{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:37:16Z","timestamp":1790743036524,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.exer.2017.09.005","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T03:31:35Z","timestamp":1506569495000},"page":"99-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Investigation of antioxidant systems in human meibomian gland and conjunctival tissues"],"prefix":"10.1016","volume":"165","author":[{"given":"Hachemi","family":"Nezzar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce N.","family":"Mbekeani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6588-7771","authenticated-orcid":false,"given":"Anais","family":"Noblanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Chiambaretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3077-6558","authenticated-orcid":false,"given":"Jo\u00ebl R.","family":"Drevet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayhan","family":"Kocer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2017.09.005_bib1","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1007\/BF00164671","article-title":"Oxidative reactions in the tear fluid of patients suffering from dry eyes","volume":"233","author":"Augustin","year":"1995","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol. Albr. Von. Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2017.09.005_bib2","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1515\/BC.2006.166","article-title":"Glutathione peroxidases and redox-regulated transcription factors","volume":"387","author":"Brigelius-Floh\u00e9","year":"2006","journal-title":"Biol. Chem."},{"key":"10.1016\/j.exer.2017.09.005_bib3","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1016\/j.bbagen.2012.11.020","article-title":"Glutathione peroxidases","volume":"1830","author":"Brigelius-Floh\u00e9","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2017.09.005_bib4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.exer.2003.09.019","article-title":"Functional aspects of the tear film lipid layer","volume":"78","author":"Bron","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.09.005_bib5","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/emmm.201302679","article-title":"Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human","volume":"5","author":"Chang","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.exer.2017.09.005_bib6","first-page":"1626","article-title":"NPGPx (GPx7): a novel oxidative stress sensor\/transmitter with multiple roles in redox homeostasis","volume":"8","author":"Chen","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.exer.2017.09.005_bib7","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1016\/S0021-9258(18)53812-6","article-title":"Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI","volume":"268","author":"Chu","year":"1993","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2017.09.005_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bss0610001","article-title":"Oxidative stress: the paradox of aerobic life","volume":"61","author":"Davies","year":"1995","journal-title":"Biochem. Soc. Symp."},{"key":"10.1016\/j.exer.2017.09.005_bib9","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/j.1365-313X.2006.02919.x","article-title":"Hydrogen peroxide, nitric oxide and cytosolic ascorbate peroxidase at the crossroad between defence and cell death","volume":"48","author":"de Pinto","year":"2006","journal-title":"Plant J. Cell Mol. Biol."},{"key":"10.1016\/j.exer.2017.09.005_bib10","first-page":"26","article-title":"Advances in understanding and managing rosacea: part 2: the central role, evaluation, and medical management of diffuse and persistent facial erythema of rosacea","volume":"5","author":"Del Rosso","year":"2012","journal-title":"J.\u00a0Clin. Aesthetic Dermatol."},{"key":"10.1016\/j.exer.2017.09.005_bib11","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3109\/02713689109020328","article-title":"Histochemical localization of superoxide production in experimental autoimmune uveitis","volume":"10","author":"Gritz","year":"1991","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2017.09.005_bib12","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1046\/j.1432-1033.2002.02905.x","article-title":"Two GPX-like proteins from Lycopersicon esculentum and Helianthus annuus are antioxidant enzymes with phospholipid hydroperoxide glutathione peroxidase and thioredoxin peroxidase activities","volume":"269","author":"Herbette","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.exer.2017.09.005_bib13","doi-asserted-by":"crossref","first-page":"e9911","DOI":"10.1371\/journal.pone.0009911","article-title":"Selenoprotein P controls oxidative stress in cornea","volume":"5","author":"Higuchi","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.09.005_bib14","doi-asserted-by":"crossref","first-page":"e99328","DOI":"10.1371\/journal.pone.0099328","article-title":"Oxidative stress induced age dependent meibomian gland dysfunction in Cu, Zn-superoxide dismutase-1 (Sod1) knockout mice","volume":"9","author":"Ibrahim","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.09.005_bib15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0891-5849(02)01197-8","article-title":"Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells","volume":"34","author":"Imai","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exer.2017.09.005_bib16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1146\/annurev.nutr.19.1.63","article-title":"Regulation of gene expression by dietary fat","volume":"19","author":"Jump","year":"1999","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.exer.2017.09.005_bib17","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1080\/01926230290166724","article-title":"Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification","volume":"30","author":"Kohen","year":"2002","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.exer.2017.09.005_bib18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2174\/1389557516666151120114605","article-title":"The role oxidative stress in the pathogenesis of eye diseases: current status and a dual role of physical activity","volume":"16","author":"Kruk","year":"2015","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.exer.2017.09.005_bib19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2013.07.036","article-title":"The thioredoxin antioxidant system","volume":"66","author":"Lu","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exer.2017.09.005_bib20","first-page":"425","article-title":"Gene expression analysis of oxidative stress and apoptosis in proton-irradiated rat retina","volume":"24","author":"Mao","year":"2010","journal-title":"Vivo Athens Greece"},{"key":"10.1016\/j.exer.2017.09.005_bib21","first-page":"19376","article-title":"Potential role of sulfur-containing antioxidant systems in highly oxidative environments","volume":"19","author":"Mukwevho","year":"2014","journal-title":"Mol. Basel Switz."},{"key":"10.1016\/j.exer.2017.09.005_bib22","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2164\/jandrol.110.012823","article-title":"Glutathione peroxidases at work on epididymal spermatozoa: an example of the dual effect of reactive oxygen species on mammalian male fertilizing ability","volume":"32","author":"Noblanc","year":"2011","journal-title":"J.\u00a0Androl."},{"key":"10.1016\/j.exer.2017.09.005_bib23","first-page":"380","article-title":"Changes in the spatial expression of genes with aging in the mouse RPE\/choroid","volume":"11","author":"Ogawa","year":"2005","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2017.09.005_bib24","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1136\/gutjnl-2011-301078","article-title":"Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells","volume":"61","author":"Peng","year":"2012","journal-title":"Gut"},{"issue":"Suppl.\u00a02","key":"10.1016\/j.exer.2017.09.005_bib25","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.1016\/S0039-6257(00)00203-4","article-title":"The ocular surface and tear film and their dysfunction in dry eye disease","volume":"45","author":"Rolando","year":"2001","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2017.09.005_bib26","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/2211-5463.12141","article-title":"Glutathione peroxidase 4 plays an important role in oxidative homeostasis and wound repair in corneal epithelial cells","volume":"6","author":"Sakai","year":"2016","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.exer.2017.09.005_bib27","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1167\/iovs.14-15463","article-title":"Role of glutathione peroxidase 4 in conjunctival epithelial cells","volume":"56","author":"Sakai","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.09.005_bib28","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1167\/iovs.10-6997e","article-title":"The international workshop on meibomian gland dysfunction: report of the subcommittee on the epidemiology of, and associated risk factors for, MGD","volume":"52","author":"Schaumberg","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.09.005_bib29","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/(SICI)1098-2795(199812)51:4<362::AID-MRD2>3.0.CO;2-L","article-title":"GPx3: the plasma-type glutathione peroxidase is expressed under androgenic control in the mouse epididymis and vas deferens","volume":"51","author":"Schwaab","year":"1998","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.exer.2017.09.005_bib30","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.freeradbiomed.2008.07.021","article-title":"Oxidative stress in diseases of the human cornea","volume":"45","author":"Shoham","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exer.2017.09.005_bib31","first-page":"1173","article-title":"Oxidative stress-induced cataract: mechanism of action","volume":"9","author":"Spector","year":"1995","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.exer.2017.09.005_bib32","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1182\/blood.V68.3.640.640","article-title":"Selenium-dependent glutathione peroxidase protein and activity: immunological investigations on cellular and plasma enzymes","volume":"68","author":"Takahashi","year":"1986","journal-title":"Blood"},{"key":"10.1016\/j.exer.2017.09.005_bib33","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3109\/10715762.2013.777155","article-title":"Antioxidants and cataract","volume":"47","author":"Thiagarajan","year":"2013","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.exer.2017.09.005_bib34","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1080\/02713683.2016.1196707","article-title":"Role of glutathione peroxidase 4 in corneal endothelial cells","volume":"42","author":"Uchida","year":"2017","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2017.09.005_bib35","doi-asserted-by":"crossref","first-page":"7675","DOI":"10.1074\/jbc.M111.335174","article-title":"Glutathione peroxidase 4 is required for maturation of photoreceptor cells","volume":"287","author":"Ueta","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2017.09.005_bib36","doi-asserted-by":"crossref","first-page":"43522","DOI":"10.1074\/jbc.M407141200","article-title":"Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells","volume":"279","author":"Utomo","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exer.2017.09.005_bib37","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.exer.2017.09.005_bib38","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1590\/S0004-27492008000700015","article-title":"Tearful relations: oxidative stress, inflammation and eye diseases","volume":"71","author":"Wakamatsu","year":"2008","journal-title":"Arq. Bras. Oftalmol."},{"key":"10.1016\/j.exer.2017.09.005_bib39","first-page":"32","article-title":"Oxidative damage and age-related macular degeneration","volume":"5","author":"Winkler","year":"1999","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2017.09.005_bib40","doi-asserted-by":"crossref","first-page":"50","DOI":"10.12703\/P6-50","article-title":"Recent advances in the understanding and management of rosacea","volume":"6","author":"Wollina","year":"2014","journal-title":"F1000prime Rep."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483517304888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483517304888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T14:39:28Z","timestamp":1617460768000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483517304888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":40,"alternative-id":["S0014483517304888"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2017.09.005","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of antioxidant systems in human meibomian gland and conjunctival tissues","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2017.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}