{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T12:01:42Z","timestamp":1772712102598,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470604"],"award-info":[{"award-number":["81470604"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.exer.2019.02.020","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T21:17:28Z","timestamp":1551993448000},"page":"19-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Interactions of thymic stromal lymphopoietin with TLR2 and TLR4 regulate anti-fungal innate immunity in Aspergillus fumigatus-induced corneal infection"],"prefix":"10.1016","volume":"182","author":[{"given":"Chenyang","family":"Dai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.exer.2019.02.020_bib1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1167\/iovs.07-0645","article-title":"A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection","volume":"49","author":"Abedin","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.exer.2019.02.020_bib2","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/eye.2010.211","article-title":"A new ocular trauma score in pediatric penetrating eye injuries","volume":"25","author":"Acar","year":"2011","journal-title":"Eye"},{"issue":"2","key":"10.1016\/j.exer.2019.02.020_bib3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1084\/jem.20062211","article-title":"Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells","volume":"204","author":"Allakhverdi","year":"2007","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.exer.2019.02.020_bib4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1471-2180-8-97","article-title":"Phagocytosis of Aspergillus fumigatus conidia by primary nasal epithelial cells in vitro","volume":"8","author":"Botterel","year":"2008","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.exer.2019.02.020_bib5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.exer.2014.01.014","article-title":"A potential link between bacterial pathogens and allergic conjunctivitis by dendritic cells","volume":"120","author":"Deng","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2019.02.020_bib6","first-page":"50","article-title":"In vitro studies on the antimicrobial peptide human beta-defensin 9 (HBD9): signalling pathways and pathogen-related response (an American ophthalmological society thesis)","volume":"112","author":"Dua","year":"2014","journal-title":"Trans. Am. Ophthalmol. Soc."},{"issue":"6","key":"10.1016\/j.exer.2019.02.020_bib7","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1167\/iovs.10-5928","article-title":"Topical flagellin-mediated innate defense against Candida albicans keratitis","volume":"52","author":"Gao","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.exer.2019.02.020_bib8","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1574-695X.2009.00551.x","article-title":"Innate responses of corneal epithelial cells against Aspergillus fumigatus challenge","volume":"56","author":"Guo","year":"2009","journal-title":"FEMS Immunol. Med. Microbiol."},{"issue":"3","key":"10.1016\/j.exer.2019.02.020_bib9","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/sj.icb.7100158","article-title":"Toll-like receptor 2 mediates the induction of IL-10 in corneal fibroblasts in response to Fusarium solu","volume":"86","author":"Guo","year":"2008","journal-title":"Immunol. Cell Biol."},{"issue":"3","key":"10.1016\/j.exer.2019.02.020_bib10","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/icb.2011.49","article-title":"Toll-like receptor 2 siRNA suppresses corneal inflammation and attenuates Aspergillus fumigatus keratitis in rats","volume":"90","author":"Guo","year":"2012","journal-title":"Immunol. Cell Biol."},{"issue":"4","key":"10.1016\/j.exer.2019.02.020_bib11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000357977","article-title":"Human corneal epithelial cells produce antimicrobial peptides LL-37 and \u03b2-defensins in response to heat-killed Candida albicans","volume":"51","author":"Hua","year":"2014","journal-title":"Ophthalmic Res."},{"issue":"3","key":"10.1016\/j.exer.2019.02.020_bib12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/1753425908101521","article-title":"Activation of Toll-like receptors 2 and 4 in Aspergillus fumigatus keratitis","volume":"15","author":"Jie","year":"2009","journal-title":"Innate Immun."},{"issue":"1","key":"10.1016\/j.exer.2019.02.020_bib13","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1128\/IAI.00762-09","article-title":"Helicobacter pylori promotes the production of thymic stromal lymphopoietin by gastric epithelial cells and induces dendritic cell-mediated inflammatory Th2 responses","volume":"78","author":"Kido","year":"2010","journal-title":"Infect. Immun."},{"issue":"5","key":"10.1016\/j.exer.2019.02.020_bib14","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1167\/iovs.16-20658","article-title":"Role of pattern recognition receptors in the modulation of antimicrobial peptide expression in the corneal epithelial innate response to F. Solani","volume":"58","author":"Kolar","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.exer.2019.02.020_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000976","article-title":"Distinct roles for dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis","volume":"6","author":"Leal","year":"2010","journal-title":"PLoS Pathog."},{"issue":"11","key":"10.1016\/j.exer.2019.02.020_bib16","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1136\/bjo.86.11.1211","article-title":"Aetiology of suppurative corneal ulcers in Ghana and south India, and epidemiology of fungal keratitis","volume":"86","author":"Leck","year":"2002","journal-title":"Br. J. Ophthalmol."},{"issue":"5","key":"10.1016\/j.exer.2019.02.020_bib17","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1172\/JCI21060","article-title":"New insights into atopic dermatitis","volume":"113","author":"Leung","year":"2004","journal-title":"J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.exer.2019.02.020_bib18","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1167\/iovs.12-11504","article-title":"Pretreatment with TLR2 and TLR4 ligand modulates innate immunity in corneal fibroblasts challenged with Aspergillus fumigatus","volume":"54","author":"Li","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.02.020_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(08)01001-8","article-title":"TSLP in epithelial cell and dendritic cell cross talk","volume":"101","author":"Liu","year":"2009","journal-title":"Adv. Immunol."},{"issue":"4","key":"10.1016\/j.exer.2019.02.020_bib20","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1167\/iovs.04-0607","article-title":"The spectrum of antimicrobial peptide expression at the ocular surface","volume":"46","author":"McIntosh","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.exer.2019.02.020_bib21","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1084\/jem.171.5.1797","article-title":"Neutrophil-activating properties of the melanoma growth-stimulatory activity","volume":"171","author":"Moser","year":"1990","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.exer.2019.02.020_bib22","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ajo.2016.05.021","article-title":"Altered patterns of fungal keratitis at a london ophthalmic referral hospital: an eight-year retrospective observational study","volume":"168","author":"Ong","year":"2016","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2019.02.020_bib23","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3389\/fimmu.2017.00803","article-title":"Thymic stromal lymphopoietin is critical for regulation of proinflammatory cytokine response and resistance to experimental trypanosoma congolense infection","volume":"8","author":"Onyilagha","year":"2017","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.exer.2019.02.020_bib24","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1136\/bjo.2009.178236","article-title":"Antimicrobial peptides expression by ocular surface cells in response to Acanthamoeba castellanii: an in vitro study","volume":"94","author":"Otri","year":"2010","journal-title":"Br. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2019.02.020_bib25","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1167\/iovs.11-8467","article-title":"Variable expression of human beta defensins 3 and 9 at the human ocular surface in infectious keratitis","volume":"53","author":"Otri","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.exer.2019.02.020_bib26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.0902-0055.2002.00127.x","article-title":"Expression and regulation of novel human \u03b2-defensins in gingival keratinocytes","volume":"19","author":"Premratanachai","year":"2004","journal-title":"Oral Microbiol. Immunol."},{"key":"10.1016\/j.exer.2019.02.020_bib27","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.molimm.2015.12.014","article-title":"A potential link between TSLP\/TSLPR\/STAT5 and TLR2\/MyD88\/NFkappaB-p65 in human corneal epithelial cells for Aspergillus fumigatus tolerance","volume":"71","author":"Ren","year":"2016","journal-title":"Mol. Immunol."},{"issue":"5","key":"10.1016\/j.exer.2019.02.020_bib28","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1586\/1744666X.2014.894886","article-title":"The CXCL8\/IL-8 chemokine family and its receptors in inflammatory diseases","volume":"10","author":"Russo","year":"2014","journal-title":"Expert Rev. Clin. Immunol."},{"issue":"6","key":"10.1016\/j.exer.2019.02.020_bib29","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1136\/bjo.2009.169607","article-title":"Geographic variations in microbial keratitis: an analysis of the peer-reviewed literature","volume":"95","author":"Shah","year":"2011","journal-title":"Br. J. Ophthalmol."},{"issue":"12","key":"10.1016\/j.exer.2019.02.020_bib30","doi-asserted-by":"crossref","first-page":"7134","DOI":"10.4049\/jimmunol.0902515","article-title":"Thymic stromal lymphopoietin receptor-mediated IL-6 and CC\/CXC chemokines expression in human airway smooth muscle cells: role of MAPKs (ERK1\/2, p38, and JNK) and STAT3 pathways","volume":"184","author":"Shan","year":"2010","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.exer.2019.02.020_bib31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2332\/allergolint.11-RAI-0395","article-title":"TSLP expression: cellular sources, triggers, and regulatory mechanisms","volume":"61","author":"Takai","year":"2012","journal-title":"Allergol. Int. : official journal of the Japanese Society of Allergology"},{"issue":"1","key":"10.1016\/j.exer.2019.02.020_bib32","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2332\/allergolint.11-RAI-0395","article-title":"TSLP expression: cellular sources, triggers, and regulatory mechanisms","volume":"61","author":"Takai","year":"2012","journal-title":"Allergol. Int."},{"issue":"3","key":"10.1016\/j.exer.2019.02.020_bib33","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/00003226-200005000-00010","article-title":"Spectrum of fungal keratitis at wills eye hospital, philadelphia, Pennsylvania","volume":"19","author":"Tanure","year":"2000","journal-title":"Cornea"},{"issue":"3","key":"10.1016\/j.exer.2019.02.020_bib34","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1084\/jem.20081499","article-title":"TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis","volume":"206","author":"Taylor","year":"2009","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.exer.2019.02.020_bib35","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.jaci.2010.09.002","article-title":"Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2-Toll-like receptor 6 pathway","volume":"126","author":"Vu","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6","key":"10.1016\/j.exer.2019.02.020_bib36","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1177\/1753425913502098","article-title":"Signaling mechanism for Aspergillus fumigatus tolerance in corneal fibroblasts induced by LPS pretreatment","volume":"20","author":"Wang","year":"2013","journal-title":"Innate Immun."},{"issue":"6","key":"10.1016\/j.exer.2019.02.020_bib37","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/ceo.12706","article-title":"Aspergillus fumigatus promotes T helper type 2 responses through thymic stromal lymphopoietin production by human corneal epithelial cells","volume":"44","author":"Wang","year":"2016","journal-title":"Clin. Exp. Ophthalmol."},{"issue":"7","key":"10.1016\/j.exer.2019.02.020_bib38","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1517\/14728222.2014.915314","article-title":"Thymic stromal lymphopoietin: a central regulator of allergic asthma","volume":"18","author":"Watson","year":"2014","journal-title":"Expert Opin. Ther. Targets"},{"issue":"3","key":"10.1016\/j.exer.2019.02.020_bib39","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1165\/rcmb.2009-0168OC","article-title":"Thymic stromal lymphopoietin induces chemotactic and prosurvival effects in eosinophils","volume":"43","author":"Wong","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"11","key":"10.1016\/j.exer.2019.02.020_bib40","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.ophtha.2006.05.035","article-title":"Spectrum of fungal keratitis in north China","volume":"113","author":"Xie","year":"2006","journal-title":"Ophthalmology"},{"issue":"5\u20136","key":"10.1016\/j.exer.2019.02.020_bib41","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/02713680802130339","article-title":"Aspergillus fumigatus antigens activate immortalized human corneal epithelial cells via toll-like receptors 2 and 4","volume":"33","author":"Zhao","year":"2008","journal-title":"Curr. Eye Res."},{"issue":"6","key":"10.1016\/j.exer.2019.02.020_bib42","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1167\/iovs.09-4122","article-title":"TSLP and downstream molecules in experimental mouse allergic conjunctivitis","volume":"51","author":"Zheng","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.exer.2019.02.020_bib43","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M112.017764","article-title":"TSLP signaling network revealed by SILAC-based phosphoproteomics","volume":"11","author":"Zhong","year":"2012","journal-title":"Mol. Cell. Proteomics : MCP"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518307498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518307498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:59:14Z","timestamp":1757998754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483518307498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":43,"alternative-id":["S0014483518307498"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2019.02.020","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interactions of thymic stromal lymphopoietin with TLR2 and TLR4 regulate anti-fungal innate immunity in Aspergillus fumigatus-induced corneal infection","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2019.02.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}