{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:07:33Z","timestamp":1793189253887,"version":"4.5.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770926"],"award-info":[{"award-number":["81770926"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800842"],"award-info":[{"award-number":["81800842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.exer.2020.108117","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T03:29:52Z","timestamp":1593228592000},"page":"108117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["In vivo evaluation of retinal ganglion cells and optic nerve's integrity in large animals by multi-modality analysis"],"prefix":"10.1016","volume":"197","author":[{"given":"Yikui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoliang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingna","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.exer.2020.108117_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10633-012-9353-y","article-title":"ISCEV standard for clinical pattern electroretinography (PERG): 2012 update","volume":"126","author":"Bach","year":"2013","journal-title":"Doc. Ophthalmol."},{"issue":"5","key":"10.1016\/j.exer.2020.108117_bib2","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1152\/jn.1984.51.5.952","article-title":"Linear and nonlinear components of human electroretinogram","volume":"51","author":"Baker","year":"1984","journal-title":"J. Neurophysiol."},{"issue":"12","key":"10.1016\/j.exer.2020.108117_bib3","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1056\/NEJMcp053247","article-title":"Optic neuritis","volume":"354","author":"Balcer","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"292","key":"10.1016\/j.exer.2020.108117_bib4","article-title":"Large animal models for anterior cruciate ligament research","volume":"6","author":"Bascu\u00f1\u00e1n","year":"2019","journal-title":"Front. Vet. Sci."},{"issue":"1\u20132","key":"10.1016\/j.exer.2020.108117_bib5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.cell.2015.11.036","article-title":"Restoration of visual function by enhancing conduction in regenerated axons","volume":"164","author":"Bei","year":"2016","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.exer.2020.108117_bib6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00000542-199307000-00006","article-title":"The pupillary light reflex. Effects of anesthetics and hyperthermia","volume":"79","author":"Belani","year":"1993","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.exer.2020.108117_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF00143211","article-title":"Spatial tuning of the pattern ERG across temporal frequency","volume":"61","author":"Berninger","year":"1985","journal-title":"Doc. Ophthalmol. Adv. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2020.108117_bib8","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1136\/jnnp.74.2.246","article-title":"Visual prognosis after indirect traumatic optic neuropathy","volume":"74","author":"Carta","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatr."},{"issue":"2","key":"10.1016\/j.exer.2020.108117_bib9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/neuros\/nyw045","article-title":"Lateral orbitotomy approach for lesions involving the middle fossa: a retrospective review of thirteen patients","volume":"80","author":"Chabot","year":"2017","journal-title":"Neurosurgery"},{"issue":"13","key":"10.1016\/j.exer.2020.108117_bib10","doi-asserted-by":"crossref","first-page":"8086","DOI":"10.1167\/iovs.12-10720","article-title":"The bioelectric field of the pattern electroretinogram in the mouse","volume":"53","author":"Chou","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.exer.2020.108117_bib11","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1167\/iovs.14-13943","article-title":"Robust mouse pattern electroretinograms derived simultaneously from each eye using a common snout electrode","volume":"55","author":"Chou","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.exer.2020.108117_bib12","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.neuroscience.2009.03.045","article-title":"Anatomical origins of ocular dominance in mouse primary visual cortex","volume":"161","author":"Coleman","year":"2009","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.exer.2020.108117_bib13","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s11914-018-0431-2","article-title":"Preclinical and translational studies in small ruminants (sheep and goat) as models for osteoporosis research","volume":"16","author":"Dias","year":"2018","journal-title":"Curr. Osteoporos. Rep."},{"issue":"5","key":"10.1016\/j.exer.2020.108117_bib14","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/bja\/ael239","article-title":"Effects of isoflurane and enflurane on GABAA and glycine receptors contribute equally to depressant actions on spinal ventral horn neurones in rats","volume":"97","author":"Grasshoff","year":"2006","journal-title":"Br. J. Anaesth."},{"issue":"4","key":"10.1016\/j.exer.2020.108117_bib15","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1365-2885.1988.tb00189.x","article-title":"Xylazine--a review of its pharmacology and use in veterinary medicine","volume":"11","author":"Greene","year":"1988","journal-title":"J. Vet. Pharmacol. Therapeut."},{"issue":"4","key":"10.1016\/j.exer.2020.108117_bib16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.preteyeres.2010.02.001","article-title":"Linking structure and function in glaucoma","volume":"29","author":"Harwerth","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"issue":"2","key":"10.1016\/j.exer.2020.108117_bib17","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4103\/0301-4738.77024","article-title":"Management of ischemic optic neuropathies","volume":"59","author":"Hayreh","year":"2011","journal-title":"Indian J. Ophthalmol."},{"issue":"10","key":"10.1016\/j.exer.2020.108117_bib18","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","article-title":"Reduction of intraocular pressure and glaucoma progression: results from the early manifest glaucoma trial","volume":"120","author":"Heijl","year":"2002","journal-title":"Arch. Ophthalmol."},{"issue":"5","key":"10.1016\/j.exer.2020.108117_bib19","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1152\/jn.1984.51.5.939","article-title":"Human pattern-evoked electroretinogram","volume":"51","author":"Hess","year":"1984","journal-title":"J. Neurophysiol."},{"issue":"7","key":"10.1016\/j.exer.2020.108117_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.329","article-title":"Neuroprotection by eIF2\u03b1-CHOP inhibition and XBP-1 activation in EAE\/optic neuritiss","volume":"8","author":"Huang","year":"2017","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.exer.2020.108117_bib21","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/00000542-199902000-00024","article-title":"Effects of temperature and volatile anesthetics on GABA(A) receptors","volume":"90","author":"Jenkins","year":"1999","journal-title":"Anesthesiology"},{"issue":"3","key":"10.1016\/j.exer.2020.108117_bib22","doi-asserted-by":"crossref","DOI":"10.3171\/2018.12.FOCUS18602","article-title":"Stem cell therapies for acute spinal cord injury in humans: a review","volume":"46","author":"Jin","year":"2019","journal-title":"Neurosurg. Focus"},{"issue":"1","key":"10.1016\/j.exer.2020.108117_bib23","first-page":"40","article-title":"Comparison of isoflurane, ketamine-dexmedetomidine, and ketamine-xylazine for general anesthesia during oral procedures in rice rats (Oryzomys palustris)","volume":"58","author":"Jiron","year":"2019","journal-title":"JAALAS : JAALAS"},{"issue":"5","key":"10.1016\/j.exer.2020.108117_bib24","first-page":"897","article-title":"Pattern-evoked potentials and optic nerve fiber loss in monocular laser-induced glaucoma","volume":"30","author":"Johnson","year":"1989","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108117_bib25","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1113\/jphysiol.1992.sp019086","article-title":"Enhancement of gamma-aminobutyric acid-activated Cl- currents in cultured rat hippocampal neurones by three volatile anaesthetics","volume":"449","author":"Jones","year":"1992","journal-title":"J. Physiol."},{"issue":"750","key":"10.1016\/j.exer.2020.108117_bib26","article-title":"Sheep and goat genome engineering: from random transgenesis to the CRISPR era","volume":"10","author":"Kalds","year":"2019","journal-title":"Front. Genet."},{"issue":"5","key":"10.1016\/j.exer.2020.108117_bib27","first-page":"657","article-title":"Effect of isoflurane and sevoflurane on evoked potentials and EEG","volume":"43","author":"Kameyama","year":"1994","journal-title":"Masui Jpn. J. Anesthesiol."},{"issue":"10","key":"10.1016\/j.exer.2020.108117_bib28","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/nn.2181","article-title":"Massive restructuring of neuronal circuits during functional reorganization of adult visual cortex","volume":"11","author":"Keck","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.exer.2020.108117_bib29","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.expneurol.2015.04.008","article-title":"Large animal and primate models of spinal cord injury for the testing of novel therapies","volume":"269","author":"Kwon","year":"2015","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.exer.2020.108117_bib30","doi-asserted-by":"crossref","first-page":"E209","DOI":"10.1073\/pnas.1616811114","article-title":"Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration","volume":"114","author":"Li","year":"2017","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"issue":"48","key":"10.1016\/j.exer.2020.108117_bib31","doi-asserted-by":"crossref","first-page":"12803","DOI":"10.1073\/pnas.1711734114","article-title":"Imaging and quantifying ganglion cells and other transparent neurons in the living human retina","volume":"114","author":"Liu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"9","key":"10.1016\/j.exer.2020.108117_bib32","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1364\/BOE.9.004246","article-title":"Trans-retinal cellular imaging with multimodal adaptive optics","volume":"9","author":"Liu","year":"2018","journal-title":"Biomed. Optic Express"},{"issue":"2","key":"10.1016\/j.exer.2020.108117_bib33","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/BF00230925","article-title":"Pattern ERG in the monkey after section of the optic nerve","volume":"59","author":"Maffei","year":"1985","journal-title":"Exp. Brain Res."},{"issue":"3","key":"10.1016\/j.exer.2020.108117_bib34","first-page":"378","article-title":"Flash and pattern electroretinograms in normal and laser-induced glaucomatous primate eyes","volume":"27","author":"Marx","year":"1986","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.exer.2020.108117_bib35","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1152\/jn.00299.2018","article-title":"Isoflurane and ketamine differentially influence spontaneous and evoked laminar electrophysiology in mouse V1","volume":"120","author":"Michelson","year":"2018","journal-title":"J. Neurophysiol."},{"issue":"2","key":"10.1016\/j.exer.2020.108117_bib36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/02713688208997683","article-title":"Pattern evoked retinal response (PERR) in human: effects of spatial frequency, temporal frequency, luminance and defocus","volume":"2","author":"Odom","year":"1982","journal-title":"Curr. Eye Res."},{"issue":"1","key":"10.1016\/j.exer.2020.108117_bib37","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10633-009-9195-4","article-title":"ISCEV standard for clinical visual evoked potentials (2009 update)","volume":"120","author":"Odom","year":"2010","journal-title":"Doc. Ophthalmol. Adv. Ophthalmol."},{"issue":"5903","key":"10.1016\/j.exer.2020.108117_bib38","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1161566","article-title":"Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway","volume":"322","author":"Park","year":"2008","journal-title":"Science (New York, NY)"},{"issue":"3","key":"10.1016\/j.exer.2020.108117_bib39","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10633-007-9059-8","article-title":"The mouse pattern electroretinogram","volume":"115","author":"Porciatti","year":"2007","journal-title":"Doc. Ophthalmol. Adv. Ophthalmol."},{"key":"10.1016\/j.exer.2020.108117_bib40","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.exer.2015.05.008","article-title":"Electrophysiological assessment of retinal ganglion cell function","volume":"141","author":"Porciatti","year":"2015","journal-title":"Exp. Eye Res."},{"issue":"4","key":"10.1016\/j.exer.2020.108117_bib41","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/WNO.0b013e3182745600","article-title":"Retinal ganglion cell functional plasticity and optic neuropathy: a comprehensive model","volume":"32","author":"Porciatti","year":"2012","journal-title":"J. Neuro Ophthalmol."},{"key":"10.1016\/j.exer.2020.108117_bib42","article-title":"Specializations of the human visual system: the monkey model meets human reality","author":"Preuss","year":"2004"},{"issue":"6","key":"10.1016\/j.exer.2020.108117_bib43","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1002\/cne.23521","article-title":"The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina","volume":"522","author":"Rodriguez","year":"2014","journal-title":"J. Comp. Neurol."},{"issue":"13","key":"10.1016\/j.exer.2020.108117_bib44","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.1167\/iovs.15-18882","article-title":"Retinal and macular ganglion cell count estimated with optical coherence tomography RTVUE-100 as a candidate biomarker for glaucoma","volume":"57","author":"Rolle","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.exer.2020.108117_bib45","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1073\/pnas.1613445114","article-title":"Imaging individual neurons in the retinal ganglion cell layer of the living eye","volume":"114","author":"Rossi","year":"2017","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"issue":"1","key":"10.1016\/j.exer.2020.108117_bib46","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/IOP.0000000000000418","article-title":"Lateral canthal position following lateral orbitotomy and the influence of ocular proptosis","volume":"32","author":"Shams","year":"2016","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"issue":"2","key":"10.1016\/j.exer.2020.108117_bib47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.joto.2018.03.002","article-title":"Isoflurane anesthesia suppresses distortion product otoacoustic emissions in rats","volume":"13","author":"Sheppard","year":"2018","journal-title":"J. Otol."},{"issue":"6","key":"10.1016\/j.exer.2020.108117_bib48","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/wcs.1323","article-title":"Pupillometry","volume":"5","author":"Sirois","year":"2014","journal-title":"WIREs Cognitive Science"},{"issue":"2","key":"10.1016\/j.exer.2020.108117_bib49","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/eye.2016.295","article-title":"Assessing retinal ganglion cell damage","volume":"31","author":"Smith","year":"2017","journal-title":"Eye"},{"issue":"2","key":"10.1016\/j.exer.2020.108117_bib50","doi-asserted-by":"crossref","DOI":"10.1167\/tvst.4.2.1","article-title":"Why do people (still) go blind from glaucoma?","volume":"4","author":"Susanna","year":"2015","journal-title":"Transl. Vis. Sci. Technol."},{"issue":"4","key":"10.1016\/j.exer.2020.108117_bib51","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1080\/19420862.2019.1589852","article-title":"From Rhesus macaque to human: structural evolutionary pathways for immunoglobulin G subclasses","volume":"11","author":"Tolbert","year":"2019","journal-title":"mAbs"},{"issue":"3","key":"10.1016\/j.exer.2020.108117_bib52","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10633-007-9079-4","article-title":"Isoflurane is an effective alternative to ketamine\/xylazine\/acepromazine as an anesthetic agent for the mouse electroretinogram","volume":"115","author":"Woodward","year":"2007","journal-title":"Doc. Ophthalmol. Adv. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2020.108117_bib53","first-page":"43","article-title":"In vivo evaluation of optic nerve aging in adult rhesus monkey by diffusion tensor imaging","volume":"4","author":"Yan","year":"2014","journal-title":"Quant. Imag. Med. Surg."},{"issue":"2","key":"10.1016\/j.exer.2020.108117_bib54","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10633-011-9288-8","article-title":"Improving reproducibility of VEP recording in rats: electrodes, stimulus source and peak analysis","volume":"123","author":"You","year":"2011","journal-title":"Doc. Ophthalmol. Adv. Ophthalmol."},{"key":"10.1016\/j.exer.2020.108117_bib55","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.45881","article-title":"Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse","volume":"8","author":"Zhang","year":"2019","journal-title":"eLife"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483520303766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483520303766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:29:44Z","timestamp":1762147784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483520303766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":55,"alternative-id":["S0014483520303766"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2020.108117","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo evaluation of retinal ganglion cells and optic nerve's integrity in large animals by multi-modality analysis","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2020.108117","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108117"}}