{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:01:48Z","timestamp":1781766108008,"version":"3.54.5"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2018SK2131"],"award-info":[{"award-number":["2018SK2131"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.exer.2019.107699","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T12:29:06Z","timestamp":1560428946000},"page":"107699","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Traditional two-dimensional mesenchymal stem cells (MSCs) are better than spheroid MSCs on promoting retinal ganglion cells survival and axon regeneration"],"prefix":"10.1016","volume":"185","author":[{"given":"Wei","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lusi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changzheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2019.107699_bib1","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1167\/iovs.08-2404","article-title":"Immediate upregulation of proteins belonging to different branches of the apoptotic cascade in the retina after optic nerve transection and optic nerve crush","volume":"50","author":"Agudo","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.107699_bib2","doi-asserted-by":"crossref","first-page":"13724","DOI":"10.1073\/pnas.1008117107","article-title":"Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties","volume":"107","author":"Bartosh","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2019.107699_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.exer.2018.07.019","article-title":"The current state of stem cell therapy for ocular disease","volume":"177","author":"Bobba","year":"2018","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2019.107699_bib4","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.biopha.2018.02.138","article-title":"Plasmid-based gene therapy with hepatocyte growth factor stimulates peripheral nerve regeneration after traumatic injury","volume":"101","author":"Boldyreva Mcapital A","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.exer.2019.107699_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035685","article-title":"Mesenchymal stem cells secrete multiple cytokines that promote angiogenesis and have contrasting effects on chemotaxis and apoptosis","volume":"7","author":"Boomsma","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2019.107699_bib6","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/jor.1100090504","article-title":"Mesenchymal stem cells","volume":"9","author":"Caplan","year":"1991","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.exer.2019.107699_bib7","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1097\/WNR.0b013e328355f1d6","article-title":"Long-term survival and axonal regeneration of retinal ganglion cells after optic nerve transection and a peripheral nerve graft","volume":"23","author":"Cen","year":"2012","journal-title":"Neuroreport"},{"key":"10.1016\/j.exer.2019.107699_bib8","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1634\/stemcells.2007-0708","article-title":"Impact of myocardial infarct proteins and oscillating pressure on the differentiation of mesenchymal stem cells: effect of acute myocardial infarction on stem cell differentiation","volume":"26","author":"Chang","year":"2008","journal-title":"Stem Cell."},{"key":"10.1016\/j.exer.2019.107699_bib9","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3727\/096368909X471189","article-title":"Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats","volume":"18","author":"Chang","year":"2009","journal-title":"Cell Transplant."},{"key":"10.1016\/j.exer.2019.107699_bib10","doi-asserted-by":"crossref","first-page":"2417268","DOI":"10.1155\/2016\/2417268","article-title":"Stem cell-released microvesicles and exosomes as novel biomarkers and treatments of diseases","volume":"2016","author":"Chen","year":"2016","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.exer.2019.107699_bib11","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1002\/jnr.22162","article-title":"Intraarterially delivered human umbilical cord blood-derived mesenchymal stem cells in canine cerebral ischemia","volume":"87","author":"Chung","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.exer.2019.107699_bib12","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.drudis.2010.02.007","article-title":"Strategies for optic nerve rescue and regeneration in glaucoma and other optic neuropathies","volume":"15","author":"Dahlmann-Noor","year":"2010","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.exer.2019.107699_bib13","doi-asserted-by":"crossref","first-page":"9149","DOI":"10.1073\/pnas.1119449109","article-title":"Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors","volume":"109","author":"de Lima","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2019.107699_bib14","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/ICU.0000000000000473","article-title":"Gene therapy in optic nerve disease","volume":"29","author":"DeBusk","year":"2018","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.exer.2019.107699_bib15","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1046\/j.1365-2141.2000.01986.x","article-title":"Mesenchymal progenitor cells in human umbilical cord blood","volume":"109","author":"Erices","year":"2000","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.exer.2019.107699_bib16","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/gt.2011.57","article-title":"Hepatocyte growth factor incorporated into herpes simplex virus vector accelerates facial nerve regeneration after crush injury","volume":"18","author":"Esaki","year":"2011","journal-title":"Gene Ther."},{"key":"10.1016\/j.exer.2019.107699_bib17","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.preteyeres.2012.06.005","article-title":"Promoting optic nerve regeneration","volume":"31","author":"Fischer","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2019.107699_bib18","first-page":"3943","article-title":"Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture","volume":"41","author":"Fischer","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.107699_bib19","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.exer.2018.09.006","article-title":"Pronounced synergistic neuroprotective effect of GDNF and CNTF on axotomized retinal ganglion cells in the adult mouse","volume":"176","author":"Flachsbarth","year":"2018","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2019.107699_bib20","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1080\/14653240701584578","article-title":"UC blood-derived mesenchymal stromal cells: an overview","volume":"9","author":"Flynn","year":"2007","journal-title":"Cytotherapy"},{"key":"10.1016\/j.exer.2019.107699_bib21","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1089\/ten.tec.2009.0432","article-title":"Dynamic three-dimensional culture methods enhance mesenchymal stem cell properties and increase therapeutic potential","volume":"16","author":"Frith","year":"2010","journal-title":"Tissue Eng. C Methods"},{"key":"10.1016\/j.exer.2019.107699_bib22","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbrc.2004.06.111","article-title":"In vitro mesengenic potential of human umbilical cord blood-derived mesenchymal stem cells","volume":"321","author":"Gang","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2019.107699_bib23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature09805","article-title":"Somatic coding mutations in human induced pluripotent stem cells","volume":"471","author":"Gore","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.exer.2019.107699_bib24","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1136\/ard.2011.150607","article-title":"Bone marrow-derived mesenchymal stem cells from early diffuse systemic sclerosis exhibit a paracrine machinery and stimulate angiogenesis in vitro","volume":"70","author":"Guiducci","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.exer.2019.107699_bib25","doi-asserted-by":"crossref","first-page":"10942","DOI":"10.1038\/srep10942","article-title":"The serum profile of hypercytokinemia factors identified in H7N9-infected patients can predict fatal outcomes","volume":"5","author":"Guo","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2019.107699_bib26","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1126\/science.1088547","article-title":"LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1","volume":"302","author":"Hacein-Bey-Abina","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.exer.2019.107699_bib27","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1167\/iovs.11-7346","article-title":"Transplantation of BDNF-secreting mesenchymal stem cells provides neuroprotection in chronically hypertensive rat eyes","volume":"52","author":"Harper","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.107699_bib28","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/sj.gt.3301498","article-title":"Gene therapy for preventing neuronal death using hepatocyte growth factor: in vivo gene transfer of HGF to subarachnoid space prevents delayed neuronal death in gerbil hippocampal CA1 neurons","volume":"8","author":"Hayashi","year":"2001","journal-title":"Gene Ther."},{"key":"10.1016\/j.exer.2019.107699_bib29","first-page":"1467","article-title":"Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma","volume":"8","author":"Hu","year":"2013","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.exer.2019.107699_bib30","doi-asserted-by":"crossref","first-page":"6929","DOI":"10.1016\/j.biomaterials.2011.05.092","article-title":"Spheroid formation of mesenchymal stem cells on chitosan and chitosan-hyaluronan membranes","volume":"32","author":"Huang","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.exer.2019.107699_bib31","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.exer.2015.10.010","article-title":"Autocrine protective mechanisms of human granulocyte colony-stimulating factor (G-CSF) on retinal ganglion cells after optic nerve crush","volume":"143","author":"Huang","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2019.107699_bib32","doi-asserted-by":"crossref","first-page":"5016768","DOI":"10.1155\/2016\/5016768","article-title":"The effect of MSCs derived from the human umbilical cord transduced by fibroblast growth factor-20 on Parkinson's disease","volume":"2016","author":"Jinfeng","year":"2016","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.exer.2019.107699_bib33","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1167\/iovs.09-4509","article-title":"Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma","volume":"51","author":"Johnson","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.107699_bib34","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/IJG.0b013e3181d12dd8","article-title":"Efficacy and mechanisms of intraocular pressure reduction with latanoprost and timolol in participants with ocular hypertension: a comparison of 1 and 6 weeks of treatment","volume":"19","author":"Johnson","year":"2010","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.exer.2019.107699_bib35","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1093\/brain\/awv125","article-title":"The MDM4\/MDM2-p53-IGF1 axis controls axonal regeneration, sprouting and functional recovery after CNS injury","volume":"138","author":"Joshi","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.exer.2019.107699_bib36","doi-asserted-by":"crossref","first-page":"933","DOI":"10.2217\/rme.10.72","article-title":"Mesenchymal stem cells for the treatment of neurodegenerative disease","volume":"5","author":"Joyce","year":"2010","journal-title":"Regen. Med."},{"key":"10.1016\/j.exer.2019.107699_bib37","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1167\/iovs.12-9712","article-title":"Retinal ganglion cell morphology after optic nerve crush and experimental glaucoma","volume":"53","author":"Kalesnykas","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.107699_bib38","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4252\/wjsc.v2.i2.34","article-title":"Application of human umbilical cord blood-derived mesenchymal stem cells in disease models","volume":"2","author":"Kim","year":"2010","journal-title":"World J. Stem Cell."},{"key":"10.1016\/j.exer.2019.107699_bib39","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1002\/jnr.21372","article-title":"Hepatocyte growth factor promotes endogenous repair and functional recovery after spinal cord injury","volume":"85","author":"Kitamura","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.exer.2019.107699_bib40","doi-asserted-by":"crossref","first-page":"8316","DOI":"10.1038\/s41598-018-26704-x","article-title":"Hepatocyte growth factor (HGF) promotes peripheral nerve regeneration by activating repair schwann cells","volume":"8","author":"Ko","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2019.107699_bib41","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.exphem.2005.01.012","article-title":"Cytokine production and hematopoiesis supporting activity of cord blood-derived unrestricted somatic stem cells","volume":"33","author":"Kogler","year":"2005","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.exer.2019.107699_bib42","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.exer.2016.08.002","article-title":"Insulin-like growth factor 1 rescues R28 retinal neurons from apoptotic death through ERK-mediated BimEL phosphorylation independent of Akt","volume":"151","author":"Kong","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2019.107699_bib43","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00701-005-0538-y","article-title":"Functional recovery after human umbilical cord blood cells transplantation with brain-derived neutrophic factor into the spinal cord injured rat","volume":"147","author":"Kuh","year":"2005","journal-title":"Acta Neurochir (Wien)"},{"key":"10.1016\/j.exer.2019.107699_bib44","doi-asserted-by":"crossref","first-page":"15654","DOI":"10.1523\/JNEUROSCI.4340-10.2010","article-title":"Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion","volume":"30","author":"Kurimoto","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2019.107699_bib45","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neulet.2010.06.045","article-title":"The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease","volume":"481","author":"Lee","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.exer.2019.107699_bib46","doi-asserted-by":"crossref","first-page":"816","DOI":"10.5966\/sctm.2015-0191","article-title":"Hypoxic conditioned medium from human adipose-derived stem cells promotes mouse liver regeneration through JAK\/STAT3 signaling","volume":"5","author":"Lee","year":"2016","journal-title":"Stem Cell. Transl. Med."},{"key":"10.1016\/j.exer.2019.107699_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.310","article-title":"Neuronal STAT3 activation is essential for CNTF- and inflammatory stimulation-induced CNS axon regeneration","volume":"4","author":"Leibinger","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2019.107699_bib48","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1038\/mt.2016.102","article-title":"Boosting central nervous system Axon regeneration by circumventing limitations of natural cytokine signaling","volume":"24","author":"Leibinger","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2019.107699_bib49","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2174\/1570159X14666161227150250","article-title":"Exploring optic nerve axon regeneration","volume":"15","author":"Li","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.exer.2019.107699_bib50","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00417-008-1009-y","article-title":"Effects of bone-marrow mesenchymal stem cells transplanted into vitreous cavity of rat injured by ischemia\/reperfusion","volume":"247","author":"Li","year":"2009","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2019.107699_bib51","doi-asserted-by":"crossref","first-page":"5078619","DOI":"10.1155\/2016\/5078619","article-title":"Bone marrow-derived cells as a therapeutic approach to optic nerve diseases","volume":"2016","author":"Mesentier-Louro","year":"2016","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.exer.2019.107699_bib52","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.14908","article-title":"mTORC1 is necessary but mTORC2 and GSK3beta are inhibitory for AKT3-induced axon regeneration in the central nervous system","volume":"5","author":"Miao","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.exer.2019.107699_bib53","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.mcn.2009.03.002","article-title":"Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF","volume":"41","author":"Muller","year":"2009","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.exer.2019.107699_bib54","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1182\/blood-2007-02-069716","article-title":"Immunomodulatory properties of mesenchymal stromal cells","volume":"110","author":"Nauta","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.exer.2019.107699_bib55","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature05934","article-title":"Generation of germline-competent induced pluripotent stem cells","volume":"448","author":"Okita","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.exer.2019.107699_bib56","doi-asserted-by":"crossref","first-page":"e1598","DOI":"10.1038\/cddis.2014.562","article-title":"Glutathione transferases P1\/P2 regulate the timing of signaling pathway activations and cell cycle progression during mouse liver regeneration","volume":"6","author":"Pajaud","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2019.107699_bib57","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1161566","article-title":"Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway","volume":"322","author":"Park","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.exer.2019.107699_bib58","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/TP.0b013e3181c7dc99","article-title":"Trophic molecules derived from human mesenchymal stem cells enhance survival, function, and angiogenesis of isolated islets after transplantation","volume":"89","author":"Park","year":"2010","journal-title":"Transplantation"},{"key":"10.1016\/j.exer.2019.107699_bib59","doi-asserted-by":"crossref","first-page":"13100","DOI":"10.1074\/jbc.M800184200","article-title":"Culturing of human mesenchymal stem cells as three-dimensional aggregates induces functional expression of CXCR4 that regulates adhesion to endothelial cells","volume":"283","author":"Potapova","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2019.107699_bib60","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/mt.2009.62","article-title":"Repair of tissues by adult stem\/progenitor cells (MSCs): controversies, myths, and changing paradigms","volume":"17","author":"Prockop","year":"2009","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2019.107699_bib61","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1089\/dna.2006.0562","article-title":"Spheroid formation and differentiation into hepatocyte-like cells of rat mesenchymal stem cell induced by co-culture with liver cells","volume":"26","author":"Qihao","year":"2007","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.exer.2019.107699_bib62","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.exer.2013.07.010","article-title":"Human embryonic stem cell applications for retinal degenerations","volume":"123","author":"Reynolds","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2019.107699_bib63","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1161\/01.CIR.0000109496.82683.49","article-title":"Novel therapeutic strategy to treat brain ischemia: overexpression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model","volume":"109","author":"Shimamura","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.exer.2019.107699_bib64","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.neuron.2009.11.021","article-title":"SOCS3 deletion promotes optic nerve regeneration in vivo","volume":"64","author":"Smith","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.exer.2019.107699_bib65","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature10594","article-title":"Sustained axon regeneration induced by co-deletion of PTEN and SOCS3","volume":"480","author":"Sun","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.exer.2019.107699_bib66","first-page":"487","article-title":"The therapeutic effects of bone marrow mesenchymal stem cells after optic nerve damage in the adult rat","volume":"10","author":"Tan","year":"2015","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.exer.2019.107699_bib67","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nri2395","article-title":"Mesenchymal stem cells in health and disease","volume":"8","author":"Uccelli","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.exer.2019.107699_bib68","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1634\/stemcells.2008-0944","article-title":"Spherically symmetric mesenchymal stromal cell bodies inherent with endogenous extracellular matrices for cellular cardiomyoplasty","volume":"27","author":"Wang","year":"2009","journal-title":"Stem Cell."},{"key":"10.1016\/j.exer.2019.107699_bib69","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12031-015-0612-8","article-title":"Raf-1 kinase inhibitory protein (RKIP) promotes retinal ganglion cell survival and axonal regeneration following optic nerve crush","volume":"57","author":"Wei","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.exer.2019.107699_bib70","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s40778-016-0060-6","article-title":"Adult versus pluripotent stem cell-derived mesenchymal stem cells: the need for more precise nomenclature","volume":"2","author":"West","year":"2016","journal-title":"Curr. Stem Cell Rep."},{"key":"10.1016\/j.exer.2019.107699_bib71","first-page":"2730472","article-title":"Signal factors secreted by 2D and spheroid mesenchymal stem cells and by cocultures of mesenchymal stem cells derived microvesicles and retinal photoreceptor neurons","volume":"2017","author":"Xie","year":"2017","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.exer.2019.107699_bib72","first-page":"2346","article-title":"[Induction of pluripotent stem cells from mouse fibroblast cultures]","volume":"51","author":"Yamanaka","year":"2006","journal-title":"Tanpakushitsu Kakusan Koso"},{"key":"10.1016\/j.exer.2019.107699_bib73","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1038\/ncomms6416","article-title":"The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration","volume":"5","author":"Yang","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2019.107699_bib74","first-page":"541","article-title":"Neuroprotective effects of gypenosides in experimental autoimmune optic neuritis","volume":"10","author":"Zhang","year":"2017","journal-title":"Int. J. Ophthalmol."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518309291?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483518309291?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:28:38Z","timestamp":1762147718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483518309291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":74,"alternative-id":["S0014483518309291"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2019.107699","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Traditional two-dimensional mesenchymal stem cells (MSCs) are better than spheroid MSCs on promoting retinal ganglion cells survival and axon regeneration","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2019.107699","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107699"}}