10.1016\/j.exer.2016.04.023_bib34","first-page":"1363","article-title":"Functional delivery of synthetic naked siRNA to the human trabecular meshwork in perfused organ cultures","volume":"13","author":"Comes","year":"2007","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2016.04.023_bib35","doi-asserted-by":"crossref","first-page":"20120496","DOI":"10.1098\/rstb.2012.0496","article-title":"Host gene evolution traces the evolutionary history of ancient primate lentiviruses","volume":"368","author":"Compton","year":"2013","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib36","first-page":"456","article-title":"Nonviral ocular gene therapy: assessment and future directions","volume":"10","author":"Conley","year":"2008","journal-title":"Curr. Opin. Mol. Ther."},{"key":"10.1016\/j.exer.2016.04.023_bib37","doi-asserted-by":"crossref","first-page":"7756","DOI":"10.1167\/iovs.13-13088","article-title":"MMPs in the trabecular meshwork: promising targets for future glaucoma therapies?","volume":"54","author":"De Groef","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib38","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1089\/hum.2010.022","article-title":"Virion-associated cofactor high-mobility group DNA-binding protein-1 facilitates transposition from the herpes simplex virus\/Sleeping Beauty amplicon vector platform","volume":"21","author":"de Silva","year":"2010","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.exer.2016.04.023_bib39","doi-asserted-by":"crossref","first-page":"12979","DOI":"10.1073\/pnas.202300099","article-title":"Functional correction of adult mdx mouse muscle using gutted adenoviral vectors expressing full-length dystrophin","volume":"99","author":"DelloRusso","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2016.04.023_bib40","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1167\/iovs.12-11056","article-title":"Stem cells from trabecular meshwork home to TM tissue in\u00a0vivo","volume":"54","author":"Du","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib41","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jconrel.2007.11.016","article-title":"Charged nanoparticles delivery to the eye using hydrogel iontophoresis","volume":"126","author":"Eljarrat-Binstock","year":"2008","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.exer.2016.04.023_bib42","doi-asserted-by":"crossref","first-page":"5817","DOI":"10.1167\/iovs.09-5072","article-title":"Endogenous regulation of human Schlemm's canal cell volume by nitric oxide signaling","volume":"51","author":"Ellis","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib43","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1167\/iovs.03-1133","article-title":"Experimental and numerical studies of adenovirus delivery to outflow tissues of perfused human anterior segments","volume":"45","author":"Ethier","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib44","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.clinbiochem.2005.11.001","article-title":"Gene mapping for primary open angle glaucoma","volume":"39","author":"Fan","year":"2006","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.exer.2016.04.023_bib45","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1371\/journal.pone.0000038","article-title":"Efficient non-viral ocular gene transfer with compacted DNA nanoparticles","volume":"1","author":"Farjo","year":"2006","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2016.04.023_bib46","doi-asserted-by":"crossref","first-page":"7029","DOI":"10.1167\/iovs.14-15266","article-title":"Neural stem cell\u2013based intraocular administration of ciliary neurotrophic factor attenuates the loss of axotomized ganglion cells in adult MiceNS cell\u2013based intraocular administration of CNTF","volume":"55","author":"Flachsbarth","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib47","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1167\/iovs.11-9229","article-title":"Morphometric analysis of aqueous humor outflow structures with spectral-domain optical coherence tomography","volume":"53","author":"Francis","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib48","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1167\/iovs.07-0290","article-title":"Using pharmacy claims data to study adherence to glaucoma medications: methodology and findings of the Glaucoma Adherence and Persistency Study (GAPS)","volume":"48","author":"Friedman","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib49","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00441-011-1274-7","article-title":"The role of TGF-\u03b2 in the pathogenesis of primary open-angle glaucoma","volume":"347","author":"Fuchshofer","year":"2012","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.exer.2016.04.023_bib50","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1167\/iovs.06-0226","article-title":"Bone morphogenetic protein-7 is an antagonist of transforming growth factor-beta2 in human trabecular meshwork cells","volume":"48","author":"Fuchshofer","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib51","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.exer.2009.01.002","article-title":"Gene expression profiling of TGFbeta2- and\/or BMP7-treated trabecular meshwork cells: identification of Smad7 as a critical inhibitor of TGF-beta2 signaling","volume":"88","author":"Fuchshofer","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.04.023_bib52","unstructured":"Gene Therapy Clinical Trials Worldwide [WWW Document], n.d. URL http:\/\/www.abedia.com\/wiley\/indications.php (accessed 1.10.16.)."},{"key":"10.1016\/j.exer.2016.04.023_bib53","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1167\/iovs.09-4920","article-title":"Treatment of sheep steroid-induced ocular hypertension with a glucocorticoid-inducible MMP1 gene therapy virus","volume":"51","author":"Gerometta","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib54","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/jgm.2698","article-title":"Gene therapy clinical trials worldwide to 2012-an update","volume":"15","author":"Ginn","year":"2013","journal-title":"J.\u00a0Gene Med."},{"key":"10.1016\/j.exer.2016.04.023_bib55","first-page":"2151","article-title":"sCD44 overexpression increases intraocular pressure and aqueous outflow resistance","volume":"19","author":"Giovingo","year":"2013","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2016.04.023_bib56","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/978-1-4939-0428-0_5","article-title":"Engineering HSV-1 vectors for gene therapy","volume":"1144","author":"Goins","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.exer.2016.04.023_bib57","article-title":"Tissue-based caldesmon silencing by naked siRNA increases F-actin in the human trabecular meshwork","volume":"55","author":"Gonzalez","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib58","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1167\/iovs.03-0537","article-title":"Expression analysis of the matrix GLA protein and VE-cadherin gene promoters in the outflow pathway","volume":"45","author":"Gonzalez","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib59","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1089\/jop.2013.0191","article-title":"Role of microRNAs in the trabecular meshwork","volume":"30","author":"Gonzalez","year":"2014","journal-title":"J.\u00a0Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.exer.2016.04.023_bib60","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1038\/nprot.2006.207","article-title":"Production and characterization of adeno-associated viral vectors","volume":"1","author":"Grieger","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.exer.2016.04.023_bib61","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.exer.2010.12.010","article-title":"Imaging the aqueous humor outflow pathway in human eyes by three-dimensional micro-computed tomography (3D micro-CT)","volume":"92","author":"Hann","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.04.023_bib62","doi-asserted-by":"crossref","first-page":"6552","DOI":"10.1093\/hmg\/ddv347","article-title":"Genetic variants and cellular stressors associated with exfoliation syndrome modulate promoter activity of a lncRNA within the LOXL1 locus","volume":"24","author":"Hauser","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2016.04.023_bib63","unstructured":"[HEK-293] ATCC \u00ae CRL-1573TM Homo sapiens embryonic kidney [WWW Document], n.d. URL http:\/\/www.atcc.org\/products\/all\/CRL-1573.aspx (accessed 22.04.16.)."},{"key":"10.1016\/j.exer.2016.04.023_bib64","doi-asserted-by":"crossref","first-page":"e197","DOI":"10.1038\/mtna.2014.48","article-title":"A\u00a0new gene therapy approach for cardiovascular disease by non-coding RNAs acting in the nucleus","volume":"3","author":"Husso","year":"2014","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.exer.2016.04.023_bib65","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1089\/hum.2011.143","article-title":"Nonviral gene delivery with the sleeping beauty transposon system","volume":"22","author":"Ivics","year":"2011","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.exer.2016.04.023_bib66","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0092-8674(00)80436-5","article-title":"Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells","volume":"91","author":"Ivics","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.exer.2016.04.023_bib67","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1167\/iovs.12-9951","article-title":"Sleeping Beauty transposon-mediated transfection of retinal and iris pigment epithelial cells","volume":"53","author":"Johnen","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib68","first-page":"2577","article-title":"Mechanisms and routes of aqueous humor drainage","volume":"4","author":"Johnson","year":"2000","journal-title":"Princ. Pract. Ophthalmol."},{"key":"10.1016\/j.exer.2016.04.023_bib69","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1016\/j.ajpath.2012.02.030","article-title":"Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork","volume":"180","author":"Junglas","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2016.04.023_bib70","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1089\/hum.2015.036","article-title":"Cellular innate immunity and restriction of viral infection: implications for lentiviral gene therapy in human hematopoietic cells","volume":"26","author":"Kajaste-Rudnitski","year":"2015","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.exer.2016.04.023_bib71","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1136\/bjophthalmol-2013-304256","article-title":"Techniques and outcomes of minimally invasive trabecular ablation and bypass surgery","volume":"98","author":"Kaplowitz","year":"2014","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2016.04.023_bib72","article-title":"Randomized controlled comparison of Titanium-Sapphire versus standard q-switched Nd: YAG laser trabeculoplasty","author":"Kaplowitz","year":"2015","journal-title":"J.\u00a0Glaucoma"},{"key":"10.1016\/j.exer.2016.04.023_bib73","doi-asserted-by":"crossref","DOI":"10.1136\/bjophthalmol-2015-307131","article-title":"Review and meta-analysis of ab-interno trabeculectomy outcomes","author":"Kaplowitz","year":"2016","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2016.04.023_bib74","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1167\/iovs.10-6948","article-title":"Segmental versican expression in the trabecular meshwork and involvement in outflow facility","volume":"52","author":"Keller","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib75","doi-asserted-by":"crossref","first-page":"4616","DOI":"10.1167\/iovs.12-9500","article-title":"Perturbation of hyaluronan synthesis in the trabecular meshwork and the effects on outflow facility","volume":"53","author":"Keller","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib76","doi-asserted-by":"crossref","first-page":"5613","DOI":"10.1167\/iovs.13-11620","article-title":"The effects of tenascin C knockdown on trabecular meshwork outflow resistance","volume":"54","author":"Keller","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib77","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/sj.mt.6300318","article-title":"Durable, safe, multi-gene lentiviral vector expression in feline trabecular meshwork","volume":"16","author":"Khare","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2016.04.023_bib78","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1089\/hum.1996.7.7-799","article-title":"Retrovirus-mediated suicide gene transduction in the vitreous cavity of the eye: feasibility in prevention of proliferative vitreoretinopathy","volume":"7","author":"Kimura","year":"1996","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.exer.2016.04.023_bib79","doi-asserted-by":"crossref","first-page":"e1001912","DOI":"10.1371\/journal.pbio.1001912","article-title":"Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process","volume":"12","author":"Kizhatil","year":"2014","journal-title":"PLoS Biol."},{"key":"10.1016\/j.exer.2016.04.023_bib80","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/978-1-62703-679-5_15","article-title":"Production of high-capacity adenovirus vectors","volume":"1089","author":"Kreppel","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.exer.2016.04.023_bib81","doi-asserted-by":"crossref","first-page":"e72447","DOI":"10.1371\/journal.pone.0072447","article-title":"Tissue plasminogen activator in trabecular meshwork attenuates steroid induced outflow resistance in mice","volume":"8","author":"Kumar","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2016.04.023_bib82","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.ymthe.2005.12.013","article-title":"Intranasal administration of the growth-compromised HSV-2 vector \u0394RR prevents kainate-induced seizures and neuronal loss in rats and mice","volume":"13","author":"Laing","year":"2006","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2016.04.023_bib83","article-title":"Direct delivery of synthetic naked siRNA to trabecular meshwork in living rats","volume":"52","author":"Lawrence","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib84","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1167\/iovs.09-4521","article-title":"COCH transgene expression in cultured human trabecular meshwork cells and its effect on outflow facility in monkey organ cultured anterior segments","volume":"51","author":"Lee","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib85","doi-asserted-by":"crossref","first-page":"20120503","DOI":"10.1098\/rstb.2012.0503","article-title":"Identification of an ancient endogenous retrovirus, predating the divergence of the placental mammals","volume":"368","author":"Lee","year":"2013","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib86","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3109\/02713683.2014.884593","article-title":"Prospects for lentiviral vector mediated prostaglandin F synthase gene delivery in monkey eyes in\u00a0vivo","volume":"39","author":"Lee","year":"2014","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2016.04.023_bib87","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1128\/JVI.68.1.510-516.1994","article-title":"Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus","volume":"68","author":"Lewis","year":"1994","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.exer.2016.04.023_bib88","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.ajo.2012.09.012","article-title":"CYP1B1, MYOC, and LTBP2 mutations in primary congenital glaucoma patients in the United States","volume":"155","author":"Lim","year":"2013","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2016.04.023_bib89","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/IJG.0b013e31815f2539","article-title":"Endoscopic and transscleral cyclophotocoagulation for the treatment of refractory glaucoma","volume":"17","author":"Lin","year":"2008","journal-title":"J.\u00a0Glaucoma"},{"key":"10.1016\/j.exer.2016.04.023_bib90","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0378-1119(02)01215-5","article-title":"Chromosome-based vectors for gene therapy","volume":"304","author":"Lipps","year":"2003","journal-title":"Gene"},{"key":"10.1016\/j.exer.2016.04.023_bib91","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1167\/iovs.04-0330","article-title":"Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase 3-like 1 promoter","volume":"46","author":"Liton","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib92","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1128\/JVI.70.4.2497-2502.1996","article-title":"Pseudotransduction of hepatocytes by using concentrated pseudotyped vesicular stomatitis virus G glycoprotein (VSV-G)-Moloney murine leukemia virus-derived retrovirus vectors: comparison of VSV-G and amphotropic vectors for hepatic gene transfer","volume":"70","author":"Liu","year":"1996","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.exer.2016.04.023_bib93","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1006\/exer.1999.0711","article-title":"Herpes simplex virus mediated gene transfer to primate ocular tissues","volume":"69","author":"Liu","year":"1999","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.04.023_bib94","first-page":"1112","article-title":"The effect of C3 transgene expression on actin and cellular adhesions in cultured human trabecular meshwork cells and on outflow facility in organ cultured monkey eyes","volume":"11","author":"Liu","year":"2005","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2016.04.023_bib95","first-page":"169","article-title":"Lentiviral vectors","volume":"99","author":"Loewen","year":"2005","journal-title":"Adv. Biochem. Eng. Biotechnol."},{"key":"10.1016\/j.exer.2016.04.023_bib96","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1089\/10430340152677449","article-title":"Genetic modification of human trabecular meshwork with lentiviral vectors","volume":"12","author":"Loewen","year":"2001","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.exer.2016.04.023_bib97","first-page":"3686","article-title":"Preservation of aqueous outflow facility after second-generation FIV vector-mediated expression of marker genes in anterior segments of human eyes","volume":"43","author":"Loewen","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib98","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/jgm.447","article-title":"Comparison of wild-type and class I integrase mutant-FIV vectors in retina demonstrates sustained expression of integrated transgenes in retinal pigment epithelium","volume":"5","author":"Loewen","year":"2003","journal-title":"J.\u00a0Gene Med."},{"key":"10.1016\/j.exer.2016.04.023_bib99","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1167\/iovs.04-0366","article-title":"Long-term, targeted genetic modification of the aqueous humor outflow tract coupled with noninvasive imaging of gene expression in\u00a0vivo","volume":"45","author":"Loewen","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib100","first-page":"272","article-title":"Long-term retinal transgene expression with FIV versus adenoviral vectors","volume":"10","author":"Loewen","year":"2004","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2016.04.023_bib101","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1167\/iovs.15-18125","article-title":"A\u00a0porcine anterior segment perfusion and transduction model with direct visualization of the trabecular meshwork","volume":"57","author":"Loewen","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib102","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.2042-7158.1991.tb03534.x","article-title":"Improvement of ocular penetration of amikacin sulphate by association to poly(butylcyanoacrylate) nanoparticles","volume":"43","author":"Losa","year":"1991","journal-title":"J.\u00a0Pharm. Pharmacol."},{"key":"10.1016\/j.exer.2016.04.023_bib103","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/nprot.2007.135","article-title":"A\u00a0protocol for rapid generation of recombinant adenoviruses using the AdEasy system","volume":"2","author":"Luo","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.exer.2016.04.023_bib104","doi-asserted-by":"crossref","first-page":"8307","DOI":"10.1128\/JVI.74.18.8307-8315.2000","article-title":"Development of minimal lentivirus vectors derived from simian immunodeficiency virus (SIVmac251) and their use for gene transfer into human dendritic cells","volume":"74","author":"Mangeot","year":"2000","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.exer.2016.04.023_bib105","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/978-1-4939-2152-2_20","article-title":"Herpes simplex virus type 1 (HSV-1)-derived recombinant vectors for gene transfer and gene therapy","volume":"1254","author":"Marconi","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.exer.2016.04.023_bib106","article-title":"Schlemm's canal (SC) and distal aqueous outflow pathways: new scanning EM (SEM) preparation technique permits identifying unique structural relationships","volume":"55","author":"Martin","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib107","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nsmb.2942","article-title":"Discovery and annotation of long noncoding RNAs","volume":"22","author":"Mattick","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.exer.2016.04.023_bib108","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.exer.2013.10.017","article-title":"Smad3 is necessary for transforming growth factor-beta2 induced ocular hypertension in mice","volume":"116","author":"McDowell","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.04.023_bib109","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrg2521","article-title":"Long non-coding RNAs: insights into functions","volume":"10","author":"Mercer","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.exer.2016.04.023_bib110","first-page":"10","article-title":"Effect of immunomodulation with anti-CD40L antibody on adenoviral-mediated transgene expression in mouse anterior segment","volume":"14","author":"Millar","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2016.04.023_bib111","first-page":"476","article-title":"Pseudogene-derived lncRNAs: emerging regulators of gene expression","volume":"5","author":"Milligan","year":"2014","journal-title":"Front. Genet."},{"key":"10.1016\/j.exer.2016.04.023_bib112","doi-asserted-by":"crossref","first-page":"E1632","DOI":"10.1073\/pnas.1423556112","article-title":"Herpes simplex viral-vector design for efficient transduction of nonneuronal cells without cytotoxicity","volume":"112","author":"Miyagawa","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2016.04.023_bib113","doi-asserted-by":"crossref","first-page":"8150","DOI":"10.1128\/JVI.72.10.8150-8157.1998","article-title":"Development of a self-inactivating lentivirus vector","volume":"72","author":"Miyoshi","year":"1998","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.exer.2016.04.023_bib114","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/ng1179","article-title":"AAV serotype 2 vectors preferentially integrate into active genes in mice","volume":"34","author":"Nakai","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2016.04.023_bib115","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1126\/science.272.5259.263","article-title":"In\u00a0vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector","volume":"272","author":"Naldini","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.exer.2016.04.023_bib116","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/2277-9175.98152","article-title":"Viral and nonviral delivery systems for gene delivery","volume":"1","author":"Nayerossadat","year":"2012","journal-title":"Adv. Biomed. Res."},{"key":"10.1016\/j.exer.2016.04.023_bib117","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1167\/iovs.13-11853","article-title":"In\u00a0vitro and in\u00a0vivo comparison of two suprachoroidal shunts","volume":"54","author":"Oatts","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib118","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1167\/iovs.12-11362","article-title":"Overexpression of SPARC in human trabecular meshwork increases intraocular pressure and alters extracellular matrix","volume":"54","author":"Oh","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib119","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/sj.gt.3300768","article-title":"Gene transfer vectors derived from equine infectious anemia virus","volume":"5","author":"Olsen","year":"1998","journal-title":"Gene Ther."},{"key":"10.1016\/j.exer.2016.04.023_bib120","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4161\/epi.27473","article-title":"Non-coding RNAs as direct and indirect modulators of epigenetic regulation","volume":"9","author":"Peschansky","year":"2014","journal-title":"Epigenetics"},{"key":"10.1016\/j.exer.2016.04.023_bib121","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nm0398-354","article-title":"Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors","volume":"4","author":"Poeschla","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.exer.2016.04.023_bib122","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2004-04-1427","article-title":"Successful correction of the human beta-thalassemia major phenotype using a lentiviral vector","author":"Puthenveetil","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.exer.2016.04.023_bib123","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1159\/000082248","article-title":"Schlemm's canal and the collector channels at different developmental stages in the human eye","volume":"178","author":"Ram\u00edrez","year":"2004","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.exer.2016.04.023_bib124","first-page":"288","article-title":"Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow","volume":"11","author":"Rao","year":"2005","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2016.04.023_bib125","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1167\/iovs.09-3380","article-title":"Ocular gene transfer of active TGF-beta induces changes in anterior segment morphology and elevated IOP in rats","volume":"51","author":"Robertson","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib126","doi-asserted-by":"crossref","first-page":"15012","DOI":"10.1038\/mtm.2015.12","article-title":"The human ankyrin 1 promoter insulator sustains gene expression in a \u03b2-globin lentiviral vector in hematopoietic stem cells","volume":"2","author":"Romero","year":"2015","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.exer.2016.04.023_bib127","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.3109\/02713688909013902","article-title":"Outflow resistance of enucleated human eyes at two different perfusion pressures and different extents of trabeculotomy","volume":"8","author":"Rosenquist","year":"1989","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2016.04.023_bib128","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1128\/JVI.78.6.2906-2920.2004","article-title":"Unintegrated lentivirus DNA persistence and accessibility to expression in nondividing cells: analysis with class I integrase mutants","volume":"78","author":"Saenz","year":"2004","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.exer.2016.04.023_bib129","series-title":"Production and Use of Feline Immunodeficiency Virus (FIV)-based Lentiviral Vectors. Gene Transfer: a Cold Spring","author":"Saenz","year":"2006"},{"key":"10.1016\/j.exer.2016.04.023_bib130","first-page":"e7","article-title":"Effects of a Schlemm canal scaffold on collector channel ostia in human anterior segments","volume":"30","author":"Schieber","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.04.023_bib131","first-page":"1676","article-title":"Excimer laser effects on outflow facility and outflow pathway morphology","volume":"40","author":"Schuman","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib132","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1159\/000088378","article-title":"Episcleral venous pressure in untreated primary open-angle and normal-tension glaucoma","volume":"219","author":"Selbach","year":"2005","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.exer.2016.04.023_bib133","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/jcmm.12755","article-title":"Role of long non-coding RNA MIAT in proliferation, apoptosis and migration of lens epithelial cells: a clinical and in\u00a0vitro study","volume":"20","author":"Shen","year":"2016","journal-title":"J.\u00a0Cell. Mol. Med."},{"key":"10.1016\/j.exer.2016.04.023_bib134","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1167\/iovs.09-4567","article-title":"Adenoviral gene transfer of active human transforming growth factor-{beta}2 elevates intraocular pressure and reduces outflow facility in rodent eyes","volume":"51","author":"Shepard","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib135","first-page":"1392","article-title":"Herpes simplex virus-mediated gene delivery to the rodent visual system","volume":"41","author":"Spencer","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib136","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1167\/iovs.09-4918","article-title":"Development of a gene therapy virus with a glucocorticoid-inducible MMP1 for the treatment of steroid glaucoma","volume":"51","author":"Spiga","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib137","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1093\/hmg\/ddv027","article-title":"ARHGEF12 influences the risk of glaucoma by increasing intraocular pressure","volume":"24","author":"Springelkamp","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2016.04.023_bib138","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/ICU.0b013e32834ff23e","article-title":"Current understanding of conventional outflow dysfunction in glaucoma","volume":"23","author":"Stamer","year":"2012","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.exer.2016.04.023_bib139","doi-asserted-by":"crossref","first-page":"9438","DOI":"10.1167\/iovs.11-7839","article-title":"eNOS, a pressure-dependent regulator of intraocular pressure","volume":"52","author":"Stamer","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib140","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/08830180212066","article-title":"Anterior chamber associated immune deviation (ACAID): regulation, biological relevance, and implications for therapy","volume":"21","author":"Stein-Streilein","year":"2002","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.exer.2016.04.023_bib141","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.275.5300.668","article-title":"Identification of a gene that causes primary open angle glaucoma","volume":"275","author":"Stone","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.exer.2016.04.023_bib142","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/00061198-200308000-00013","article-title":"Episcleral venous pressure in younger and older subjects in the sitting and supine positions","volume":"12","author":"Sultan","year":"2003","journal-title":"J.\u00a0Glaucoma"},{"key":"10.1016\/j.exer.2016.04.023_bib143","doi-asserted-by":"crossref","first-page":"C1164","DOI":"10.1152\/ajpcell.00437.2010","article-title":"S1P\u2082 receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology","volume":"300","author":"Sumida","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.exer.2016.04.023_bib144","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/ng.661","article-title":"Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma","volume":"42","author":"Thorleifsson","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2016.04.023_bib145","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/jgm.2756","article-title":"Sleeping Beauty baculovirus hybrid vectors for long-term gene expression in the eye","volume":"16","author":"Turunen","year":"2014","journal-title":"J.\u00a0Gene Med."},{"key":"10.1016\/j.exer.2016.04.023_bib146","doi-asserted-by":"crossref","first-page":"e108071","DOI":"10.1371\/journal.pone.0108071","article-title":"Ocular localization and transduction by adenoviral vectors are serotype-dependent and can be modified by inclusion of RGD fiber modifications","volume":"9","author":"Ueyama","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2016.04.023_bib147","first-page":"63","article-title":"Trabeculotomy in the immature, enucleated human eye","volume":"16","author":"Van Buskirk","year":"1977","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib148","doi-asserted-by":"crossref","first-page":"e1002611","DOI":"10.1371\/journal.pgen.1002611","article-title":"Common genetic determinants of intraocular pressure and primary open-angle glaucoma","volume":"8","author":"van Koolwijk","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.exer.2016.04.023_bib149","first-page":"32","article-title":"Gene transfer of dominant-negative RhoA increases outflow facility in perfused human anterior segment cultures","volume":"8","author":"Vittitow","year":"2002","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2016.04.023_bib150","series-title":"Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis","article-title":"Persistence in the population: epidemiology, transmission","author":"Wald","year":"2011"},{"key":"10.1016\/j.exer.2016.04.023_bib151","first-page":"1056","article-title":"Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure","volume":"118","author":"Wang","year":"2008","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.exer.2016.04.023_bib152","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.3892\/ijo.2013.2100","article-title":"Rho\/Rho-associated kinase pathway in glaucoma (Review)","volume":"43","author":"Wang","year":"2013","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.exer.2016.04.023_bib153","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-61779-095-9_1","article-title":"Introduction to viral vectors","volume":"737","author":"Warnock","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.exer.2016.04.023_bib154","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ymgme.2008.12.016","article-title":"Lessons learned from the gene therapy trial for ornithine transcarbamylase deficiency","volume":"96","author":"Wilson","year":"2009","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.exer.2016.04.023_bib155","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1167\/iovs.06-0296","article-title":"Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma","volume":"48","author":"Wordinger","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib156","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1089\/jop.2013.0220","article-title":"The role of TGF-\u03b22 and bone morphogenetic proteins in the trabecular meshwork and glaucoma","volume":"30","author":"Wordinger","year":"2014","journal-title":"J.\u00a0Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.exer.2016.04.023_bib157","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1126\/science.1083413","article-title":"Transcription start regions in the human genome are favored targets for MLV integration","volume":"300","author":"Wu","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.exer.2016.04.023_bib158","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1128\/JVI.79.1.364-379.2005","article-title":"Inverted terminal repeat sequences are important for intermolecular recombination and circularization of adeno-associated virus genomes","volume":"79","author":"Yan","year":"2005","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.exer.2016.04.023_bib159","doi-asserted-by":"crossref","DOI":"10.1089\/hum.2006.17.ft-274","article-title":"Hybrid adeno-associated virus bearing nonhomologous inverted terminal repeats enhances dual-vector reconstruction of minigenes in\u00a0vivo","author":"Yan","year":"2006","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.exer.2016.04.023_bib160","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nm1365","article-title":"Effective gene therapy with nonintegrating lentiviral vectors","volume":"12","author":"Y\u00e1\u00f1ez-Mu\u00f1oz","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.exer.2016.04.023_bib161","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201606749","article-title":"Long non-coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling","author":"Yao","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.exer.2016.04.023_bib162","first-page":"689","article-title":"B-cell-specific elements enhance sustained gene expression mediated by self-replicating extrachromosomal vectors","volume":"3","author":"Zehnpfennig","year":"2010","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.exer.2016.04.023_bib163","doi-asserted-by":"crossref","first-page":"C1057","DOI":"10.1152\/ajpcell.00481.2007","article-title":"Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork","volume":"295","author":"Zhang","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.exer.2016.04.023_bib164","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.brainres.2011.12.011","article-title":"Overexpression of either lysine-specific demethylase-1 or CLOCK, but not Co-Rest, improves long-term expression from a modified neurofilament promoter, in a helper virus-free HSV-1 vector system","volume":"1436","author":"Zhang","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.exer.2016.04.023_bib165","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1167\/iovs.13-12890","article-title":"Outflow tract ablation using a conditionally cytotoxic feline immunodeficiency viral vector","volume":"55","author":"Zhang","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.04.023_bib166","doi-asserted-by":"crossref","first-page":"e28720","DOI":"10.1371\/journal.pone.0028720","article-title":"Intraocular pressure changes: an important determinant of the biocompatibility of intravitreous implants","volume":"6","author":"Zou","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2016.04.023_bib167","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jconrel.2015.10.007","article-title":"Non-viral therapeutic approaches to ocular diseases: an overview and future directions","volume":"219","author":"Zulliger","year":"2015","journal-title":"J.\u00a0Control. Release"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483516300963?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483516300963?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T08:18:07Z","timestamp":1600503487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483516300963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":167,"alternative-id":["S0014483516300963"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2016.04.023","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene transfer to the outflow tract","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2016.04.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}