{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:04:21Z","timestamp":1789913061016,"version":"4.0.1"},"reference-count":113,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.exer.2016.08.006","type":"journal-article","created":{"date-parts":[[2016,8,13]],"date-time":"2016-08-13T00:40:49Z","timestamp":1471048849000},"page":"96-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"special_numbering":"C","title":["Evaluating retinal ganglion cell loss and dysfunction"],"prefix":"10.1016","volume":"151","author":[{"given":"Ben","family":"Mead","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav","family":"Tomarev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2016.08.006_bib1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.brainres.2005.09.046","article-title":"Tracer coupling of neurons in the rat retina inner nuclear layer labeled by Fluorogold","volume":"1063","author":"Abdel-Majid","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.exer.2016.08.006_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.coph.2012.09.006","article-title":"Anatomical and functional damage in experimental glaucoma","volume":"13","author":"Agudo-Barriuso","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.exer.2016.08.006_bib3","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1016\/j.visres.2010.08.014","article-title":"ERG changes in albino and pigmented mice after optic nerve transection","volume":"50","author":"Alarcon-Martinez","year":"2010","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2016.08.006_bib4","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1113\/jphysiol.1984.sp015518","article-title":"The photocurrent, noise and spectral sensitivity of rods of the monkey Macaca fascicularis","volume":"357","author":"Baylor","year":"1984","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.exer.2016.08.006_bib5","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.1523\/JNEUROSCI.14-07-04368.1994","article-title":"Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats","volume":"14","author":"Berkelaar","year":"1994","journal-title":"J.\u00a0Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.exer.2016.08.006_bib6","first-page":"147","article-title":"Regeneration of axons in the visual system","volume":"26","author":"Berry","year":"2008","journal-title":"Restor. Neurol. Neurosci."},{"key":"10.1016\/j.exer.2016.08.006_bib7","doi-asserted-by":"crossref","first-page":"e0144341","DOI":"10.1371\/journal.pone.0144341","article-title":"Synapse loss and dendrite remodeling in a mouse model of glaucoma","volume":"10","author":"Berry","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2016.08.006_bib8","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1523\/JNEUROSCI.4443-07.2008","article-title":"Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma","volume":"28","author":"Buckingham","year":"2008","journal-title":"J.\u00a0Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.exer.2016.08.006_bib9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1113\/jphysiol.2003.052738","article-title":"Ganglion cell contributions to the rat full-field electroretinogram","volume":"555","author":"Bui","year":"2004","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.exer.2016.08.006_bib10","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/0014-4886(74)90119-8","article-title":"Vinblastine-induced blockage of orthograde and retrograde axonal-transport of protein in retinal ganglion-cells","volume":"45","author":"Bunt","year":"1974","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.exer.2016.08.006_bib11","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1167\/iovs.10-7106","article-title":"Quantification of deficits in spatial visual function of mouse models for glaucoma","volume":"52","author":"Burroughs","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib12","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1167\/iovs.14-15691","article-title":"Progressive degeneration of retinal and superior collicular functions in mice with sustained ocular hypertension","volume":"56","author":"Chen","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib13","doi-asserted-by":"crossref","first-page":"e113011","DOI":"10.1371\/journal.pone.0113011","article-title":"Comparison of longitudinal in\u00a0vivo measurements of retinal nerve fiber layer thickness and retinal ganglion cell density after optic nerve transection in rat","volume":"9","author":"Choe","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2016.08.006_bib14","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1167\/iovs.12-11188","article-title":"Retrograde signaling in the optic nerve is necessary for electrical responsiveness of retinal ganglion cells","volume":"54","author":"Chou","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib15","doi-asserted-by":"crossref","first-page":"5602","DOI":"10.1167\/iovs.14-14793","article-title":"Transgenic mice expressing mutated Tyr437His human myocilin develop progressive loss of retinal ganglion cell electrical responsiveness and axonopathy with normal iop","volume":"55","author":"Chou","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib16","doi-asserted-by":"crossref","first-page":"17444","DOI":"10.1523\/JNEUROSCI.5461-12.2013","article-title":"Differential progression of structural and functional alterations in distinct retinal ganglion cell types in a mouse model of glaucoma","volume":"33","author":"Della Santina","year":"2013","journal-title":"J.\u00a0Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.exer.2016.08.006_bib17","doi-asserted-by":"crossref","first-page":"e115579","DOI":"10.1371\/journal.pone.0115579","article-title":"Rescue of retinal function by BDNF in a mouse model of glaucoma","volume":"9","author":"Domenici","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2016.08.006_bib18","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.neuron.2015.02.017","article-title":"Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling","volume":"85","author":"Duan","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.exer.2016.08.006_bib19","doi-asserted-by":"crossref","first-page":"8330","DOI":"10.1167\/iovs.14-15468","article-title":"Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243","volume":"55","author":"Dutca","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.exer.2016.03.001","article-title":"Axonal transport along retinal ganglion cells is grossly intact during reduced function post-injury","volume":"146","author":"Fahy","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.08.006_bib21","first-page":"2184","article-title":"Effect of short-term intraocular pressure elevation on the rabbit electroretinogram","volume":"32","author":"Feghali","year":"1991","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0896-6273(00)00084-2","article-title":"Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP","volume":"28","author":"Feng","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.exer.2016.08.006_bib23","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1167\/iovs.05-0955","article-title":"Topographic and morphologic analyses of retinal ganglion cell loss in old DBA\/2NNia mice","volume":"47","author":"Filippopoulos","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib24","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1167\/iovs.03-1411","article-title":"Selective ganglion cell functional loss in rats with experimental glaucoma","volume":"45","author":"Fortune","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib25","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neulet.2010.05.080","article-title":"The ERG responses to light stimuli of melanopsin-expressing retinal ganglion cells that are independent of rods and cones","volume":"479","author":"Fukuda","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.exer.2016.08.006_bib26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0304-3940(91)90778-R","article-title":"Fluoro-golds toxicity makes it inferior to true blue for long-term studies of dorsal-root ganglion neurons and motoneurons","volume":"128","author":"Garrett","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.exer.2016.08.006_bib27","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.exer.2015.06.025","article-title":"Psychophysical testing in rodent models of glaucomatous optic neuropathy","volume":"141","author":"Grillo","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.08.006_bib28","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.exer.2009.08.003","article-title":"Does elevated intraocular pressure reduce retinal TRKB-mediated survival signaling in experimental glaucoma?","volume":"89","author":"Guo","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.08.006_bib29","doi-asserted-by":"crossref","first-page":"13468","DOI":"10.1523\/JNEUROSCI.3626-07.2007","article-title":"Light-evoked calcium responses of isolated melanopsin-expressing retinal ganglion cells","volume":"27","author":"Hartwick","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.exer.2016.08.006_bib30","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1167\/iovs.09-3606","article-title":"Electrophysiological and histologic assessment of retinal ganglion cell fate in a mouse model for OPA1-associated autosomal dominant optic atrophy","volume":"51","author":"Heiduschka","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib31","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1167\/iovs.05-0708","article-title":"In\u00a0vivo imaging and counting of rat retinal ganglion cells using a scanning laser ophthalmoscope","volume":"47","author":"Higashide","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib32","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1167\/iovs.14-15622","article-title":"Decorin reduces intraocular pressure and retinal ganglion cell loss in rodents through fibrolysis of the scarred trabecular meshwork","volume":"56","author":"Hill","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib33","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/sj.eye.6701573","article-title":"Electrophysiological assessment of optic nerve disease","volume":"18","author":"Holder","year":"2004","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.exer.2016.08.006_bib34","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.4103\/1673-5374.121613","article-title":"Neurological function following intra-neural injection of fluorescent neuronal tracers in rats","volume":"8","author":"Hu","year":"2013","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.exer.2016.08.006_bib35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/02713680500545671","article-title":"Downregulation of Thy1 in retinal ganglion cells in experimental glaucoma","volume":"31","author":"Huang","year":"2006","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2016.08.006_bib36","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2011.07.002","article-title":"What can mice tell us about how vision works?","volume":"34","author":"Huberman","year":"2011","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.exer.2016.08.006_bib37","first-page":"643","article-title":"Beta-III-Tubulin: a reliable marker for retinal ganglion cell labeling in experimental models of glaucoma","volume":"8","author":"Jiang","year":"2015","journal-title":"Int. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2016.08.006_bib38","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/brain\/awt292","article-title":"Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome","volume":"137","author":"Johnson","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.exer.2016.08.006_bib39","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/nn.2181","article-title":"Massive restructuring of neuronal circuits during functional reorganization of adult visual cortex","volume":"11","author":"Keck","year":"2008","journal-title":"Nat. Neurosci."},{"issue":"1126","key":"10.1016\/j.exer.2016.08.006_bib40","first-page":"e1115","article-title":"Impact of aging and diet restriction on retinal function during and after acute intraocular pressure injury","volume":"33","author":"Kong","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.exer.2016.08.006_bib41","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1167\/iovs.09-4098","article-title":"RNA binding protein with multiple splicing: a new marker for retinal ganglion cells","volume":"51","author":"Kwong","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib42","doi-asserted-by":"crossref","first-page":"9694","DOI":"10.1167\/iovs.11-7869","article-title":"Quantitative analysis of retinal ganglion cell survival with Rbpms immunolabeling in animal models of optic neuropathies","volume":"52","author":"Kwong","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.310","article-title":"Neuronal STAT3 activation is essential for CNTF- and inflammatory stimulation-induced CNS axon regeneration","volume":"4","author":"Leibinger","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2016.08.006_bib44","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1167\/iovs.07-1447","article-title":"Longitudinal profile of retinal ganglion cell damage after optic nerve crush with blue-light confocal scanning laser ophthalmoscopy","volume":"49","author":"Leung","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib45","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.exer.2008.09.006","article-title":"Experimental detection of retinal ganglion cell damage in\u00a0vivo","volume":"88","author":"Leung","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.08.006_bib46","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1167\/iovs.10-6012","article-title":"Long-term in\u00a0vivo imaging and measurement of dendritic shrinkage of retinal ganglion cells","volume":"52","author":"Leung","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib47","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10633-005-2629-8","article-title":"The decline of the photopic negative response (PhNR) in the rat after optic nerve transection","volume":"111","author":"Li","year":"2005","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.exer.2016.08.006_bib48","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1167\/iovs.05-1295","article-title":"Melanopsin-expressing retinal ganglion cells are more injury-resistant in a chronic ocular hypertension model","volume":"47","author":"Li","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib49","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1371\/journal.pgen.0010004","article-title":"Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage","volume":"1","author":"Libby","year":"2005","journal-title":"Plos Genet."},{"key":"10.1016\/j.exer.2016.08.006_bib50","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/nn.4340","article-title":"Neural activity promotes long-distance, target-specific regeneration of adult retinal axons","volume":"19","author":"Lim","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.exer.2016.08.006_bib51","doi-asserted-by":"crossref","first-page":"e68084","DOI":"10.1371\/journal.pone.0068084","article-title":"Retinal ganglion cells are resistant to photoreceptor loss in retinal degeneration","volume":"8","author":"Lin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2016.08.006_bib52","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1167\/iovs.14-13895","article-title":"Monitoring retinal morphologic and functional changes in mice following optic nerve crush","volume":"55","author":"Liu","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib53","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1167\/iovs.07-0291","article-title":"Photopic ERG negative response from amacrine cell signaling in RCS rat retinal degeneration","volume":"49","author":"Machida","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib54","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jcyt.2015.12.002","article-title":"Mesenchymal stromal cell-mediated neuroprotection and functional preservation of retinal ganglion cells in a rodent model of glaucoma","volume":"18","author":"Mead","year":"2016","journal-title":"Cytotherapy"},{"key":"10.1016\/j.exer.2016.08.006_bib55","doi-asserted-by":"crossref","first-page":"7544","DOI":"10.1167\/iovs.13-13045","article-title":"Intravitreally transplanted dental pulp stem cells promote neuroprotection and axon regeneration of retinal ganglion cells after optic nerve injury","volume":"54","author":"Mead","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib56","doi-asserted-by":"crossref","first-page":"e110612","DOI":"10.1371\/journal.pone.0110612","article-title":"Comparative evaluation of methods for estimating retinal ganglion cell loss in retinal sections and wholemounts","volume":"9","author":"Mead","year":"2014","journal-title":"Plos One"},{"key":"10.1016\/j.exer.2016.08.006_bib57","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.exer.2009.02.009","article-title":"Retinal pathway origins of the pattern ERG of the mouse","volume":"89","author":"Miura","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.08.006_bib58","article-title":"Melanopsin ganglion cells are the most resistant retinal ganglion cell type to axonal injury in the rat retina","volume":"9","author":"Muller","year":"2014","journal-title":"Plos One"},{"key":"10.1016\/j.exer.2016.08.006_bib59","doi-asserted-by":"crossref","first-page":"6505","DOI":"10.1167\/iovs.14-14525","article-title":"Nerve fiber layer thinning lags retinal ganglion cell density following crush axonopathy","volume":"55","author":"Munguba","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib60","doi-asserted-by":"crossref","first-page":"e49830","DOI":"10.1371\/journal.pone.0049830","article-title":"Whole number, distribution and co-expression of brn3 transcription factors in retinal ganglion cells of adult albino and pigmented rats","volume":"7","author":"Nadal-Nicolas","year":"2012","journal-title":"Plos One"},{"key":"10.1016\/j.exer.2016.08.006_bib61","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1167\/iovs.08-3267","article-title":"Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas","volume":"50","author":"Nadal-Nicolas","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib62","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.exer.2014.12.005","article-title":"Two methods to trace retinal ganglion cells with fluorogold: from the intact optic nerve or by stereotactic injection into the optic tract","volume":"131","author":"Nadal-Nicolas","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.08.006_bib63","doi-asserted-by":"crossref","first-page":"6095","DOI":"10.1167\/iovs.15-17195","article-title":"Long-term effect of optic nerve axotomy on the retinal ganglion cell layer","volume":"56","author":"Nadal-Nicolas","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib64","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.exer.2015.06.006","article-title":"Assessment of retinal ganglion cell damage in glaucomatous optic neuropathy: axon transport, injury and soma loss","volume":"141","author":"Nuschke","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.08.006_bib65","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.exer.2014.02.022","article-title":"Assessment of inner retina dysfunction and progressive ganglion cell loss in a mouse model of glaucoma","volume":"122","author":"Perez de Lara","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.08.006_bib66","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0306-4522(81)90174-3","article-title":"Evidence for an amacrine cell system in the ganglion-cell layer of the rat retina","volume":"6","author":"Perry","year":"1981","journal-title":"Neuroscience"},{"key":"10.1016\/j.exer.2016.08.006_bib67","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/BF01148495","article-title":"Is Thy-1 expressed only by ganglion-cells and their axons in the retina and optic-nerve","volume":"13","author":"Perry","year":"1984","journal-title":"J.\u00a0Neurocytol."},{"key":"10.1016\/j.exer.2016.08.006_bib68","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s003350010102","article-title":"Tests of the mouse visual system","volume":"11","author":"Pinto","year":"2000","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.exer.2016.08.006_bib69","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.exer.2015.05.008","article-title":"Electrophysiological assessment of retinal ganglion cell function","volume":"141","author":"Porciatti","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.08.006_bib70","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.exer.2009.12.005","article-title":"Head-up tilt lowers IOP and improves RGC dysfunction in glaucomatous DBA\/2J mice","volume":"90","author":"Porciatti","year":"2010","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.08.006_bib71","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1167\/iovs.12-11201","article-title":"Photopic negative response versus pattern electroretinogram in early glaucoma","volume":"54","author":"Preiser","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib72","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1021\/mp400313u","article-title":"17beta-estradiol eye drops protect the retinal ganglion cell layer and preserve visual function in an in\u00a0vivo model of glaucoma","volume":"10","author":"Prokai-Tatrai","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.exer.2016.08.006_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088855","article-title":"Single-cell resolution imaging of retinal ganglion cell apoptosis in\u00a0vivo using a cell-penetrating caspaseactivatable peptide probe","volume":"9","author":"Qiu","year":"2014","journal-title":"Plos One"},{"key":"10.1016\/j.exer.2016.08.006_bib74","first-page":"3460","article-title":"Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats","volume":"41","author":"Quigley","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib75","doi-asserted-by":"crossref","first-page":"11595","DOI":"10.1523\/JNEUROSCI.2837-05.2005","article-title":"Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways","volume":"25","author":"Quina","year":"2005","journal-title":"J.\u00a0Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.exer.2016.08.006_bib76","first-page":"1559","article-title":"Cyan fluorescent protein expression in ganglion and amacrine cells in a thy1-CFP transgenic mouse retina","volume":"14","author":"Raymond","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2016.08.006_bib77","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.visres.2005.09.006","article-title":"The visual evoked potential in the mouse\u2013origins and response characteristics","volume":"46","author":"Ridder","year":"2006","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2016.08.006_bib78","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1002\/cne.23521","article-title":"The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina","volume":"522","author":"Rodriguez","year":"2014","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.exer.2016.08.006_bib79","doi-asserted-by":"crossref","first-page":"4487","DOI":"10.1167\/iovs.15-17145","article-title":"Comparison of retinal nerve fiber layer thinning and retinal ganglion cell loss after optic nerve transection in adult albino rats","volume":"56","author":"Rovere","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib80","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.exer.2009.10.003","article-title":"Ocular hypertension impairs optic nerve axonal transport leading to progressive retinal ganglion cell degeneration","volume":"90","author":"Salinas-Navarro","year":"2010","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.08.006_bib81","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.visres.2009.01.010","article-title":"Retinal ganglion cell population in adult albino and pigmented mice: a computerized analysis of the entire population and its spatial distribution","volume":"49","author":"Salinas-Navarro","year":"2009","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2016.08.006_bib82","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.visres.2008.09.029","article-title":"A\u00a0computerized analysis of the entire retinal ganglion cell population and its spatial distribution in adult rats","volume":"49","author":"Salinas-Navarro","year":"2009","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2016.08.006_bib83","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.exer.2011.02.001","article-title":"Brain derived neurotrophic factor maintains Brn3a expression in axotomized rat retinal ganglion cells","volume":"92","author":"Sanchez-Migallon","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2016.08.006_bib84","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev-neuro-071714-034120","article-title":"The types of retinal ganglion cells: current status and implications for neuronal classification","volume":"38","author":"Sanes","year":"2015","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.exer.2016.08.006_bib85","first-page":"1387","article-title":"Evaluation of the percentage of ganglion cells in the ganglion cell layer of the rodent retina","volume":"19","author":"Schlamp","year":"2013","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2016.08.006_bib86","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1167\/iovs.07-1335","article-title":"Real-time in\u00a0vivo imaging of retinal cell apoptosis after laser exposure","volume":"49","author":"Schmitz-Valckenberg","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib87","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s00401-003-0816-9","article-title":"Retinal neurodegeneration in the DBA\/2J mouse-a model for ocular hypertension","volume":"107","author":"Schuettauf","year":"2004","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.exer.2016.08.006_bib88","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2007.07.090","article-title":"Early born lineage of retinal neurons express class III beta-tubulin isotype","volume":"1176","author":"Sharma","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.exer.2016.08.006_bib89","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1152\/jn.1986.56.4.1049","article-title":"Scotopic threshold response of proximal retina in cat","volume":"56","author":"Sieving","year":"1986","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.exer.2016.08.006_bib90","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10633-014-9433-2","article-title":"Contribution of retinal ganglion cells to the mouse electroretinogram","volume":"128","author":"Smith","year":"2014","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.exer.2016.08.006_bib91","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1523\/JNEUROSCI.3714-07.2008","article-title":"Retinal ganglion cells downregulate gene expression and lose their Axons within the optic nerve head in a mouse glaucoma model","volume":"28","author":"Soto","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.exer.2016.08.006_bib92","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1167\/iovs.10-5856","article-title":"Retinal ganglion cell loss in a rat ocular hypertension model is sectorial and involves early optic nerve axon loss","volume":"52","author":"Soto","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib93","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1085\/jgp.93.1.101","article-title":"B-wave of the electroretinogram. A reflection of ON bipolar cell activity","volume":"93","author":"Stockton","year":"1989","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.exer.2016.08.006_bib94","doi-asserted-by":"crossref","first-page":"e99299","DOI":"10.1371\/journal.pone.0099299","article-title":"Hydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush","volume":"9","author":"Sun","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2016.08.006_bib95","first-page":"1540","article-title":"Gamma-Synuclein as a marker of retinal ganglion cells","volume":"14","author":"Surgucheva","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2016.08.006_bib96","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/jnr.1129","article-title":"Synucleins in ocular tissues","volume":"65","author":"Surguchov","year":"2001","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.exer.2016.08.006_bib97","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/jmri.20400","article-title":"Manganese-enhanced MRI of the optic visual pathway and optic nerve injury in adult rats","volume":"22","author":"Thuen","year":"2005","journal-title":"J.\u00a0Magn. Reson Imaging"},{"key":"10.1016\/j.exer.2016.08.006_bib98","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1167\/iovs.15-16454","article-title":"BDNF rescues RGCs but not intrinsically photosensitive RGCs in ocular hypertensive albino rat retinas","volume":"56","author":"Valiente-Soriano","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib99","first-page":"514","article-title":"The photopic negative response of the flash electroretinogram in primary open angle glaucoma","volume":"42","author":"Viswanathan","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib100","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/cne.22253","article-title":"Birthdays of retinal amacrine cell subtypes are systematically related to their molecular identity and soma position (vol. 517, pg 737, 2009)","volume":"518","author":"Voinescu","year":"2010","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.exer.2016.08.006_bib101","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neulet.2009.10.077","article-title":"Cyan fluorescent protein (CFP) expressing cells in the retina of Thy1-CFP transgenic mice before and after optic nerve injury","volume":"468","author":"Wang","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.exer.2016.08.006_bib102","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0006-8993(91)90241-M","article-title":"Fluoro-Gold: composition, and mechanism of uptake","volume":"553","author":"Wessendorf","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.exer.2016.08.006_bib103","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13024-016-0091-6","article-title":"Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma","volume":"11","author":"Williams","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.exer.2016.08.006_bib104","doi-asserted-by":"crossref","first-page":"e108524","DOI":"10.1371\/journal.pone.0108524","article-title":"Protection of pattern electroretinogram and retinal ganglion cells by oncostatin M after optic nerve injury","volume":"9","author":"Xia","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2016.08.006_bib105","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.1523\/JNEUROSCI.15-07-04762.1995","article-title":"The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons","volume":"15","author":"Xiang","year":"1995","journal-title":"J.\u00a0Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.exer.2016.08.006_bib106","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1167\/iovs.12-11375","article-title":"A\u00a0new mouse model of inducible, chronic retinal ganglion cell dysfunction not associated with cell death","volume":"54","author":"Yang","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib107","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1515\/revneuro-2013-0003","article-title":"Optic neuropathies: characteristic features and mechanisms of retinal ganglion cell loss","volume":"24","author":"You","year":"2013","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.exer.2016.08.006_bib108","doi-asserted-by":"crossref","first-page":"6911","DOI":"10.1167\/iovs.11-7434","article-title":"Latency delay of visual evoked potential is a real measurement of demyelination in a rat model of optic neuritis","volume":"52","author":"You","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib109","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10633-014-9478-2","article-title":"Molecular, anatomical and functional changes in the retinal ganglion cells after optic nerve crush in mice","volume":"130","author":"Yukita","year":"2015","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.exer.2016.08.006_bib110","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1007\/s11427-013-4493-1","article-title":"Melanopsin-expressing retinal ganglion cell loss and behavioral analysis in the Thy1-CFP-DBA\/2J mouse model of glaucoma","volume":"56","author":"Zhang","year":"2013","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib111","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1167\/iovs.07-1339","article-title":"Transgenic mice expressing the Tyr437His mutant of human myocilin protein develop glaucoma","volume":"49","author":"Zhou","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2016.08.006_bib112","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1172\/JCI58183","article-title":"Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma","volume":"121","author":"Zode","year":"2011","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.exer.2016.08.006_bib113","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.1167\/iovs.13-12157","article-title":"SIRT1 promotes RGC survival and delays loss of function following optic nerve crush","volume":"54","author":"Zuo","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483516302160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483516302160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T22:32:28Z","timestamp":1657060348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483516302160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":113,"alternative-id":["S0014483516302160"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2016.08.006","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluating retinal ganglion cell loss and dysfunction","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2016.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}