{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T10:22:36Z","timestamp":1763202156911},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Natural Scientific Research Foundation of China","award":["81770936","81200708","81570232","81200151"],"award-info":[{"award-number":["81770936","81200708","81570232","81200151"]}]},{"name":"Scientific Research Foundation for Outstanding Young Scientists"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.exer.2018.06.010","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T08:53:45Z","timestamp":1529052825000},"page":"115-123","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["MicroRNA-188-5p regulates contribution of bone marrow-derived cells to choroidal neovascularization development by targeting MMP-2\/13"],"prefix":"10.1016","volume":"175","author":[{"given":"Huiyuan","family":"Hou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongliang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libo","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guorui","family":"Dou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2018.06.010_bib1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1167\/iovs.02-0180","article-title":"Reduced choroidal neovascular membrane formation in matrix metalloproteinase-2-deficient mice","volume":"44","author":"Berglin","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.06.010_bib2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1742-2094-11-88","article-title":"Roles of NFkappaB-miR-29s-MMP-2 circuitry in experimental choroidal neovascularization","volume":"11","author":"Cai","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.exer.2018.06.010_bib3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.exer.2014.04.012","article-title":"Hyperglycemia promotes vasculogenesis in choroidal neovascularization in diabetic mice by stimulating VEGF and SDF-1 expression in retinal pigment epithelial cells","volume":"123","author":"Cai","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2018.06.010_bib4","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/phar.1264","article-title":"Age-related macular degeneration","volume":"33","author":"Cheung","year":"2013","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.exer.2018.06.010_bib5","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1089\/hum.2015.064","article-title":"Antiangiogenic eye gene therapy","volume":"26","author":"Corydon","year":"2015","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.exer.2018.06.010_bib6","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.ijrobp.2011.09.030","article-title":"A specific miRNA signature correlates with complete pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer","volume":"83","author":"Della Vittoria Scarpati","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.exer.2018.06.010_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018481","article-title":"Influence of Dll4 via HIF-1alpha-VEGF signaling on the angiogenesis of choroidal neovascularization under hypoxic conditions","volume":"6","author":"Dong","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2018.06.010_bib8","doi-asserted-by":"crossref","first-page":"7439","DOI":"10.1167\/iovs.13-12546","article-title":"Bone marrow transplantation transfers age-related susceptibility to neovascular remodeling in murine laser-induced choroidal neovascularization","volume":"54","author":"Espinosa-Heidmann","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.06.010_bib9","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.exer.2004.10.005","article-title":"Quantitative enumeration of vascular smooth muscle cells and endothelial cells derived from bone marrow precursors in experimental choroidal neovascularization","volume":"80","author":"Espinosa-Heidmann","year":"2005","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2018.06.010_bib10","first-page":"1567","article-title":"Age as an independent risk factor for severity of experimental choroidal neovascularization","volume":"43","author":"Espinosa-Heidmann","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.06.010_bib11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.diff.2010.12.003","article-title":"The ratio of VEGF\/PEDF expression in bone marrow mesenchymal stem cells regulates neovascularization","volume":"81","author":"Fan","year":"2011","journal-title":"Differentiation"},{"key":"10.1016\/j.exer.2018.06.010_bib12","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.jhep.2015.05.008","article-title":"MicroRNA-188-5p suppresses tumor cell proliferation and metastasis by directly targeting FGF5 in hepatocellular carcinoma","volume":"63","author":"Fang","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.exer.2018.06.010_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10456-016-9497-6","article-title":"Bone marrow-derived cells in ocular neovascularization: contribution and mechanisms","volume":"19","author":"Gao","year":"2016","journal-title":"Angiogenesis"},{"key":"10.1016\/j.exer.2018.06.010_bib14","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/mrd.22638","article-title":"MicroRNA-195a-3p inhibits angiogenesis by targeting Mmp2 in murine mesenchymal stem cells","volume":"83","author":"Gao","year":"2016","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.exer.2018.06.010_bib15","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1167\/iovs.04-1050","article-title":"Reduced foveolar choroidal blood flow in eyes with increasing AMD severity","volume":"46","author":"Grunwald","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.06.010_bib16","first-page":"683","article-title":"Estimation of time-dependent microRNA expression patterns in brain tissue, leukocytes, and blood plasma of rats under photochemically induced focal cerebral ischemia","volume":"51","author":"Gusar","year":"2017","journal-title":"Mol. Biol. (Mosc.)"},{"key":"10.1016\/j.exer.2018.06.010_bib17","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2014.06.005","article-title":"MicroRNAs in cancer: biomarkers, functions and therapy","volume":"20","author":"Hayes","year":"2014","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.exer.2018.06.010_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000313983","article-title":"Bone marrow-derived cells in neovascular age-related macular degeneration: contribution and potential application","volume":"45","author":"Hou","year":"2011","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.exer.2018.06.010_bib19","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1038\/mt.2010.144","article-title":"A therapeutic strategy for choroidal neovascularization based on recruitment of mesenchymal stem cells to the sites of lesions","volume":"18","author":"Hou","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2018.06.010_bib20","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.exer.2008.03.018","article-title":"Nicotine promotes contribution of bone marrow-derived cells to experimental choroidal neovascularization in mice","volume":"86","author":"Hou","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2018.06.010_bib21","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1080\/02713680601100459","article-title":"The dynamic conduct of bone marrow-derived cells in the choroidal neovascularization microenvironment","volume":"31","author":"Hou","year":"2006","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2018.06.010_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0118099","article-title":"Identification of let-7a-2-3p or\/and miR-188-5p as prognostic biomarkers in cytogenetically normal acute myeloid leukemia","volume":"10","author":"Jinlong","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2018.06.010_bib23","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1111\/j.1582-4934.2008.00619.x","article-title":"Wnt signalling in mouse mesenchymal stem cells: impact on proliferation, invasion and MMP expression","volume":"13","author":"Karow","year":"2009","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.exer.2018.06.010_bib24","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1093\/eurheartj\/ehn456","article-title":"Bone marrow cells are a rich source of growth factors and cytokines: implications for cell therapy trials after myocardial infarction","volume":"29","author":"Korf-Klingebiel","year":"2008","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.exer.2018.06.010_bib25","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00018-010-0476-6","article-title":"Bone marrow-derived mesenchymal cells and MMP13 contribute to experimental choroidal neovascularization","volume":"68","author":"Lecomte","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.exer.2018.06.010_bib26","doi-asserted-by":"crossref","first-page":"12163","DOI":"10.1073\/pnas.1508426112","article-title":"Endothelial microRNA-150 is an intrinsic suppressor of pathologic ocular neovascularization","volume":"112","author":"Liu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2018.06.010_bib27","doi-asserted-by":"crossref","first-page":"19171","DOI":"10.18632\/oncotarget.8280","article-title":"MicroRNA signatures in vitreous humour and plasma of patients with exudative AMD","volume":"7","author":"Menard","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.exer.2018.06.010_bib28","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.cell.2006.07.031","article-title":"A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes","volume":"126","author":"Miranda","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.exer.2018.06.010_bib29","first-page":"4953","article-title":"Expression and function of microRNA-188-5p in activated rheumatoid arthritis synovial fibroblasts","volume":"8","author":"Ruedel","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.exer.2018.06.010_bib30","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1167\/iovs.04-0153","article-title":"Preventing stem cell incorporation into choroidal neovascularization by targeting homing and attachment factors","volume":"46","author":"Sengupta","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.06.010_bib31","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/mt.2008.104","article-title":"MicroRNAs regulate ocular neovascularization","volume":"16","author":"Shen","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2018.06.010_bib32","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1167\/iovs.05-0779","article-title":"The presence of AC133-positive cells suggests a possible role of endothelial progenitor cells in the formation of choroidal neovascularization","volume":"47","author":"Sheridan","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.06.010_bib33","article-title":"miR-126 regulation of angiogenesis in age-related macular degeneration in CNV mouse model","volume":"17","author":"Wang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2018.06.010_bib34","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4155\/fmc.11.176","article-title":"miRNAs as potential therapeutic targets for age-related macular degeneration","volume":"4","author":"Wang","year":"2012","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.exer.2018.06.010_bib35","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1172\/JCI70230","article-title":"Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting","volume":"123","author":"Westenskow","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exer.2018.06.010_bib36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1674-8301(12)60022-0","article-title":"Baicalin modulates microRNA expression in UVB irradiated mouse skin","volume":"26","author":"Xu","year":"2012","journal-title":"J. Biomed. Res."},{"key":"10.1016\/j.exer.2018.06.010_bib37","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.003042","article-title":"miR-342-5p is a notch downstream molecule and regulates multiple angiogenic pathways including notch, vascular endothelial growth factor and transforming growth factor beta signaling","volume":"5","author":"Yan","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.exer.2018.06.010_bib38","doi-asserted-by":"crossref","first-page":"5464","DOI":"10.1167\/iovs.07-0093","article-title":"Circulating hematopoietic stem cells in patients with neovascular age-related macular degeneration","volume":"48","author":"Yodoi","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.06.010_bib39","doi-asserted-by":"crossref","first-page":"6092","DOI":"10.18632\/oncotarget.3341","article-title":"miR-188-5p inhibits tumour growth and metastasis in prostate cancer by repressing LAPTM4B expression","volume":"6","author":"Zhang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.exer.2018.06.010_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2006.09.002","article-title":"Ocular neovascularization: implication of endogenous angiogenic inhibitors and potential therapy","volume":"26","author":"Zhang","year":"2007","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2018.06.010_bib41","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.7150\/thno.19646","article-title":"Decoding noncoding RNAs: role of MicroRNAs and long noncoding RNAs in ocular neovascularization","volume":"7","author":"Zhang","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.exer.2018.06.010_bib42","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1038\/mt.2016.108","article-title":"Strand and cell type-specific function of microRNA-126 in angiogenesis","volume":"24","author":"Zhou","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2018.06.010_bib43","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/mt.2013.243","article-title":"Repression of choroidal neovascularization through actin cytoskeleton pathways by microRNA-24","volume":"22","author":"Zhou","year":"2014","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2018.06.010_bib44","doi-asserted-by":"crossref","first-page":"8287","DOI":"10.1073\/pnas.1105254108","article-title":"Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23\u223c27\u223c24 clusters","volume":"108","author":"Zhou","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2018.06.010_bib45","first-page":"1173","article-title":"Down-regulation of microRNA-155 attenuates retinal neovascularization via the PI3K\/Akt pathway","volume":"21","author":"Zhuang","year":"2015","journal-title":"Mol. Vis."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518301465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518301465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T18:19:53Z","timestamp":1604427593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483518301465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":45,"alternative-id":["S0014483518301465"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2018.06.010","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA-188-5p regulates contribution of bone marrow-derived cells to choroidal neovascularization development by targeting MMP-2\/13","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2018.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}