{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:40:06Z","timestamp":1790887206186,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100001641","name":"Glaucoma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001641","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.exer.2018.03.007","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T13:13:46Z","timestamp":1520514826000},"page":"54-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":83,"special_numbering":"C","title":["Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury"],"prefix":"10.1016","volume":"171","author":[{"given":"Kimberly A.","family":"Fernandes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia J.","family":"Marola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Shrager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J.","family":"Zack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2844-7632","authenticated-orcid":false,"given":"Richard T.","family":"Libby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek S.","family":"Welsbie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2018.03.007_bib1","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.1098014","article-title":"Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration","volume":"305","author":"Araki","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.exer.2018.03.007_bib2","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1111\/j.1460-9568.2008.06426.x","article-title":"The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model","volume":"28","author":"Beirowski","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.exer.2018.03.007_bib3","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1167\/iovs.06-0486","article-title":"Neuron stress and loss following rodent anterior ischemic optic neuropathy in double-reporter transgenic mice","volume":"48","author":"Bernstein","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.03.007_bib4","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1083\/jcb.201008050","article-title":"Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology","volume":"193","author":"Chen","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.exer.2018.03.007_bib5","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00401-011-0807-1","article-title":"The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma","volume":"121","author":"Chidlow","year":"2011","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.exer.2018.03.007_bib6","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.nbd.2012.07.026","article-title":"Interleukin-6 is an efficacious marker of axonal transport disruption during experimental glaucoma and stimulates neuritogenesis in cultured retinal ganglion cells","volume":"48","author":"Chidlow","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.exer.2018.03.007_bib7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.chembiol.2012.01.012","article-title":"Chemical genetic-mediated spatial regulation of protein expression in neurons reveals an axonal function for wld(s)","volume":"19","author":"Cohen","year":"2012","journal-title":"Chem. Biol."},{"key":"10.1016\/j.exer.2018.03.007_bib8","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex genome engineering using CRISPR\/Cas systems","volume":"339","author":"Cong","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.exer.2018.03.007_bib9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1044-7431(02)00037-4","article-title":"Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons","volume":"22","author":"Cui","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.exer.2018.03.007_bib10","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1038\/ncomms2910","article-title":"Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning","volume":"4","author":"Cusack","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2018.03.007_bib11","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/cdd.2014.164","article-title":"A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration","volume":"22","author":"Di Stefano","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.exer.2018.03.007_bib65","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.neuron.2017.02.022","article-title":"The SARM1 toll\/interleukin-1 receptor domain possesses intrinsic NAD(+) cleavage activity that promotes pathological axonal degeneration","volume":"93","author":"Essuman","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.exer.2018.03.007_bib12","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.nbd.2012.02.003","article-title":"JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death","volume":"46","author":"Fernandes","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.exer.2018.03.007_bib13","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.nbd.2014.05.015","article-title":"DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury","volume":"69","author":"Fernandes","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.exer.2018.03.007_bib14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.exer.2015.06.019","article-title":"Using genetic mouse models to gain insight into glaucoma: past results and future possibilities","volume":"141","author":"Fernandes","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2018.03.007_bib15","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.cub.2017.01.062","article-title":"Death receptor 6 promotes wallerian degeneration in peripheral axons","volume":"27","author":"Gamage","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.exer.2018.03.007_bib16","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.conb.2016.05.002","article-title":"Axon degeneration: context defines distinct pathways","volume":"39","author":"Geden","year":"2016","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.exer.2018.03.007_bib17","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1093\/brain\/aww251","article-title":"Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice","volume":"139","author":"Geisler","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.exer.2018.03.007_bib18","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1126\/science.1258366","article-title":"SARM1 activation triggers axon degeneration locally via NAD(+) destruction","volume":"348","author":"Gerdts","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.exer.2018.03.007_bib19","doi-asserted-by":"crossref","first-page":"13569","DOI":"10.1523\/JNEUROSCI.1197-13.2013","article-title":"Sarm1-Mediated axon degeneration requires both SAM and TIR interactions","volume":"33","author":"Gerdts","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2018.03.007_bib20","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1083\/jcb.201103153","article-title":"DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity","volume":"194","author":"Ghosh","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.exer.2018.03.007_bib21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1750-1326-6-50","article-title":"BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina","volume":"6","author":"Harder","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.exer.2018.03.007_bib22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1750-1326-6-50","article-title":"BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina","volume":"6","author":"Harder","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.exer.2018.03.007_bib23","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/cdd.2012.119","article-title":"Deficiency in Bim, Bid and Bbc3 (Puma) do not prevent axonal injury induced death","volume":"20","author":"Harder","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.exer.2018.03.007_bib24","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1523\/JNEUROSCI.19-11-04349.1999","article-title":"c-jun Is dispensable for developmental cell death and axogenesis in the retina","volume":"19","author":"Herzog","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2018.03.007_bib25","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.neuron.2006.05.013","article-title":"Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruning","volume":"50","author":"Hoopfer","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.exer.2018.03.007_bib26","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1083\/jcb.200706181","article-title":"Axons of retinal ganglion cells are insulted in the optic nerve early in DBA\/2J glaucoma","volume":"179","author":"Howell","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.exer.2018.03.007_bib27","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.febslet.2013.12.010","article-title":"Agonist antibody activates death receptor 6 downstream signaling involving TRADD recruitment","volume":"588","author":"Hu","year":"2014","journal-title":"FEBS Lett."},{"key":"10.1016\/j.exer.2018.03.007_bib28","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.4103\/1673-5374.193225","article-title":"Axon injury induced endoplasmic reticulum stress and neurodegeneration","volume":"11","author":"Hu","year":"2016","journal-title":"Neural. Regen. Res."},{"key":"10.1016\/j.exer.2018.03.007_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.110","article-title":"A DR6\/p75(NTR) complex is responsible for beta-amyloid-induced cortical neuron death","volume":"4","author":"Hu","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2018.03.007_bib30","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.neuron.2011.11.026","article-title":"Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells","volume":"73","author":"Hu","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.exer.2018.03.007_bib31","doi-asserted-by":"crossref","first-page":"e841","DOI":"10.1038\/cddis.2013.378","article-title":"Death receptor 6 (DR6) antagonist antibody is neuroprotective in the mouse SOD1G93A model of amyotrophic lateral sclerosis","volume":"4","author":"Huang","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2018.03.007_bib32","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1084\/jem.20070868","article-title":"MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival","volume":"204","author":"Kim","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.exer.2018.03.007_bib33","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1167\/iovs.09-4098","article-title":"RNA binding protein with multiple splicing: a new marker for retinal ganglion cells","volume":"51","author":"Kwong","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.03.007_bib34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/exer.2000.0873","article-title":"Bax-dependent and independent pathways of retinal ganglion cell death induced by different damaging stimuli","volume":"71","author":"Li","year":"2000","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2018.03.007_bib35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1371\/journal.pgen.0010004","article-title":"Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage","volume":"1","author":"Libby","year":"2005","journal-title":"PLoS Genet."},{"key":"10.1016\/j.exer.2018.03.007_bib36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1460-9568.1989.tb00771.x","article-title":"Absence of wallerian degeneration does not hinder regeneration in peripheral nerve","volume":"1","author":"Lunn","year":"1989","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.exer.2018.03.007_bib37","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/nn770","article-title":"Wallerian degeneration of injured axons and synapses is delayed by a Ube4b\/Nmnat chimeric gene","volume":"4","author":"Mack","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.exer.2018.03.007_bib66","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1167\/iovs.12-10973","article-title":"Excitotoxicity upregulates SARM1 protein expression and promotes Wallerian-like degeneration of retinal ganglion cells and their axons","volume":"54","author":"Massoll","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.03.007_bib38","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nn.2290","article-title":"A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration","volume":"12","author":"Miller","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.exer.2018.03.007_bib39","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.immuni.2013.02.013","article-title":"Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death","volume":"38","author":"Mukherjee","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.exer.2018.03.007_bib40","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/nature07767","article-title":"APP binds DR6 to trigger axon pruning and neuron death via distinct caspases","volume":"457","author":"Nikolaev","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.exer.2018.03.007_bib41","doi-asserted-by":"crossref","first-page":"6438","DOI":"10.1523\/JNEUROSCI.3522-13.2014","article-title":"Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of beta-secretase","volume":"34","author":"Olsen","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2018.03.007_bib42","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.1223899","article-title":"dSarm\/Sarm1 is required for activation of an injury-induced axon death pathway","volume":"337","author":"Osterloh","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.exer.2018.03.007_bib43","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0014-5793(98)00791-1","article-title":"Identification and functional characterization of DR6, a novel death domain-containing TNF receptor","volume":"431","author":"Pan","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.exer.2018.03.007_bib44","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cell.2014.09.014","article-title":"CRISPR-Cas9 knockin mice for genome editing and cancer modeling","volume":"159","author":"Platt","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.exer.2018.03.007_bib67","doi-asserted-by":"crossref","first-page":"e0141137","DOI":"10.1371\/journal.pone.0141137","article-title":"Losartan treatment protects retinal ganglion cells and alters scleral remodeling in experimental glaucoma","volume":"10","author":"Quigley","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2018.03.007_bib45","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1016\/j.visres.2004.06.010","article-title":"Axotomized mouse retinal ganglion cells containing melanopsin show enhanced survival, but not enhanced axon regrowth into a peripheral nerve graft","volume":"44","author":"Robinson","year":"2004","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2018.03.007_bib46","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1002\/cne.23521","article-title":"The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina","volume":"522","author":"Rodriguez","year":"2014","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.exer.2018.03.007_bib47","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.19749","article-title":"NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion","volume":"5","author":"Sasaki","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.exer.2018.03.007_bib48","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.cell.2016.01.032","article-title":"Axon degeneration gated by retrograde activation of somatic pro-apoptotic signaling","volume":"164","author":"Simon","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.exer.2018.03.007_bib49","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0006-8993(91)91154-S","article-title":"Compound action potential of nerve recorded by suction electrode: a theoretical and experimental analysis","volume":"546","author":"Stys","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.exer.2018.03.007_bib50","doi-asserted-by":"crossref","first-page":"9338","DOI":"10.1523\/JNEUROSCI.0877-14.2014","article-title":"Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons","volume":"34","author":"Summers","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2018.03.007_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.338","article-title":"JUN is important for ocular hypertension-induced retinal ganglion cell degeneration","volume":"8","author":"Syc-Mazurek","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2018.03.007_bib52","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13024-017-0214-8","article-title":"Together JUN and DDIT3 (CHOP) control retinal ganglion cell death after axonal injury","volume":"12","author":"Syc-Mazurek","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.exer.2018.03.007_bib53","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/jns.12219","article-title":"Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy","volume":"22","author":"Turkiew","year":"2017","journal-title":"J. Peripher. Nerv. Syst."},{"key":"10.1016\/j.exer.2018.03.007_bib54","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.22540","article-title":"MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2","volume":"6","author":"Walker","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.exer.2018.03.007_bib55","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1083\/jcb.200504028","article-title":"A local mechanism mediates NAD-dependent protection of axon degeneration","volume":"170","author":"Wang","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.exer.2018.03.007_bib56","doi-asserted-by":"crossref","first-page":"10093","DOI":"10.1073\/pnas.1508337112","article-title":"Local axonal protection by WldS as revealed by conditional regulation of protein stability","volume":"112","author":"Wang","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2018.03.007_bib57","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1007\/s12031-015-0562-1","article-title":"Death receptor 6 and caspase-6 regulate prion peptide-induced axonal degeneration in rat spinal neurons","volume":"56","author":"Wang","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.exer.2018.03.007_bib58","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1073\/pnas.1211074110","article-title":"DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury","volume":"110","author":"Watkins","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2018.03.007_bib59","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.neuron.2017.06.008","article-title":"Enhanced functional genomic screening identifies novel mediators of dual leucine zipper kinase-dependent injury signaling in neurons","volume":"94","author":"Welsbie","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.exer.2018.03.007_bib60","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1073\/pnas.1211284110","article-title":"Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death","volume":"110","author":"Welsbie","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2018.03.007_bib61","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.preteyeres.2005.04.004","article-title":"Glaucoma: thinking in new ways-a role for autonomous axonal self-destruction and other compartmentalised processes?","volume":"24","author":"Whitmore","year":"2005","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2018.03.007_bib62","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cell.2014.11.053","article-title":"Pathological axonal death through a MAPK cascade that triggers a local energy deficit","volume":"160","author":"Yang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.exer.2018.03.007_bib63","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1523\/JNEUROSCI.3709-15.2016","article-title":"Rescue of glaucomatous neurodegeneration by differentially modulating neuronal endoplasmic reticulum stress molecules","volume":"36","author":"Yang","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2018.03.007_bib64","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1084\/jem.194.10.1441","article-title":"Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice","volume":"194","author":"Zhao","year":"2001","journal-title":"J. Exp. Med."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483517308448?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483517308448?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:28:13Z","timestamp":1762147693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483517308448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":67,"alternative-id":["S0014483517308448"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2018.03.007","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2018.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}