{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T14:21:48Z","timestamp":1772720508652,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.exer.2016.05.006","type":"journal-article","created":{"date-parts":[[2016,5,8]],"date-time":"2016-05-08T11:52:23Z","timestamp":1462708343000},"page":"94-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Identification and localization of lamina cribrosa cells in the human optic nerve head"],"prefix":"10.1016","volume":"147","author":[{"given":"Tara","family":"Tovar-Vidales","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Wordinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbot F.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2016.05.006_bib1","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1001\/archopht.1969.00990020792015","article-title":"Ultrastructure of human and monkey lamina cribrosa and optic nerve head","volume":"82","author":"Anderson","year":"1969","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2016.05.006_bib2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.exer.2010.09.005","article-title":"A\u00a0biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma","volume":"93","author":"Burgoyne","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.05.006_bib3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.exer.2010.08.004","article-title":"Glaucomatous cupping of the lamina cribrosa: a review of the evidence for active progressive remodeling as a mechanism","volume":"93","author":"Crawford Downs","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.05.006_bib4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.exer.2010.07.014","article-title":"The pathogenic role of transforming growth factor-beta2 in glaucomatous damage to the optic nerve head","volume":"93","author":"Fuchshofer","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.05.006_bib5","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.ajpath.2013.10.022","article-title":"Loss of caveolin-1 causes blood-retinal barrier breakdown, venous enlargement, and mural cell alteration","volume":"184","author":"Gu","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2016.05.006_bib6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/glia.440040215","article-title":"Astroglia in CNS injury","volume":"4","author":"Hatten","year":"1991","journal-title":"Glia"},{"key":"10.1016\/j.exer.2016.05.006_bib7","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","article-title":"Reduction of intraocular pressure and glaucoma progression: results from the early manifest glaucoma trial","volume":"120","author":"Heijl","year":"2002","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2016.05.006_bib8","first-page":"2891","article-title":"Ultrastructural immunocytochemical analysis of elastin in the human lamina cribrosa. Changes in elastic fibers in primary open-angle glaucoma","volume":"33","author":"Hernandez","year":"1992","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.05.006_bib9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1350-9462(99)00017-8","article-title":"The optic nerve head in glaucoma: role of astrocytes in tissue remodeling","volume":"19","author":"Hernandez","year":"2000","journal-title":"Prog. Retin Eye Res."},{"key":"10.1016\/j.exer.2016.05.006_bib10","first-page":"78","article-title":"Cell culture of the human lamina cribrosa","volume":"29","author":"Hernandez","year":"1988","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.05.006_bib11","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1167\/iovs.08-1937","article-title":"Activation of stretch-activated channels and maxi-K+ channels by membrane stress of human lamina cribrosa cells","volume":"50","author":"Irnaten","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.05.006_bib12","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/archopht.120.6.701","article-title":"The ocular hypertension treatment study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma","volume":"120","author":"Kass","year":"2002","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2016.05.006_bib13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00061198-200408000-00011","article-title":"Effect of cyclical mechanical stretch and exogenous transforming growth factor-beta1 on matrix metalloproteinase-2 activity in lamina cribrosa cells from the human optic nerve head","volume":"13","author":"Kirwan","year":"2004","journal-title":"J.\u00a0Glaucoma"},{"key":"10.1016\/j.exer.2016.05.006_bib14","first-page":"798","article-title":"Influence of cyclical mechanical strain on extracellular matrix gene expression in human lamina cribrosa cells in\u00a0vitro","volume":"11","author":"Kirwan","year":"2005","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2016.05.006_bib15","first-page":"76","article-title":"Differential global and extra-cellular matrix focused gene expression patterns between normal and glaucomatous human lamina cribrosa cells","volume":"15","author":"Kirwan","year":"2009","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2016.05.006_bib16","first-page":"2315","article-title":"Neurotrophin and neurotrophin receptor expression by cells of the human lamina cribrosa","volume":"42","author":"Lambert","year":"2001","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.05.006_bib17","first-page":"2315","article-title":"Neurotrophin and neurotrophin receptor expression by cells of the human lamina cribrosa","volume":"42","author":"Lambert","year":"2001","journal-title":"Investig. Ophthalmol Vis. Sci."},{"key":"10.1016\/j.exer.2016.05.006_bib18","first-page":"289","article-title":"Effect of exogenous neurotrophins on Trk receptor phosphorylation, cell proliferation, and neurotrophin secretion by cells isolated from the human lamina cribrosa","volume":"10","author":"Lambert","year":"2004","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2016.05.006_bib19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1471-2202-5-51","article-title":"Neurotrophin and Trk expression by cells of the human lamina cribrosa following oxygen-glucose deprivation","volume":"5","author":"Lambert","year":"2004","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.exer.2016.05.006_bib20","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1006\/exer.1998.0539","article-title":"Elastosis of the lamina cribrosa in glaucomatous optic neuropathy","volume":"67","author":"Pena","year":"1998","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.05.006_bib21","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/bjo.80.5.389","article-title":"Number of people with glaucoma worldwide","volume":"80","author":"Quigley","year":"1996","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2016.05.006_bib22","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1167\/iovs.11-8480","article-title":"Proteomics analyses of activated human optic nerve head lamina cribrosa cells following biomechanical strain","volume":"53","author":"Rogers","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.05.006_bib23","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.012302","article-title":"Proteomics analyses of human optic nerve head astrocytes following biomechanical strain","volume":"11","author":"Rogers","year":"2012","journal-title":"Mol. Cell Proteom."},{"key":"10.1016\/j.exer.2016.05.006_bib24","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0304-3940(98)00813-1","article-title":"Immunocytochemical evidence for a distinct GFAP-negative subpopulation of astrocytes in the adult rat hippocampus","volume":"257","author":"Walz","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.exer.2016.05.006_bib25","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1750-1326-5-32","article-title":"Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling","volume":"5","author":"Winkler","year":"2010","journal-title":"Mol. Neurodegener."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483516301099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483516301099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T02:50:02Z","timestamp":1536720602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483516301099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":25,"alternative-id":["S0014483516301099"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2016.05.006","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and localization of lamina cribrosa cells in the human optic nerve head","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2016.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}