{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:29:13Z","timestamp":1790188153476,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"The Norwegian Research Council","doi-asserted-by":"crossref","award":["EY019470"],"award-info":[{"award-number":["EY019470"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Health","award":["R01GM038765"],"award-info":[{"award-number":["R01GM038765"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.exer.2018.11.018","type":"journal-article","created":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T11:00:58Z","timestamp":1543662058000},"page":"53-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Resolvin D1, but not resolvin E1, transactivates the epidermal growth factor receptor to increase intracellular calcium and glycoconjugate secretion in rat and human conjunctival goblet cells"],"prefix":"10.1016","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1504-3201","authenticated-orcid":false,"given":"Rebecca","family":"Kaye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Botten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marit","family":"Lippestad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5867-9130","authenticated-orcid":false,"given":"Robin R.","family":"Hodges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor P.","family":"Utheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4627-8545","authenticated-orcid":false,"given":"Charles N.","family":"Serhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darlene A.","family":"Dartt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2018.11.018_bib1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/1521-1878(200008)22:8<697::AID-BIES3>3.0.CO;2-1","article-title":"The EGF receptor: a nexus for trafficking and signaling","volume":"22","author":"Carpenter","year":"2000","journal-title":"Bioessays"},{"key":"10.1016\/j.exer.2018.11.018_bib2","doi-asserted-by":"crossref","first-page":"C946","DOI":"10.1152\/ajpcell.00014.2006","article-title":"Effects of alpha1D-adrenergic receptors on shedding of biologically active EGF in freshly isolated lacrimal gland epithelial cells","volume":"291","author":"Chen","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.exer.2018.11.018_bib3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.mam.2017.03.005","article-title":"Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors","volume":"58","author":"Chiang","year":"2017","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.exer.2018.11.018_bib4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/sj.bjp.0705220","article-title":"A novel rat lipoxin A4 receptor that is conserved in structure and function","volume":"139","author":"Chiang","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.exer.2018.11.018_bib5","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1124\/pr.58.3.4","article-title":"The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo","volume":"58","author":"Chiang","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.exer.2018.11.018_bib6","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.exer.2003.10.005","article-title":"Control of mucin production by ocular surface epithelial cells","volume":"78","author":"Dartt","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2018.11.018_bib7","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.4049\/jimmunol.1000833","article-title":"Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation","volume":"186","author":"Dartt","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2018.11.018_bib8","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1097\/ICO.0b013e31823f789e","article-title":"Resolvin E1 (RX-10001) reduces corneal epithelial barrier disruption and protects against goblet cell loss in a murine model of dry eye","volume":"31","author":"de Paiva","year":"2012","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2018.11.018_bib9","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1089\/jop.2015.0064","article-title":"Ocular adverse events associated with antibody-drug conjugates in human clinical trials","volume":"31","author":"Eaton","year":"2015","journal-title":"J. Ocul. Pharmacol. Therapeut."},{"key":"10.1016\/j.exer.2018.11.018_bib10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1124\/jpet.300.2.385","article-title":"Novel lipid mediator regulators of endothelial cell proliferation and migration: aspirin-triggered-15R-lipoxin A(4) and lipoxin A(4)","volume":"300","author":"Fierro","year":"2002","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.exer.2018.11.018_bib11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3109\/15569527.2011.636118","article-title":"Trichomegaly and other external eye side effects associated with epidermal growth factor","volume":"31","author":"Fraunfelder","year":"2012","journal-title":"Cutan. Ocul. Toxicol."},{"key":"10.1016\/j.exer.2018.11.018_bib12","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.ejca.2006.11.016","article-title":"Classification and management of skin, hair, nail and mucosal side-effects of epidermal growth factor receptor (EGFR) inhibitors","volume":"43","author":"Galimont-Collen","year":"2007","journal-title":"Eur. J. Canc."},{"key":"10.1016\/j.exer.2018.11.018_bib13","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/mi.2015.53","article-title":"Interaction of IFN-gamma with cholinergic agonists to modulate rat and human goblet cell function","volume":"9","author":"Garcia-Posadas","year":"2016","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.exer.2018.11.018_bib14","doi-asserted-by":"crossref","first-page":"12162","DOI":"10.1038\/s41598-018-30002-x","article-title":"Context-dependent regulation of conjunctival goblet cell function by allergic mediators","volume":"8","author":"Garcia-Posadas","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2018.11.018_bib15","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.exer.2007.11.004","article-title":"Presence of EGF growth factor ligands and their effects on cultured rat conjunctival goblet cell proliferation","volume":"86","author":"Gu","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2018.11.018_bib16","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1167\/iovs.11-8748","article-title":"Role of histamine and its receptor subtypes in stimulation of conjunctival goblet cell secretion","volume":"53","author":"Hayashi","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.11.018_bib17","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1096\/fj.11-197061","article-title":"Histamine may induce airway remodeling through release of epidermal growth factor receptor ligands from bronchial epithelial cells","volume":"26","author":"Hirota","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.exer.2018.11.018_bib18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.exer.2012.08.010","article-title":"Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion","volume":"103","author":"Hodges","year":"2012","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2018.11.018_bib19","doi-asserted-by":"crossref","first-page":"36124","DOI":"10.1038\/srep36124","article-title":"Lipoxin A4 counter-regulates histamine-stimulated glycoconjugate secretion in conjunctival goblet cells","volume":"6","author":"Hodges","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2018.11.018_bib20","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/mi.2016.33","article-title":"Lipoxin A4 activates ALX\/FPR2 receptor to regulate conjunctival goblet cell secretion","volume":"10","author":"Hodges","year":"2017","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.exer.2018.11.018_bib21","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1167\/iovs.02-1117","article-title":"Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells","volume":"44","author":"Horikawa","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.11.018_bib22","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1006\/bbrc.1997.7051","article-title":"Cloning of rat Muc5AC mucin gene: comparison of its structure and tissue distribution to that of human and mouse homologues","volume":"236","author":"Inatomi","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2018.11.018_bib23","first-page":"43","article-title":"MUC5AC mucin is a component of the human precorneal tear film","volume":"40","author":"Jumblatt","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.11.018_bib24","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1167\/iovs.10-6199","article-title":"EGF stimulates lipoxin A4 synthesis and modulates repair in corneal epithelial cells through ERK and p38 activation","volume":"52","author":"Kenchegowda","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.11.018_bib25","doi-asserted-by":"crossref","first-page":"6928","DOI":"10.1167\/iovs.12-10163","article-title":"Effect of histamine on Ca(2+)-dependent signaling pathways in rat conjunctival goblet cells","volume":"53","author":"Li","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.11.018_bib26","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/mi.2013.7","article-title":"Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion","volume":"6","author":"Li","year":"2013","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.exer.2018.11.018_bib27","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1167\/iovs.17-21914","article-title":"Resolvin D1 increases mucin secretion in cultured rat conjunctival goblet cells via multiple signaling pathways","volume":"58","author":"Lippestad","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2018.11.018_bib28","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.exer.2018.04.015","article-title":"Signaling pathways activated by resolvin E1 to stimulate mucin secretion and increase intracellular Ca(2+) in cultured rat conjunctival goblet cells","volume":"173","year":"2018","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2018.11.018_bib29","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jtos.2015.11.002","article-title":"Economic and humanistic burden of dry eye disease in Europe, North America, and asia: a systematic literature review","volume":"14","author":"McDonald","year":"2016","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2018.11.018_bib30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1677\/erc.0.0080011","article-title":"The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification","volume":"8","author":"Prenzel","year":"2001","journal-title":"Endocr. Relat. Canc."},{"key":"10.1016\/j.exer.2018.11.018_bib31","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1465-9921-7-42","article-title":"CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1\/2 phosphorylation","volume":"7","author":"Ravasi","year":"2006","journal-title":"Respir. Res."},{"key":"10.1016\/j.exer.2018.11.018_bib32","series-title":"'Resolvyx Announces Positive Data \u2014 Phase 2 Trial of Resolvin RX-10045 for Dry Eye Syndrome'","year":"2009"},{"key":"10.1016\/j.exer.2018.11.018_bib33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.prostaglandins.2018.06.001","article-title":"Drawing a link between the thromboxane A2 pathway and the role of platelets and tumor cells in ovarian cancer","volume":"137","author":"Serhan","year":"2018","journal-title":"Prostag. Other Lipid Mediat."},{"key":"10.1016\/j.exer.2018.11.018_bib34","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/00003226-199907000-00003","article-title":"Results of a population-based questionnaire on the symptoms and lifestyles associated with dry eye","volume":"18","author":"Shimmura","year":"1999","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2018.11.018_bib35","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1073\/pnas.96.6.3081","article-title":"Epidermal growth factor system regulates mucin production in airways","volume":"96","author":"Takeyama","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2018.11.018_bib36","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1542-0124(12)70082-4","article-title":"The epidemiology of dry eye disease: report of the epidemiology subcommittee of the international dry eye WorkShop","volume":"5","year":"2007","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2018.11.018_bib37","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/sj.ki.5000025","article-title":"Lipoxin A4 inhibits connective tissue growth factor-induced production of chemokines in rat mesangial cells","volume":"69","author":"Wu","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.exer.2018.11.018_bib38","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1097\/ICO.0b013e318064584a","article-title":"Acquired trichomegaly and symptomatic external ocular changes in patients receiving epidermal growth factor receptor inhibitors: case reports and a review of literature","volume":"26","author":"Zhang","year":"2007","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2018.11.018_bib39","first-page":"274","article-title":"Resolvin D1 promotes corneal epithelial wound healing and restoration of mechanical sensation in diabetic mice","volume":"24","author":"Zhang","year":"2018","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2018.11.018_bib40","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/j.bbamcr.2017.07.001","article-title":"The shedding protease ADAM17: physiology and pathophysiology","volume":"1864","author":"Zunke","year":"2017","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518306973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518306973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T16:47:47Z","timestamp":1550854067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483518306973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":40,"alternative-id":["S0014483518306973"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2018.11.018","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resolvin D1, but not resolvin E1, transactivates the epidermal growth factor receptor to increase intracellular calcium and glycoconjugate secretion in rat and human conjunctival goblet cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2018.11.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}