{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:30:28Z","timestamp":1772998228164,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570849"],"award-info":[{"award-number":["81570849"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2015A030313446"],"award-info":[{"award-number":["2015A030313446"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Joint Shantou International Eye Center of Shantou University"},{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011840","name":"Shantou University Medical College","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011840","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.exer.2018.08.010","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T22:40:39Z","timestamp":1534286439000},"page":"153-159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Casein kinase-II inhibition promotes retinal ganglion cell survival and axonal regeneration"],"prefix":"10.1016","volume":"177","author":[{"given":"Ling-Ping","family":"Cen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Fen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7863-7229","authenticated-orcid":false,"given":"Tsz Kin","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Min","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nico","family":"van Rooijen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi Pui","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2018.08.010_bib1","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1091\/mbc.e05-12-1144","article-title":"Activation of casein kinase II and inhibition of phosphatase and tensin homologue deleted on chromosome 10 phosphatase by nerve growth factor\/p75NTR inhibit glycogen synthase Kinase-3beta and stimulate axonal growth","volume":"17","author":"Arevalo","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.exer.2018.08.010_bib2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cellsig.2005.07.008","article-title":"The shape of things to come: an emerging role for protein kinase CK2 in the regulation of cell morphology and the cytoskeleton","volume":"18","author":"Canton","year":"2006","journal-title":"Cell. Signal."},{"key":"10.1016\/j.exer.2018.08.010_bib3","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/stem.2812","article-title":"Human periodontal ligament-derived stem cells promote retinal ganglion cell survival and axon regeneration after optic nerve injury","volume":"36","author":"Cen","year":"2018","journal-title":"Stem Cell."},{"key":"10.1016\/j.exer.2018.08.010_bib4","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.neuroscience.2016.12.027","article-title":"AAV-mediated transfer of RhoA shRNA and CNTF promotes retinal ganglion cell survival and axon regeneration","volume":"343","author":"Cen","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.exer.2018.08.010_bib5","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1097\/WNR.0b013e328355f1d6","article-title":"Long-term survival and axonal regeneration of retinal ganglion cells after optic nerve transection and a peripheral nerve graft","volume":"23","author":"Cen","year":"2012","journal-title":"Neuroreport"},{"key":"10.1016\/j.exer.2018.08.010_bib6","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1167\/iovs.06-0791","article-title":"Chemotactic effect of ciliary neurotrophic factor on macrophages in retinal ganglion cell survival and axonal regeneration","volume":"48","author":"Cen","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.08.010_bib7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.yexcr.2018.01.031","article-title":"DN604: a platinum(II) drug candidate with classic SAR can induce apoptosis via suppressing CK2-mediated p-cdc25C subcellular localization in cancer cells","volume":"364","author":"Chen","year":"2018","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.exer.2018.08.010_bib8","doi-asserted-by":"crossref","first-page":"11930","DOI":"10.1523\/JNEUROSCI.0443-17.2017","article-title":"CK2 oppositely modulates l-DOPA-induced dyskinesia via striatal projection neurons expressing D1 or D2 receptors","volume":"37","author":"Cort\u00e9s","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2018.08.010_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1089\/08977150360517155","article-title":"A new approach to CNS repair using chimeric peripheral nerve grafts","volume":"20","author":"Cui","year":"2003","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.exer.2018.08.010_bib10","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.neuroscience.2008.07.036","article-title":"The role of macrophages in optic nerve regeneration","volume":"158","author":"Cui","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.exer.2018.08.010_bib11","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/sj.cdd.4401604","article-title":"Protein kinase CK2 phosphorylates and upregulates Akt\/PKB","volume":"12","author":"Di Maira","year":"2005","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.exer.2018.08.010_bib12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s11010-011-0964-5","article-title":"Ikaros, CK2 kinase, and the road to leukemia","volume":"356","author":"Dovat","year":"2011","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.exer.2018.08.010_bib13","doi-asserted-by":"crossref","first-page":"8726","DOI":"10.1523\/JNEUROSCI.2774-04.2004","article-title":"Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation","volume":"24","author":"Fischer","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2018.08.010_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/(SICI)1097-4695(199907)40:1<55::AID-NEU5>3.0.CO;2-E","article-title":"Laminar restriction of retinal macrophagic response to optic nerve axotomy in the rat","volume":"40","author":"Garcia-Valenzuela","year":"1999","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.exer.2018.08.010_bib15","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1016\/j.cellsig.2008.08.016","article-title":"The interferon-gamma-mediated inhibition of lipoprotein lipase gene transcription in macrophages involves casein kinase 2- and phosphoinositide-3-kinase-mediated regulation of transcription factors Sp1 and Sp3","volume":"20","author":"Harris","year":"2008","journal-title":"Cell. Signal."},{"key":"10.1016\/j.exer.2018.08.010_bib16","doi-asserted-by":"crossref","first-page":"17221","DOI":"10.1074\/jbc.M410440200","article-title":"Casein kinase 2- and protein kinase A-regulated adenomatous polyposis coli and beta-catenin cellular localization is dependent on p38 MAPK","volume":"280","author":"Hildesheim","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2018.08.010_bib17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1471-2202-9-78","article-title":"Roles of PI3K and JAK pathways in viability of retinal ganglion cells after acute elevation of intraocular pressure in rats with different autoimmune backgrounds","volume":"9","author":"Huang","year":"2008","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.exer.2018.08.010_bib18","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.nbd.2015.07.001","article-title":"Dimethyl fumarate confers neuroprotection by casein kinase 2 phosphorylation of Nrf2 in murine intracerebral hemorrhage","volume":"82","author":"Iniaghe","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.exer.2018.08.010_bib19","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.intimp.2010.06.004","article-title":"Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2, JNK, NF-kappaB and AP-1 activation","volume":"10","author":"Jung","year":"2010","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.exer.2018.08.010_bib20","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.2353\/ajpath.2006.050533","article-title":"Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina","volume":"168","author":"Kramerov","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2018.08.010_bib21","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1523\/JNEUROSCI.20-12-04615.2000","article-title":"Lens injury stimulates axon regeneration in the mature rat optic nerve","volume":"20","author":"Leon","year":"2000","journal-title":"J. Neurosci. : Offic. J. Soc. Neurosci."},{"key":"10.1016\/j.exer.2018.08.010_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jep.2016.12.041","article-title":"Esculentoside A suppresses lipopolysaccharide-induced pro-inflammatory molecule production partially by casein kinase 2","volume":"198","author":"Li","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.exer.2018.08.010_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20021469","article-title":"Protein kinase CK2: structure, regulation and role in cellular decisions of life and death","volume":"369","author":"Litchfield","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.exer.2018.08.010_bib24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1084\/jem.20101202","article-title":"Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages","volume":"208","author":"London","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.exer.2018.08.010_bib25","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1111\/j.1460-9568.2007.05957.x","article-title":"Influence of macrophages and lymphocytes on the survival and axon regeneration of injured retinal ganglion cells in rats from different autoimmune backgrounds","volume":"26","author":"Luo","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.exer.2018.08.010_bib26","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/jnr.10520","article-title":"Pyrrolidine dithiocarbamate-induced neuronal cell death is mediated by Akt, casein kinase 2, c-Jun N-terminal kinase, and IkappaB kinase in embryonic hippocampal progenitor cells","volume":"71","author":"Min","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.exer.2018.08.010_bib27","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4252\/wjsc.v6.i2.111","article-title":"Progress of mesenchymal stem cell therapy for neural and retinal diseases","volume":"6","author":"Ng","year":"2014","journal-title":"World J. Stem Cell."},{"key":"10.1016\/j.exer.2018.08.010_bib28","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1139\/o04-116","article-title":"Order or chaos? An evaluation of the regulation of protein kinase CK2","volume":"82","author":"Olsten","year":"2004","journal-title":"Biochem. Cell. Biol.= Biochimie et Biol. Cellulaire"},{"key":"10.1016\/j.exer.2018.08.010_bib29","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1042\/BJ20080309","article-title":"The selectivity of inhibitors of protein kinase CK2: an update","volume":"415","author":"Pagano","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.exer.2018.08.010_bib30","doi-asserted-by":"crossref","first-page":"10806","DOI":"10.1523\/JNEUROSCI.3532-04.2004","article-title":"Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells","volume":"24","author":"Park","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2018.08.010_bib31","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1161566","article-title":"Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway","volume":"322","author":"Park","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.exer.2018.08.010_bib32","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/med.20207","article-title":"Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases","volume":"31","author":"Perez","year":"2011","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.exer.2018.08.010_bib33","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1242\/jcs.00074","article-title":"Protein kinase CK2: a challenge to canons","volume":"115","author":"Pinna","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.exer.2018.08.010_bib34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11010-005-3079-z","article-title":"Development and exploitation of CK2 inhibitors","volume":"274","author":"Sarno","year":"2005","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.exer.2018.08.010_bib35","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/BF02088827","article-title":"Depletion of catalytic and regulatory subunits of protein kinase CK2 by antisense oligonucleotide treatment of neuroblastoma cells","volume":"14","author":"Ulloa","year":"1994","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.exer.2018.08.010_bib36","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2174\/1568009043481687","article-title":"Protein kinase CK2 as regulator of cell survival: implications for cancer therapy","volume":"4","author":"Unger","year":"2004","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.exer.2018.08.010_bib37","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ncb1961","article-title":"MyosinV controls PTEN function and neuronal cell size","volume":"11","author":"van Diepen","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.exer.2018.08.010_bib38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0022-1759(94)90012-4","article-title":"Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications","volume":"174","author":"Van Rooijen","year":"1994","journal-title":"J. Immunol. Meth."},{"key":"10.1016\/j.exer.2018.08.010_bib39","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1073\/pnas.1211284110","article-title":"Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death","volume":"110","author":"Welsbie","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2018.08.010_bib40","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1523\/JNEUROSCI.23-06-02284.2003","article-title":"Macrophage-derived factors stimulate optic nerve regeneration","volume":"23","author":"Yin","year":"2003","journal-title":"J. Neurosci. : Offic. J. Soc. Neurosci."},{"key":"10.1016\/j.exer.2018.08.010_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/167323","article-title":"CK2 secreted by Leishmania braziliensis Mediates macrophage association invasion: a comparative study between virulent and avirulent promastigotes","volume":"2015","author":"Zylbersztejn","year":"2015","journal-title":"BioMed Res. Int."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518304676?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518304676?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,24]],"date-time":"2018-11-24T13:25:22Z","timestamp":1543065922000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483518304676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":41,"alternative-id":["S0014483518304676"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2018.08.010","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Casein kinase-II inhibition promotes retinal ganglion cell survival and axonal regeneration","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2018.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}