{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:22:41Z","timestamp":1792635761187,"version":"4.5.0"},"reference-count":194,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008071","name":"Glaucoma Research Society of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.exer.2018.11.005","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T02:44:13Z","timestamp":1542163453000},"page":"88-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"special_numbering":"C","title":["All roads lead to glaucoma: Induced retinal injury cascades contribute to a common neurodegenerative outcome"],"prefix":"10.1016","volume":"183","author":[{"given":"Samih","family":"Alqawlaq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Flanagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8776-223X","authenticated-orcid":false,"given":"Jeremy M.","family":"Sivak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.exer.2018.11.005_bib1","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1523\/JNEUROSCI.3882-16.2017","article-title":"Axonal degeneration in retinal ganglion cells is associated with a membrane polarity-sensitive redox process","volume":"37","author":"Almasieh","year":"2017","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","article-title":"The molecular basis of retinal ganglion cell death in glaucoma","volume":"31","author":"Almasieh","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"issue":"7598","key":"10.1016\/j.exer.2018.11.005_bib3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nature17623","article-title":"Astrocyte scar formation aids central nervous system axon regeneration","volume":"532","author":"Anderson","year":"2016","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.optom.2014.05.005","article-title":"Diurnal versus office-hour intraocular pressure fluctuation in primary adult onset glaucoma","volume":"8","author":"Arora","year":"2015","journal-title":"J Optom"},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib5","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00061198-200004000-00002","article-title":"Large diurnal fluctuations in intraocular pressure are an independent risk factor in patients with glaucoma","volume":"9","author":"Asrani","year":"2000","journal-title":"J. Glaucoma"},{"issue":"12","key":"10.1016\/j.exer.2018.11.005_bib6","doi-asserted-by":"crossref","first-page":"5412","DOI":"10.1167\/iovs.08-2228","article-title":"Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study","volume":"49","author":"Berdahl","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.11.005_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2016.00013","article-title":"Cellular senescence as the causal nexus of aging","volume":"7","author":"Bhatia-Dey","year":"2016","journal-title":"Front. Genet."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ophtha.2007.03.086","article-title":"Comparison of optic nerve head topography and visual field in eyes with open-angle and angle-closure glaucoma","volume":"115","author":"Boland","year":"2008","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib9","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1167\/iovs.07-1337","article-title":"Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA\/2J mouse model of glaucoma","volume":"49","author":"Bosco","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.exer.2018.11.005_bib10","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1242\/dmm.018788","article-title":"Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma","volume":"8","author":"Bosco","year":"2015","journal-title":"Disease Models & Mechanisms"},{"issue":"6","key":"10.1016\/j.exer.2018.11.005_bib11","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1001\/archopht.120.6.791","article-title":"The distribution of mitochondrial activity in relation to optic nerve structure","volume":"120","author":"Bristow","year":"2002","journal-title":"Arch. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2018.11.005_bib12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.preteyeres.2004.06.001","article-title":"The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage","volume":"24","author":"Burgoyne","year":"2005","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2018.11.005_bib13","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.exer.2017.01.007","article-title":"The challenge of regenerative therapies for the optic nerve in glaucoma","volume":"157","author":"Calkins","year":"2017","journal-title":"Exp. Eye Res."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib14","doi-asserted-by":"crossref","first-page":"021005","DOI":"10.1115\/1.4026286","article-title":"Biomechanics of the posterior eye: a critical role in health and disease","volume":"136","author":"Campbell","year":"2014","journal-title":"J. Biomech. Eng."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.neuroscience.2003.08.018","article-title":"Investigating the synergistic effect of combined neurotrophic factor concentration gradients to guide axonal growth","volume":"122","author":"Cao","year":"2003","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib193","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.ophtha.2015.11.031","article-title":"Associations with intraocular pressure in a large cohort: results from the UK biobank","volume":"123","author":"Chan","year":"2016","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.exer.2018.11.005_bib16","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S1044-7431(03)00068-X","article-title":"Neurons and astrocytes secrete factors that cause stem cells to differentiate into neurons and astrocytes, respectively","volume":"23","author":"Chang","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"issue":"10","key":"10.1016\/j.exer.2018.11.005_bib17","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.ophtha.2014.04.016","article-title":"Nocturnal systemic hypotension increases the risk of glaucoma progression","volume":"121","author":"Charlson","year":"2014","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.exer.2018.11.005_bib18","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1038\/s41467-018-05681-9","article-title":"Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma","volume":"9","author":"Chen","year":"2018","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib19","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/IJG.0b013e31814b9971","article-title":"Comparing glaucomatous optic neuropathy in primary open angle and primary angle closure glaucoma eyes by scanning laser polarimetry-variable corneal compensation","volume":"17","author":"Chen","year":"2008","journal-title":"J. Glaucoma"},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib20","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/IJG.0b013e31824083ca","article-title":"The prevalence of primary glaucoma in mainland China: a systematic review and meta-analysis","volume":"22","author":"Cheng","year":"2013","journal-title":"J. Glaucoma"},{"issue":"1","key":"10.1016\/j.exer.2018.11.005_bib21","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.coph.2012.09.003","article-title":"Ocular perfusion pressure and ocular blood flow in glaucoma","volume":"13","author":"Cherecheanu","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/ICU.0000000000000125","article-title":"Glial cell interactions and glaucoma","volume":"26","author":"Chong","year":"2015","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.exer.2018.11.005_bib23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neulet.2014.01.014","article-title":"Astrogliosis as a therapeutic target for neurodegenerative diseases","volume":"565","author":"Colangelo","year":"2014","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.exer.2018.11.005_bib24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jcjo.2012.02.003","article-title":"Epidemiology of glaucoma: what's new?","volume":"47","author":"Cook","year":"2012","journal-title":"Can. J. Ophthalmol."},{"key":"10.1016\/j.exer.2018.11.005_bib25","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1093\/brain\/awx088","article-title":"Real-time imaging of single neuronal cell apoptosis in patients with glaucoma","volume":"140","author":"Cordeiro","year":"2017","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.exer.2018.11.005_bib26","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1167\/iovs.15-18193","article-title":"Effects of peripapillary scleral stiffening on the deformation of the lamina cribrosa","volume":"57","author":"Coudrillier","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.exer.2018.11.005_bib27","first-page":"1954","article-title":"Expression of trkA, trkB, and trkC in injured and regenerating retinal ganglion cells of adult rats","volume":"43","author":"Cui","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"53\u201354","key":"10.1016\/j.exer.2018.11.005_bib28","first-page":"467","article-title":"Microglia and macrophages are increased in response to ischemia-induced retinopathy in the mouse retina","volume":"12","author":"Davies","year":"2006","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2018.11.005_bib29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.exer.2018.03.006","article-title":"Bilateral early activation of retinal microglial cells in a mouse model of unilateral laser-induced experimental ocular hypertension","volume":"171","author":"de Hoz","year":"2018","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2018.11.005_bib30","doi-asserted-by":"crossref","DOI":"10.1097\/IJG.0000000000000981","article-title":"Perspective: new recommendations for the treatment of systemic hypertension and their potential implications for glaucoma management","author":"De Moraes","year":"2018","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.exer.2018.11.005_bib31","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.brainresbull.2017.01.021","article-title":"Drugs targeting intermediate filaments can improve neurosupportive properties of astrocytes","volume":"136","author":"de Pablo","year":"2018","journal-title":"Brain Res. Bull."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib32","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1088\/1741-2560\/3\/2\/011","article-title":"Optimizing neurotrophic factor combinations for neurite outgrowth","volume":"3","author":"Deister","year":"2006","journal-title":"J. Neural. Eng."},{"issue":"1","key":"10.1016\/j.exer.2018.11.005_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087420","article-title":"Astrocyte-derived proinflammatory cytokines induce hypomyelination in the periventricular white matter in the hypoxic neonatal brain","volume":"9","author":"Deng","year":"2014","journal-title":"PloS One"},{"issue":"7","key":"10.1016\/j.exer.2018.11.005_bib34","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1073\/pnas.95.7.3978","article-title":"Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Muller cells temporarily rescues injured retinal ganglion cells","volume":"95","author":"Di Polo","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2018.11.005_bib35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.exer.2015.02.011","article-title":"Optic nerve head biomechanics in aging and disease","volume":"133","author":"Downs","year":"2015","journal-title":"Exp. Eye Res."},{"issue":"12","key":"10.1016\/j.exer.2018.11.005_bib36","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.1167\/iovs.10-5284","article-title":"Microglial activation in the visual pathway in experimental glaucoma: spatiotemporal characterization and correlation with axonal injury","volume":"51","author":"Ebneter","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib37","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.yexcr.2015.11.023","article-title":"Biomechanical insult switches PEA-15 activity to uncouple its anti-apoptotic function and promote erk mediated tissue remodeling","volume":"340","author":"Exler","year":"2016","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.exer.2018.11.005_bib38","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.pneurobio.2016.03.009","article-title":"Targeting astrocytes in CNS injury and disease: a translational research approach","volume":"144","author":"Filous","year":"2016","journal-title":"Prog. Neurobiol."},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib39","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1001\/archopht.122.4.532","article-title":"Prevalence of open-angle glaucoma among adults in the United States","volume":"122","author":"Friedman","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2018.11.005_bib40","doi-asserted-by":"crossref","DOI":"10.1186\/1742-2094-9-92","article-title":"IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma","volume":"9","author":"Gallego","year":"2012","journal-title":"J. Neuroinflammation"},{"issue":"6","key":"10.1016\/j.exer.2018.11.005_bib194","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1001\/archopht.120.6.714","article-title":"The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma","volume":"120","author":"Gordon","year":"2002","journal-title":"Arch. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0057557","article-title":"Enhanced insight into the autoimmune component of glaucoma: IgG autoantibody accumulation and pro-inflammatory conditions in human glaucomatous retina","volume":"8","author":"Gramlich","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.exer.2018.11.005_bib42","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12974-016-0542-6","article-title":"Immune response after intermittent minimally invasive intraocular pressure elevations in an experimental animal model of glaucoma","volume":"13","author":"Gramlich","year":"2016","journal-title":"J. Neuroinflammation"},{"issue":"6203","key":"10.1016\/j.exer.2018.11.005_bib43","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1126\/science.1250256","article-title":"Metabolic control of cell death","volume":"345","author":"Green","year":"2014","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.exer.2018.11.005_bib44","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1167\/iovs.04-0832","article-title":"Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix","volume":"46","author":"Guo","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib45","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.ajpath.2013.12.012","article-title":"PGC-1 alpha signaling coordinates susceptibility to metabolic and oxidative injury in the inner retina","volume":"184","author":"Guo","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2018.11.005_bib46","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.nbd.2018.02.004","article-title":"The AMPK-PGC-1alpha signaling axis regulates the astrocyte glutathione system to protect against oxidative and metabolic injury","volume":"113","author":"Guo","year":"2018","journal-title":"Neurobiol. Dis."},{"issue":"21","key":"10.1016\/j.exer.2018.11.005_bib47","doi-asserted-by":"crossref","first-page":"9228","DOI":"10.1523\/JNEUROSCI.22-21-09228.2002","article-title":"Microglia-Muller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration","volume":"22","author":"Harada","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2018.11.005_bib48","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0079-6123(08)01125-4","article-title":"Astrocytes in glaucomatous optic neuropathy","volume":"173","author":"Hernandez","year":"2008","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.exer.2018.11.005_bib49","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ejphar.2016.04.031","article-title":"Autoimmune aspects in glaucoma","volume":"787","author":"Hohenstein-Blaul","year":"2016","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib50","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/eye.2016.300","article-title":"Biomarkers for glaucoma: from the lab to the clinic","volume":"31","author":"Hohenstein-Blaul","year":"2017","journal-title":"Eye"},{"key":"10.1016\/j.exer.2018.11.005_bib51","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ceb.2015.02.004","article-title":"Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system","volume":"32","author":"Hol","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib52","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1172\/JCI61135","article-title":"Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma","volume":"122","author":"Howell","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.exer.2018.11.005_bib53","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/ng.3087","article-title":"Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma","volume":"46","author":"Hysi","year":"2014","journal-title":"Nat. Genet."},{"issue":"Suppl. 1","key":"10.1016\/j.exer.2018.11.005_bib54","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1463-5224.2007.00504.x","article-title":"Retrograde axonal transport obstruction of brain-derived neurotrophic factor (BDNF) and its TrkB receptor in the retina and optic nerve of American Cocker Spaniel dogs with spontaneous glaucoma","volume":"10","author":"Iwabe","year":"2007","journal-title":"Vet. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib55","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.0953-816X.2003.03107.x","article-title":"CNTF promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathway","volume":"19","author":"Ji","year":"2004","journal-title":"Eur. J. Neurosci."},{"issue":"7","key":"10.1016\/j.exer.2018.11.005_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040616","article-title":"Retinal ganglion cell loss is accompanied by antibody depositions and increased levels of microglia after immunization with retinal antigens","volume":"7","author":"Joachim","year":"2012","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib57","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s12031-013-0125-2","article-title":"Apoptotic retinal ganglion cell death in an autoimmune glaucoma model is accompanied by antibody depositions","volume":"52","author":"Joachim","year":"2014","journal-title":"J. Mol. Neurosci."},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib58","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.exer.2009.02.004","article-title":"Neurotrophin roles in retinal ganglion cell survival: lessons from rat glaucoma models","volume":"88","author":"Johnson","year":"2009","journal-title":"Exp. Eye Res."},{"issue":"5","key":"10.1016\/j.exer.2018.11.005_bib59","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/IJG.0b013e31818c6ef6","article-title":"Friend or foe? Resolving the impact of glial responses in glaucoma","volume":"18","author":"Johnson","year":"2009","journal-title":"J. Glaucoma"},{"issue":"7432","key":"10.1016\/j.exer.2018.11.005_bib60","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nature11861","article-title":"mTOR is a key modulator of ageing and age-related disease","volume":"493","author":"Johnson","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.exer.2018.11.005_bib61","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.preteyeres.2015.01.002","article-title":"Facts and myths of cerebrospinal fluid pressure for the physiology of the eye","volume":"46","author":"Jonas","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2018.11.005_bib62","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.preteyeres.2015.01.002","article-title":"Facts and myths of cerebrospinal fluid pressure for the physiology of the eye","volume":"46","author":"Jonas","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"issue":"1","key":"10.1016\/j.exer.2018.11.005_bib63","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1111\/aos.12480","article-title":"Estimated trans-lamina cribrosa pressure difference versus intraocular pressure as biomarker for open-angle glaucoma. The Beijing Eye Study 2011","volume":"93","author":"Jonas","year":"2015","journal-title":"Acta Ophthalmol."},{"issue":"106","key":"10.1016\/j.exer.2018.11.005_bib64","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2015.0066","article-title":"Quantitative analysis of three-dimensional fibrillar collagen microstructure within the normal, aged and glaucomatous human optic nerve head","volume":"12","author":"Jones","year":"2015","journal-title":"J. R. Soc. Interface"},{"issue":"9","key":"10.1016\/j.exer.2018.11.005_bib65","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1093\/brain\/awq105","article-title":"Superoxide is an associated signal for apoptosis in axonal injury","volume":"133","author":"Kanamori","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.exer.2018.11.005_bib66","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.preteyeres.2014.11.004","article-title":"Retinal microglia: just bystander or target for therapy?","volume":"45","author":"Karlstetter","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"issue":"6","key":"10.1016\/j.exer.2018.11.005_bib67","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/archopht.120.6.701","article-title":"The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma","volume":"120","author":"Kass","year":"2002","journal-title":"Arch. Ophthalmol."},{"issue":"10","key":"10.1016\/j.exer.2018.11.005_bib68","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1038\/cdd.2017.101","article-title":"Ageing and hypoxia cause protein aggregation in mitochondria","volume":"24","author":"Kaufman","year":"2017","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib69","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2147\/OPTH.S3361","article-title":"Hypoxia-ischemia and retinal ganglion cell damage","volume":"2","author":"Kaur","year":"2008","journal-title":"Clin. Ophthalmol."},{"issue":"8","key":"10.1016\/j.exer.2018.11.005_bib70","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1001\/archopht.1997.01100160201010","article-title":"TUNEL-positive ganglion cells in human primary open-angle glaucoma","volume":"115","author":"Kerrigan","year":"1997","journal-title":"Arch. Ophthalmol."},{"issue":"9","key":"10.1016\/j.exer.2018.11.005_bib71","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17091584","article-title":"Neuroprotection, growth factors and BDNF-TrkB signalling in retinal degeneration","volume":"17","author":"Kimura","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib72","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1474-9726.2011.00690.x","article-title":"Increase in mitochondrial DNA mutations impairs retinal function and renders the retina vulnerable to injury","volume":"10","author":"Kong","year":"2011","journal-title":"Aging Cell"},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib73","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.bbagen.2013.10.041","article-title":"Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health","volume":"1840","author":"Kotiadis","year":"2014","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"issue":"32","key":"10.1016\/j.exer.2018.11.005_bib74","doi-asserted-by":"crossref","first-page":"13469","DOI":"10.1073\/pnas.0906678106","article-title":"Experimental and clinical evidence of neuroprotection by nerve growth factor eye drops: implications for glaucoma","volume":"106","author":"Lambiase","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"17","key":"10.1016\/j.exer.2018.11.005_bib75","doi-asserted-by":"crossref","first-page":"5536","DOI":"10.1523\/JNEUROSCI.0831-09.2009","article-title":"Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism","volume":"29","author":"Lebrun-Julien","year":"2009","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib76","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1167\/iovs.13-12564","article-title":"Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma","volume":"55","author":"Lee","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.11.005_bib77","first-page":"9","article-title":"Fluctuation in systolic blood pressure is a major systemic risk factor for development of primary open-angle glaucoma","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib78","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/ICU.0b013e32831eef82","article-title":"Ocular perfusion pressure and glaucoma: clinical trial and epidemiologic findings","volume":"20","author":"Leske","year":"2009","journal-title":"Curr. Opin. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2018.11.005_bib79","first-page":"89","article-title":"Incidence of open-angle glaucoma: the Barbados eye studies. The Barbados eye studies group","volume":"119","author":"Leske","year":"2001","journal-title":"Arch. Ophthalmol."},{"issue":"11","key":"10.1016\/j.exer.2018.11.005_bib80","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.ophtha.2007.03.016","article-title":"Predictors of long-term progression in the early manifest glaucoma trial","volume":"114","author":"Leske","year":"2007","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2018.11.005_bib81","first-page":"341","article-title":"p53 regulates apoptotic retinal ganglion cell death induced by N-methyl-D-aspartate","volume":"8","author":"Li","year":"2002","journal-title":"Mol. Vis."},{"issue":"7638","key":"10.1016\/j.exer.2018.11.005_bib82","doi-asserted-by":"crossref","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.exer.2018.11.005_bib83","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1001\/jamaophthalmol.2015.1440","article-title":"Association of geroprotective effects of metformin and risk of open-angle glaucoma in persons with diabetes mellitus","volume":"133","author":"Lin","year":"2015","journal-title":"Jama Ophthalmology"},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib84","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.expneurol.2004.02.002","article-title":"GDNF, Ret, GFRalpha1 and 2 in the adult rat retino-tectal system after optic nerve transection","volume":"187","author":"Lindqvist","year":"2004","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib85","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/(SICI)1098-1136(200004)30:2<178::AID-GLIA7>3.0.CO;2-C","article-title":"Expression of nitric oxide synthase-2 (NOS-2) in reactive astrocytes of the human glaucomatous optic nerve head","volume":"30","author":"Liu","year":"2000","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.exer.2018.11.005_bib86","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1167\/iovs.16-20576","article-title":"A mouse model of chronic ocular hypertension induced by circumlimbal suture","volume":"58","author":"Liu","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"9","key":"10.1016\/j.exer.2018.11.005_bib87","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1001\/jamaophthalmol.2015.2225","article-title":"Optical coherence tomography angiography of the peripapillary retina in glaucoma","volume":"133","author":"Liu","year":"2015","journal-title":"JAMA Ophthalmol"},{"issue":"9","key":"10.1016\/j.exer.2018.11.005_bib88","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.277","article-title":"Pharmacologic inhibition of reactive gliosis blocks TNF-alpha-mediated neuronal apoptosis","volume":"7","author":"Livne-Bar","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2018.11.005_bib89","doi-asserted-by":"crossref","DOI":"10.1172\/JCI77398","article-title":"Astrocyte-derived lipoxins A4 and B4 promote neuroprotection from acute and chronic injury","author":"Livne-Bar","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exer.2018.11.005_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.01.002","article-title":"BAX to basics: how the BCL2 gene family controls the death of retinal ganglion cells","volume":"57","author":"Maes","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"issue":"5","key":"10.1016\/j.exer.2018.11.005_bib92","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1073\/pnas.91.5.1632","article-title":"Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion-cells","volume":"91","author":"Mansourrobaey","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.exer.2018.11.005_bib93","doi-asserted-by":"crossref","first-page":"588","DOI":"10.5301\/ejo.5000789","article-title":"Relationship between blood pressure and retrobulbar blood flow in dipper and nondipper primary open-angle glaucoma patients","volume":"26","author":"Marjanovic","year":"2016","journal-title":"Eur. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib94","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.exer.2005.11.025","article-title":"Optic nerve dynein motor protein distribution changes with intraocular pressure elevation in a rat model of glaucoma","volume":"83","author":"Martin","year":"2006","journal-title":"Exp. Eye Res."},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib95","first-page":"1077","article-title":"Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension","volume":"43","author":"McKinnon","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.exer.2018.11.005_bib96","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.ophtha.2014.01.017","article-title":"Rates of retinal nerve fiber layer thinning in glaucoma suspect eyes","volume":"121","author":"Miki","year":"2014","journal-title":"Ophthalmology"},{"issue":"12","key":"10.1016\/j.exer.2018.11.005_bib97","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/nn.4428","article-title":"Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles","volume":"19","author":"Mishra","year":"2016","journal-title":"Nat. Neurosci."},{"issue":"3","key":"10.1016\/j.exer.2018.11.005_bib98","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.tibs.2013.12.006","article-title":"Many players in BCL-2 family affairs","volume":"39","author":"Moldoveanu","year":"2014","journal-title":"Trends Biochem. Sci."},{"issue":"10","key":"10.1016\/j.exer.2018.11.005_bib99","first-page":"3236","article-title":"Optic disc movement with variations in intraocular and cerebrospinal fluid pressure","volume":"43","author":"Morgan","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib100","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/cdd.2014.149","article-title":"REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury","volume":"22","author":"Morquette","year":"2015","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.exer.2018.11.005_bib101","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.coph.2012.10.001","article-title":"New insights in the pathogenesis and treatment of normal tension glaucoma","volume":"13","author":"Mozaffarieh","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"issue":"1","key":"10.1016\/j.exer.2018.11.005_bib102","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1001\/2013.jamaophthalmol.1","article-title":"Primary open-angle glaucoma vs normal-tension glaucoma: the vascular perspective","volume":"131","author":"Mroczkowska","year":"2013","journal-title":"JAMA Ophthalmol"},{"issue":"12","key":"10.1016\/j.exer.2018.11.005_bib103","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083049","article-title":"ROS detoxification and proinflammatory cytokines are linked by p38 MAPK signaling in a model of mature astrocyte activation","volume":"8","author":"Nahirnyj","year":"2013","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib104","article-title":"Microglia in the optic nerve head and the parapapillary region of normal and glaucomatous human eyes","volume":"40","author":"Neufeld","year":"1999","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.exer.2018.11.005_bib105","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1177\/1073858403253460","article-title":"Glaucornatous optic neuropathy: when glia misbehave","volume":"9","author":"Neufeld","year":"2003","journal-title":"Neuroscientist"},{"key":"10.1016\/j.exer.2018.11.005_bib106","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.exer.2015.05.024","article-title":"Biomechanical assessment in models of glaucomatous optic neuropathy","volume":"141","author":"Nguyen","year":"2015","journal-title":"Exp. Eye Res."},{"issue":"Suppl. 1","key":"10.1016\/j.exer.2018.11.005_bib107","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.1016\/S0039-6257(99)00029-6","article-title":"Apoptosis of retinal ganglion cells in glaucoma: an update of the molecular pathways involved in cell death","volume":"43","author":"Nickells","year":"1999","journal-title":"Surv. Ophthalmol."},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib108","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s12031-015-0707-2","article-title":"Retinal and optic nerve damage is associated with early glial responses in an experimental autoimmune glaucoma model","volume":"58","author":"Noristani","year":"2016","journal-title":"J. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.exer.2018.11.005_bib109","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.exer.2010.09.014","article-title":"Finite element modeling of the human sclera: influence on optic nerve head biomechanics and connections with glaucoma","volume":"93","author":"Norman","year":"2011","journal-title":"Exp. Eye Res."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib110","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0021-5155(97)00013-0","article-title":"Apoptosis in retinal ganglion cell decrease in human glaucomatous eyes","volume":"41","author":"Okisaka","year":"1997","journal-title":"Jpn. J. Ophthalmol."},{"issue":"6","key":"10.1016\/j.exer.2018.11.005_bib195","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s00417-006-0457-5","article-title":"Vascular risk factors in glaucoma: the results of a national survey","volume":"245","author":"Orzalesi","year":"2007","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"issue":"10","key":"10.1016\/j.exer.2018.11.005_bib111","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.drudis.2014.05.010","article-title":"Targeting mitochondrial dysfunction as in aging and glaucoma","volume":"19","author":"Osborne","year":"2014","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.exer.2018.11.005_bib112","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mito.2016.11.009","article-title":"Visual light effects on mitochondria: the potential implications in relation to glaucoma","volume":"36","author":"Osborne","year":"2017","journal-title":"Mitochondrion"},{"key":"10.1016\/j.exer.2018.11.005_bib113","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejphar.2016.04.032","article-title":"Glaucoma: focus on mitochondria in relation to pathogenesis and neuroprotection","volume":"787","author":"Osborne","year":"2016","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.exer.2018.11.005_bib114","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00439-013-1349-5","article-title":"Genome-wide association study and meta-analysis of intraocular pressure","volume":"133","author":"Ozel","year":"2014","journal-title":"Hum. Genet."},{"key":"10.1016\/j.exer.2018.11.005_bib115","series-title":"Biology and Pathology of Astrocyte-neuron Interactions","first-page":"103","article-title":"Neurotrophic factors produced by astrocytes involved in the regulation of cholinergic neurons in the central nervous system","author":"Patel","year":"1993"},{"issue":"3","key":"10.1016\/j.exer.2018.11.005_bib116","first-page":"764","article-title":"Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma","volume":"41","author":"Pease","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib117","first-page":"489","article-title":"Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative in vivo study","volume":"37","author":"Peinado-Ram\u00f3n","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib118","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1152\/physrev.00041.2013","article-title":"Astrocyte reactivity and reactive astrogliosis: costs and benefits","volume":"94","author":"Pekny","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exer.2018.11.005_bib119","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neulet.2013.12.071","article-title":"The dual role of astrocyte activation and reactive gliosis","volume":"565","author":"Pekny","year":"2014","journal-title":"Neurosci. Lett."},{"issue":"6","key":"10.1016\/j.exer.2018.11.005_bib120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067094","article-title":"The Time Course of Gene Expression during Reactive Gliosis in the Optic Nerve","volume":"8","author":"Qu","year":"2013","journal-title":"PloS One"},{"issue":"15","key":"10.1016\/j.exer.2018.11.005_bib121","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1056\/NEJM199304153281507","article-title":"Open-angle glaucoma","volume":"328","author":"Quigley","year":"1993","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.exer.2018.11.005_bib122","first-page":"3460","article-title":"Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats","volume":"41","author":"Quigley","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"9","key":"10.1016\/j.exer.2018.11.005_bib123","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1001\/archopht.1980.01020040416003","article-title":"Clinical evaluation of nerve fiber layer atrophy as an indicator of glaucomatous optic nerve damage","volume":"98","author":"Quigley","year":"1980","journal-title":"Arch. Ophthalmol."},{"issue":"5","key":"10.1016\/j.exer.2018.11.005_bib124","first-page":"774","article-title":"Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis","volume":"36","author":"Quigley","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.11.005_bib125","article-title":"Neural control of choroidal blood flow","author":"Reiner","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib126","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ophtha.2009.06.058","article-title":"Cerebrospinal fluid pressure in glaucoma: a prospective study","volume":"117","author":"Ren","year":"2010","journal-title":"Ophthalmology"},{"issue":"7","key":"10.1016\/j.exer.2018.11.005_bib127","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s00417-011-1657-1","article-title":"Trans-lamina cribrosa pressure difference correlated with neuroretinal rim area in glaucoma","volume":"249","author":"Ren","year":"2011","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib128","doi-asserted-by":"crossref","first-page":"e142","DOI":"10.1111\/j.1755-3768.2010.02015.x","article-title":"Cerebrospinal fluid pressure in ocular hypertension","volume":"89","author":"Ren","year":"2011","journal-title":"Acta Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib129","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.012302","article-title":"Proteomics analyses of human optic nerve head astrocytes following biomechanical strain","volume":"11","author":"Rogers","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.exer.2018.11.005_bib130","doi-asserted-by":"crossref","DOI":"10.1186\/1742-2094-11-133","article-title":"Microglia in mouse retina contralateral to experimental glaucoma exhibit multiple signs of activation in all retinal layers","volume":"11","author":"Rojas","year":"2014","journal-title":"J. Neuroinflammation"},{"issue":"10","key":"10.1016\/j.exer.2018.11.005_bib131","first-page":"1968","article-title":"Anti-rhodopsin antibodies in sera from patients with normal-pressure glaucoma","volume":"36","author":"Romano","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"15","key":"10.1016\/j.exer.2018.11.005_bib132","doi-asserted-by":"crossref","first-page":"6652","DOI":"10.1167\/iovs.16-20146","article-title":"Melanopsin-containing or non-melanopsin-containing retinal ganglion cells response to acute ocular hypertension with or without brain-derived neurotrophic factor neuroprotection","volume":"57","author":"Rovere","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib133","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/(SICI)1096-9861(20000221)417:4<431::AID-CNE4>3.0.CO;2-G","article-title":"Microglial cells in the retina of Carassius auratus: effects of optic nerve crush","volume":"417","author":"Salvador-Silva","year":"2000","journal-title":"J. Comp. Neurol."},{"issue":"7","key":"10.1016\/j.exer.2018.11.005_bib134","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1136\/bjo.2009.158279","article-title":"Ethnic differences in optic nerve head and retinal nerve fibre layer thickness parameters in children","volume":"94","author":"Samarawickrama","year":"2010","journal-title":"Br. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2018.11.005_bib135","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1167\/iovs.15-17841","article-title":"Apoptotic retinal ganglion cell death after optic nerve transection or crush in mice: delayed RGC loss with BDNF or a caspase 3 inhibitor","volume":"57","author":"Sanchez-Migallon","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.exer.2018.11.005_bib136","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S0002-9394(02)02156-6","article-title":"Rate of progression of glaucoma correlates with retrobulbar circulation and intraocular pressure","volume":"135","author":"Satilmis","year":"2003","journal-title":"Am. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib137","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1167\/iovs.09-4247","article-title":"Tumor necrosis factor-alpha concentrations in the aqueous humor of patients with glaucoma","volume":"51","author":"Sawada","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib138","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1046\/j.1460-9568.2002.01893.x","article-title":"Dose-dependent rescue of axotomized rat retinal ganglion cells by adenovirus-mediated expression of glial cell-line derived neurotrophic factor in vivo","volume":"15","author":"Schmeer","year":"2002","journal-title":"Eur. J. Neurosci."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib139","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1167\/iovs.04-1033","article-title":"Relative change in diurnal mean ocular perfusion pressure: a risk factor for the diagnosis of primary open-angle glaucoma","volume":"46","author":"Sehi","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.11.005_bib140","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-1-62703-080-9_7","article-title":"N-methyl-D-aspartate (NMDA)-mediated excitotoxic damage: a mouse model of acute retinal ganglion cell damage","volume":"935","author":"Seitz","year":"2013","journal-title":"Methods Mol. Biol."},{"issue":"9","key":"10.1016\/j.exer.2018.11.005_bib141","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s11064-005-7936-7","article-title":"Muller cells as a source of brain-derived neurotrophic factor in the retina: noradrenaline upregulates brain-derived neurotrophic factor levels in cultured rat Muller cells","volume":"30","author":"Seki","year":"2005","journal-title":"Neurochem. Res."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib142","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/ICU.0b013e3282f3919b","article-title":"Normal-tension glaucoma: is it different from primary open-angle glaucoma?","volume":"19","author":"Shields","year":"2008","journal-title":"Curr. Opin. Ophthalmol."},{"issue":"12","key":"10.1016\/j.exer.2018.11.005_bib143","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186678","article-title":"Genetic analysis of Japanese primary open-angle glaucoma patients and clinical characterization of risk alleles near CDKN2B-AS1, SIX6 and GAS7","volume":"12","author":"Shiga","year":"2017","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib144","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1080\/02713683.2017.1396617","article-title":"Brain-derived neurotrophic factor in patients with primary open-angle glaucoma and age-related cataract","volume":"43","author":"Shpak","year":"2018","journal-title":"Curr. Eye Res."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib145","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10237-008-0120-7","article-title":"Modeling individual-specific human optic nerve head biomechanics. Part I: IOP-induced deformations and influence of geometry","volume":"8","author":"Sigal","year":"2009","journal-title":"Biomechanics Model. Mechanobiol."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib146","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10237-008-0119-0","article-title":"Modeling individual-specific human optic nerve head biomechanics. Part II: influence of material properties","volume":"8","author":"Sigal","year":"2009","journal-title":"Biomechanics Model. Mechanobiol."},{"key":"10.1016\/j.exer.2018.11.005_bib147","series-title":"Computational Fluid and Solid Mechanics 2003","first-page":"1810","article-title":"- Investigation of the biomechanical environment within the optic nerve head by finite element modelling","author":"Sigal","year":"2003"},{"issue":"1","key":"10.1016\/j.exer.2018.11.005_bib148","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1167\/iovs.12-10827","article-title":"The aging eye: common degenerative mechanisms between the Alzheimer's brain and retinal disease","volume":"54","author":"Sivak","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.exer.2018.11.005_bib149","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/cne.21279","article-title":"Rat retinal microglial cells under normal conditions, after optic nerve section, and after optic nerve section and intravitreal injection of trophic factors or macrophage inhibitory factor","volume":"501","author":"Sobrado-Calvo","year":"2007","journal-title":"J. Comp. Neurol."},{"issue":"8","key":"10.1016\/j.exer.2018.11.005_bib150","first-page":"1090","article-title":"Relationship between intraocular pressure and primary open angle glaucoma among white and black Americans","volume":"109","author":"Sommer","year":"1991","journal-title":"The Baltimore Eye Survey. Arch Ophthalmol"},{"issue":"3","key":"10.1016\/j.exer.2018.11.005_bib151","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/neu.20028","article-title":"Target-derived and locally derived neurotrophins support retinal ganglion cell survival in the neonatal rat retina","volume":"60","author":"Spalding","year":"2004","journal-title":"J. Neurobiol."},{"issue":"5","key":"10.1016\/j.exer.2018.11.005_bib152","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1084\/jem.20160412","article-title":"Optic nerve astrocyte reactivity protects function in experimental glaucoma and other nerve injuries","volume":"214","author":"Sun","year":"2017","journal-title":"J. Exp. Med."},{"issue":"8","key":"10.1016\/j.exer.2018.11.005_bib153","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/glia.22507","article-title":"Reversible reactivity by optic nerve astrocytes","volume":"61","author":"Sun","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.exer.2018.11.005_bib154","first-page":"145","article-title":"Jaskra prosta doswiadczalna","volume":"3","author":"Szymansky","year":"1925","journal-title":"Klin. Oczna."},{"issue":"Suppl. 3","key":"10.1016\/j.exer.2018.11.005_bib155","doi-asserted-by":"crossref","first-page":"S268","DOI":"10.1016\/S0039-6257(01)00204-1","article-title":"In situ detection of apoptosis in normal pressure glaucoma. a preliminary examination","volume":"45","author":"Tatton","year":"2001","journal-title":"Surv. Ophthalmol."},{"issue":"11","key":"10.1016\/j.exer.2018.11.005_bib156","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167364","article-title":"Astrocyte structural and molecular response to elevated intraocular pressure occurs rapidly and precedes axonal tubulin rearrangement within the optic nerve head in a rat model","volume":"11","author":"Tehrani","year":"2016","journal-title":"PloS One"},{"issue":"5","key":"10.1016\/j.exer.2018.11.005_bib157","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.preteyeres.2006.07.003","article-title":"Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences","volume":"25","author":"Tezel","year":"2006","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2018.11.005_bib158","first-page":"409","article-title":"TNF-alpha signaling in glaucomatous neurodegeneration","volume":"173","author":"Tezel","year":"2008","journal-title":"Glaucoma: an Open Window to Neurodegeneration and Neuroprotection"},{"issue":"3","key":"10.1016\/j.exer.2018.11.005_bib159","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1167\/iovs.08-2717","article-title":"The role of glia, mitochondria, and the immune system in glaucoma","volume":"50","author":"Tezel","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.exer.2018.11.005_bib160","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1001\/archopht.117.7.917","article-title":"Serum autoantibodies to optic nerve head glycosaminoglycans in patients with glaucoma","volume":"117","author":"Tezel","year":"1999","journal-title":"Arch. Ophthalmol."},{"issue":"12","key":"10.1016\/j.exer.2018.11.005_bib161","first-page":"2277","article-title":"Autoantibodies to small heat shock proteins in glaucoma","volume":"39","author":"Tezel","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"9","key":"10.1016\/j.exer.2018.11.005_bib162","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1001\/archopht.122.9.1348","article-title":"Hypoxia-inducible factor 1alpha in the glaucomatous retina and optic nerve head","volume":"122","author":"Tezel","year":"2004","journal-title":"Arch. Ophthalmol."},{"issue":"7","key":"10.1016\/j.exer.2018.11.005_bib163","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1016\/j.ophtha.2015.01.005","article-title":"Author reply: to PMID 24974815","volume":"122","author":"Tham","year":"2015","journal-title":"Ophthalmology"},{"issue":"11","key":"10.1016\/j.exer.2018.11.005_bib164","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"issue":"12","key":"10.1016\/j.exer.2018.11.005_bib165","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1111\/j.1460-9568.1991.tb00054.x","article-title":"The relationship of microglial cells to dying neurons during natural neuronal cell-death and axotomy-induced degeneration of the rat retina","volume":"3","author":"Thanos","year":"1991","journal-title":"Eur. J. Neurosci."},{"issue":"5","key":"10.1016\/j.exer.2018.11.005_bib166","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/09286580600850983","article-title":"Heidelberg Retinal Tomograph (HRT 2) parameters in primary open angle glaucoma and primary angle closure glaucoma: a comparative study in an Indian population","volume":"13","author":"Thomas","year":"2006","journal-title":"Ophthalmic Epidemiol."},{"issue":"3","key":"10.1016\/j.exer.2018.11.005_bib167","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/jama.1991.03470030069026","article-title":"Racial variations in the prevalence of primary open-angle glaucoma. The Baltimore Eye Survey","volume":"266","author":"Tielsch","year":"1991","journal-title":"J. Am. Med. Assoc."},{"issue":"3","key":"10.1016\/j.exer.2018.11.005_bib168","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1167\/iovs.15-16454","article-title":"BDNF rescues RGCs but not intrinsically photosensitive RGCs in ocular hypertensive albino rat retinas","volume":"56","author":"Valiente-Soriano","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"1\u20132","key":"10.1016\/j.exer.2018.11.005_bib169","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainresbull.2010.02.011","article-title":"Reaction of Muller cells in an experimental rat model of increased intraocular pressure following timolol, latanoprost and brimonidine","volume":"82","author":"Vidal","year":"2010","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.exer.2018.11.005_bib170","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-018-1056-2","article-title":"Essential roles of lactate in m\u00fcller cell survival and function","author":"Vohra","year":"2018","journal-title":"Mol. Neurobiol."},{"issue":"7","key":"10.1016\/j.exer.2018.11.005_bib171","first-page":"500","article-title":"[Essential element of the glaucomatous process neglected in clinical practice]","volume":"31","author":"Volkov","year":"1976","journal-title":"Oftalmol. Zh."},{"issue":"12","key":"10.1016\/j.exer.2018.11.005_bib172","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1167\/iovs.17-22015","article-title":"Lamina cribrosa pore shape and size as predictors of neural tissue mechanical insult","volume":"58","author":"Voorhees","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"11","key":"10.1016\/j.exer.2018.11.005_bib173","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/j.neurobiolaging.2008.10.019","article-title":"Age-related increase in mitochondrial DNA damage and loss of DNA repair capacity in the neural retina","volume":"31","author":"Wang","year":"2010","journal-title":"Neurobiol. Aging"},{"issue":"9","key":"10.1016\/j.exer.2018.11.005_bib174","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s00417-015-3095-y","article-title":"Correlation between optic disc perfusion and glaucomatous severity in patients with open-angle glaucoma: an optical coherence tomography angiography study","volume":"253","author":"Wang","year":"2015","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2018.11.005_bib175","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.exer.2010.08.016","article-title":"The case for autoimmunity in glaucoma","volume":"93","author":"Wax","year":"2011","journal-title":"Exp. Eye Res."},{"issue":"4","key":"10.1016\/j.exer.2018.11.005_bib176","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.exer.2009.02.005","article-title":"Immunoregulation of retinal ganglion cell fate in glaucoma","volume":"88","author":"Wax","year":"2009","journal-title":"Exp. Eye Res."},{"issue":"8","key":"10.1016\/j.exer.2018.11.005_bib177","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1001\/archopht.116.8.993","article-title":"Clinical and ocular histopathological findings in a patient with normal-pressure glaucoma","volume":"116","author":"Wax","year":"1998","journal-title":"Arch. Ophthalmol."},{"issue":"46","key":"10.1016\/j.exer.2018.11.005_bib178","doi-asserted-by":"crossref","first-page":"12085","DOI":"10.1523\/JNEUROSCI.3200-08.2008","article-title":"Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand","volume":"28","author":"Wax","year":"2008","journal-title":"J. Neurosci."},{"issue":"18","key":"10.1016\/j.exer.2018.11.005_bib179","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: a review","volume":"311","author":"Weinreb","year":"2014","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.exer.2018.11.005_bib180","doi-asserted-by":"crossref","first-page":"16067","DOI":"10.1038\/nrdp.2016.67","article-title":"Primary open-angle glaucoma","volume":"2","author":"Weinreb","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"6326","key":"10.1016\/j.exer.2018.11.005_bib181","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1126\/science.aal0092","article-title":"Vitamin B-3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice","volume":"355","author":"Williams","year":"2017","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.exer.2018.11.005_bib182","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1444-0938.2010.00546.x","article-title":"Clinical and experimental links between diabetes and glaucoma","volume":"94","author":"Wong","year":"2011","journal-title":"Clin. Exp. Optom."},{"issue":"Suppl. l","key":"10.1016\/j.exer.2018.11.005_bib183","first-page":"165","article-title":"Effect of decreased intracranial pressure on optic disc","volume":"18","author":"Yablonski","year":"1979","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.exer.2018.11.005_bib184","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1167\/iovs.13-13657","article-title":"Optic neuropathy induced by experimentally reduced cerebrospinal fluid pressure in monkeys","volume":"55","author":"Yang","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"12","key":"10.1016\/j.exer.2018.11.005_bib185","doi-asserted-by":"crossref","first-page":"5539","DOI":"10.1167\/iovs.07-0542","article-title":"Changes in gene expression in experimental glaucoma and optic nerve transection: the equilibrium between protective and detrimental mechanisms","volume":"48","author":"Yang","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.exer.2018.11.005_bib186","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/1098-1136(200010)32:1<42::AID-GLIA40>3.0.CO;2-3","article-title":"Tumor necrosis factor-alpha: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head","volume":"32","author":"Yuan","year":"2000","journal-title":"Glia"},{"issue":"3","key":"10.1016\/j.exer.2018.11.005_bib187","doi-asserted-by":"crossref","first-page":"563","DOI":"10.18388\/abp.2004_3545","article-title":"HIF-1: the knowns and unknowns of hypoxia sensing","volume":"51","author":"Zagorska","year":"2004","journal-title":"Acta Biochim. Pol."},{"issue":"18","key":"10.1016\/j.exer.2018.11.005_bib188","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1523\/JNEUROSCI.6221-11.2012","article-title":"Genomic analysis of reactive astrogliosis","volume":"32","author":"Zamanian","year":"2012","journal-title":"J. Neurosci. : the official journal of the Society for Neuroscience"},{"issue":"8","key":"10.1016\/j.exer.2018.11.005_bib189","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1167\/iovs.14-16045","article-title":"Axonal transport in the rat optic nerve following short-term reduction in cerebrospinal fluid pressure or elevation in intraocular pressure","volume":"56","author":"Zhang","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.exer.2018.11.005_bib190","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ajo.2014.05.029","article-title":"The association of blood pressure and primary open-angle glaucoma: a meta-analysis","volume":"158","author":"Zhao","year":"2014","journal-title":"Am. J. Ophthalmol."},{"issue":"8","key":"10.1016\/j.exer.2018.11.005_bib191","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102972","article-title":"Diabetes mellitus as a risk factor for open-angle glaucoma: a systematic review and meta-analysis","volume":"9","author":"Zhou","year":"2014","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.exer.2018.11.005_bib192","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) AND ROS-INDUCED ROS RELEASE","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518303774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518303774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:00:56Z","timestamp":1757998856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483518303774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":194,"alternative-id":["S0014483518303774"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2018.11.005","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"All roads lead to glaucoma: Induced retinal injury cascades contribute to a common neurodegenerative outcome","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2018.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}