{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:15:27Z","timestamp":1792653327124,"version":"4.5.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100001116","name":"Foundation Fighting Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001116","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.exer.2019.04.009","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T09:53:10Z","timestamp":1554976390000},"page":"107641","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["High-throughput screening identifies compounds that protect RPE cells from physiological stressors present in AMD"],"prefix":"10.1016","volume":"185","author":[{"given":"Hui","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Abriola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9464-424X","authenticated-orcid":false,"given":"Denton","family":"Hoyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"NYSCF Global Stem Cell Array Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Noggle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Paull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucian V.","family":"Del Priore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Fields","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2019.04.009_bib1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3389\/fphar.2016.00133","article-title":"Inhibition of soluble epoxide hydrolase limits mitochondrial damage and preserves function following ischemic injury","volume":"7","author":"Akhnokh","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.exer.2019.04.009_bib2","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1167\/iovs.03-0351","article-title":"Oxidative stress affects the junctional integrity of retinal pigment epithelial cells","volume":"45","author":"Bailey","year":"2004","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.04.009_bib3","first-page":"33","article-title":"Evaluation of ultraviolet light toxicity on cultured retinal pigment epithelial and retinal ganglion cells","volume":"4","author":"Balaiya","year":"2010","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.exer.2019.04.009_bib4","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1124\/mol.105.018911","article-title":"Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways","volume":"69","author":"Blackburn","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.exer.2019.04.009_bib5","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2741\/S380","article-title":"Potential of epigenetic mechanisms in AMD pathology","volume":"5","author":"Blasiak","year":"2013","journal-title":"Front. Biosci."},{"key":"10.1016\/j.exer.2019.04.009_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fnana.2015.00091","article-title":"Oxidative stress and Parkinson's disease","volume":"9","author":"Blesa","year":"2015","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.exer.2019.04.009_bib7","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1067\/mjd.2000.109072","article-title":"Dermatopharmacology of ciclopirox nail lacquer topical solution 8% in the treatment of onychomycosis","volume":"43","author":"Bohn","year":"2000","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.exer.2019.04.009_bib8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/ije\/16.1.31","article-title":"Nitric oxide yields of contemporary UK, US and French cigarettes","volume":"16","author":"Borland","year":"1987","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.exer.2019.04.009_bib9","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.febslet.2010.02.042","article-title":"Mitochondrial respiratory chain involvement in peroxiredoxin 3 oxidation by phenethyl isothiocyanate and auranofin","volume":"584","author":"Brown","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.exer.2019.04.009_bib10","first-page":"959","article-title":"Oxidant-induced apoptosis in cultured human retinal pigment epithelial cells","volume":"40","author":"Cai","year":"1999","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.04.009_bib11","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0891-5849(94)00166-H","article-title":"Permeabilization of the inner mitochondrial membrane by Ca2+ ions is stimulated by t-butyl hydroperoxide and mediated by reactive oxygen species generated by mitochondria","volume":"18","author":"Castilho","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exer.2019.04.009_bib12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/01.psp.0000249918.19016.f6","article-title":"Effect of cigarette smoking on the oxidant\/antioxidant balance in healthy subjects","volume":"14","author":"Chavez","year":"2007","journal-title":"Am. J. Therapeut."},{"key":"10.1016\/j.exer.2019.04.009_bib13","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0028-3908(02)00081-3","article-title":"Ciclopirox prevents peroxynitrite toxicity in astrocytes by maintaining their mitochondrial function: a novel mechanism for cytoprotection by ciclopirox","volume":"43","author":"Choi","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.exer.2019.04.009_bib14","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.tiv.2013.05.002","article-title":"The role of SIRT1\/AKT\/ERK pathway in ultraviolet B induced damage on human retinal pigment epithelial cells","volume":"27","author":"Chou","year":"2013","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.exer.2019.04.009_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2008.10.001","article-title":"Molecular pathology of age-related macular degeneration","volume":"28","author":"Ding","year":"2009","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2019.04.009_bib16","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/FJC.0b013e318247f642","article-title":"Induced pluripotent stem cells as a disease modeling and drug screening platform","volume":"60","author":"Ebert","year":"2012","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.exer.2019.04.009_bib17","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1523\/JNEUROSCI.16-03-01150.1996","article-title":"Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support","volume":"16","author":"Farinelli","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2019.04.009_bib18","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.neurobiolaging.2005.05.012","article-title":"Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration","volume":"27","author":"Feher","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.exer.2019.04.009_bib19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.redox.2017.05.015","article-title":"Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration","volume":"13","author":"Ferrington","year":"2017","journal-title":"Redox Biol"},{"key":"10.1016\/j.exer.2019.04.009_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0177763","article-title":"Extracellular matrix nitration alters growth factor release and activates bioactive complement in human retinal pigment epithelial cells","volume":"12","author":"Fields","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2019.04.009_bib21","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1167\/iovs.15-16438","article-title":"Nitrite modification of extracellular matrix alters CD46 expression and VEGF release in human retinal pigment epithelium","volume":"56","author":"Fields","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.04.009_bib23","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1001\/archopht.122.4.564","article-title":"Prevalence of age-related macular degeneration in the United States","volume":"122","author":"Friedman","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2019.04.009_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143272","article-title":"Differentiation of human protein-induced pluripotent stem cells toward a retinal pigment epithelial cell fate","volume":"10","author":"Gong","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2019.04.009_bib25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3945\/an.116.013177","article-title":"The age-related eye disease 2 study: micronutrients in the treatment of macular degeneration","volume":"8","author":"Gorusupudi","year":"2017","journal-title":"Adv Nutr"},{"key":"10.1016\/j.exer.2019.04.009_bib26","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/BF02631017","article-title":"SK HEP-1: a human cell line of endothelial origin","volume":"28A","author":"Heffelfinger","year":"1992","journal-title":"Vitro Cell Dev. Biol."},{"issue":"Pt 2","key":"10.1016\/j.exer.2019.04.009_bib27","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1042\/bj3120485","article-title":"Oxidized glutathione decreases luminal Ca2+ content of the endothelial cell ins(1,4,5)P3-sensitive Ca2+ store","volume":"312","author":"Henschke","year":"1995","journal-title":"Biochem. J."},{"key":"10.1016\/j.exer.2019.04.009_bib28","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1111\/j.1460-9568.2004.03554.x","article-title":"Dynamic changes of the anti- and pro-apoptotic proteins Bcl-w, Bcl-2, and Bax with Smac\/Diablo mitochondrial release after photothrombotic ring stroke in rats","volume":"20","author":"Hu","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.exer.2019.04.009_bib29","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1056\/NEJMra0801537","article-title":"Age-related macular degeneration","volume":"358","author":"Jager","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exer.2019.04.009_bib30","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.mam.2012.03.009","article-title":"Consequences of oxidative stress in age-related macular degeneration","volume":"33","author":"Jarrett","year":"2012","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.exer.2019.04.009_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017084","article-title":"Modeling retinal degeneration using patient-specific induced pluripotent stem cells","volume":"6","author":"Jin","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2019.04.009_bib32","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11010-010-0563-x","article-title":"Metals, oxidative stress and neurodegenerative disorders","volume":"345","author":"Jomova","year":"2010","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.exer.2019.04.009_bib33","doi-asserted-by":"crossref","first-page":"5470","DOI":"10.1167\/iovs.10-5429","article-title":"Mitochondrial DNA damage as a potential mechanism for age-related macular degeneration","volume":"51","author":"Karunadharma","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.04.009_bib34","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1136\/bjo.79.10.944","article-title":"Preparation of Bruch's membrane and analysis of the age-related changes in the structural collagens","volume":"79","author":"Karwatowski","year":"1995","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2019.04.009_bib35","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/ICU.0b013e32833866ee","article-title":"Nutritional supplements for age-related macular degeneration","volume":"21","author":"Krishnadev","year":"2010","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.exer.2019.04.009_bib36","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/sj.bjp.0706206","article-title":"Ciclopirox protects mitochondria from hydrogen peroxide toxicity","volume":"145","author":"Lee","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.exer.2019.04.009_bib37","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0014-4835(03)00023-X","article-title":"Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration","volume":"76","author":"Liang","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2019.04.009_bib38","doi-asserted-by":"crossref","first-page":"12858","DOI":"10.1074\/jbc.273.21.12858","article-title":"Endoplasmic reticulum stress proteins block oxidant-induced Ca2+ increases and cell death","volume":"273","author":"Liu","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2019.04.009_bib39","doi-asserted-by":"crossref","first-page":"9208489","DOI":"10.1155\/2017\/9208489","article-title":"Retinal diseases associated with oxidative stress and the effects of a free radical scavenger (Edaravone)","volume":"2017","author":"Masuda","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.exer.2019.04.009_bib40","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1167\/iovs.02-0813","article-title":"Novel role for a complement regulatory protein (CD46) in retinal pigment epithelial adhesion","volume":"44","author":"McLaughlin","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.04.009_bib41","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0891-5849(94)90079-5","article-title":"Importance of Se-glutathione peroxidase, catalase, and Cu\/Zn-SOD for cell survival against oxidative stress","volume":"17","author":"Michiels","year":"1994","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exer.2019.04.009_bib42","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/ajh.23640","article-title":"Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies","volume":"89","author":"Minden","year":"2014","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.exer.2019.04.009_bib43","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.exer.2010.01.014","article-title":"Age-related accumulation of 3-nitrotyrosine and nitro-A2E in human Bruch's membrane","volume":"90","author":"Murdaugh","year":"2010","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2019.04.009_bib44","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3390\/jcm4040567","article-title":"Patient-specific iPSC-derived RPE for modeling of retinal diseases","volume":"4","author":"Nguyen","year":"2015","journal-title":"J. Clin. Med."},{"issue":"Pt 1","key":"10.1016\/j.exer.2019.04.009_bib45","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1042\/bj3070099","article-title":"Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide","volume":"307","author":"Nieminen","year":"1995","journal-title":"Biochem. J."},{"key":"10.1016\/j.exer.2019.04.009_bib46","doi-asserted-by":"crossref","first-page":"3164734","DOI":"10.1155\/2016\/3164734","article-title":"The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age-related ocular diseases and other pathologies of the anterior and posterior eye segments in adults","author":"Nita","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.exer.2019.04.009_bib47","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1186\/1756-0500-7-437","article-title":"Aneuploidy is permissive for hepatocyte-like cell differentiation from human induced pluripotent stem cells","volume":"7","author":"Noto","year":"2014","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.exer.2019.04.009_bib48","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3109\/03008200109014253","article-title":"The nitrite\/collagen reaction: non-enzymatic nitration as a model system for age-related damage","volume":"42","author":"Paik","year":"2001","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.exer.2019.04.009_bib50","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nmeth.3507","article-title":"Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells","volume":"12","author":"Paull","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.exer.2019.04.009_bib51","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1002\/art.21964","article-title":"Modeling of tumor necrosis factor receptor superfamily 1A mutants associated with tumor necrosis factor receptor-associated periodic syndrome indicates misfolding consistent with abnormal function","volume":"54","author":"Rebelo","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.exer.2019.04.009_bib52","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/ICL.0b013e31821cbcc9","article-title":"Ultraviolet radiation as a risk factor for cataract and macular degeneration","volume":"37","author":"Roberts","year":"2011","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.exer.2019.04.009_bib53","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/978-3-319-17121-0_106","article-title":"Reduced metabolic capacity in aged primary retinal pigment epithelium (RPE) is correlated with increased susceptibility to oxidative stress","volume":"854","author":"Rohrer","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2019.04.009_bib54","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.pathophys.2012.05.001","article-title":"Tertiary butyl hydroperoxide induced oxidative damage in mice erythrocytes: protection by taurine","volume":"19","author":"Roy","year":"2012","journal-title":"Pathophysiology"},{"key":"10.1016\/j.exer.2019.04.009_bib55","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.stem.2009.11.009","article-title":"Technical challenges in using human induced pluripotent stem cells to model disease","volume":"5","author":"Saha","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exer.2019.04.009_bib56","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.stem.2016.12.015","article-title":"Nicotinamide ameliorates disease phenotypes in a human iPSC model of age-related macular degeneration","volume":"20","author":"Saini","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exer.2019.04.009_bib57","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0021-9258(17)35230-4","article-title":"Increases in cytosolic calcium ion concentration can be dissociated from the killing of cultured hepatocytes by tert-butyl hydroperoxide","volume":"266","author":"Sakaida","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2019.04.009_bib58","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1136\/bjo.60.5.324","article-title":"Ageing and degeneration in the macular region: a clinico-pathological study","volume":"60","author":"Sarks","year":"1976","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2019.04.009_bib59","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1021\/tx00039a013","article-title":"The role of thiols in mitochondrial susceptibility to iron and tert-butyl hydroperoxide-mediated toxicity in cultured mouse hepatocytes","volume":"7","author":"Shertzer","year":"1994","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.exer.2019.04.009_bib60","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0039-6257(98)00002-2","article-title":"The association between cigarette smoking and ocular diseases","volume":"42","author":"Solberg","year":"1998","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2019.04.009_bib61","first-page":"1356","article-title":"Blue light-induced apoptosis of A2E-containing RPE: involvement of caspase-3 and protection by Bcl-2","volume":"42","author":"Sparrow","year":"2001","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.04.009_bib62","first-page":"1222","article-title":"Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE","volume":"43","author":"Sparrow","year":"2002","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.04.009_bib63","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1167\/iovs.15-17053","article-title":"The mitochondrial-derived peptide humanin protects RPE cells from oxidative stress, senescence, and mitochondrial dysfunction","volume":"57","author":"Sreekumar","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.04.009_bib64","doi-asserted-by":"crossref","first-page":"224","DOI":"10.5966\/sctm.2014-0186","article-title":"An atypical human induced pluripotent stem cell line with a complex, stable, and balanced genomic rearrangement including a large de novo 1q uniparental disomy","volume":"4","author":"Steichen","year":"2015","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.exer.2019.04.009_bib65","series-title":"Webvision: the Organization of the Retina and Visual System, Salt Lake City (UT)","article-title":"The retinal pigment epithelium","author":"Strauss","year":"1995"},{"key":"10.1016\/j.exer.2019.04.009_bib66","first-page":"2310","article-title":"Bruch's membrane aging decreases phagocytosis of outer segments by retinal pigment epithelium","volume":"13","author":"Sun","year":"2007","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2019.04.009_bib67","doi-asserted-by":"crossref","first-page":"16754","DOI":"10.1073\/pnas.1419576111","article-title":"Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-alpha","volume":"111","author":"Sur","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2019.04.009_bib68","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nrm2952","article-title":"Mitochondria and cell death: outer membrane permeabilization and beyond","volume":"11","author":"Tait","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.exer.2019.04.009_bib69","doi-asserted-by":"crossref","first-page":"7304","DOI":"10.1523\/JNEUROSCI.0190-15.2015","article-title":"Investigating mitochondria as a target for treating age-related macular degeneration","volume":"35","author":"Terluk","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2019.04.009_bib70","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.23","article-title":"The anti-apoptotic Bcl-2 family protein A1\/Bfl-1 regulates neutrophil survival and homeostasis and is controlled via PI3K and JAK\/STAT signaling","volume":"7","author":"Vier","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2019.04.009_bib71","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.exer.2011.06.002","article-title":"Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy","volume":"93","author":"Vogt","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2019.04.009_bib72","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-genet-102108-134850","article-title":"The role of mitochondria in apoptosis*","volume":"43","author":"Wang","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.exer.2019.04.009_bib73","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1080\/02713680590968259","article-title":"Nitrite-modified extracellular matrix proteins deleteriously affect retinal pigment epithelial cell function and viability: a comparison study with nonenzymatic glycation mechanisms","volume":"30","author":"Wang","year":"2005","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2019.04.009_bib74","doi-asserted-by":"crossref","first-page":"22781","DOI":"10.1074\/jbc.M201469200","article-title":"Bcl-2 family member Bfl-1\/A1 sequesters truncated bid to inhibit is collaboration with pro-apoptotic Bak or Bax","volume":"277","author":"Werner","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2019.04.009_bib75","first-page":"743","article-title":"The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration","volume":"66","author":"Yildirim","year":"2011","journal-title":"Clinics"},{"key":"10.1016\/j.exer.2019.04.009_bib76","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jphotobiol.2007.04.012","article-title":"In vitro assays for evaluating the ultraviolet B-induced damage in cultured human retinal pigment epithelial cells","volume":"88","author":"Youn","year":"2007","journal-title":"J. Photochem. Photobiol., B"},{"key":"10.1016\/j.exer.2019.04.009_bib77","first-page":"237","article-title":"In vitro ultraviolet-induced damage in human corneal, lens, and retinal pigment epithelial cells","volume":"17","author":"Youn","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2019.04.009_bib78","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.stem.2012.03.002","article-title":"Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells","volume":"10","author":"Young","year":"2012","journal-title":"Cell Stem Cell"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518307036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518307036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:03:08Z","timestamp":1757998988000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483518307036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":76,"alternative-id":["S0014483518307036"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2019.04.009","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-throughput screening identifies compounds that protect RPE cells from physiological stressors present in AMD","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2019.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107641"}}