{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:17:39Z","timestamp":1790777859603,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.exer.2019.01.002","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T23:19:51Z","timestamp":1546989591000},"page":"90-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Suppression of neovascularization in corneal stroma in a TRPA1-null mouse"],"prefix":"10.1016","volume":"181","author":[{"given":"Keiko","family":"Usui-Kusumoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Iwanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Sumioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayasu","family":"Miyajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Reinach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuya","family":"Saika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2019.01.002_bib1","first-page":"264","article-title":"Corneal angiogenic privilege: angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society (Thesis)","volume":"104","author":"Azar","year":"2006","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"10.1016\/j.exer.2019.01.002_bib2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0896-6273(04)00150-3","article-title":"Noxious cold ion channel TRPA1 is activated by compounds and bradykinin","volume":"41","author":"Bandell","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.exer.2019.01.002_bib3","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1073\/pnas.0505356102","article-title":"Pungent oroducts from garlic activate the sensory ion channel TRPA1","volume":"102","author":"Bautista","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2019.01.002_bib4","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.cell.2006.02.023","article-title":"TRPA1 mediates the inflammatory actions of environmental irritants and oroalgesic agents","volume":"124","author":"Bautista","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.exer.2019.01.002_bib5","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1111\/bph.13917","article-title":"The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel","volume":"174","author":"Benemei","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.exer.2019.01.002_bib6","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.preteyeres.2013.01.001","article-title":"Novel anti (lymph) angiogenic treatment strategies for corneal and ocular surface diseases","volume":"34","author":"Bock","year":"2013","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2019.01.002_bib7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3109\/08820538.2011.588652","article-title":"Inflammatory corneal neovascularization: etiopathogenesis","volume":"26","author":"Clements","year":"2011","journal-title":"Semin. Ophthalmol."},{"key":"10.1016\/j.exer.2019.01.002_bib8","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1177\/154405910708600612","article-title":"NGF up-regulates TRPA1: implications for orfacial pain","volume":"86","author":"Diogenes","year":"2007","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.exer.2019.01.002_bib9","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1744-8069-4-48","article-title":"HC-030031, a TRPA1 selective antagonist, attenuates inflammatory and neuropathy-induced mechanical hypersensitivity","volume":"4","author":"Eid","year":"2008","journal-title":"Mol. Pain"},{"key":"10.1016\/j.exer.2019.01.002_bib10","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1053\/j.gastro.2011.07.002","article-title":"TRPA1 and substance P mediate colitis in mice","volume":"141","author":"Engel","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.exer.2019.01.002_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/teb.2007.0115","article-title":"Endothelial cell-matrix interactions in neovascularization","volume":"14","author":"Francis","year":"2008","journal-title":"Tissue Eng. Part B"},{"key":"10.1016\/j.exer.2019.01.002_bib12","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1167\/iovs.06-1083","article-title":"Endogenous TNF\u03b1 suppression of neovascularization in corneal stroma in mice","volume":"48","author":"Fujita","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.01.002_bib13","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1172\/JCI35957","article-title":"Intracellular alkalization causes pain sensation through activation of TRPA1 in mice","volume":"118","author":"Fujita","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exer.2019.01.002_bib14","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature02282","article-title":"Mustard oils and cannabinoida excite sensory nerve fibers through the TRP channel ANKTM1","volume":"427","author":"Jordt","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.exer.2019.01.002_bib15","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1159\/000096231","article-title":"Genipin suppresses subconjunctival fibroblast migration, proliferation and myofibroblast transdifferentiation","volume":"36","author":"Kitano","year":"2006","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.exer.2019.01.002_bib16","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.cub.2005.04.018","article-title":"The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin","volume":"15","author":"Macpherson","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.exer.2019.01.002_bib17","doi-asserted-by":"crossref","first-page":"11412","DOI":"10.1523\/JNEUROSCI.3600-07.2007","article-title":"An ion channel essential for sensing chemical damage","volume":"27","author":"Macpherson","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2019.01.002_bib18","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.yexcr.2005.12.009","article-title":"Dissociation of ERK and Akt signaling in endothelial cell angiogenic responses to beta-amyloid","volume":"312","author":"Magrane","year":"2006","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.exer.2019.01.002_bib19","doi-asserted-by":"crossref","first-page":"13525","DOI":"10.1073\/pnas.0705924104","article-title":"TRPA1 mediates formalin-induced pain","volume":"104","author":"McNamara","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2019.01.002_bib20","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/S0161-6420(00)00024-5","article-title":"Amnioticmembrane transplantation for acute chemical or thermal burns","volume":"107","author":"Meller","year":"2000","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2019.01.002_bib21","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000365334","article-title":"Temperature-sensitive transient receptor potential channels in corneal tissue layers and cells","volume":"52","author":"Mergler","year":"2014","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.exer.2019.01.002_bib22","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0092-8674(02)00670-0","article-title":"The TRP channels, a remarkably functional family","volume":"108","author":"Montell","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.exer.2019.01.002_bib23","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3109\/10799893.2011.602413","article-title":"Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells","volume":"31","author":"Mukhopadhyay","year":"2011","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"10.1016\/j.exer.2019.01.002_bib24","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1097\/00001756-200506210-00015","article-title":"TRPA1 and TRPM8 avtivation in humans: effects of cinnamaldehyde and menthol","volume":"16","author":"Namer","year":"2005","journal-title":"Neuroreport"},{"key":"10.1016\/j.exer.2019.01.002_bib25","doi-asserted-by":"crossref","first-page":"5447","DOI":"10.1038\/s41598-017-05348-3","article-title":"Inflammatory pain control by blocking oxidized phospholipid-mediated TRP channel activation","volume":"7","author":"Oehler","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2019.01.002_bib26","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1016\/j.ajpath.2011.02.043","article-title":"TRPV1 involvement in inflammatory tissue fibrosis in mice","volume":"178","author":"Okada","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2019.01.002_bib27","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/labinvest.2014.85","article-title":"TRPA1 is required for TGF-e signaling and its loss blocks inflammatory fibrosis in mouse corneal stroma","volume":"94","author":"Okada","year":"2014","journal-title":"Lab. Invest."},{"key":"10.1016\/j.exer.2019.01.002_bib28","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1146\/annurev.physiol.68.040204.101406","article-title":"Permeation and selectivity of TRP channels","volume":"68","author":"Owsianik","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.exer.2019.01.002_bib29","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.ajo.2007.11.003","article-title":"Inhibition of corneal neovascularization by subconjunctival bevacizumab in an animal model","volume":"145","author":"Papathanassiou","year":"2008","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2019.01.002_bib30","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ceca.2005.06.028","article-title":"TRP channels: an overview","volume":"38","author":"Pedersen","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1016\/j.exer.2019.01.002_bib31","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1053\/j.gastro.2011.04.049","article-title":"Transient receptor potential ankyrin 1 is expressed by inhibitory motoneurons of the mouse intestine","volume":"141","author":"Poole","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.exer.2019.01.002_bib32","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1146\/annurev.physiol.68.040204.100431","article-title":"An introduction to TRP channels","volume":"68","author":"Ramsey","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.exer.2019.01.002_bib33","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.pain.2009.04.021","article-title":"Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia","volume":"144","author":"Ro","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.exer.2019.01.002_bib34","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/bph.12120","article-title":"The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis","volume":"169","author":"Romano","year":"2013","journal-title":"Br J Phamacol"},{"key":"10.1016\/j.exer.2019.01.002_bib35","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/labinvest.3700375","article-title":"TGF-\u03b2 pathobiology in the eye","volume":"86","author":"Saika","year":"2006","journal-title":"Lab. Invest."},{"key":"10.1016\/j.exer.2019.01.002_bib36","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.2353\/ajpath.2006.050980","article-title":"Loss of tumor necrosis factor a potentiates transforming growth factor b-mediated pathogenic tissue response during wound healing","volume":"168","author":"Saika","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2019.01.002_bib37","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.preteyeres.2007.12.002","article-title":"Fibrotic disorders in the eye: targets of gene therapy","volume":"27","author":"Saika","year":"2008","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2019.01.002_bib38","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jtos.2012.01.005","article-title":"Corneal neovascularization and the utility of topical VEGF inhibition: ranibizumab (Lucentis) vs bevacizumab (Avastin)","volume":"10","author":"Stevenson","year":"2012","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2019.01.002_bib39","doi-asserted-by":"crossref","first-page":"ra2","DOI":"10.1126\/scisignal.2005659","article-title":"Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation","volume":"8","author":"Sullivan","year":"2015","journal-title":"Sci. Signal."},{"key":"10.1016\/j.exer.2019.01.002_bib40","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1167\/iovs.13-13077","article-title":"Impairment of corneal epithelial wound healing in a TRPV1-deficient mouse","volume":"55","author":"Sumioka","year":"2014","journal-title":"Invest. Ophthalmol."},{"key":"10.1016\/j.exer.2019.01.002_bib41","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1124\/mol.107.040832","article-title":"Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1(TRPA1)","volume":"73","author":"Thomas","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.exer.2019.01.002_bib42","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-1-4939-7553-2_13","article-title":"Methods for evaluation of vascular endothelial cell function with transient receptor potential (TRP) channel drugs","volume":"1722","author":"Tjong","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.exer.2019.01.002_bib43","first-page":"706404","article-title":"Suppression of in vivo neovascularization by the loss of TRPV1 in mouse cornea","volume":"2015","author":"Tomoyose","year":"2015","journal-title":"J Ophtalmol"},{"key":"10.1016\/j.exer.2019.01.002_bib44","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0304-3959(95)00080-1","article-title":"A comparison of the effects of noxious and innocuous counterstimuli on experimentally induced itch and pain","volume":"64","author":"Ward","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.exer.2019.01.002_bib45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.exer.2009.09.020","article-title":"Functional expression of transient receptor potential vanilloid 3 (TRPV3) in corneal epithelial cells: involvement in thermosensation and wound healing","volume":"90","author":"Yamada","year":"2010","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2019.01.002_bib46","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M504553200","article-title":"TRPC4 knockdown suppresses epidermal growth factor-induced store-operated channel activation and growth in human corneal epithelial cells","author":"Yang","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.exer.2019.01.002_bib47","article-title":"TRPV1 potentiates TGF\u03b2-induction of corneal myofibroblast development through an oxidative stress-mediated p38-SMAD2 signaling loop","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2019.01.002_bib48","doi-asserted-by":"crossref","first-page":"812","DOI":"10.7150\/ijbs.15229","article-title":"Transient receptor potential ankyrin 1 channel involved in atherosclerosis and macrophage-foam cell formation","volume":"12","author":"Zhao","year":"2016","journal-title":"Int. J. Biol. Sci."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518300812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518300812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T20:17:36Z","timestamp":1573676256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483518300812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":48,"alternative-id":["S0014483518300812"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2019.01.002","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suppression of neovascularization in corneal stroma in a TRPA1-null mouse","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2019.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}