{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:33:46Z","timestamp":1778754826977,"version":"3.51.4"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Engineering Research Center","award":["2011-0030075"],"award-info":[{"award-number":["2011-0030075"]}]},{"DOI":"10.13039\/501100004085","name":"National Research Foundation (NRF)","doi-asserted-by":"publisher","award":["NRF-2017R1A2A1A18070960"],"award-info":[{"award-number":["NRF-2017R1A2A1A18070960"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea Government (MEST)"},{"DOI":"10.13039\/501100003052","name":"Ministry Of Trade, Industry & Energy (MI, Korea)","doi-asserted-by":"publisher","award":["10048358"],"award-info":[{"award-number":["10048358"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.exer.2018.05.018","type":"journal-article","created":{"date-parts":[[2018,5,19]],"date-time":"2018-05-19T19:28:04Z","timestamp":1526758084000},"page":"51-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Two-photon microscopy of fungal keratitis-affected rabbit cornea ex vivo using moxifloxacin as a labeling agent"],"prefix":"10.1016","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0481-3151","authenticated-orcid":false,"given":"Jun Ho","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viet-Hoan","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seunghun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Hyoung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Ah","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hungwon","family":"Tchah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungjee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3832-7039","authenticated-orcid":false,"given":"Myoung Joon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Hean","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2018.05.018_bib1","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1136\/bjo.2006.107243","article-title":"In vivo confocal microscopy in fungal keratitis","volume":"91","author":"Brasnu","year":"2007","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2018.05.018_bib2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ab.2006.03.016","article-title":"Determination of ofloxacin and moxifloxacin and their penetration in human aqueous and vitreous humor by using high-performance liquid chromatography fluorescence detection","volume":"353","author":"Chan","year":"2006","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.exer.2018.05.018_bib3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1126\/science.2321027","article-title":"Two-photon laser scanning fluorescence microscopy","volume":"248","author":"Denk","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.exer.2018.05.018_bib4","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/870879","article-title":"Multiphoton microscopy for ophthalmic imaging","volume":"2011","author":"Gibson","year":"2011","journal-title":"J. Ophthalmol."},{"key":"10.1016\/j.exer.2018.05.018_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/srep27734","article-title":"Ultrastructural analysis of the decellularized cornea after interlamellar keratoplasty and microkeratome-assisted anterior lamellar keratoplasty in a rabbit model","volume":"6","author":"Hashimoto","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2018.05.018_bib6","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1097\/ICO.0b013e318191695b","article-title":"Fungal keratitis: changing pathogens and risk factors","volume":"28","author":"Jurkunas","year":"2009","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2018.05.018_bib7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1046\/j.1365-2818.2000.00738.x","article-title":"Multiphoton microscopy in life sciences","volume":"200","author":"Konig","year":"2000","journal-title":"J. Microsc."},{"key":"10.1016\/j.exer.2018.05.018_bib8","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3109\/08820538.2010.518516","article-title":"Current state of in vivo confocal microscopy in management of microbial keratitis","volume":"25","author":"Kumar","year":"2010","journal-title":"Semin. Ophthalmol."},{"key":"10.1016\/j.exer.2018.05.018_bib9","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.exer.2009.11.016","article-title":"Characterization of corneal keratocyte morphology and mechanical activity within 3-D collagen matrices","volume":"90","author":"Lakshman","year":"2010","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2018.05.018_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1463-5224.2010.00822.x","article-title":"In vivo confocal microscopy of equine fungal keratitis","volume":"14","author":"Ledbetter","year":"2011","journal-title":"Vet. Ophthalmol."},{"key":"10.1016\/j.exer.2018.05.018_bib11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.exer.2015.01.013","article-title":"Comparison of confocal microscopy and two-photon microscopy in mouse cornea in vivo","volume":"132","author":"Lee","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2018.05.018_bib12","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1364\/BOE.7.000677","article-title":"Comparison of reflectance confocal microscopy and two-photon second harmonic generation microscopy in fungal keratitis rabbit model ex vivo","volume":"7","author":"Lee","year":"2016","journal-title":"Biomed. Optic Express"},{"key":"10.1016\/j.exer.2018.05.018_bib13","doi-asserted-by":"crossref","first-page":"25339","DOI":"10.1038\/srep25339","article-title":"In vivo 3D measurement of moxifloxacin and gatifloxacin distributions in the mouse cornea using multiphoton microscopy","volume":"6","author":"Lee","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2018.05.018_bib14","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3109\/08820538.2010.518542","article-title":"In vivo imaging of corneal inflammation: new tools for clinical practice and research","volume":"25","author":"Mantopoulos","year":"2010","journal-title":"Semin. Ophthalmol."},{"key":"10.1016\/j.exer.2018.05.018_bib15","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1002\/app.1982.070270827","article-title":"Adsorption of dyes on chitin I. Equilibrium studies","volume":"27","author":"Mckay","year":"1982","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.exer.2018.05.018_bib16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.preteyeres.2009.11.001","article-title":"Clinical in vivo confocal microscopy of the human cornea in health and disease","volume":"29","author":"Niederer","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2018.05.018_bib17","doi-asserted-by":"crossref","DOI":"10.1117\/1.3275475","article-title":"Comparison of Cornea Module and DermaInspect for noninvasive imaging of ocular surface pathologies","volume":"14","author":"Steven","year":"2009","journal-title":"J. Biomed. Optic."},{"key":"10.1016\/j.exer.2018.05.018_bib18","doi-asserted-by":"crossref","DOI":"10.1117\/1.2717133","article-title":"Multiphoton fluorescence and second harmonic generation microscopy for imaging infectious keratitis","volume":"12","author":"Tan","year":"2007","journal-title":"J. Biomed. Optic."},{"key":"10.1016\/j.exer.2018.05.018_bib19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/QCO.0b013e328017f878","article-title":"Infectious keratitis","volume":"20","author":"Thomas","year":"2007","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.exer.2018.05.018_bib20","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/462918","article-title":"Improved HPLC method for the determination of moxifloxacin in application to a pharmacokinetics study in patients with infectious diseases","volume":"2013","author":"Wang","year":"2013","journal-title":"ISRN Pharmacol."},{"key":"10.1016\/j.exer.2018.05.018_bib21","doi-asserted-by":"crossref","first-page":"27142","DOI":"10.1038\/srep27142","article-title":"Moxifloxacin: clinically compatible contrast agent for multiphoton imaging","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2018.05.018_bib22","first-page":"214","article-title":"Corneal blindness: a global perspective","volume":"79","author":"Whitcher","year":"2001","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.exer.2018.05.018_bib23","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/sj.eye.6702414","article-title":"Penetration of second-, third-, and fourth-generation topical fluoroquinolone into aqueous and vitreous humour in a rabbit endophthalmitis model","volume":"21","author":"Yagci","year":"2007","journal-title":"Eye"},{"key":"10.1016\/j.exer.2018.05.018_bib24","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/nbt899","article-title":"Nonlinear magic: multiphoton microscopy in the biosciences","volume":"21","author":"Zipfel","year":"2003","journal-title":"Nat. Biotechnol."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483517307790?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483517307790?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T07:43:38Z","timestamp":1535010218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483517307790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":24,"alternative-id":["S0014483517307790"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2018.05.018","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Two-photon microscopy of fungal keratitis-affected rabbit cornea ex vivo using moxifloxacin as a labeling agent","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2018.05.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}