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Biol."},{"key":"10.1016\/j.exer.2016.05.011_bib85","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.febslet.2013.01.068","article-title":"Activation of beta 1 but not beta 3 integrin increases cell traction forces","volume":"587","author":"Lin","year":"2013","journal-title":"FEBS Lett."},{"key":"10.1016\/j.exer.2016.05.011_bib86","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1083\/jcb.201207115","article-title":"A\u00a0novel pathway spatiotemporally activates Rac1 and redox signaling in response to fluid shear stress","volume":"201","author":"Liu","year":"2013","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.exer.2016.05.011_bib87","first-page":"563","article-title":"Antagonists of integrin alpha v beta 3 inhibit retinal neovascularization in a murine model","volume":"75","author":"Luna","year":"1996","journal-title":"Lab. 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