{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:07:10Z","timestamp":1779188830499,"version":"3.51.4"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:00:00Z","timestamp":1559865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.exer.2019.107690","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T19:53:48Z","timestamp":1559937228000},"page":"107690","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["A chronic hypoxic response in photoreceptors alters the vitreous proteome in mice"],"prefix":"10.1016","volume":"185","author":[{"given":"Christian","family":"Schori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Trachsel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Grossmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Barben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Klee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Storti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijana","family":"Samardzija","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Grimm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2019.107690_bib1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1748-1716.1972.tb05182.x","article-title":"The oxygen supply to the retina. II. Effects of high intraocular pressure and of increased arterial carbon dioxide tension on uveal and retinal blood flow in cats. A study with radioactively labelled microspheres including flow determinations in brain and","volume":"84","author":"Alm","year":"1972","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.exer.2019.107690_bib80","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.preteyeres.2009.11.003","article-title":"The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited","volume":"29","author":"Anderson","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2019.107690_bib81","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103216","article-title":"CNN3 regulates trophoblast invasion and is upregulated by hypoxia in BeWo cells","volume":"9","author":"Appel","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2019.107690_bib2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1477-5956-11-22","article-title":"In-depth mass spectrometric mapping of the human vitreous proteome","volume":"11","author":"Aretz","year":"2013","journal-title":"Proteome Sci."},{"key":"10.1016\/j.exer.2019.107690_bib3","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.arr.2009.06.002","article-title":"Regulatory role of HIF-1alpha in the pathogenesis of age-related macular degeneration (AMD)","volume":"8","author":"Arjamaa","year":"2009","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.exer.2019.107690_bib4","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1038\/s41418-018-0094-7","article-title":"Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress","volume":"25","author":"Barben","year":"2018","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.exer.2019.107690_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13024-018-0243-y","article-title":"Targeting Hif1a rescues cone degeneration and prevents subretinal neovascularization in a model of chronic hypoxia","volume":"13","author":"Barben","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.exer.2019.107690_bib82","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1096\/fj.12-221598","article-title":"Activated \u03b12-macroglobulin induces M\u00fcller glial cell migration by regulating MT1-MMP activity through LRP1","volume":"27","author":"Barcelona","year":"2013","journal-title":"FASEB J"},{"key":"10.1016\/j.exer.2019.107690_bib83","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1167\/iovs.10-5759","article-title":"alpha2-Macroglobulin induces glial fibrillary acidic protein expression mediated by low-density lipoprotein receptor-related protein 1 in M\u00fcller cells","volume":"52","author":"Barcelona","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.107690_bib6","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.celrep.2014.08.056","article-title":"Fatty acid uptake and lipid storage induced by HIF-1\u03b1 contribute to cell growth and survival after hypoxia-reoxygenation","volume":"9","author":"Bensaad","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.exer.2019.107690_bib7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00018-008-8364-z","article-title":"Vaults and the major vault protein: novel roles in signal pathway regulation and immunity","volume":"66","author":"Berger","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.exer.2019.107690_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1750-1326-9-53","article-title":"SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer's disease","volume":"9","author":"Brinkmalm","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.exer.2019.107690_bib9","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1056\/NEJMoa062655","article-title":"Ranibizumab versus verteporfin for neovascular age-related macular degeneration","volume":"355","author":"Brown","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exer.2019.107690_bib10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.preteyeres.2011.11.003","article-title":"From oxygen to erythropoietin: relevance of hypoxia for retinal development, health and disease","volume":"31","author":"Caprara","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2019.107690_bib11","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.bbadis.2017.03.022","article-title":"Impaired vitreous composition and retinal pigment epithelium function in the FoxG1::LRP2 myopic mice","volume":"1863","author":"Cases","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.exer.2019.107690_bib12","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.molcel.2011.03.030","article-title":"A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2","volume":"42","author":"Choksi","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.exer.2019.107690_bib13","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.ophtha.2010.09.012","article-title":"Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration","volume":"118","author":"Chung","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2019.107690_bib84","first-page":"65","article-title":"The eye as a complement dysregulation hotspot","volume":"84","author":"Clark","year":"2017","journal-title":"Semin. Immunopathol"},{"key":"10.1016\/j.exer.2019.107690_bib85","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00403-013-1343-8","article-title":"Calponin 3 regulates stress fiber formation in dermal fibroblasts during wound healing","volume":"305","author":"Daimon","year":"2013","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.exer.2019.107690_bib14","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1016\/S0140-6736(08)61348-3","article-title":"Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study","volume":"372","author":"Ennis","year":"2008","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.exer.2019.107690_bib15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.preteyeres.2008.11.004","article-title":"Age-related maculopathy - linking aetiology and pathophysiological changes to the ischaemia hypothesis","volume":"28","author":"Feigl","year":"2009","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2019.107690_bib86","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1111\/j.1460-9568.1996.tb01612.x","article-title":"Acidic calponin cloned from neural cells is differentially expressed during rat brain development","volume":"8","author":"Ferhat","year":"1996","journal-title":"Eur. J. Neurosci"},{"key":"10.1016\/j.exer.2019.107690_bib16","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1001\/archopht.1984.01040031330019","article-title":"Age-related macular degeneration and blindness due to neovascular maculopathy","volume":"102","author":"Ferris","year":"1984","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2019.107690_bib17","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.expneurol.2013.11.016","article-title":"Short-term psychosocial stress protects photoreceptors from damage via corticosterone-mediated activation of the AKT pathway","volume":"252","author":"Forkwa","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.exer.2019.107690_bib18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/tpj.2009.60","article-title":"A multistep validation process of biomarkers for preclinical drug development","volume":"10","author":"Freeman","year":"2010","journal-title":"Pharmacogenomics J."},{"key":"10.1016\/j.exer.2019.107690_bib19","first-page":"539","article-title":"Retinal and choroidal blood flow determined with Krypton-85 anesthetized animals","volume":"3","author":"Friedman","year":"1964","journal-title":"Investig. Ophthalmol."},{"key":"10.1016\/j.exer.2019.107690_bib20","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1021\/pr800112g","article-title":"Characterization of the vitreous proteome in diabetes without diabetic retinopathy and diabetes with proliferative diabetic retinopathy","volume":"7","author":"Gao","year":"2008","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.exer.2019.107690_bib21","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1038\/emboj.2012.125","article-title":"The updated biology of hypoxia-inducible factor","volume":"31","author":"Greer","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.exer.2019.107690_bib22","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/nm723","article-title":"HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration","volume":"8","author":"Grimm","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.exer.2019.107690_bib87","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12974-015-0376-7","article-title":"Granzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo","volume":"12","author":"Haile","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.exer.2019.107690_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ophtha.2005.10.052","article-title":"Ranibizumab for treatment of neovascular age-related macular degeneration: a phase I\/II multicenter, controlled, multidose study","volume":"113","author":"Heier","year":"2006","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2019.107690_bib24","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.mcn.2009.10.009","article-title":"Postsynaptic PDLIM5\/Enigma Homolog binds SPAR and causes dendritic spine shrinkage","volume":"43","author":"Herrick","year":"2010","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.exer.2019.107690_bib25","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/cne.22562","article-title":"SNAP25 expression in mammalian retinal horizontal cells","volume":"519","author":"Hirano","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.exer.2019.107690_bib26","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1161\/STROKEAHA.114.005116","article-title":"Delayed hyperbaric oxygen therapy promotes neurogenesis through reactive oxygen species\/hypoxia-inducible factor-1\u03b1\/\u03b2-catenin pathway in middle cerebral artery occlusion rats","volume":"45","author":"Hu","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.exer.2019.107690_bib27","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/1471-2164-9-488","article-title":"BioVenn - a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams","volume":"9","author":"Hulsen","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.exer.2019.107690_bib28","doi-asserted-by":"crossref","first-page":"10712","DOI":"10.1128\/JVI.01014-06","article-title":"Loss of VHL confers hypoxia-inducible factor (HIF)-dependent resistance to vesicular stomatitis virus: role of HIF in antiviral response","volume":"80","author":"Hwang","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.exer.2019.107690_bib88","first-page":"920","article-title":"Major vault protein forms complexes with hypoxia-inducible factor (HIF)-1\u03b1 and reduces HIF-1\u03b1 level in ACHN human renal adenocarcinoma cells","volume":"101","author":"Iwashita","year":"2010","journal-title":"Cancer Sci."},{"key":"10.1016\/j.exer.2019.107690_bib29","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1074\/jbc.M007663200","article-title":"The molecular mechanism of lead inhibition of human porphobilinogen synthase","volume":"276","author":"Jaffe","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2019.107690_bib89","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1016\/j.molimm.2007.06.145","article-title":"The role of complement system in ocular diseases including uveitis and macular degeneration","volume":"44","author":"Jha","year":"2007","journal-title":"Mol. Immunol"},{"key":"10.1016\/j.exer.2019.107690_bib30","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jchemneu.2007.03.007","article-title":"Expression of corticosteroid binding globulin in the rat central nervous system","volume":"34","author":"Jirikowski","year":"2007","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.exer.2019.107690_bib31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1021\/pr700600n","article-title":"Assigning significance to peptides identified by tandem mass spectrometry using decoy databases","volume":"7","author":"K\u00e4ll","year":"2008","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.exer.2019.107690_bib32","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s00018-016-2147-8","article-title":"Inflammation and its role in age-related macular degeneration","volume":"73","author":"Kauppinen","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.exer.2019.107690_bib90","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1126\/science.1201711","article-title":"A family of IFN-\u03b3-inducible 65-kD GTPases protects against bacterial infection","volume":"332","author":"Kim","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.exer.2019.107690_bib33","doi-asserted-by":"crossref","first-page":"454","DOI":"10.2353\/ajpath.2008.070876","article-title":"Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury","volume":"172","author":"Koike","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2019.107690_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096895","article-title":"Proteomics of vitreous humor of patients with exudative age-related macular degeneration","volume":"9","author":"Koss","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2019.107690_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.14319","article-title":"Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration","volume":"5","author":"Kurihara","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.exer.2019.107690_bib36","doi-asserted-by":"crossref","first-page":"D488","DOI":"10.1093\/nar\/gkv1024","article-title":"WikiPathways: capturing the full diversity of pathway knowledge","volume":"44","author":"Kutmon","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2019.107690_bib37","doi-asserted-by":"crossref","first-page":"5872","DOI":"10.1167\/iovs.11-7204","article-title":"Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration","volume":"52","author":"Lange","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.107690_bib38","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1748-717X-4-29","article-title":"Severe hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expression","volume":"4","author":"Lara","year":"2009","journal-title":"Radiat. Oncol."},{"key":"10.1016\/j.exer.2019.107690_bib39","first-page":"335","article-title":"The Framingham Eye Study monograph: an ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975","volume":"24","author":"Leibowitz","year":"1980","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2019.107690_bib40","first-page":"3117","article-title":"Metabolic dependence of photoreceptors on the choroid in the normal and detached retina","volume":"41","author":"Linsenmeier","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.107690_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5402\/2012\/480212","article-title":"Today and future of age-related macular degeneration","volume":"2012","author":"Liu","year":"2012","journal-title":"ISRN Ophthalmol"},{"key":"10.1016\/j.exer.2019.107690_bib42","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1021\/acs.jproteome.5b00900","article-title":"Quantitative proteomics analysis of vitreous humor from diabetic retinopathy patients","volume":"14","author":"Loukovaara","year":"2015","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.exer.2019.107690_bib91","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0002-9440(10)64452-5","article-title":"Guanylate-binding protein-1 expression is selectively induced by inflammatory cytokines and is an activation marker of endothelial cells during inflammatory diseases","volume":"161","author":"Lubeseder-Martellato","year":"2002","journal-title":"Am. J. Pathol"},{"key":"10.1016\/j.exer.2019.107690_bib43","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1186\/s13104-015-1633-7","article-title":"Effects of oxygen on the antigenic landscape of prostate cancer cells","volume":"8","author":"Ma","year":"2015","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.exer.2019.107690_bib44","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.stem.2017.10.005","article-title":"Hypoxic induction of vasorin regulates Notch1 turnover to maintain glioma stem-like cells","volume":"22","author":"Man","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exer.2019.107690_bib45","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1002\/2211-5463.12252","article-title":"The proteomic profile of a mouse model of proliferative vitreoretinopathy","volume":"7","author":"M\u00e1rkus","year":"2017","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.exer.2019.107690_bib46","doi-asserted-by":"crossref","first-page":"D183","DOI":"10.1093\/nar\/gkw1138","article-title":"PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements","volume":"45","author":"Mi","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2019.107690_bib47","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1007\/s11064-017-2208-x","article-title":"Up-regulation of GBP2 is associated with neuronal apoptosis in rat brain cortex following traumatic brain injury","volume":"42","author":"Miao","year":"2017","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.exer.2019.107690_bib48","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/prca.201400133","article-title":"Vitreous humor in the pathologic scope: insights from proteomic approaches","volume":"9","author":"Monteiro","year":"2015","journal-title":"Proteonomics Clin. Appl."},{"key":"10.1016\/j.exer.2019.107690_bib49","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.exer.2016.01.001","article-title":"Proteomics of vitreous in neovascular age-related macular degeneration","volume":"146","author":"Nobl","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2019.107690_bib50","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.redox.2016.11.007","article-title":"Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission","volume":"11","author":"O'Mealey","year":"2017","journal-title":"Redox Biol"},{"key":"10.1016\/j.exer.2019.107690_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072638","article-title":"Ensemble of gene signatures identifies novel biomarkers in colorectal cancer activated through PPAR\u03b3 and TNF\u03b1 signaling","volume":"8","author":"Pagnotta","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2019.107690_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-079X.1998.tb00359.x","article-title":"In vivo protection by melatonin against delta-aminolevulinic acid-induced oxidative damage and its antioxidant effect on the activity of haem enzymes","volume":"24","author":"Princ","year":"1998","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.exer.2019.107690_bib53","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/cdd.2011.95","article-title":"HIF-1\u03b1 is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway","volume":"19","author":"Qiang","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.exer.2019.107690_bib54","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1056\/NEJMoa054481","article-title":"Ranibizumab for neovascular age-related macular degeneration","volume":"355","author":"Rosenfeld","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exer.2019.107690_bib55","doi-asserted-by":"crossref","first-page":"5304","DOI":"10.1167\/iovs.14-14789","article-title":"A mouse model for studying cone photoreceptor pathologies","volume":"55","author":"Samardzija","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.107690_bib92","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.exer.2006.07.016","article-title":"Low-density lipoprotein receptor-related protein-1 (LRP-1) expression in a rat model of oxygen-induced retinal neovascularization","volume":"83","author":"S\u00e1nchez","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2019.107690_bib56","doi-asserted-by":"crossref","first-page":"AMD31","DOI":"10.1167\/iovs.18-24122","article-title":"The proteomic landscape in the vitreous of patients with age-related and diabetic retinal disease","volume":"59","author":"Schori","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.107690_bib57","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1158\/1541-7786.MCR-13-0607","article-title":"HIFs enhance the transcriptional activation and splicing of adrenomedullin","volume":"12","author":"Sena","year":"2014","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.exer.2019.107690_bib58","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1074\/jbc.274.3.1359","article-title":"Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L","volume":"274","author":"Shih","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2019.107690_bib59","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/prca.200800017","article-title":"Proteome profiling of vitreoretinal diseases by cluster Analysis. Proteomics","volume":"2","author":"Shitama","year":"2008","journal-title":"Clin. Appl."},{"key":"10.1016\/j.exer.2019.107690_bib60","doi-asserted-by":"crossref","first-page":"893","DOI":"10.2337\/dc13-2002","article-title":"Ocular Anti-VEGF therapy for diabetic retinopathy: the role of VEGF in the pathogenesis of diabetic retinopathy","volume":"37","author":"Sim\u00f3","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.exer.2019.107690_bib61","first-page":"245","article-title":"Intrinsic expression of transcortin in neural cells of the mouse brain: a histochemical and molecular study","volume":"216","author":"Sivukhina","year":"2013","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.exer.2019.107690_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082140","article-title":"Proteomic interactions in the mouse vitreous-retina complex","volume":"8","author":"Skeie","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2019.107690_bib63","first-page":"12","article-title":"Evisceration of mouse vitreous and retina for proteomic analyses","author":"Skeie","year":"2011","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.exer.2019.107690_bib64","series-title":"The PluriNetWork\u202f: an Electronic Representation of the Network Underlying Pluripotency in Mouse , and its Applications 5","author":"Som","year":"2010"},{"key":"10.1016\/j.exer.2019.107690_bib65","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.preteyeres.2010.09.003","article-title":"Metabolic physiology in age related macular degeneration","volume":"30","author":"Stef\u00e1nsson","year":"2011","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2019.107690_bib66","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.exer.2019.107690_bib93","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.bbrc.2017.05.067","article-title":"Identification of vitreous proteins in retinopathy of prematurity","volume":"488","author":"Sugioka","year":"2017","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.exer.2019.107690_bib67","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.bbrc.2010.07.084","article-title":"Cathepsin B-dependent motor neuron death after nerve injury in the adult mouse","volume":"399","author":"Sun","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2019.107690_bib68","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13287-015-0062-9","article-title":"Influence of vascular endothelial growth factor stimulation and serum deprivation on gene activation patterns of human adipose tissue-derived stromal cells","volume":"6","author":"Tratwal","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.exer.2019.107690_bib69","series-title":"Proceedings of the 13th International Conference on Extending Database Technology - EDBT \u201910","first-page":"717","article-title":"B-Fabric","author":"T\u00fcrker","year":"2010"},{"key":"10.1016\/j.exer.2019.107690_bib70","first-page":"1261","article-title":"Age-related alterations in retinal neurovascular and inflammatory transcripts","volume":"17","author":"Van Kirk","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2019.107690_bib71","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gkv1145","article-title":"2016 update of the PRIDE database and its related tools","volume":"44","author":"Vizca\u00edno","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2019.107690_bib72","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.exer.2012.11.023","article-title":"Differentiating vitreous proteomes in proliferative diabetic retinopathy using high-performance liquid chromatography coupled to tandem mass spectrometry","volume":"108","author":"Wang","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2019.107690_bib73","doi-asserted-by":"crossref","first-page":"W130","DOI":"10.1093\/nar\/gkx356","article-title":"WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2019.107690_bib74","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nmeth.1322","article-title":"Universal sample preparation method for proteome analysis","volume":"6","author":"Wi\u015bniewski","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.exer.2019.107690_bib75","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet. Glob. Heal."},{"key":"10.1016\/j.exer.2019.107690_bib76","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1111\/cas.13830","article-title":"Mitochondrial network structure homeostasis and cell death","volume":"109","author":"Xie","year":"2018","journal-title":"Cancer Sci."},{"key":"10.1016\/j.exer.2019.107690_bib77","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1074\/mcp.M300038-MCP200","article-title":"Proteome analysis of human vitreous proteins","volume":"2","author":"Yamane","year":"2003","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.exer.2019.107690_bib78","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2350-13-91","article-title":"Peripheral PDLIM5 expression in bipolar disorder and the effect of olanzapine administration","volume":"13","author":"Zain","year":"2012","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.exer.2019.107690_bib79","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.559","article-title":"Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion","volume":"8","author":"Zhang","year":"2017","journal-title":"Cell Death Dis."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483519301174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483519301174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:01:07Z","timestamp":1757998867000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483519301174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":93,"alternative-id":["S0014483519301174"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2019.107690","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A chronic hypoxic response in photoreceptors alters the vitreous proteome in mice","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2019.107690","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107690"}}