{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:54:48Z","timestamp":1780055688017,"version":"3.54.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24590329"],"award-info":[{"award-number":["24590329"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K07971"],"award-info":[{"award-number":["15K07971"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K06689"],"award-info":[{"award-number":["18K06689"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.exer.2018.07.028","type":"journal-article","created":{"date-parts":[[2018,7,29]],"date-time":"2018-07-29T06:12:09Z","timestamp":1532844729000},"page":"45-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Brilliant Blue G protects against photoreceptor injury in a murine endotoxin-induced uveitis model"],"prefix":"10.1016","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1326-6580","authenticated-orcid":false,"given":"Kenji","family":"Sakamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Inukai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asami","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Nakahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2018.07.028_bib1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1097\/IAE.0b013e318227ab39","article-title":"Techniques, rationale, and outcomes of internal limiting membrane peeling","volume":"32","author":"Almony","year":"2012","journal-title":"Retina"},{"key":"10.1016\/j.exer.2018.07.028_bib2","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1016\/j.ophtha.2012.06.048","article-title":"Comparison of vitrectomy with brilliant blue G or indocyanine green on retinal microstructure and function of eyes with macular hole","volume":"119","author":"Baba","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2018.07.028_bib3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0169-328X(98)00254-X","article-title":"Expression of the P2X7-receptor subunit in neurons of the rat retina. Brain Res","volume":"62","author":"Br\u00e4ndle","year":"1998","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.exer.2018.07.028_bib4","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/dmrr.415","article-title":"Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives","volume":"19","author":"Caldwell","year":"2003","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.exer.2018.07.028_bib5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bbrc.2016.10.140","article-title":"Lack of the P2X7 receptor protects against AMD-like defects and microparticle accumulation in a chronic oxidative stress-induced mouse model of AMD","volume":"482","author":"Carver","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2018.07.028_bib6","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/S0028-3908(97)00140-8","article-title":"Tissue distribution of the P2X7 receptor","volume":"36","author":"Collo","year":"1997","journal-title":"Neuropharmacology"},{"issue":"Suppl. l","key":"10.1016\/j.exer.2018.07.028_bib7","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.3233\/JRS-150697","article-title":"Rat paw oedema modeling and NSAIDs: timing of effects","volume":"27","author":"Cong","year":"2015","journal-title":"Int. J. Risk Saf. Med."},{"key":"10.1016\/j.exer.2018.07.028_bib8","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1523\/JNEUROSCI.5429-03.2004","article-title":"Contribution of calcium ions to P2X channel responses","volume":"24","author":"Egan","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2018.07.028_bib9","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.4049\/jimmunol.159.3.1451","article-title":"Extracellular ATP triggers IL-1\u03b2 release by activating the purinergic P2Z receptor of human macrophages","volume":"159","author":"Ferrari","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2018.07.028_bib10","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1084\/jem.185.3.579","article-title":"Purinergic modulation of interleukin-1\u03b2 release from microglial cells stimulated with bacterial endotoxin","volume":"185","author":"Ferrari","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.exer.2018.07.028_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1350-9462(00)00017-3","article-title":"Retinal pigment epithelium-immune system interactions: cytokine production and cytokine-induced changes","volume":"20","author":"Holtkamp","year":"2001","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2018.07.028_bib12","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/cne.10608","article-title":"Neuron-specific distribution of P2X7 purinergic receptors in the monkey retina","volume":"459","author":"Ishii","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.exer.2018.07.028_bib13","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.2353\/ajpath.2007.061018","article-title":"Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization","volume":"170","author":"Izumi-Nagai","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2018.07.028_bib14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.neulet.2012.11.060","article-title":"Involvement of P2X7 receptors in retinal ganglion cell death after optic nerve crush injury in rats","volume":"534","author":"Kakurai","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.exer.2018.07.028_bib1a","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1167\/iovs.06-0478","article-title":"Neuroprotective effects of angiotensin II type 1 receptor (AT1R) blocker, telmisartan, via modulating AT1R and AT2R signaling in retinal inflammation","volume":"47","author":"Kurihara","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.07.028_bib15","series-title":"Global Medical Knowledge 2020","article-title":"Endophthalmitis","author":"LaMattina","year":"2017"},{"key":"10.1016\/j.exer.2018.07.028_bib16","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00417-007-0761-8","article-title":"Electrophysiological effects of Brilliant Blue G in the model of the isolated perfused vertebrate retina","volume":"246","author":"L\u00fcke","year":"2008","journal-title":"Graefes Arch, Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2018.07.028_bib17","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.biocel.2010.06.021","article-title":"Microglia: proliferation and activation driven by the P2X7 receptor","volume":"42","author":"Monif","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.exer.2018.07.028_bib18","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1167\/iovs.04-1476","article-title":"Suppression of ocular inflammation in endotoxin-induced uveitis by blocking the angiotensin II type 1 receptor","volume":"46","author":"Nagai","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.07.028_bib19","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1152\/physrev.00015.2002","article-title":"Molecular physiology of P2X receptors","volume":"82","author":"North","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exer.2018.07.028_bib20","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1016\/j.ajpath.2011.08.035","article-title":"Critical involvement of extracellular ATP acting on P2RX7 purinergic receptors in photoreceptor cell death","volume":"179","author":"Notomi","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2018.07.028_bib21","doi-asserted-by":"crossref","first-page":"24561","DOI":"10.1074\/jbc.M802238200","article-title":"Roles of STAT3\/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation","volume":"283","author":"Ozawa","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2018.07.028_bib22","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.1523\/JNEUROSCI.20-16-05965.2000","article-title":"P2X7 receptors in M\u00fcller glial cells from the human retina","volume":"20","author":"Pannicke","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2018.07.028_bib23","doi-asserted-by":"crossref","first-page":"12489","DOI":"10.1073\/pnas.0902531106","article-title":"Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury","volume":"106","author":"Peng","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2018.07.028_bib24","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0301-0082(99)00017-9","article-title":"Trophic effects of purines in neurons and glial cells","volume":"59","author":"Rathbone","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.exer.2018.07.028_bib25","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.neuroscience.2008.08.036","article-title":"Elevated pressure triggers a physiological release of ATP from the retina: possible role for pannexin hemichannels","volume":"157","author":"Reigada","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.exer.2018.07.028_bib26","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1111\/j.1460-9568.2007.05528.x","article-title":"Acute retinal ganglion cell injury caused by intraocular pressure spikes is mediated by endogenous extracellular ATP","volume":"25","author":"Resta","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.exer.2018.07.028_bib27","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.exer.2008.12.011","article-title":"Histological protection by cilnidipine, a dual L\/N-type Ca2+ channel blocker, against neurotoxicity induced by ischemia-reperfusion in rat retina","volume":"88","author":"Sakamoto","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2018.07.028_bib28","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejphar.2010.03.001","article-title":"Protective effect of all-trans retinoic acid on NMDA-induced neuronal cell death in rat retina","volume":"635","author":"Sakamoto","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.exer.2018.07.028_bib29","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1254\/jphs.09302FP","article-title":"Histological protection by donepezil against neurodegeneration induced by ischemia-reperfusion in the rat retina","volume":"112","author":"Sakamoto","year":"2010","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.exer.2018.07.028_bib30","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1089\/jop.2010.0141","article-title":"Small molecule cyclin-dependent kinase inhibitors protect against neuronal cell death in the ischemic-reperfused rat retina","volume":"27","author":"Sakamoto","year":"2011","journal-title":"J. Ocul. Pharmacol. Therapeut."},{"key":"10.1016\/j.exer.2018.07.028_bib31","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.exer.2014.01.008","article-title":"Hydrogen sulfide attenuates NMDA-induced neuronal injury via its anti-oxidative activity in the rat retina","volume":"120","author":"Sakamoto","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2018.07.028_bib32","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejphar.2015.03.008","article-title":"P2X7 receptor antagonists protect against N-methyl-D-aspartic acid-induced neuronal injury in the rat retina","volume":"756","author":"Sakamoto","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.exer.2018.07.028_bib33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1248\/bpb.b14-00491","article-title":"Effect of long-term treatment of L-ornithine on visual function and retinal histology in the rats","volume":"38","author":"Sakamoto","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.exer.2018.07.028_bib34","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1167\/iovs.08-2493","article-title":"Neuroprotective effect of an antioxidant, lutein, during retinal inflammation","volume":"50","author":"Sasaki","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.07.028_bib35","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1096\/fj.09-138883","article-title":"The P2X7 purinergic receptor: from physiology to neurological disorders","volume":"24","author":"Skaper","year":"2010","journal-title":"Faseb. J."},{"key":"10.1016\/j.exer.2018.07.028_bib36","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00005-010-0069-y","article-title":"P2X7 receptor signaling pathway as a therapeutic target for neurodegenerative diseases","volume":"58","author":"Takenouchi","year":"2010","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.exer.2018.07.028_bib37","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1167\/iovs.10-6172","article-title":"Activation of P2X receptors induces apoptosis in human retinal pigment epithelium","volume":"52","author":"Yang","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.07.028_bib38","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1167\/iovs.05-0052","article-title":"Stimulation of P2X7 receptors elevates Ca2+ and kills retinal ganglion cells","volume":"46","author":"Zhang","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518304019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518304019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T01:00:11Z","timestamp":1693789211000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483518304019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":39,"alternative-id":["S0014483518304019"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2018.07.028","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brilliant Blue G protects against photoreceptor injury in a murine endotoxin-induced uveitis model","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2018.07.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}