{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:47:18Z","timestamp":1787060838944,"version":"build-2736575974"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.exer.2018.03.010","type":"journal-article","created":{"date-parts":[[2018,3,18]],"date-time":"2018-03-18T11:17:48Z","timestamp":1521371868000},"page":"183-191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Successful single treatment with ziv-aflibercept for existing corneal neovascularization following ocular chemical insult in the rabbit model"],"prefix":"10.1016","volume":"171","author":[{"given":"Ariel","family":"Gore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vered","family":"Horwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maayan","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hila","family":"Gutman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liat","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rellie","family":"Gez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Kadar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomit","family":"Dachir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2018.03.010_bib1","first-page":"1","article-title":"A review on symptoms, treatments protocols and proteomic profile in sulfur mustardexposed victims","author":"Abdolghaffari","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.exer.2018.03.010_bib2","first-page":"39","article-title":"Tear film physiology","volume":"vol. 1","author":"Agarwal","year":"2002"},{"key":"10.1016\/j.exer.2018.03.010_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/nature05249","article-title":"Corneal avascularity is due to soluble VEGF receptor-1","volume":"443","author":"Ambati","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.exer.2018.03.010_bib4","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1046\/j.1538-7836.2003.00263.x","article-title":"Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders","volume":"1","author":"Autiero","year":"2003","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.exer.2018.03.010_bib5","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1136\/bjo.2008.154906","article-title":"Penetration of topical and subconjunctival corticosteroids into human aqueous humour and its therapeutic significance","volume":"93","author":"Awan","year":"2009","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2018.03.010_bib6","first-page":"264","article-title":"Corneal angiogenic privilage: angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing","volume":"104","author":"Azar","year":"2006","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"10.1016\/j.exer.2018.03.010_bib7","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/bjc.1998.158","article-title":"Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: significance for VEGF measurements and cancer biology","volume":"77","author":"Banks","year":"1998","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.exer.2018.03.010_bib8","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1182\/blood.V87.8.3336.bloodjournal8783336","article-title":"Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is medicated via the VEGF receptor flt-1","volume":"15","author":"Barleon","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.exer.2018.03.010_bib9","first-page":"369","article-title":"Treatment of bacterial ulcers of the cornea in the rabbit: a comparison of administration by eye drops and subconjunctival injections","author":"Baum","year":"1982","journal-title":"Tr. Am. Ophth. Soc."},{"key":"10.1016\/j.exer.2018.03.010_bib10","series-title":"Proceedings of the 36th Annual Israely Society for Vision & Eye Research Meeting","article-title":"Cellular characterization of the inflammatory response associated with corneal neovascularization in a chemical injury model and potential therapy","author":"Berg","year":"2016"},{"key":"10.1016\/j.exer.2018.03.010_bib11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1091\/mbc.3.2.211","article-title":"Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors","volume":"3","author":"Berse","year":"1992","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.exer.2018.03.010_bib12","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1161\/01.CIR.90.2.649","article-title":"Indirect angiogenetic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only","volume":"90","author":"Brogi","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.exer.2018.03.010_bib13","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.ophtha.2011.02.039","article-title":"Primary endpoint results of a phase II study of vascular endothelial growth factor trap-eye in wet age-related macular degeneration","volume":"118","author":"Brown","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2018.03.010_bib14","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1152\/physrev.00028.2013","article-title":"Vascular endothelial growth factor-B in physiology and disease","volume":"94","author":"Bry","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exer.2018.03.010_bib15","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/87904","article-title":"Synergisim between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasme extravasation in pathological conditions","volume":"7","author":"Carmeliet","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.exer.2018.03.010_bib16","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/00055735-200108000-00002","article-title":"Corneal neovascularizatio","volume":"12","author":"Chang","year":"2001","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.exer.2018.03.010_bib17","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.survophthal.2012.01.007","article-title":"Corneal neovascularization: an anti-VEGF therapy review","volume":"57","author":"Chang","year":"2012","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2018.03.010_bib18","first-page":"404","article-title":"Effects of amniotic membrane suspension in the rat alkali burn model","volume":"17","author":"Choi","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2018.03.010_bib19","doi-asserted-by":"crossref","first-page":"636812","DOI":"10.1155\/2013\/636812","article-title":"Modulation of conjunctival goblet cell function by inflammatory cytokines","volume":"2013","author":"Contreras-Ruiz","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.exer.2018.03.010_bib20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/bjo.87.1.101","article-title":"Pericyte recruitment in human corneal angiogenesis: an ultrastructural study with clinicopathological correlation","volume":"87","author":"Cursiefen","year":"2003","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2018.03.010_bib21","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00003226-200304000-00021","article-title":"Corneal lymphangiogenesis: evidence, mechanisms, and implications for corneal transplant immunology","volume":"22","author":"Cursiefen","year":"2003","journal-title":"Cornea"},{"issue":"8","key":"10.1016\/j.exer.2018.03.010_bib22","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1097\/ICO.0000000000001234","article-title":"Ocular surface changes following sulfur mustard exposdure in rabbits, monitored by impression cytology","volume":"36","author":"Dachir","year":"2017","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2018.03.010_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1172\/JCI6127","article-title":"Blood vessel maturation: vascular development comes of age","volume":"103","author":"Darland","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exer.2018.03.010_bib24","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1517\/13543780903201684","article-title":"VEGF trap-eye for the treatment of neovascular age-related macular degeneration","volume":"18","author":"Dixon","year":"2009","journal-title":"Expet Opin. Invest. Drugs"},{"key":"10.1016\/j.exer.2018.03.010_bib25","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1016\/j.ophtha.2011.02.018","article-title":"The DA VINCI Study: phase 2 primary results of VEGF Trap-Eye in patients with diabetic macular edema","volume":"118","author":"Do","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2018.03.010_bib26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.preteyeres.2010.01.002","article-title":"Novel aspects of corneal angiogenic and lymphangiogenic privilege","volume":"29","author":"Ellenberg","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2018.03.010_bib27","series-title":"Pre-clinical Investigation of Intraviteral Zaltrap","author":"Farah","year":"2014"},{"key":"10.1016\/j.exer.2018.03.010_bib28","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nm0603-669","article-title":"The biology of VEGF and its receptors","volume":"9","author":"Ferrara","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.exer.2018.03.010_bib29","first-page":"6625","article-title":"Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin fab","volume":"10","author":"Fuh","year":"2006","journal-title":"J. Biochem."},{"key":"10.1016\/j.exer.2018.03.010_bib30","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1097\/ICO.0000000000000849","article-title":"Efficacy of subconjunctival aflibercept versus bevacizumab for prevention of corneal neovascularization in a rat model","volume":"35","author":"Gal-Or","year":"2016","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2018.03.010_bib31","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1182\/blood.V90.10.4153","article-title":"Intracellular pool of vascular endothelial growth factor in human neutrophils","volume":"90","author":"Gaudry","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.exer.2018.03.010_bib32","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1345\/aph.1K445","article-title":"Mustard gas: imminent danger or eminent threat?","volume":"42","author":"Geraci","year":"2008","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.exer.2018.03.010_bib33","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0161-6420(90)32587-3","article-title":"Tear film and ocular surface changes in a rabbit model of neurotrophic keratitis","volume":"97","author":"Gilbard","year":"1990","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2018.03.010_bib34","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.cbi.2013.06.013","article-title":"Historical perspective on effects and treatment of sulfur mustard injuries","volume":"206","author":"Graham","year":"2013","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.exer.2018.03.010_bib35","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/IIO.0b013e31829ceefa","article-title":"Corneal alkali burns: a review of the literature and proposed protocol for evaluation and treatment","volume":"53","author":"Hamill","year":"2013","journal-title":"Int. Ophthalmol. Clin."},{"key":"10.1016\/j.exer.2018.03.010_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/162692","article-title":"VEGF spliced variants: possibile role of anti-angiogenic therapy","author":"Hilmi","year":"2012","journal-title":"J. Nucleic Acids"},{"key":"10.1016\/j.exer.2018.03.010_bib37","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S0181-5512(07)92618-2","article-title":"Retinotopic organization of the human visual cortex: a 3T fMRI study","volume":"30","author":"Hoffart","year":"2007","journal-title":"J. Fr. Ophtalmol."},{"key":"10.1016\/j.exer.2018.03.010_bib38","doi-asserted-by":"crossref","first-page":"11393","DOI":"10.1073\/pnas.172398299","article-title":"VEGF-trap: a VEGF blocker with potent antitumor effects","volume":"99","author":"Holash","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2018.03.010_bib39","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4103\/2008-322X.156089","article-title":"Topical cyclosarine a for mustard gas infuced ocular surface disorders","volume":"10","author":"Jadidi","year":"2015","journal-title":"J. Ophthalmic Vis. Res."},{"key":"10.1016\/j.exer.2018.03.010_bib40","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.2353\/ajpath.2006.050588","article-title":"Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization","volume":"168","author":"Jo","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2018.03.010_bib41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1076\/ceyr.22.1.42.6975","article-title":"Characterization of acute and delayed ocular lesions induced by sulfur mustard in rabbits","volume":"22","author":"Kadar","year":"2001","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2018.03.010_bib42","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3109\/15569527.2012.717571","article-title":"Endothelial cell damage following sulfur mustard exposure in rabbits and its association with the delayed-onset ocular lesions","volume":"32","author":"Kadar","year":"2013","journal-title":"Cutan. Ocul. Toxicol."},{"key":"10.1016\/j.exer.2018.03.010_bib43","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3109\/02713683.2013.850098","article-title":"Anti-VEGF therapy (bevacizumab) for sulfur mustard-induced corneal neovascularization associated with delayed limbal stem cell deficiency in rabbits","volume":"39","author":"Kadar","year":"2014","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2018.03.010_bib44","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.tox.2008.10.026","article-title":"Ocular injuries following sulfur mustard exposure\u2013pathological mechanism and potential therapy","volume":"263","author":"Kadar","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.exer.2018.03.010_bib45","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/IIO.0b013e318036bd8b","article-title":"Advances in Boston Keratoprosthesis: enhancing retention and prevention of infection and inflammation","volume":"47","author":"Khan","year":"2007","journal-title":"Int. Ophthalmol. Clin."},{"key":"10.1016\/j.exer.2018.03.010_bib46","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1001\/archopht.1983.01040020286025","article-title":"Goblet cell density in ocular surface disease. A better indicator than tear mucin","volume":"101","author":"Kinoshita","year":"1983","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2018.03.010_bib47","first-page":"1541","article-title":"Effect of Trapping vascular endothilial growth factor -A in a murine model of dry eye with inflammatory neovasularization","volume":"9","author":"Kwon","year":"2016","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.exer.2018.03.010_bib48","first-page":"850","article-title":"Ophthalmic preparations","volume":"vol. 1","author":"Lang","year":"2005"},{"key":"10.1016\/j.exer.2018.03.010_bib49","first-page":"1397","article-title":"An in vivo confocal microscopy and impression cytology analysis of goblet cells in patients with chemical burns","volume":"51","author":"Le","year":"2010","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2018.03.010_bib50","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0039-6257(98)00035-6","article-title":"Ocular neovascularization: an epidemiologic review","volume":"43","author":"Lee","year":"1998","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2018.03.010_bib51","first-page":"221","article-title":"Report of the national eye institue\/industry workshop on clinical trials in dry eyes","volume":"21","author":"Lemp","year":"2015","journal-title":"CLAO (Contact Lens Assoc. Ophthalmol.) J."},{"key":"10.1016\/j.exer.2018.03.010_bib52","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/BCR.0b013e31822b0f29","article-title":"Managment of ocular conditions in the burn unit: thermal and chemical burns and stevens-johnson syndrome\/toxic epidermal necrolysis","volume":"32","author":"Lin","year":"2011","journal-title":"J. Burn Care Res."},{"key":"10.1016\/j.exer.2018.03.010_bib53","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00417-008-0936-y","article-title":"Are intravitreal bevacizumab and ranibizumab effective in a rat model of choroidal neovascularization?","volume":"247","author":"Lu","year":"2009","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2018.03.010_bib54","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1136\/bjophthalmol-2016-308679","article-title":"Three-month outcome of intravitreal ziv-aflibercept in eyes with diabetic macular oedema","volume":"101","author":"Mansour","year":"2017","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2018.03.010_bib55","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1136\/bjophthalmol-2015-308319","article-title":"Three-month outcome of ziv-aflibercept for exudative age-related macular degeneration","volume":"12","author":"Mansour","year":"2016","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2018.03.010_bib56","first-page":"1","article-title":"Ziv-aflibercept in macular disease","volume":"0","author":"Mansour","year":"2015","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2018.03.010_bib57","first-page":"1237","article-title":"Retinal detachment from hyperosmotic intraviteral injections","volume":"18","author":"Marmor","year":"1979","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.03.010_bib58","first-page":"1016","article-title":"Osmotically induced retinal detachment in rabbit and primate","volume":"19","author":"Marmor","year":"1980","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.03.010_bib59","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1182\/blood-2015-03-631572","article-title":"Identification and characterization of VEGF-A- responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans","volume":"126","author":"Massena","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.exer.2018.03.010_bib60","first-page":"549","article-title":"Elevated expression of transglutaminase 1 and keratinization-related proteins in conjunctiva in severe ocular surface disease","volume":"42","author":"Nakamura","year":"2001","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.03.010_bib61","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000099263","article-title":"Regulatory T cells and the eye","volume":"92","author":"Niederkorn","year":"2007","journal-title":"Chem. Immunol. Allergy"},{"key":"10.1016\/j.exer.2018.03.010_bib62","first-page":"176","article-title":"Immune response and the eye","volume":"92","author":"Niederkorn","year":"2007","journal-title":"Clin. Allergy Immunol."},{"key":"10.1016\/j.exer.2018.03.010_bib63","first-page":"1445","article-title":"Vascular endothelial growth factor mediats angiogenic activity during the proliferation phase of wound healing","volume":"152","author":"Nissen","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2018.03.010_bib64","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1001\/archopht.116.11.1470","article-title":"Inflammatory response in the early stages of wound healing after excimer laser keratectomy","volume":"116","author":"O'Brien","year":"1998","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2018.03.010_bib65","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10456-011-9249-6","article-title":"Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab","volume":"15","author":"Papadopoulos","year":"2012","journal-title":"Angiogenesis"},{"key":"10.1016\/j.exer.2018.03.010_bib66","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/ICO.0000000000000507","article-title":"Inhibitory effect of topical aflibercept on corneal neovascularization in rabbits","volume":"34","author":"Park","year":"2015","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2018.03.010_bib67","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3390\/toxics2030391","article-title":"The use of chemical weapons in the syrian conflict","volume":"2","author":"Pita","year":"2014","journal-title":"Toxics"},{"key":"10.1016\/j.exer.2018.03.010_bib68","first-page":"2006","article-title":"Study of human precorneal tear film thickness and structure using laser interferometry","volume":"33","author":"Prydal","year":"1992","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.03.010_bib69","article-title":"An in-vivo confocal microscopy and impresion cytology analysis of goblet cells in patients with chemical burns","volume":"51","author":"Qi-bua","year":"2010","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2018.03.010_bib70","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1167\/iovs.02-1092","article-title":"Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization","volume":"44","author":"Rakic","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.03.010_bib71","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bbcan.2005.11.002","article-title":"Regulation of tumor angiogenesis by thrombospoundin-1","volume":"1765","author":"Ren","year":"2006","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"key":"10.1016\/j.exer.2018.03.010_bib72","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0733-8635(18)30318-8","article-title":"Ocular effects of topical and systemic steroids","volume":"10","author":"Renfro","year":"1992","journal-title":"Dermatol. Clin."},{"key":"10.1016\/j.exer.2018.03.010_bib73","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.bbrc.2007.02.156","article-title":"Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor","volume":"356","author":"Roskoski","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2018.03.010_bib74","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/milmed\/166.1.67","article-title":"Ocular injuries caused by mustard gas: diagnosis, treatment, ABD medical defence","volume":"166","author":"Safarinejad","year":"2001","journal-title":"Mil. Med."},{"key":"10.1016\/j.exer.2018.03.010_bib75","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.exer.2016.03.021","article-title":"Efficacy of topical aflibercept versus topical bevacizumab for the prevention of corneal neovascularization in a rat model","volume":"146","author":"Sella","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2018.03.010_bib76","series-title":"Proceedings of the 16th Medical Chemical Defence Conference 5\u20136 April 2017","article-title":"A Syrian Familly who were exposed to blister agent","author":"Sezigen","year":"2017"},{"key":"10.1016\/j.exer.2018.03.010_bib77","first-page":"2767","article-title":"Characterization of vascular permeability factor\/vascular endothelial growth factor receptors on mononuclear phagocytes","volume":"15","author":"She","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.exer.2018.03.010_bib78","first-page":"1","article-title":"European medicines agency approval summary: Zaltrap for the treatment of patients with oxaliplatin-resistant metastatic colorectal cancer","volume":"2","author":"Stanel","year":"2017","journal-title":"ESMO"},{"key":"10.1016\/j.exer.2018.03.010_bib79","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S1542-0124(12)70148-9","article-title":"Inflamation in dry eye","volume":"2","author":"Stern","year":"2004","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2018.03.010_bib80","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.exer.2003.09.003","article-title":"The role of the lacrimal functional unit in the pathophysiology of dry eye","volume":"78","author":"Stern","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2018.03.010_bib81","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1136\/bjo.2007.134874","article-title":"Predicted biological activity of intravitreal VEGF Trap","volume":"92","author":"Stewart","year":"2008","journal-title":"Br. J. Clin. Ophthalmol."},{"key":"10.1016\/j.exer.2018.03.010_bib82","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/jlb.62.3.397","article-title":"Human neutrophilis secrete vascular ebdothelial growth factor","volume":"62","author":"Taichman","year":"1997","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.exer.2018.03.010_bib83","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1042\/CS20040370","article-title":"The vascular endothelial growth factor (VEGF)\/VEGF receptor system and its role under physiological and pthological conditions","volume":"109","author":"Takahashi","year":"2005","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.exer.2018.03.010_bib84","first-page":"1470","article-title":"Inflamatory response in the early stages of wound healing after excimer laser keratectomy","volume":"116","author":"Terrence","year":"1998","journal-title":"Lab. Sci."},{"key":"10.1016\/j.exer.2018.03.010_bib85","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.survophthal.2010.08.006","article-title":"Systemic and ocular safety of intravitreal anti-VEGF therapies for ocular neovascular disease","volume":"56","author":"Tolentino","year":"2011","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2018.03.010_bib86","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0161-6420(84)34251-8","article-title":"Possibile mechanisims for the loss of goblet cells in mucin deficient disorders","volume":"91","author":"Tseng","year":"1984","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2018.03.010_bib87","first-page":"81","article-title":"Glomerular endothelial cells in culture express and secrete vascular endothelial growth factor","volume":"266","author":"Uchida","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.exer.2018.03.010_bib88","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1600-0420.1997.tb00623.x","article-title":"Vascular endothelial growth factor (VEGF) in normal human corneal epithelium: detection and physiological importance","volume":"75","author":"van Setten","year":"1997","journal-title":"Acta Ophthalmol. Scand."},{"key":"10.1016\/j.exer.2018.03.010_bib89","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2015-212988","article-title":"Ziv-aflibercept: a novel option for the treatment of polypoidal choroidal vasculopathy","author":"Videkar","year":"2015","journal-title":"BMJ Case Rep."},{"key":"10.1016\/j.exer.2018.03.010_bib90","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0039-6257(96)00007-0","article-title":"Chemical injuries of the eye: current concepts in pathophysiology and therapy","volume":"41","author":"Wagoner","year":"1997","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2018.03.010_bib91","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1350-9462(01)00008-8","article-title":"The corneal wound healing response: cytokine-mediated interaction of the epitheliu, stroma, and inflammatory cells","volume":"20","author":"Wilson","year":"2001","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2018.03.010_bib92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1350-9462(02)00043-5","article-title":"Vascular endothelial growth factors and angiogenesis in eye disease","volume":"22","author":"Witmer","year":"2003","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2018.03.010_bib93","first-page":"517","article-title":"Placenta growth factor-1 is chemotactic, mitogenic, and angiogenic","volume":"76","author":"Ziche","year":"1997","journal-title":"Lab. Invest."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518300642?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518300642?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:00:29Z","timestamp":1757998829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483518300642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":93,"alternative-id":["S0014483518300642"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2018.03.010","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Successful single treatment with ziv-aflibercept for existing corneal neovascularization following ocular chemical insult in the rabbit model","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2018.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}