{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T14:02:58Z","timestamp":1777816978126,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Eye and Ear Infirmary Research Foundation"},{"DOI":"10.13039\/501100004699","name":"Chung Shan Medical University Hospital","doi-asserted-by":"publisher","award":["CSH-2017-E-001-Y2"],"award-info":[{"award-number":["CSH-2017-E-001-Y2"]}],"id":[{"id":"10.13039\/501100004699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.exer.2018.06.023","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T04:15:19Z","timestamp":1529640919000},"page":"181-191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Uveal melanocytes express high constitutive levels of MMP-8 which can be upregulated by TNF-\u03b1 via the MAPK pathway"],"prefix":"10.1016","volume":"175","author":[{"given":"Dan-Ning","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard B.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9460-8049","authenticated-orcid":false,"given":"Chi-Chao","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-En","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0365-7927","authenticated-orcid":false,"given":"Shun-Fa","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2018.06.023_bib1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1034\/j.1600-0765.2001.360303.x","article-title":"Induction of collagenase-2 (matrix metalloproteinase-8) gene expression by interleukin-1beta in human gingival fibroblasts","volume":"36","author":"Abe","year":"2001","journal-title":"J. Periodontal. Res."},{"key":"10.1016\/j.exer.2018.06.023_bib2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.biochi.2004.12.009","article-title":"Collagenases in cancer","volume":"87","author":"Ala-aho","year":"2005","journal-title":"Biochimie"},{"key":"10.1016\/j.exer.2018.06.023_bib3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1755-148X.2009.00573.x","article-title":"Wild-type versus mutant MMP-8 in melanoma: 'when you come to a fork in the road, take it'","volume":"22","author":"Blackburn","year":"2009","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.exer.2018.06.023_bib4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.exer.2009.12.004","article-title":"Curcumin protects against hyperosmoticity-induced IL-1beta elevation in human corneal epithelial cell via MAPK pathways","volume":"90","author":"Chen","year":"2010","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2018.06.023_bib5","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/j.1600-0749.2004.00181.x","article-title":"Uveal melanocytes produce matrix metalloproteinases-2 and -9 in vitro","volume":"17","author":"Chu","year":"2004","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.exer.2018.06.023_bib6","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1002\/art.27757","article-title":"Matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression","volume":"62","author":"Cox","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.exer.2018.06.023_bib7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cytogfr.2011.02.002","article-title":"Matrix metalloproteinase8 has a central role in inflammatory disorders and cancer progression","volume":"22","author":"Dejonckheere","year":"2011","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.exer.2018.06.023_bib8","doi-asserted-by":"crossref","first-page":"9465","DOI":"10.1074\/jbc.M709522200","article-title":"Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice","volume":"283","author":"Folgueras","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2018.06.023_bib9","doi-asserted-by":"crossref","DOI":"10.1186\/ar3211","article-title":"Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K\/BxN serum-transfer arthritis model","volume":"12","author":"Garcia","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.exer.2018.06.023_bib10","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0945-053X(98)90019-1","article-title":"Overview of matrix metalloproteinase expression in cultured human cells","volume":"16","author":"Giambernardi","year":"1998","journal-title":"Matrix Biol."},{"key":"10.1016\/j.exer.2018.06.023_bib11","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0945-053X(01)00166-4","article-title":"Neutrophil collagenase (MMP-8) is expressed during early development in neural crest cells as well as in adult melanoma cells","volume":"20","author":"Giambernardi","year":"2001","journal-title":"Matrix Biol."},{"key":"10.1016\/j.exer.2018.06.023_bib12","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1158\/0008-5472.CAN-07-5154","article-title":"Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion","volume":"68","author":"Gutierrez-Fernandez","year":"2008","journal-title":"Canc. Res."},{"key":"10.1016\/j.exer.2018.06.023_bib13","doi-asserted-by":"crossref","first-page":"31504","DOI":"10.1074\/jbc.272.50.31504","article-title":"Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline","volume":"272","author":"Hanemaaijer","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2018.06.023_bib14","doi-asserted-by":"crossref","first-page":"10048","DOI":"10.1016\/S0021-9258(18)61073-7","article-title":"The collagen substrate specificity of human neutrophil collagenase","volume":"262","author":"Hasty","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2018.06.023_bib15","doi-asserted-by":"crossref","first-page":"11421","DOI":"10.1016\/S0021-9258(19)38413-3","article-title":"Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases","volume":"265","author":"Hasty","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"Suppl. 8","key":"10.1016\/j.exer.2018.06.023_bib16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1034\/j.1600-0749.13.s8.15.x","article-title":"Regulation of growth and melanogenesis of uveal melanocytes","volume":"13","author":"Hu","year":"2000","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.exer.2018.06.023_bib17","doi-asserted-by":"crossref","first-page":"5760","DOI":"10.1167\/iovs.14-14685","article-title":"Constitutive and LPS-induced expression of MCP-1 and IL-8 by human uveal melanocytes in vitro and relevant signal pathways","volume":"55","author":"Hu","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.06.023_bib18","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1167\/iovs.10-6908","article-title":"Interleukin-1beta increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via the p38 MAPK\/NF-kappaB pathway","volume":"52","author":"Hu","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.06.023_bib19","first-page":"2210","article-title":"Studies of human uveal melanocytes in vitro: isolation, purification and cultivation of human uveal melanocytes","volume":"34","author":"Hu","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.06.023_bib20","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.intimp.2015.02.021","article-title":"Melittin has a chondroprotective effect by inhibiting MMP-1 and MMP-8 expressions via blocking NF-kappaB and AP-1 signaling pathway in chondrocytes","volume":"25","author":"Jeong","year":"2015","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.exer.2018.06.023_bib21","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0163-7258(99)00008-X","article-title":"p38 mitogen-activated protein kinase inhibitors\u2013mechanisms and therapeutic potentials","volume":"82","author":"Lee","year":"1999","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.exer.2018.06.023_bib22","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3109\/02713680903521944","article-title":"Curcumin induces cell death in human uveal melanoma cells through mitochondrial pathway","volume":"35","author":"Lu","year":"2010","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2018.06.023_bib23","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/ICO.0b013e31815c18d6","article-title":"Elevated expression and activation of matrix metalloproteinase 8 in tear fluid in atopic blepharoconjunctivitis","volume":"27","author":"Maatta","year":"2008","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2018.06.023_bib24","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/01.ijg.0000212229.57922.72","article-title":"Levels and activation of matrix metalloproteinases in aqueous humor are elevated in uveitis-related secondary glaucoma","volume":"15","author":"Maatta","year":"2006","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.exer.2018.06.023_bib25","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1350-9462(02)00063-0","article-title":"Role of the sclera in the development and pathological complications of myopia","volume":"22","author":"McBrien","year":"2003","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2018.06.023_bib26","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.mam.2008.05.002","article-title":"Progress in matrix metalloproteinase research","volume":"29","author":"Murphy","year":"2008","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.exer.2018.06.023_bib27","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/ng.340","article-title":"Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma","volume":"41","author":"Palavalli","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2018.06.023_bib28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/01.ico.0000248384.16896.7d","article-title":"Matrix metalloproteinases (MMP-8, MMP-9) and the tissue inhibitors of metalloproteinases (TIMP-1, TIMP-2) in patients with fungal keratitis","volume":"26","author":"Rohini","year":"2007","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2018.06.023_bib29","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1139\/o96-083","article-title":"Collagenase: a key enzyme in collagen turnover","volume":"74","author":"Shingleton","year":"1996","journal-title":"Biochem. Cell. Biol."},{"key":"10.1016\/j.exer.2018.06.023_bib30","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1601-0825.2004.01038.x","article-title":"Matrix metalloproteinases (MMPs) in oral diseases","volume":"10","author":"Sorsa","year":"2004","journal-title":"Oral Dis."},{"key":"10.1016\/j.exer.2018.06.023_bib31","doi-asserted-by":"crossref","first-page":"e312","DOI":"10.1371\/journal.pone.0000312","article-title":"LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity","volume":"2","author":"Tester","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2018.06.023_bib32","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.4049\/jimmunol.173.8.5209","article-title":"Key metalloproteinases are expressed by specific cell types in experimental autoimmune encephalomyelitis","volume":"173","author":"Toft-Hansen","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2018.06.023_bib33","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cytogfr.2006.04.001","article-title":"Matrix metalloproteinase-8: cleavage can be decisive","volume":"17","author":"Van Lint","year":"2006","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.exer.2018.06.023_bib34","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/CMR.0b013e3283090031","article-title":"Serum matrix metalloproteinase-8 is associated with ulceration and vascular invasion of malignant melanoma","volume":"18","author":"Vihinen","year":"2008","journal-title":"Melanoma Res."},{"key":"10.1016\/j.exer.2018.06.023_bib35","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1034\/j.1600-0749.2002.02041.x","article-title":"Tissue plasminogen activator is released into cultured medium by cultured human uveal melanocytes","volume":"15","author":"Wang","year":"2002","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.exer.2018.06.023_bib36","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1167\/iovs.08-2390","article-title":"Expression of matrix metalloproteinases during experimental Candida albicans keratitis","volume":"50","author":"Yuan","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483517306358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483517306358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T04:14:12Z","timestamp":1661487252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483517306358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":36,"alternative-id":["S0014483517306358"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2018.06.023","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Uveal melanocytes express high constitutive levels of MMP-8 which can be upregulated by TNF-\u03b1 via the MAPK pathway","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2018.06.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}