{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:02:11Z","timestamp":1790402531413,"version":"4.1.0"},"reference-count":303,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["EY01919"],"award-info":[{"award-number":["EY01919"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["EY6842"],"award-info":[{"award-number":["EY6842"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["EY02162"],"award-info":[{"award-number":["EY02162"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["EY00415"],"award-info":[{"award-number":["EY00415"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["EY010609"],"award-info":[{"award-number":["EY010609"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["EY08656"],"award-info":[{"award-number":["EY08656"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["EY026499"],"award-info":[{"award-number":["EY026499"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["EY12155"],"award-info":[{"award-number":["EY12155"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["EY027193"],"award-info":[{"award-number":["EY027193"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["EY027387"],"award-info":[{"award-number":["EY027387"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001116","name":"Foundation Fighting Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001116","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007044","name":"Macula Vision Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007044","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.exer.2017.10.023","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T21:36:48Z","timestamp":1510004208000},"page":"56-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"special_numbering":"C","title":["Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration"],"prefix":"10.1016","volume":"167","author":[{"given":"Matthew M.","family":"LaVail","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimpei","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy H.","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muna I.","family":"Naash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacque L.","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Trautmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Matthes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Yasumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Lau-Villacorta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ward M.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Flannery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2017.10.023_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40259-014-0110-5","article-title":"Neurotrophin family members as neuroprotectants in retinal degenerations","volume":"29","author":"Abed","year":"2015","journal-title":"BioDrugs"},{"key":"10.1016\/j.exer.2017.10.023_bib2","first-page":"109","article-title":"Mass spectrometric analysis of rhodopsin from light damaged rats","volume":"6","author":"Ablonczy","year":"2000","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2017.10.023_bib3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0014-4835(87)80160-4","article-title":"Retinal degenerations in the dog: IV. Early retinal degeneration (erd) in Norwegian elkhounds","volume":"44","author":"Acland","year":"1987","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/ng0501-92","article-title":"Gene therapy restores vision in a canine model of childhood blindness","volume":"28","author":"Acland","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2017.10.023_bib5","doi-asserted-by":"crossref","first-page":"C764","DOI":"10.1152\/ajpcell.00253.2009","article-title":"Retinal metabolic state of the proline-23-histidine rat model of retinitis pigmentosa","volume":"298","author":"Acosta","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.exer.2017.10.023_bib6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1167\/tvst.4.4.5","article-title":"Integration of perforated subretinal prostheses with retinal tissue","volume":"4","author":"Adekunle","year":"2015","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.exer.2017.10.023_bib7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ejpb.2014.12.028","article-title":"Nanoparticle-based technologies for retinal gene therapy","volume":"95","author":"Adijanto","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.exer.2017.10.023_bib8","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1093\/hmg\/ddt613","article-title":"Hsp90 inhibition protects against inherited retinal degeneration","volume":"23","author":"Aguila","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2017.10.023_bib9","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1016\/S0042-6989(01)00157-2","article-title":"Augmented rod bipolar cell function in partial receptor loss: an ERG study in P23H rhodopsin transgenic and aging normal rats","volume":"41","author":"Aleman","year":"2001","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2017.10.023_bib10","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1089\/hum.2012.2506","article-title":"Gene therapy for retinal dystrophies: twenty years in the making","volume":"23","author":"Ali","year":"2012","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.exer.2017.10.023_bib11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1076\/ceyr.24.1.26.5432","article-title":"Ganglion cell responses to retinal light stimulation in the absence of photoreceptor outer segments from retinal degenerate rodents","volume":"24","author":"An","year":"2002","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib12","first-page":"351","article-title":"Low docosahexaenoic acid levels in rod outer segments of rats with P23H and S334ter rhodopsin mutations","volume":"8","author":"Anderson","year":"2002","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2017.10.023_bib13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/exer.2002.2001","article-title":"Transplanted sheets of human retina and retinal pigment epithelium develop normally in nude rats","volume":"75","author":"Aramant","year":"2002","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112142","article-title":"Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration","volume":"9","author":"Arango-Gonzalez","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.10.023_bib15","first-page":"305","article-title":"Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration","volume":"26","author":"Athanasiou","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2017.10.023_bib16","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/j.visres.2009.04.008","article-title":"Naturally occurring animal models with outer retina phenotypes","volume":"49","author":"Baehr","year":"2009","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2017.10.023_bib17","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/mt.2015.220","article-title":"In Vivo CRISPR\/Cas9 gene editing corrects retinal dystrophy in the S334ter-3 rat model of autosomal dominant retinitis pigmentosa","volume":"24","author":"Bakondi","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2017.10.023_bib18","first-page":"2857","article-title":"Real-time, noninvasive in vivo assessment of adeno-associated virus-mediated retinal transduction","volume":"38","author":"Bennett","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib19","doi-asserted-by":"crossref","first-page":"9920","DOI":"10.1073\/pnas.96.17.9920","article-title":"Stable transgene expression in rod photoreceptors after recombinant adeno-associated virus-mediated gene transfer to monkey retina","volume":"96","author":"Bennett","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2017.10.023_bib20","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nm0696-649","article-title":"Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy","volume":"2","author":"Bennett","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.exer.2017.10.023_bib21","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1001\/archopht.1991.01080010094039","article-title":"Ocular findings in patients with autosomal dominant retinitis pigmentosa and a rhodopsin gene defect (Pro-23-His)","volume":"109","author":"Berson","year":"1991","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2017.10.023_bib22","first-page":"333","article-title":"Alterations in retinal rod outer segment fatty acids and light-damage susceptibility in P23H rats","volume":"8","author":"Bicknell","year":"2002","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2017.10.023_bib23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/cne.902120303","article-title":"Retinal degeneration in the pcd cerebellar mutant mouse. II. Electron microscopic analysis","volume":"212","author":"Blanks","year":"1982","journal-title":"J. Comp. Neur"},{"key":"10.1016\/j.exer.2017.10.023_bib24","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0014-4835(92)90019-O","article-title":"Retinal degeneration in the pcd\/pcd mutant mouse: accumulation of spherules in the interphotoreceptor space","volume":"54","author":"Blanks","year":"1992","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib25","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.mito.2007.05.003","article-title":"Relationship between mitochondrial DNA damage and photoreceptor death in developing and adult retina, assessed in normal and degenerative rat strains","volume":"7","author":"Bravo-Nuevo","year":"2007","journal-title":"Mitochondrion"},{"key":"10.1016\/j.exer.2017.10.023_bib26","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.preteyeres.2006.05.003","article-title":"Muller cells in the healthy and diseased retina","volume":"25","author":"Bringmann","year":"2006","journal-title":"Prog. Retin Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib27","first-page":"2697","article-title":"The effect of calcium channel blocker diltiazem on photoreceptor degeneration in the rhodopsin Pro213His rat","volume":"41","author":"Bush","year":"2000","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib28","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.mcn.2005.03.005","article-title":"Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective","volume":"29","author":"Butovsky","year":"2005","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1172\/JCI65654","article-title":"Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration","volume":"125","author":"Byrne","year":"2015","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.exer.2017.10.023_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exer.2014.12.009","article-title":"Relationship between rat retinal degeneration and potassium channel KCNQ5 expression","volume":"131","author":"Caminos","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib31","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/jcp.21213","article-title":"Seeing the light: new insights into the molecular pathogenesis of retinal diseases","volume":"213","author":"Campochiaro","year":"2007","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.exer.2017.10.023_bib32","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1006\/exer.2001.0990","article-title":"Development of normal and injury-induced gene expression of aFGF, bFGF, CNTF, BDNF, GFAP and IGF-I in the rat retina","volume":"72","author":"Cao","year":"2001","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib33","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/cne.901880204","article-title":"Rods and cones in the mouse retina. I. Structural analysis using light and electron microscopy","volume":"188","author":"Carter-Dawson","year":"1979","journal-title":"J. Comp. Neur"},{"key":"10.1016\/j.exer.2017.10.023_bib34","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/cne.901880205","article-title":"Rods and cones in the mouse retina. II. Autoradiographic analysis of cell generation using tritiated thymidine","volume":"188","author":"Carter-Dawson","year":"1979","journal-title":"J. Comp. Neur"},{"key":"10.1016\/j.exer.2017.10.023_bib35","first-page":"489","article-title":"Differential effect of the rd mutation on rods and cones in the mouse retina","volume":"17","author":"Carter-Dawson","year":"1978","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib36","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0042-6989(01)00212-7","article-title":"Animal models in research on retinal degenerations: past progress and future hope","volume":"42","author":"Chader","year":"2002","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2017.10.023_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098939","article-title":"Initiation of rod outer segment disc formation requires RDS","volume":"9","author":"Chakraborty","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.10.023_bib38","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1152\/jn.00619.2010","article-title":"Both electrical stimulation thresholds and SMI-32-immunoreactive retinal ganglion cell density correlate with age in S334ter line 3 rat retina","volume":"105","author":"Chan","year":"2011","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.exer.2017.10.023_bib39","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0042-6989(01)00146-8","article-title":"Retinal degeneration mutants in the mouse","volume":"42","author":"Chang","year":"2002","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2017.10.023_bib40","first-page":"1605","article-title":"Mass spectrometric analyses of phospholipids in the S334ter-3 rat model of retinal degeneration","volume":"20","author":"Chen","year":"2014","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2017.10.023_bib41","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1126\/science.7824934","article-title":"Mechanisms of rhodopsin inactivation in vivo as revealed by COOH-terminal truncation mutant","volume":"267","author":"Chen","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.exer.2017.10.023_bib42","first-page":"2978","article-title":"Increased susceptibility to light damage in an arrestin knockout mouse model of Oguchi disease (stationary night blindness)","volume":"40","author":"Chen","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib43","doi-asserted-by":"crossref","first-page":"26793","DOI":"10.1038\/srep26793","article-title":"Electrophysiology alterations in primary visual cortex neurons of retinal degeneration (S334ter-line-3) rats","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2017.10.023_bib44","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s12035-014-8881-8","article-title":"Robust endoplasmic reticulum-associated degradation of rhodopsin precedes retinal degeneration","volume":"52","author":"Chiang","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.exer.2017.10.023_bib45","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1091\/mbc.e11-08-0663","article-title":"IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin","volume":"23","author":"Chiang","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.exer.2017.10.023_bib46","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1167\/iovs.07-1158","article-title":"The status of cones in the rhodopsin mutant P23H-3 retina: light-regulated damage and repair in parallel with rods","volume":"49","author":"Chrysostomou","year":"2008","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib47","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1167\/iovs.08-3003","article-title":"Life history of cones in the rhodopsin-mutant P23H-3 rat: evidence of long-term survival","volume":"50","author":"Chrysostomou","year":"2009","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib48","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1167\/iovs.08-3004","article-title":"Cone-rod dependence in the rat retina: variation with the rate of rod damage","volume":"50","author":"Chrysostomou","year":"2009","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib49","first-page":"832","article-title":"Some cytological and initial biochemical observations on photoreceptors in retinas of rds mice","volume":"24","author":"Cohen","year":"1983","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib50","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1073\/pnas.92.7.3070","article-title":"Defective intracellular transport is the molecular basis of rhodopsin-dependent dominant retinal degeneration","volume":"92","author":"Colley","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2017.10.023_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010904","article-title":"Q344ter mutation causes mislocalization of rhodopsin molecules that are catalytically active: a mouse model of Q344ter-induced retinal degeneration","volume":"5","author":"Concepcion","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.10.023_bib52","first-page":"23","article-title":"Preclinical potency and safety studies of an AAV2-mediated gene therapy vector for the treatment of MERTK associated retinitis pigmentosa. Human gene therapy","volume":"24","author":"Conlon","year":"2013","journal-title":"Clin. Dev."},{"key":"10.1016\/j.exer.2017.10.023_bib53","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.preteyeres.2014.07.001","article-title":"Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases","volume":"43","author":"Cuenca","year":"2014","journal-title":"Prog. Retin Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib54","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neuroscience.2004.04.042","article-title":"Regressive and reactive changes in the connectivity patterns of rod and cone pathways of P23H transgenic rat retina","volume":"127","author":"Cuenca","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.exer.2017.10.023_bib55","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/hmg\/9.4.645","article-title":"Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat","volume":"9","author":"D'Cruz","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2017.10.023_bib56","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1016\/j.ophtha.2016.06.049","article-title":"Five-year safety and performance results from the argus II retinal prosthesis system clinical trial","volume":"123","author":"da Cruz","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2017.10.023_bib57","series-title":"RetNet Retinal Information Network","author":"Daiger","year":"2017"},{"key":"10.1016\/j.exer.2017.10.023_bib58","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1089\/hum.2015.147","article-title":"Let there Be light: gene and cell therapy for blindness","volume":"27","author":"Dalkara","year":"2016","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.exer.2017.10.023_bib59","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.crvi.2014.01.002","article-title":"Gene therapy for inherited retinal degenerations","volume":"337","author":"Dalkara","year":"2014","journal-title":"C R. Biol."},{"key":"10.1016\/j.exer.2017.10.023_bib60","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1167\/iovs.11-8831","article-title":"Tyrosine-mutant AAV8 delivery of human MERTK provides long-term retinal preservation in RCS rats","volume":"53","author":"Deng","year":"2012","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib61","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fnana.2017.00014","article-title":"Early events in retinal degeneration caused by rhodopsin mutation or pigment epithelium malfunction: differences and similarities","volume":"11","author":"Di Pierdomenico","year":"2017","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.exer.2017.10.023_bib62","first-page":"681","article-title":"Ribozyme-targeted destruction of RNA associated with autosomal-dominant retinitis pigmentosa","volume":"39","author":"Drenser","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib63","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/343364a0","article-title":"A point mutation of the rhodopsin gene in one form of retinitis pigmentosa","volume":"343","author":"Dryja","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.exer.2017.10.023_bib64","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/ICU.0000000000000140","article-title":"Optogenetics","volume":"26","author":"Duebel","year":"2015","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.exer.2017.10.023_bib65","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/cxo.12444","article-title":"Improvements in vision-related quality of life in blind patients implanted with the Argus II Epiretinal Prosthesis","volume":"100","author":"Duncan","year":"2017","journal-title":"Clin. Exp. Optom."},{"key":"10.1016\/j.exer.2017.10.023_bib66","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1562\/2005-10-05-RA-712","article-title":"Effect of visible light on normal and P23H-3 transgenic rat retinas: characterization of a novel retinoic acid derivative present in the P23H-3 retina","volume":"82","author":"Duncan","year":"2006","journal-title":"Photochem Photobiol."},{"key":"10.1016\/j.exer.2017.10.023_bib67","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1016\/j.bcp.2004.06.042","article-title":"Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog","volume":"68","author":"Dykens","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.exer.2017.10.023_bib68","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1167\/iovs.13-12120","article-title":"Impairment of intrinsically photosensitive retinal ganglion cells associated with late stages of retinal degeneration","volume":"54","author":"Esquiva","year":"2013","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib69","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/347083a0","article-title":"Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor","volume":"347","author":"Faktorovich","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.exer.2017.10.023_bib70","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1523\/JNEUROSCI.12-09-03554.1992","article-title":"Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat","volume":"12","author":"Faktorovich","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib71","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/jnc.12353","article-title":"Retinitis Pigmentosa: over-expression of anti-ageing protein Klotho in degenerating photoreceptors","volume":"127","author":"Farinelli","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.exer.2017.10.023_bib72","doi-asserted-by":"crossref","first-page":"e1558","DOI":"10.1038\/cddis.2014.512","article-title":"DNA methylation and differential gene regulation in photoreceptor cell death","volume":"5","author":"Farinelli","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2017.10.023_bib73","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/gt.2011.172","article-title":"Gene-based therapies for dominantly inherited retinopathies","volume":"19","author":"Farrar","year":"2012","journal-title":"Gene Ther."},{"key":"10.1016\/j.exer.2017.10.023_bib74","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0039-6257(02)00314-4","article-title":"Genetic animal models for retinal degeneration","volume":"47","author":"Fauser","year":"2002","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2017.10.023_bib75","doi-asserted-by":"crossref","first-page":"e0177998","DOI":"10.1371\/journal.pone.0177998","article-title":"Controlled delivery of tauroursodeoxycholic acid from biodegradable microspheres slows retinal degeneration and vision loss in P23H rats","volume":"12","author":"Fernandez-Sanchez","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.10.023_bib76","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3389\/fncel.2015.00484","article-title":"Astrocytes and muller cell alterations during retinal degeneration in a transgenic rat model of retinitis pigmentosa","volume":"9","author":"Fernandez-Sanchez","year":"2015","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib77","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0043074","article-title":"Safranal, a saffron constituent, attenuates retinal degeneration in P23H rats","volume":"7","author":"Fernandez-Sanchez","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.10.023_bib78","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1089\/hum.2012.067","article-title":"Proinsulin slows retinal degeneration and vision loss in the P23H rat model of retinitis pigmentosa","volume":"23","author":"Fernandez-Sanchez","year":"2012","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.exer.2017.10.023_bib79","doi-asserted-by":"crossref","first-page":"13875","DOI":"10.3390\/molecules200813875","article-title":"Natural compounds from saffron and bear bile prevent vision loss and retinal degeneration","volume":"20","author":"Fernandez-Sanchez","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.exer.2017.10.023_bib80","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1167\/iovs.11-7496","article-title":"Tauroursodeoxycholic acid prevents retinal degeneration in transgenic P23H rats","volume":"52","author":"Fernandez-Sanchez","year":"2011","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib81","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1167\/iovs.09-4877","article-title":"Glutamate stimulation of retinal ganglion cells in normal and s334ter-4 rat retinas: a candidate for a neurotransmitter-based retinal prosthesis","volume":"51","author":"Finlayson","year":"2010","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib82","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/ilar.40.2.51","article-title":"Transgenic animal models for the study of inherited retinal dystrophies","volume":"40","author":"Flannery","year":"1999","journal-title":"ILAR J."},{"key":"10.1016\/j.exer.2017.10.023_bib83","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0014-4835(84)90005-8","article-title":"Glycoprotein synthesis in the human retina: localization of the lipid intermediate pathway","volume":"39","author":"Fliesler","year":"1984","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib84","doi-asserted-by":"crossref","first-page":"046012","DOI":"10.1088\/1741-2560\/11\/4\/046012","article-title":"Local signaling from a retinal prosthetic in a rodent retinitis pigmentosa model in vivo","volume":"11","author":"Fransen","year":"2014","journal-title":"J. Neural Eng."},{"key":"10.1016\/j.exer.2017.10.023_bib85","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042017","article-title":"Taurine provides neuroprotection against retinal ganglion cell degeneration","volume":"7","author":"Froger","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.10.023_bib86","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/81555","article-title":"Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa","volume":"26","author":"Gal","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2017.10.023_bib87","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1167\/iovs.15-16808","article-title":"Inherited photoreceptor degeneration causes the death of melanopsin-positive retinal ganglion cells and increases their coexpression of Brn3a","volume":"56","author":"Garcia-Ayuso","year":"2015","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib88","doi-asserted-by":"crossref","first-page":"5888","DOI":"10.1167\/iovs.13-12643","article-title":"Changes in the photoreceptor mosaic of P23H-1 rats during retinal degeneration: implications for rod-cone dependent survival","volume":"54","author":"Garcia-Ayuso","year":"2013","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib89","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.exer.2010.10.003","article-title":"Retinal ganglion cell numbers and delayed retinal ganglion cell death in the P23H rat retina","volume":"91","author":"Garcia-Ayuso","year":"2010","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib90","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1167\/iovs.09-4492","article-title":"Intravitreous delivery of the corticosteroid fluocinolone acetonide attenuates retinal degeneration in S334ter-4 rats","volume":"51","author":"Glybina","year":"2010","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib91","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.exer.2006.08.014","article-title":"Preservation of photoreceptor morphology and function in P23H rats using an allele independent ribozyme","volume":"84","author":"Gorbatyuk","year":"2007","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib92","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/978-1-4614-0631-0_26","article-title":"Functional rescue of P23H rhodopsin photoreceptors by gene delivery","volume":"723","author":"Gorbatyuk","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2017.10.023_bib93","doi-asserted-by":"crossref","first-page":"5961","DOI":"10.1073\/pnas.0911991107","article-title":"Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP\/Grp78","volume":"107","author":"Gorbatyuk","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2017.10.023_bib94","first-page":"1546","article-title":"Characterization of rhodopsin mis-sorting and constitutive activation in a transgenic rat model of retinitis pigmentosa","volume":"41","author":"Green","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib95","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1006\/mthe.2001.0289","article-title":"Two animal models of retinal degeneration are rescued by recombinant adeno-associated virus-mediated production of FGF-5 and FGF-18","volume":"3","author":"Green","year":"2001","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2017.10.023_bib96","doi-asserted-by":"crossref","first-page":"5651","DOI":"10.1523\/JNEUROSCI.1288-04.2004","article-title":"Constitutive overexpression of human erythropoietin protects the mouse retina against induced but not inherited retinal degeneration","volume":"24","author":"Grimm","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib97","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.exer.2011.08.005","article-title":"Immunocytochemical evidence of Tulp1-dependent outer segment protein transport pathways in photoreceptor cells","volume":"93","author":"Grossman","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib98","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.exer.2008.05.016","article-title":"Systemic aminoglycoside treatment in rodent models of retinitis pigmentosa","volume":"87","author":"Guerin","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib99","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0014-4835(02)00332-9","article-title":"Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration","volume":"76","author":"Gupta","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib100","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1136\/bjo.84.8.922","article-title":"Molecular ophthalmology: an update on animal models for retinal degenerations and dystrophies","volume":"84","author":"Hafezi","year":"2000","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2017.10.023_bib101","first-page":"2795","article-title":"Retinal degeneration in tulp1-\/- mice: vesicular accumulation in the interphotoreceptor matrix","volume":"40","author":"Hagstrom","year":"1999","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib102","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.exer.2016.06.010","article-title":"Whole-eye electrical stimulation therapy preserves visual function and structure in P23H-1 rats","volume":"149","author":"Hanif","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib103","doi-asserted-by":"crossref","first-page":"9228","DOI":"10.1523\/JNEUROSCI.22-21-09228.2002","article-title":"Microglia-M\u00fcller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration","volume":"22","author":"Harada","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib104","doi-asserted-by":"crossref","first-page":"11100","DOI":"10.1073\/pnas.92.24.11100","article-title":"Mouse model for Usher syndrome: linkage mapping suggests homology to Usher type I reported at human chromosome 11p15","volume":"92","author":"Heckenlively","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2017.10.023_bib105","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.brainres.2010.01.051","article-title":"Morphological changes of short-wavelength cones in the developing S334ter-3 transgenic rat","volume":"1321","author":"Hombrebueno","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.exer.2017.10.023_bib106","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/ng0297-216","article-title":"Retinopathy induced in mice by targeted disruption of the rhodopsin gene","volume":"15","author":"Humphries","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2017.10.023_bib107","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/(SICI)1096-9861(20000515)420:4<437::AID-CNE3>3.0.CO;2-1","article-title":"Retinal cell addition and rod production depend on early stages of ocular melanin synthesis","volume":"420","author":"Ilia","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.exer.2017.10.023_bib108","doi-asserted-by":"crossref","first-page":"34150","DOI":"10.1074\/jbc.M204955200","article-title":"A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome system","volume":"277","author":"Illing","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2017.10.023_bib109","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/cne.902240107","article-title":"Development and degeneration of retina in rds mutant mice: electron microscopy","volume":"224","author":"Jansen","year":"1984","journal-title":"J. Comp. Neur"},{"key":"10.1016\/j.exer.2017.10.023_bib110","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0014-4835(87)80170-7","article-title":"Development and degeneration of retina in rds mutant mice: ultraimmunohistochemical localization of opsin","volume":"44","author":"Jansen","year":"1987","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib111","doi-asserted-by":"crossref","first-page":"323","DOI":"10.5966\/sctm.2013-0112","article-title":"Transplantation of photoreceptors derived from human Muller glia restore rod function in the P23H rat","volume":"3","author":"Jayaram","year":"2014","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.exer.2017.10.023_bib112","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1089\/jop.2016.0102","article-title":"Effects of antipsychotic drugs haloperidol and clozapine on visual responses of retinal ganglion cells in a rat model of retinitis pigmentosa","volume":"32","author":"Jensen","year":"2016","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.exer.2017.10.023_bib113","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1167\/iovs.14-15398","article-title":"The effect of TIMP-1 on the cone mosaic in the retina of the rat model of retinitis pigmentosa","volume":"56","author":"Ji","year":"2014","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib114","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/cne.22800","article-title":"Rearrangement of the cone mosaic in the retina of the rat model of retinitis pigmentosa","volume":"520","author":"Ji","year":"2012","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.exer.2017.10.023_bib115","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.exer.2005.03.006","article-title":"Retinal remodeling during retinal degeneration","volume":"81","author":"Jones","year":"2005","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.10703","article-title":"Retinal remodeling triggered by photoreceptor degenerations","volume":"464","author":"Jones","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.exer.2017.10.023_bib117","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.exer.2006.05.012","article-title":"Reversal of functional loss in the P23H-3 rat retina by management of ambient light","volume":"83","author":"Jozwick","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib118","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0014-4835(02)00334-2","article-title":"L-NAME protects against acute light damage in albino rats, but not against retinal degeneration in P23H and S334ter transgenic rats","volume":"76","author":"Kaldi","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib119","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/BF00400119","article-title":"D\u00e9g\u00e9n\u00e9rescence des cellules visuelles photor\u00e9ceptrices et persistance d'une sensibilit\u00e9 de la r\u00e9tine \u00e0 la stimulation photique. Observations au microscope \u00e9lectronique","volume":"65","author":"Karli","year":"1965","journal-title":"Z. Zellforsch"},{"key":"10.1016\/j.exer.2017.10.023_bib120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022181","article-title":"Calpain and PARP activation during photoreceptor cell death in P23H and S334ter rhodopsin mutant rats","volume":"6","author":"Kaur","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.10.023_bib121","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.nbd.2009.12.025","article-title":"Late histological and functional changes in the P23H rat retina after photoreceptor loss","volume":"38","author":"Kolomiets","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.exer.2017.10.023_bib122","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1089\/hum.2009.194","article-title":"Changes in adeno-associated virus-mediated gene delivery in retinal degeneration","volume":"21","author":"Kolstad","year":"2010","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.exer.2017.10.023_bib123","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1167\/iovs.08-2863","article-title":"Generation of a transgenic rabbit model of retinal degeneration","volume":"50","author":"Kondo","year":"2009","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib124","doi-asserted-by":"crossref","first-page":"7590","DOI":"10.1167\/iovs.12-10221","article-title":"Induction of endoplasmic reticulum stress genes, BiP and chop, in genetic and environmental models of retinal degeneration","volume":"53","author":"Kroeger","year":"2012","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib125","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.exer.2017.10.023_bib126","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1189\/jlb.0207114","article-title":"Microglia activation in retinal degeneration","volume":"81","author":"Langmann","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.exer.2017.10.023_bib127","first-page":"3622","article-title":"Retinal degeneration is slowed in transgenic rats by AAV-mediated delivery of FGF-2","volume":"41","author":"Lau","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib128","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1126\/science.982063","article-title":"Rod outer segment disc shedding in rat retina: relationship to cyclic lighting","volume":"194","author":"LaVail","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.exer.2017.10.023_bib129","first-page":"64","article-title":"Survival of some photoreceptor cells in albino rats following long-term exposure to continuous light","volume":"15","author":"LaVail","year":"1976","journal-title":"Invest. Ophthalmol."},{"key":"10.1016\/j.exer.2017.10.023_bib130","first-page":"638","article-title":"Analysis of neurological mutants with inherited retinal degeneration","volume":"21","author":"LaVail","year":"1981","journal-title":"Invest. Ophthalmol. Vis. Res."},{"key":"10.1016\/j.exer.2017.10.023_bib131","series-title":"Concepts and Challenges in Retinal Biology. A Tribute to John E. Dowling","first-page":"617","article-title":"Legacy of the RCS rat: impact of a seminal study on retinal cell biology and retinal degenerative diseases","author":"LaVail","year":"2001"},{"key":"10.1016\/j.exer.2017.10.023_bib132","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0014-4835(75)90080-9","article-title":"Influence of eye pigmentation and light deprivation on inherited retinal dystrophy in the rat","volume":"21","author":"LaVail","year":"1975","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib133","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/cne.902120302","article-title":"Retinal degeneration in the pcd cerebellar mutant mouse. I. Light microscopic and autoradiographic analysis","volume":"212","author":"LaVail","year":"1982","journal-title":"J. Comp. Neur"},{"key":"10.1016\/j.exer.2017.10.023_bib134","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/cne.21858","article-title":"Sustained delivery of NT-3 from lens fiber cells in transgenic mice reveals specificity of neuroprotection in retinal degenerations","volume":"511","author":"LaVail","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.exer.2017.10.023_bib135","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0042-6989(74)90066-2","article-title":"Discrimination of light intensity by rats with inherited retinal degeneration: a behavioral and cytological study","volume":"14","author":"LaVail","year":"1974","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2017.10.023_bib136","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1001\/archopht.1974.03900060406015","article-title":"C57BL\/6J mice with inherited retinal degeneration","volume":"91","author":"LaVail","year":"1974","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2017.10.023_bib137","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/oxfordjournals.jhered.a108621","article-title":"Congenic strains of RCS rats with inherited retinal dystrophy","volume":"66","author":"LaVail","year":"1975","journal-title":"J. Hered."},{"key":"10.1016\/j.exer.2017.10.023_bib138","doi-asserted-by":"crossref","first-page":"11249","DOI":"10.1073\/pnas.89.23.11249","article-title":"Multiple growth factors, cytokines and neurotrophins rescue photoreceptors from the damaging effects of constant light","volume":"89","author":"LaVail","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2017.10.023_bib139","doi-asserted-by":"crossref","first-page":"11488","DOI":"10.1073\/pnas.210319397","article-title":"Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy","volume":"97","author":"LaVail","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2017.10.023_bib140","first-page":"592","article-title":"Protection of mouse photoreceptors by survival factors in retinal degenerations","volume":"39","author":"LaVail","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib141","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.exer.2014.01.019","article-title":"Neuroprotective effects of the cannabinoid agonist HU210 on retinal degeneration","volume":"120","author":"Lax","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib142","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3109\/07420528.2016.1151025","article-title":"Age-related changes in photosensitive melanopsin-expressing retinal ganglion cells correlate with circadian rhythm impairments in sighted and blind rats","volume":"33","author":"Lax","year":"2016","journal-title":"Chronobiol Int."},{"key":"10.1016\/j.exer.2017.10.023_bib143","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/978-1-4615-0067-4_36","article-title":"Photoreceptor degeneration in Pro23His and S334ter transgenic rats","volume":"533","author":"Lee","year":"2003","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2017.10.023_bib144","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/glia.21183","article-title":"Role of Muller cells in cone mosaic rearrangement in a rat model of retinitis pigmentosa","volume":"59","author":"Lee","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.exer.2017.10.023_bib145","doi-asserted-by":"crossref","first-page":"e314","DOI":"10.1371\/journal.pone.0000314","article-title":"XIAP protection of photoreceptors in animal models of retinitis pigmentosa","volume":"2","author":"Leonard","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.exer.2017.10.023_bib146","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.crvi.2013.12.002","article-title":"Therapeutic strategy for handling inherited retinal degenerations in a gene-independent manner using rod-derived cone viability factors","volume":"337","author":"Leveillard","year":"2014","journal-title":"C R. Biol."},{"key":"10.1016\/j.exer.2017.10.023_bib147","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nm0898-967","article-title":"Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa","volume":"4","author":"Lewin","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.exer.2017.10.023_bib148","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/0014-4835(88)90073-5","article-title":"Inherited retinal dystrophy in the RCS rat: prevention of photoreceptor degeneration by pigment epithelial cell transplantation","volume":"47","author":"Li","year":"1988","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib149","doi-asserted-by":"crossref","first-page":"14176","DOI":"10.1073\/pnas.93.24.14176","article-title":"Transgenic mice carrying the dominant rhodopsin mutation P347S: evidence for defective vectorial transport of rhodopsin to the outer segments","volume":"93","author":"Li","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2017.10.023_bib150","doi-asserted-by":"crossref","first-page":"e9495","DOI":"10.1371\/journal.pone.0009495","article-title":"CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration","volume":"5","author":"Li","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.10.023_bib151","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1006\/mthe.2001.0473","article-title":"Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa","volume":"4","author":"Liang","year":"2001","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2017.10.023_bib152","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.exer.2014.09.004","article-title":"Inner retinal preservation in rat models of retinal degeneration implanted with subretinal photovoltaic arrays","volume":"128","author":"Light","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib153","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-4419-1399-9_14","article-title":"Misfolded proteins and retinal dystrophies","volume":"664","author":"Lin","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2017.10.023_bib154","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1126\/science.1146361","article-title":"IRE1 signaling affects cell fate during the unfolded protein response","volume":"318","author":"Lin","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.exer.2017.10.023_bib155","doi-asserted-by":"crossref","first-page":"612","DOI":"10.5301\/ijao.5000213","article-title":"Long-term in vivo impedance changes of subretinal microelectrodes implanted in dystrophic P23H rats","volume":"36","author":"Linderholm","year":"2013","journal-title":"Int. J. Artif. Organs"},{"key":"10.1016\/j.exer.2017.10.023_bib156","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.1523\/JNEUROSCI.19-12-04778.1999","article-title":"Activation of caspase-3 in the retina of transgenic rats with the rhodopsin mutation S334ter during photoreceptor degeneration","volume":"19","author":"Liu","year":"1999","journal-title":"J. Neurosci."},{"issue":"Pt 20","key":"10.1016\/j.exer.2017.10.023_bib157","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1242\/jcs.110.20.2589","article-title":"Defective phototransductive disk membrane morphogenesis in transgenic mice expressing opsin with a mutated N-terminal domain","volume":"110","author":"Liu","year":"1997","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib158","article-title":"Retinal degeneration is slowed by eye pigmentation in P23H but not in S334ter mutant rhodopsin transgenic rats","volume":"46","author":"Lowe","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib159","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1017\/S0952523813000011","article-title":"Retinal morphological and functional changes in an animal model of retinitis pigmentosa","volume":"30","author":"Lu","year":"2013","journal-title":"Vis. Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib160","first-page":"1087","article-title":"Lens epithelium-derived growth factor promotes photoreceptor survival in light-damaged and RCS rats","volume":"42","author":"Machida","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib161","first-page":"3200","article-title":"P23H rhodopsin transgenic rat: correlation of retinal function with histopathology","volume":"41","author":"Machida","year":"2000","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib162","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1167\/iovs.07-0291","article-title":"Photopic ERG negative response from amacrine cell signaling in RCS rat retinal degeneration","volume":"49","author":"Machida","year":"2008","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib163","doi-asserted-by":"crossref","first-page":"16004","DOI":"10.1117\/1.JBO.18.1.016004","article-title":"Optical imaging of mitochondrial redox state in rodent model of retinitis pigmentosa","volume":"18","author":"Maleki","year":"2013","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.exer.2017.10.023_bib164","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1021\/cn5001233","article-title":"Retinal prosthetics, optogenetics, and chemical photoswitches","volume":"5","author":"Marc","year":"2014","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib165","first-page":"338","article-title":"Lipid differences in rod outer segment membranes of rats with P23H and S334ter opsin mutations","volume":"11","author":"Martin","year":"2005","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2017.10.023_bib166","first-page":"199","article-title":"P23H and S334ter opsin mutations: increasing photoreceptor outer segment n-3 fatty acid content does not affect the course of retinal degeneration","volume":"10","author":"Martin","year":"2004","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2017.10.023_bib167","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.exer.2010.12.001","article-title":"Retinal degeneration in two lines of transgenic S334ter rats","volume":"92","author":"Martinez-Navarrete","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib168","first-page":"1667","article-title":"Tissue oxygen during a critical developmental period controls the death and survival of photoreceptors","volume":"38","author":"Maslim","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib169","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1006\/mthe.2001.0498","article-title":"Glial cell line derived neurotrophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa","volume":"4","author":"McGee Sanftner","year":"2001","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2017.10.023_bib170","doi-asserted-by":"crossref","first-page":"6232","DOI":"10.1167\/iovs.12-9569","article-title":"Discordant anatomical, electrophysiological, and visual behavioral profiles of retinal degeneration in rat models of retinal degenerative disease","volume":"53","author":"McGill","year":"2012","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib171","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.exer.2012.09.006","article-title":"Optomotor and immunohistochemical changes in the juvenile S334ter rat","volume":"104","author":"McGill","year":"2012","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib172","first-page":"280","article-title":"A comparative study of methods of photoreceptor morphometry","volume":"32","author":"Michon","year":"1991","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib173","first-page":"175","article-title":"Histopathology of the human retina in retinitis pigmentosa","volume":"17","author":"Milam","year":"1998","journal-title":"Prog. Ret. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib174","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1126\/science.1265483","article-title":"Inherited retinal dystrophy: primary defect in pigment epithelium determined with experimental rat chimeras","volume":"192","author":"Mullen","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.exer.2017.10.023_bib175","doi-asserted-by":"crossref","first-page":"6362","DOI":"10.1167\/iovs.15-16400","article-title":"Allele-specific inhibition of rhodopsin with an antisense oligonucleotide slows photoreceptor cell degeneration","volume":"56","author":"Murray","year":"2015","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib176","first-page":"775","article-title":"Light-induced acceleration of photoreceptor degeneration in transgenic mice expressing mutant opsin","volume":"37","author":"Naash","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib177","doi-asserted-by":"crossref","first-page":"7853","DOI":"10.1523\/JNEUROSCI.16-24-07853.1996","article-title":"Polygenic disease and retinitis pigmentosa: albinism exacerbates photoreceptor degeneration induced by the expression of a mutant opsin in transgenic mice","volume":"16","author":"Naash","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib178","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/cne.20283","article-title":"Retinal abnormalities associated with the G90D mutation in opsin","volume":"478","author":"Naash","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.exer.2017.10.023_bib179","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1002\/jbm.b.33522","article-title":"Protective effects of sustained transscleral unoprostone delivery against retinal degeneration in S334ter rhodopsin mutant rats","volume":"104","author":"Nagai","year":"2016","journal-title":"J. Biomed. Mater Res. B Appl. Biomater."},{"key":"10.1016\/j.exer.2017.10.023_bib180","first-page":"3301","article-title":"Light-induced migration of retinal microglia into the subretinal space","volume":"42","author":"Ng","year":"2001","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib181","first-page":"842","article-title":"Extended photoreceptor viability by light stress in the RCS rats but not in the opsin P23H mutant rats","volume":"42","author":"Nir","year":"2001","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib182","first-page":"836","article-title":"Immunocytochemical localization of opsin in the inner segment and ciliary plasma membrane of photoreceptors in retinas of rds mutant mice","volume":"27","author":"Nir","year":"1986","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib183","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12974-014-0186-3","article-title":"Microglia activation in a model of retinal degeneration and TUDCA neuroprotective effects","volume":"11","author":"Noailles","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.exer.2017.10.023_bib184","doi-asserted-by":"crossref","first-page":"33356","DOI":"10.1038\/srep33356","article-title":"Persistent inflammatory state after photoreceptor loss in an animal model of retinal degeneration","volume":"6","author":"Noailles","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2017.10.023_bib185","first-page":"7","article-title":"New drug therapy for retinal degeneration","volume":"112","author":"Ohguro","year":"2008","journal-title":"Nippon. Ganka Gakkai Zasshi"},{"key":"10.1016\/j.exer.2017.10.023_bib186","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0896-6273(92)90236-7","article-title":"Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa","volume":"9","author":"Olsson","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.exer.2017.10.023_bib187","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1562\/2005-06-30-RA-599","article-title":"Genetic, age and light mediated effects on crystallin protein expression in the retina","volume":"82","author":"Organisciak","year":"2006","journal-title":"Photochem Photobiol."},{"key":"10.1016\/j.exer.2017.10.023_bib188","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1167\/iovs.02-0708","article-title":"Susceptibility to retinal light damage in transgenic rats with rhodopsin mutations","volume":"44","author":"Organisciak","year":"2003","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib189","series-title":"Progress in Retinal and Eye Research","first-page":"1","article-title":"Retinal light damage: practical and theoretical considerations","author":"Organisciak","year":"1994"},{"key":"10.1016\/j.exer.2017.10.023_bib190","doi-asserted-by":"crossref","first-page":"e0127319","DOI":"10.1371\/journal.pone.0127319","article-title":"Genotypic and phenotypic characterization of P23H line 1 rat model","volume":"10","author":"Orhan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.10.023_bib191","doi-asserted-by":"crossref","first-page":"e71650","DOI":"10.1371\/journal.pone.0071650","article-title":"Inhibitory peptide of mitochondrial \u03bc-calpain protects against photoreceptor degeneration in rhodopsin transgenic S334ter and P23H rats","volume":"8","author":"Ozaki","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.10.023_bib192","doi-asserted-by":"crossref","first-page":"e1236","DOI":"10.1038\/cddis.2014.214","article-title":"The heat-shock response co-inducer arimoclomol protects against retinal degeneration in rhodopsin retinitis pigmentosa","volume":"5","author":"Parfitt","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2017.10.023_bib193","first-page":"4007","article-title":"Ambient hypoxia reverses retinal vascular attenuation in a transgenic mouse model of autosomal dominant retinitis pigmentosa","volume":"41","author":"Penn","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib194","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.exer.2008.09.004","article-title":"The relationship of photoreceptor degeneration to retinal vascular development and loss in mutant rhodopsin transgenic and RCS rats","volume":"87","author":"Pennesi","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib195","first-page":"S1117","article-title":"Enhanced survival of photoreceptors in P23H mutant rhodopsin transgenic rats by adeno-associated virus (AAV)-mediated delivery of neurotrophic genes","volume":"39","author":"Peterson","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib196","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.freeradbiomed.2015.08.018","article-title":"Targeting iron-mediated retinal degeneration by local delivery of transferrin","volume":"89","author":"Picard","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exer.2017.10.023_bib197","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.exer.2015.10.012","article-title":"Long time remodeling during retinal degeneration evaluated by optical coherence tomography, immunocytochemistry and fundus autofluorescence","volume":"150","author":"Pinilla","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib198","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neulet.2005.02.055","article-title":"Enhanced cone dysfunction in rats homozygous for the P23H rhodopsin mutation","volume":"382","author":"Pinilla","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.exer.2017.10.023_bib199","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.pneurobio.2010.06.009","article-title":"Microglia and neuroprotection: from in vitro studies to therapeutic applications","volume":"92","author":"Polazzi","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.exer.2017.10.023_bib200","doi-asserted-by":"crossref","first-page":"9728","DOI":"10.1167\/iovs.11-8654","article-title":"Mislocalization and degradation of human P23H-rhodopsin-GFP in a knockin mouse model of retinitis pigmentosa","volume":"52","author":"Price","year":"2011","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib201","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nn.2234","article-title":"Stimulation of the insulin\/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa","volume":"12","author":"Punzo","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib202","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1074\/jbc.R111.304428","article-title":"Loss of daylight vision in retinal degeneration: are oxidative stress and metabolic dysregulation to blame?","volume":"287","author":"Punzo","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2017.10.023_bib203","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.exer.2004.11.001","article-title":"Photoreceptor differentiation and integration of retinal progenitor cells transplanted into transgenic rats","volume":"80","author":"Qiu","year":"2005","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib204","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.visres.2012.10.016","article-title":"Chronic delivery of low-level exogenous current preserves retinal function in pigmented P23H rat","volume":"76","author":"Rahmani","year":"2013","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2017.10.023_bib205","doi-asserted-by":"crossref","first-page":"6050","DOI":"10.1523\/JNEUROSCI.23-14-06050.2003","article-title":"Free radical trap phenyl-N-tert-butylnitrone protects against light damage but does not rescue P23H and S334ter rhodopsin transgenic rats from inherited retinal degeneration","volume":"23","author":"Ranchon","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib206","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/cne.20134","article-title":"Timing and topography of cell genesis in the rat retina","volume":"474","author":"Rapaport","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.exer.2017.10.023_bib207","series-title":"The Effects of Constant Light on Visual Processes","first-page":"135","article-title":"A parametric study of retinal light damage in albino and pigmented rats","author":"Rapp","year":"1980"},{"key":"10.1016\/j.exer.2017.10.023_bib208","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00441-009-0916-5","article-title":"Morphological alterations in retinal neurons in the S334ter-line3 transgenic rat","volume":"339","author":"Ray","year":"2010","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.exer.2017.10.023_bib209","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1167\/iovs.08-3153","article-title":"Photoreceptor protection by adeno-associated virus-mediated LEDGF expression in the RCS rat model of retinal degeneration: probing the mechanism","volume":"50","author":"Raz-Prag","year":"2009","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib210","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/mt.2011.308","article-title":"Stanniocalcin-1 rescued photoreceptor degeneration in two rat models of inherited retinal degeneration","volume":"20","author":"Roddy","year":"2012","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2017.10.023_bib211","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0006-8993(99)01625-X","article-title":"Retina-derived microglial cells induce photoreceptor cell death in vitro","volume":"836","author":"Roque","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.exer.2017.10.023_bib212","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1167\/iovs.02-0615","article-title":"Retinal transplantation-induced recovery of retinotectal visual function in a rodent model of retinitis pigmentosa","volume":"44","author":"Sagdullaev","year":"2003","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib213","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1097\/00006982-200512001-00015","article-title":"Saving cone cells in hereditary rod diseases: a possible role for rod-derived cone viability factor (RdCVF) therapy","volume":"25","author":"Sahel","year":"2005","journal-title":"Retina"},{"key":"10.1016\/j.exer.2017.10.023_bib214","first-page":"821","article-title":"Misregulation of rhodopsin phosphorylation and dephosphorylation found in P23H rat retinal degeneration","volume":"2","author":"Saito","year":"2008","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.exer.2017.10.023_bib215","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1093\/hmg\/ddt561","article-title":"P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis","volume":"23","author":"Sakami","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2017.10.023_bib216","doi-asserted-by":"crossref","first-page":"10551","DOI":"10.1074\/jbc.M110.209759","article-title":"Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations","volume":"286","author":"Sakami","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2017.10.023_bib217","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1136\/bjo.2005.089110","article-title":"Subretinal electrode implantation in the P23H rat for chronic stimulations","volume":"90","author":"Salzmann","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2017.10.023_bib218","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.visres.2013.10.008","article-title":"Biochemical analysis of a rhodopsin photoactivatable GFP fusion as a model of G-protein coupled receptor transport","volume":"93","author":"Sammons","year":"2013","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2017.10.023_bib219","first-page":"1934","article-title":"Clinical expression correlates with location of rhodopsin mutation in dominant retinitis pigmentosa","volume":"36","author":"Sandberg","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib220","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.tins.2005.12.005","article-title":"Microglial phenotype: is the commitment reversible?","volume":"29","author":"Schwartz","year":"2006","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib221","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1167\/iovs.15-17257","article-title":"Assessment of visual and chromatic functions in a rodent model of retinal degeneration","volume":"56","author":"Segura","year":"2015","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib222","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00417-014-2638-y","article-title":"A new immunodeficient pigmented retinal degenerate rat strain to study transplantation of human cells without immunosuppression","volume":"252","author":"Seiler","year":"2014","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2017.10.023_bib223","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/j.1460-9568.2010.07085.x","article-title":"Visual restoration and transplant connectivity in degenerate rats implanted with retinal progenitor sheets","volume":"31","author":"Seiler","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib224","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1111\/j.1460-9568.2012.08078.x","article-title":"Computational molecular phenotyping of retinal sheet transplants to rats with retinal degeneration","volume":"35","author":"Seiler","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib225","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1167\/iovs.15-19028","article-title":"Vision recovery and connectivity by fetal retinal sheet transplantation in an immunodeficient retinal degenerate rat model","volume":"58","author":"Seiler","year":"2017","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib226","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jneumeth.2010.02.018","article-title":"Three-dimensional optical coherence tomography imaging of retinal sheet implants in live rats","volume":"188","author":"Seiler","year":"2010","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.exer.2017.10.023_bib227","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1460-9568.2004.03851.x","article-title":"Transsynaptic virus tracing from host brain to subretinal transplants","volume":"21","author":"Seiler","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib228","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.exer.2007.09.012","article-title":"BDNF-treated retinal progenitor sheets transplanted to degenerate rats: improved restoration of visual function","volume":"86","author":"Seiler","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib229","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1460-9568.2008.06279.x","article-title":"Retinal transplants restore visual responses: trans-synaptic tracing from visually responsive sites labels transplant neurons","volume":"28","author":"Seiler","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib230","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1152\/jn.00663.2009","article-title":"Loss of responses to visual but not electrical stimulation in ganglion cells of rats with severe photoreceptor degeneration","volume":"102","author":"Sekirnjak","year":"2009","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.exer.2017.10.023_bib231","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1152\/jn.01061.2010","article-title":"Changes in physiological properties of rat ganglion cells during retinal degeneration","volume":"105","author":"Sekirnjak","year":"2011","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.exer.2017.10.023_bib232","doi-asserted-by":"crossref","first-page":"e0167102","DOI":"10.1371\/journal.pone.0167102","article-title":"Inhibition of matrix metalloproteinase 9 enhances rod survival in the S334ter-line3 retinitis pigmentosa model","volume":"11","author":"Shin","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.10.023_bib233","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2016.04.023","article-title":"Neuronatin is a stress-responsive protein of rod photoreceptors","volume":"328","author":"Shinde","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.exer.2017.10.023_bib234","doi-asserted-by":"crossref","first-page":"e33266","DOI":"10.1371\/journal.pone.0033266","article-title":"ER stress in retinal degeneration in S334ter Rho rats","volume":"7","author":"Shinde","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.10.023_bib235","series-title":"The Structure of the Eye","first-page":"497","article-title":"Histogenesis of the mouse eye studied with thymidine [3H]","author":"Sidman","year":"1961"},{"key":"10.1016\/j.exer.2017.10.023_bib236","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cellsig.2013.12.008","article-title":"Modulation of cellular signaling pathways in P23H rhodopsin photoreceptors","volume":"26","author":"Sizova","year":"2014","journal-title":"Cell Signal"},{"key":"10.1016\/j.exer.2017.10.023_bib237","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/0014-4835(92)90017-M","article-title":"C57BL\/6J-vit\/vit mouse model of retinal degeneration: light microscopic analysis and evaluation of rhodopsin levels","volume":"55","author":"Smith","year":"1992","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib238","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.1167\/iovs.02-1130","article-title":"Photoreceptor protection by cardiotrophin-1 in transgenic rats with the rhodopsin mutation s334ter","volume":"44","author":"Song","year":"2003","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib239","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3389\/fnins.2014.00297","article-title":"Hearing impairment in the P23H-1 retinal degeneration rat model","volume":"8","author":"Sotoca","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib240","first-page":"S698","article-title":"Transgenic rat models of inherited retinal degeneration caused by mutant opsin genes","volume":"37","author":"Steinberg","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib241","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1194\/jlr.M063719","article-title":"Sphingolipid profile alters in retinal dystrophic P23H-1 rats and systemic FTY720 can delay retinal degeneration","volume":"57","author":"Stiles","year":"2016","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.exer.2017.10.023_bib242","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000354424","article-title":"Electronic approaches to restitute vision in patients with neurodegenerative diseases of the retina","volume":"50","author":"Stingl","year":"2013","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.exer.2017.10.023_bib243","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S1350-9462(98)00032-9","article-title":"Mechanisms of photoreceptor death and survival in mammalian retina","volume":"18","author":"Stone","year":"1999","journal-title":"Prog. Retin Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib244","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000046474","article-title":"The Royal College of Surgeons rat: an animal model for inherited retinal degeneration with a still unknown genetic defect","volume":"162","author":"Strauss","year":"1998","journal-title":"Acta Anat."},{"key":"10.1016\/j.exer.2017.10.023_bib245","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.preteyeres.2015.12.002","article-title":"PRPH2\/RDS and ROM-1: historical context, current views and future considerations","volume":"52","author":"Stuck","year":"2016","journal-title":"Prog. Retin Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib246","doi-asserted-by":"crossref","first-page":"6481","DOI":"10.1073\/pnas.88.15.6481","article-title":"Rhodopsin mutations in autosomal dominant retinitis pigmentosa","volume":"88","author":"Sung","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2017.10.023_bib247","doi-asserted-by":"crossref","first-page":"5818","DOI":"10.1523\/JNEUROSCI.14-10-05818.1994","article-title":"A rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segment","volume":"14","author":"Sung","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib248","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0074-7696(08)62706-0","article-title":"Rhodopsin trafficking and its role in retinal dystrophies","volume":"195","author":"Sung","year":"2000","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.exer.2017.10.023_bib249","first-page":"913","article-title":"The early appearance of disc shedding in the rat retina","volume":"18","author":"Tamai","year":"1979","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib250","first-page":"589","article-title":"The relationship between opsin overexpression and photoreceptor degeneration","volume":"42","author":"Tan","year":"2001","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib251","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/bjophthalmol-2016-308823","article-title":"Stargardt disease: clinical features, molecular genetics, animal models and therapeutic options","volume":"101","author":"Tanna","year":"2017","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2017.10.023_bib252","first-page":"3292","article-title":"Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa","volume":"43","author":"Tao","year":"2002","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib253","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.ymthe.2006.07.008","article-title":"Preferential silencing of a common dominant rhodopsin mutation does not inhibit retinal degeneration in a transgenic model","volume":"14","author":"Tessitore","year":"2006","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2017.10.023_bib254","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0006-8993(92)91340-K","article-title":"Sick photoreceptors attract activated microglia from the ganglion cell layer: a model to study the inflammatory cascades in rats with inherited retinal dystrophy","volume":"588","author":"Thanos","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.exer.2017.10.023_bib255","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jneumeth.2005.07.004","article-title":"Retinal transplants evaluated by optical coherence tomography in photoreceptor degenerate rats","volume":"151","author":"Thomas","year":"2006","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.exer.2017.10.023_bib256","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jneumeth.2006.12.010","article-title":"Behavioral evaluation of visual function of rats using a visual discrimination apparatus","volume":"162","author":"Thomas","year":"2007","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.exer.2017.10.023_bib257","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1562\/2006-09-19-RA-1044","article-title":"Visual functional effects of constant blue light in a retinal degenerate rat model","volume":"83","author":"Thomas","year":"2007","journal-title":"Photochem Photobiol."},{"key":"10.1016\/j.exer.2017.10.023_bib258","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.exer.2004.02.016","article-title":"Superior colliculus responses to light - preserved by transplantation in a slow degeneration rat model","volume":"79","author":"Thomas","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib259","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jneumeth.2004.03.007","article-title":"Optokinetic test to evaluate visual acuity of each eye independently","volume":"138","author":"Thomas","year":"2004","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.exer.2017.10.023_bib260","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neulet.2010.05.031","article-title":"Modulatory influence of stimulus parameters on optokinetic head-tracking response","volume":"479","author":"Thomas","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.exer.2017.10.023_bib261","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1167\/iovs.14-16049","article-title":"Advancing therapeutic strategies for inherited retinal degeneration: recommendations from the Monaciano symposium","volume":"56","author":"Thompson","year":"2015","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib262","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1086\/338455","article-title":"Retinal dystrophy due to paternal isodisomy for chromosome 1 or chromosome 2, with homoallelism for mutations in RPE65 or MERTK, respectively","volume":"70","author":"Thompson","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.exer.2017.10.023_bib263","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1089\/hum.2015.030","article-title":"Gene therapy of inherited retinal degenerations: prospects and challenges","volume":"26","author":"Trapani","year":"2015","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.exer.2017.10.023_bib264","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.preteyeres.2014.08.001","article-title":"Vector platforms for gene therapy of inherited retinopathies","volume":"43","author":"Trapani","year":"2014","journal-title":"Prog. Retin Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib265","first-page":"1655","article-title":"Retinal cAMP levels during the progression of retinal degeneration in rhodopsin P23H and S334ter transgenic rats","volume":"43","author":"Traverso","year":"2002","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib266","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1128\/MCB.8.4.1570","article-title":"Opsin expression in the rat retina is developmentally regulated by transcriptional activation","volume":"8","author":"Treisman","year":"1988","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.exer.2017.10.023_bib267","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0014-4835(87)80061-1","article-title":"Changes in the localization and content of opsin during retinal development in the rds mutant mouse: immunocytochemistry and immunoassay","volume":"45","author":"Usukura","year":"1987","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib268","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/978-0-387-74904-4_22","article-title":"The potential of ambient light restriction to restore function to the degenerating P23H-3 rat retina","volume":"613","author":"Valter","year":"2008","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2017.10.023_bib269","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.exer.2009.08.009","article-title":"Optimising the structure and function of the adult P23H-3 retina by light management in the juvenile and adult","volume":"89","author":"Valter","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182389","article-title":"Protective effect of clusterin on rod photoreceptor in rat model of retinitis pigmentosa","volume":"12","author":"Vargas","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.10.023_bib271","doi-asserted-by":"crossref","first-page":"e21193","DOI":"10.1371\/journal.pone.0021193","article-title":"Rescue of photoreceptor degeneration by curcumin in transgenic rats with P23H rhodopsin mutation","volume":"6","author":"Vasireddy","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.10.023_bib272","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1167\/iovs.02-0709","article-title":"A morphometric study of light-induced damage in transgenic rat models of retinitis pigmentosa","volume":"44","author":"Vaughan","year":"2003","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib273","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1242\/dmm.017913","article-title":"Biology and therapy of inherited retinal degenerative disease: insights from mouse models","volume":"8","author":"Veleri","year":"2015","journal-title":"Dis. Model Mech."},{"key":"10.1016\/j.exer.2017.10.023_bib274","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1002\/cne.23558","article-title":"Adenosine triphosphate-induced photoreceptor death and retinal remodeling in rats","volume":"522","author":"Vessey","year":"2014","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.exer.2017.10.023_bib275","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1093\/hmg\/ddw029","article-title":"NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration","volume":"25","author":"Viringipurampeer","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2017.10.023_bib276","doi-asserted-by":"crossref","first-page":"12584","DOI":"10.1073\/pnas.221364198","article-title":"Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk","volume":"98","author":"Vollrath","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2017.10.023_bib277","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.brainres.2004.04.030","article-title":"Multiple vulnerability of photoreceptors to mesopic ambient light in the P23H transgenic rat","volume":"1013","author":"Walsh","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.exer.2017.10.023_bib278","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1017\/S0952523800008750","article-title":"Expression of a mutant opsin gene increases the susceptibility of the retina to light damage","volume":"14","author":"Wang","year":"1997","journal-title":"Vis. Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib279","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.preteyeres.2011.11.005","article-title":"CNTF and retina","volume":"31","author":"Wen","year":"2012","journal-title":"Prog. Retin Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib280","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.preteyeres.2004.08.002","article-title":"Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration","volume":"24","author":"Wenzel","year":"2005","journal-title":"Prog. Retin Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib281","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/cne.903330205","article-title":"Retinal degeneration in the nervous mutant mouse. II. Electron microscopic analysis","volume":"333","author":"White","year":"1993","journal-title":"J. Comp. Neur"},{"key":"10.1016\/j.exer.2017.10.023_bib282","article-title":"Defining the catalytic activity of nanoceria in the P23H-1 rat, a photoreceptor degeneration model","volume":"10","author":"Wong","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.10.023_bib283","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018282","article-title":"Oncostatin M protects rod and cone photoreceptors and promotes regeneration of cone outer segment in a rat model of retinal degeneration","volume":"6","author":"Xia","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.10.023_bib284","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.3727\/096368911X627435","article-title":"Focused magnetic stem cell targeting to the retina using superparamagnetic iron oxide nanoparticles","volume":"21","author":"Yanai","year":"2012","journal-title":"Cell Transpl."},{"key":"10.1016\/j.exer.2017.10.023_bib285","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.exer.2010.08.022","article-title":"Trophic factors GDNF and BDNF improve function of retinal sheet transplants","volume":"91","author":"Yang","year":"2010","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib286","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1038\/mt.2015.177","article-title":"BEST1: the best target for gene and cell therapies","volume":"23","author":"Yang","year":"2015","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2017.10.023_bib287","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/mt.2009.28","article-title":"Functional cone rescue by RdCVF protein in a dominant model of retinitis pigmentosa","volume":"17","author":"Yang","year":"2009","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2017.10.023_bib288","doi-asserted-by":"crossref","first-page":"e13469","DOI":"10.1371\/journal.pone.0013469","article-title":"Transplantation of photoreceptor and total neural retina preserves cone function in P23H rhodopsin transgenic rat","volume":"5","author":"Yang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.10.023_bib289","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0165-3806(85)90211-1","article-title":"Cell proliferation during postnatal development of the retina in the mouse","volume":"21","author":"Young","year":"1985","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.exer.2017.10.023_bib290","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1167\/iovs.03-0845","article-title":"Photoreceptor death, trophic factor expression, retinal oxygen status, and photoreceptor function in the P23H rat","volume":"45","author":"Yu","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib291","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.exer.2005.01.018","article-title":"Retinal degeneration and local oxygen metabolism","volume":"80","author":"Yu","year":"2005","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2017.10.023_bib292","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/j.1471-4159.2007.04766.x","article-title":"Light exposure causes functional changes in the retina: increased photoreceptor cation channel permeability, photoreceptor apoptosis, and altered retinal metabolic function","volume":"103","author":"Yu","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.exer.2017.10.023_bib293","doi-asserted-by":"crossref","first-page":"e0151668","DOI":"10.1371\/journal.pone.0151668","article-title":"Reshaping the cone-mosaic in a rat model of retinitis pigmentosa: modulatory role of ZO-1 expression in DL-alpha-aminoadipic acid reshaping","volume":"11","author":"Yu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2017.10.023_bib294","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1152\/jn.00826.2016","article-title":"Cell type-specific changes in retinal ganglion cell function induced by rod death and cone reorganization in rats","volume":"118","author":"Yu","year":"2017","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.exer.2017.10.023_bib295","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1002\/glia.23016","article-title":"Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa","volume":"64","author":"Zabel","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.exer.2017.10.023_bib296","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.molmed.2015.12.007","article-title":"Cell-based therapy for degenerative retinal disease","volume":"22","author":"Zarbin","year":"2016","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.exer.2017.10.023_bib297","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.mayocp.2013.05.025","article-title":"Regenerative nanomedicine for vision restoration","volume":"88","author":"Zarbin","year":"2013","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.exer.2017.10.023_bib298","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1167\/iovs.03-0301","article-title":"Proliferation of microglia, but not photoreceptors, in the outer nuclear layer of the rd-1 mouse","volume":"45","author":"Zeiss","year":"2004","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib299","first-page":"887","article-title":"Activation of microglia and chemokines in light-induced retinal degeneration","volume":"11","author":"Zhang","year":"2005","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2017.10.023_bib300","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1167\/iovs.02-0450","article-title":"Accumulation of neurocan, a brain chondroitin sulfate proteoglycan, in association with the retinal vasculature in RCS rats","volume":"44","author":"Zhang","year":"2003","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2017.10.023_bib301","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00441-012-1522-5","article-title":"Spatiotemporal pattern of rod degeneration in the S334ter-line-3 rat model of retinitis pigmentosa","volume":"351","author":"Zhu","year":"2013","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.exer.2017.10.023_bib302","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1017\/S0952523813000047","article-title":"Mapping cation entry in photoreceptors and inner retinal neurons during early degeneration in the P23H-3 rat retina","volume":"30","author":"Zhu","year":"2013","journal-title":"Vis. Neurosci."},{"key":"10.1016\/j.exer.2017.10.023_bib303","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jconrel.2015.10.007","article-title":"Non-viral therapeutic approaches to ocular diseases: an overview and future directions","volume":"219","author":"Zulliger","year":"2015","journal-title":"J. Control Release"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483517306668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483517306668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T15:51:44Z","timestamp":1659801104000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483517306668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":303,"alternative-id":["S0014483517306668"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2017.10.023","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2017.10.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}