{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:23:58Z","timestamp":1783646638033,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2016-75681-R"],"award-info":[{"award-number":["SAF2016-75681-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["CSD2010-00045"],"award-info":[{"award-number":["CSD2010-00045"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["000306"],"award-info":[{"award-number":["000306"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013616","name":"American Society for Biochemistry and Molecular Biology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013616","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.exer.2019.04.008","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T03:56:13Z","timestamp":1554868573000},"page":"24-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["PEDF peptides promote photoreceptor survival in rd10 retina models"],"prefix":"10.1016","volume":"184","author":[{"given":"Alberto","family":"Hern\u00e1ndez-Pinto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Polato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s de la","family":"Rocha-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Vitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique J.","family":"de la Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Patricia","family":"Becerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.exer.2019.04.008_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112142","article-title":"Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration","volume":"9","author":"Arango-Gonzalez","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2019.04.008_bib2","doi-asserted-by":"crossref","first-page":"9124","DOI":"10.1167\/iovs.11-7736","article-title":"Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pigmentosa","volume":"52","author":"Arroba","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.04.008_bib3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/978-1-4615-5391-5_21","article-title":"Structure-function studies on PEDF. A noninhibitory serpin with neurotrophic activity","volume":"425","author":"Becerra","year":"1997","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2019.04.008_bib4","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.exer.2005.10.016","article-title":"Focus on molecules: pigment epithelium-derived factor (PEDF)","volume":"82","author":"Becerra","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2019.04.008_bib5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.exer.2003.10.013","article-title":"Pigment epithelium-derived factor in the monkey retinal pigment epithelium and interphotoreceptor matrix: apical secretion and distribution","volume":"78","author":"Becerra","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2019.04.008_bib6","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nrc3484","article-title":"The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential","volume":"13","author":"Becerra","year":"2013","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.exer.2019.04.008_bib7","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0891-0618(01)00140-5","article-title":"Mouse retina explants after long-term culture in serum free medium","volume":"22","author":"Caffe","year":"2001","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.exer.2019.04.008_bib8","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1006\/nbdi.1999.0263","article-title":"Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations","volume":"6","author":"Cayouette","year":"1999","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.exer.2019.04.008_bib9","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0042-6989(01)00146-8","article-title":"Retinal degeneration mutants in the mouse","volume":"42","author":"Chang","year":"2002","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2019.04.008_bib10","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41419-018-0613-y","article-title":"Pigment epithelium-derived factor hinders photoreceptor cell death by reducing intracellular calcium in the degenerating retina","volume":"9","author":"Comitato","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2019.04.008_bib11","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1167\/iovs.08-2182","article-title":"Attenuation of vision loss and delay in apoptosis of photoreceptors induced by proinsulin in a mouse model of retinitis pigmentosa","volume":"49","author":"Corrochano","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.04.008_bib12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.preteyeres.2015.06.005","article-title":"Pharmacological approaches to retinitis pigmentosa: a laboratory perspective","volume":"48","author":"Guadagni","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2019.04.008_bib13","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1167\/iovs.16-19300","article-title":"Intravitreal injection of proinsulin-loaded microspheres delays photoreceptor cell death and vision loss in the rd10 mouse model of retinitis pigmentosa","volume":"57","author":"Isiegas","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.04.008_bib14","doi-asserted-by":"crossref","first-page":"7149","DOI":"10.1523\/JNEUROSCI.20-19-07149.2000","article-title":"Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal","volume":"20","author":"Jablonski","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2019.04.008_bib15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/jnc.13388","article-title":"Progesterone receptor signalling in retinal photoreceptor neuroprotection","volume":"136","author":"Jackson","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.exer.2019.04.008_bib40","first-page":"4414","article-title":"Vitreous volume of the mouse measured by quantitativehigh-resolution MRI","volume":"51","author":"Kaplan","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.04.008_bib16","doi-asserted-by":"crossref","first-page":"25241","DOI":"10.1074\/jbc.M115.645846","article-title":"Small retinoprotective peptides reveal a receptor-binding region on pigment epithelium-derived factor","volume":"290","author":"Kenealey","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2019.04.008_bib17","doi-asserted-by":"crossref","first-page":"11764","DOI":"10.1038\/srep11764","article-title":"Adalimumab reduces photoreceptor cell death in A mouse model of retinal degeneration","volume":"5","author":"Martinez-Fernandez de la Camara","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2019.04.008_bib18","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.2353\/ajpath.2008.080466","article-title":"Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of the neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration","volume":"173","author":"Murakami","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2019.04.008_bib19","doi-asserted-by":"crossref","first-page":"38022","DOI":"10.1074\/jbc.M600353200","article-title":"Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor","volume":"281","author":"Notari","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2019.04.008_bib20","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1167\/iovs.04-1489","article-title":"Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia","volume":"46","author":"Notari","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.04.008_bib21","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.ajo.2003.11.080","article-title":"Decreased levels of pigment epithelium-derived factor in eyes with neuroretinal dystrophic diseases","volume":"137","author":"Ogata","year":"2004","journal-title":"Am. J. Ophthalmol."},{"issue":"12","key":"10.1016\/j.exer.2019.04.008_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113798","article-title":"A novel in vivo model of focal light emitting diode-induced cone-photoreceptor phototoxicity: neuroprotection afforded by brimonidine, BDNF, PEDF or bFGF","volume":"9","author":"Ortin-Martinez","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2019.04.008_bib23","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/978-1-4614-3209-8_73","article-title":"How long does a photoreceptor cell take to die? Implications for the causative cell death mechanisms","volume":"801","author":"Paquet-Durand","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2019.04.008_bib24","doi-asserted-by":"crossref","first-page":"18486","DOI":"10.1074\/jbc.M117.801472","article-title":"Defining a mechanistic link between pigment epithelium-derived factor, docosahexaenoic acid, and corneal nerve regeneration","volume":"292","author":"Pham","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.exer.2019.04.008_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.306","article-title":"p75(NTR) antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa","volume":"8","author":"Platon-Corchado","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2019.04.008_bib26","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/978-3-319-17121-0_93","article-title":"Pigment epithelium-derived factor, a protective factor for photoreceptors in vivo","volume":"854","author":"Polato","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2019.04.008_bib27","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/978-1-4614-3209-8_102","article-title":"Pigment epithelium-derived factor protects cone photoreceptor-derived 661W cells from light damage through Akt activation","volume":"801","author":"Rapp","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2019.04.008_bib28","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.exer.2019.04.008_bib29","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1002\/pro.5560051220","article-title":"Recombinant human pigment epithelium-derived factor (PEDF): characterization of PEDF overexpressed and secreted by eukaryotic cells","volume":"5","author":"Stratikos","year":"1996","journal-title":"Protein Sci."},{"key":"10.1016\/j.exer.2019.04.008_bib30","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1152\/physrev.00021.2004","article-title":"The retinal pigment epithelium in visual function","volume":"85","author":"Strauss","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exer.2019.04.008_bib31","doi-asserted-by":"crossref","first-page":"23928","DOI":"10.1074\/jbc.M113.487884","article-title":"Pigment epithelium-derived factor (PEDF) prevents retinal cell death via PEDF Receptor (PEDF-R): identification of a functional ligand binding site","volume":"288","author":"Subramanian","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2019.04.008_bib32","first-page":"109","article-title":"Pigment epithelium-derived factor promotes neurite outgrowth of retinal cells","volume":"55","author":"Tanimoto","year":"2006","journal-title":"Hiroshima J. Med. Sci."},{"key":"10.1016\/j.exer.2019.04.008_bib33","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1007\/s11064-012-0747-8","article-title":"Pigment epithelium-derived factor released by Muller glial cells exerts neuroprotective effects on retinal ganglion cells","volume":"37","author":"Unterlauft","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.exer.2019.04.008_bib34","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1167\/iovs.13-11803","article-title":"Pigment epithelium-derived factor is retinal ganglion cell neuroprotective and axogenic after optic nerve crush injury","volume":"54","author":"Vigneswara","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.04.008_bib35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.cccn.2004.08.004","article-title":"Gene mutations in retinitis pigmentosa and their clinical implications","volume":"351","author":"Wang","year":"2005","journal-title":"Clin. Chim. Acta"},{"issue":"5","key":"10.1016\/j.exer.2019.04.008_bib36","doi-asserted-by":"crossref","DOI":"10.1042\/AN20130028","article-title":"Pigment epithelium-derived factor reduces apoptosis and pro-inflammatory cytokine gene expression in a murine model of focal retinal degeneration","volume":"5","author":"Wang","year":"2013","journal-title":"ASN Neuro"},{"key":"10.1016\/j.exer.2019.04.008_bib37","first-page":"372","article-title":"Comparison of two neurotrophic serpins reveals a small fragment with cell survival activity","volume":"23","author":"Winokur","year":"2017","journal-title":"Mol. Vis."},{"issue":"9","key":"10.1016\/j.exer.2019.04.008_bib38","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1167\/iovs.05-0257","article-title":"Efficacy and selectivity of phosphodiesterase-targeted drugs in inhibiting photoreceptor phosphodiesterase (PDE6) in retinal photoreceptors","volume":"46","author":"Zhang","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.04.008_bib39","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1167\/iovs.10-6413","article-title":"Polarized secretion of PEDF from human embryonic stem cell-derived RPE promotes retinal progenitor cell survival","volume":"52","author":"Zhu","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518306274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518306274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:59:35Z","timestamp":1757998775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483518306274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":40,"alternative-id":["S0014483518306274"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2019.04.008","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PEDF peptides promote photoreceptor survival in rd10 retina models","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2019.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}