{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:15:50Z","timestamp":1793121350592,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.exer.2019.107900","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T11:18:57Z","timestamp":1577099937000},"page":"107900","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"special_numbering":"C","title":["Piezo channel plays a part in retinal ganglion cell damage"],"prefix":"10.1016","volume":"191","author":[{"given":"Wataru","family":"Morozumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Inagaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamitsu","family":"Shimazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2019.107900_bib1","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1167\/iovs.17-23276","article-title":"Topical ripasudil suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma","volume":"59","author":"Akaiwa","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.107900_bib2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0896-6273(03)00462-8","article-title":"Hypotonicity induces TRPV4-mediated nociception in rat","volume":"39","author":"Alessandri-haber","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.exer.2019.107900_bib3","first-page":"749","article-title":"Astrocytes in the optic nerve head express putative mechanosensitive channels","volume":"21","author":"Choi","year":"2015","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2019.107900_bib4","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature10812","article-title":"Piezo proteins are pore-forming subunits of mechanically activated channels","volume":"483","author":"Coste","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.exer.2019.107900_bib5","article-title":"CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells","volume":"1\u201312","author":"Giese","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2019.107900_bib6","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0896-6273(02)00602-5","article-title":"Retinal ganglion cells do not extend axons by default","volume":"33","author":"Goldberg","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.exer.2019.107900_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/nature25744","article-title":"Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel","author":"He","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.exer.2019.107900_bib8","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/jnr.21906","article-title":"A Na+\/Ca2+exchanger isoform, NCX1, is involved in retinal cell death after N-methyl-D-aspartate injection and ischemia-reperfusion","volume":"87","author":"Inokuchi","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.exer.2019.107900_bib9","doi-asserted-by":"crossref","first-page":"14531","DOI":"10.1073\/pnas.2235619100","article-title":"Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans","volume":"100","author":"Liedtke","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.exer.2019.107900_bib10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nn1406","article-title":"Local calcium transients regulate the spontaneous motility of dendritic filopodia","volume":"8","author":"Lohmann","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.exer.2019.107900_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-04132-7","article-title":"Behavioral abnormalities with disruption of brain structure in mice overexpressing VGF","volume":"7","author":"Mizoguchi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2019.107900_bib12","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jphs.2017.02.012","article-title":"Toll-like receptor 4 inhibitor protects against retinal ganglion cell damage induced by optic nerve crush in mice","volume":"133","author":"Nakano","year":"2017","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.exer.2019.107900_bib13","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature20793","article-title":"Piezo2 senses airway stretch and mediates lung inflation-induced apnoea","volume":"541","author":"Nonomura","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.exer.2019.107900_bib14","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1083\/jcb.200503157","article-title":"Cell adhesion molecules regulate Ca2+-mediated steering of growth cones via cyclic AMP and ryanodine receptor type 3","author":"Ooashi","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.exer.2019.107900_bib15","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.3109\/02713683.2015.1127392","article-title":"Astaxanthin protects against retinal damage: evidence from in vivo and in vitro retinal ischemia and reperfusion models","volume":"41","author":"Otsuka","year":"2016","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2019.107900_bib16","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1093\/emboj\/17.15.4283","article-title":"A mammalian two pore domain mechano-gated S-like K+ channel","volume":"17","author":"Patel","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.exer.2019.107900_bib17","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1080\/09168451.2014.932664","article-title":"Mechanical compression insults induce nanoscale changes of membrane-skeleton arrangement which could cause apoptosis and necrosis in dorsal root ganglion neurons neurons","volume":"78","author":"Quan","year":"2014","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.exer.2019.107900_bib18","doi-asserted-by":"crossref","first-page":"7089","DOI":"10.1523\/JNEUROSCI.0359-11.2011","article-title":"The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux , spiking rate , and apoptosis of mouse retinal ganglion cells","volume":"31","author":"Ryskamp","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2019.107900_bib19","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1167\/iovs.08-2321","article-title":"TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure","volume":"50","author":"Sappington","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2019.107900_bib20","author":"Shimazawa"},{"key":"10.1016\/j.exer.2019.107900_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-18089-0","article-title":"Piezo type mechanosensitive ion channel component 1 functions as a regulator of the cell fate determination of mesenchymal stem cells","volume":"7","author":"Sugimoto","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2019.107900_bib22","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/excr.1997.3666","article-title":"Pressure-induced apoptosis in human lymphoblasts","volume":"160","author":"Takano","year":"1997","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.exer.2019.107900_bib23","article-title":"VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush","volume":"1\u201313","author":"Takeuchi","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2019.107900_bib24","first-page":"254","article-title":"NGF increases VEGF expression and promotes cell proliferation via ERK1\/2 and AKT signaling in M\u00fcller cells","volume":"22","author":"Wang","year":"2016","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2019.107900_bib25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.tibs.2016.09.004","article-title":"Touch, tension, and transduction \u2013 the function and regulation of Piezo ion channels","volume":"42","author":"Wu","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.exer.2019.107900_bib26","article-title":"Piezo2 protein: a novel regulator of tumor angiogenesis and hyperpermeability","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483519307031?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483519307031?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:01:16Z","timestamp":1757998876000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483519307031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":26,"alternative-id":["S0014483519307031"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2019.107900","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Piezo channel plays a part in retinal ganglion cell damage","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2019.107900","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107900"}}