{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:53:32Z","timestamp":1792644812294,"version":"4.5.0"},"reference-count":164,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"am","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015728","name":"Clinical Science Research and Development","doi-asserted-by":"publisher","award":["I01 CX002015"],"award-info":[{"award-number":["I01 CX002015"]}],"id":[{"id":"10.13039\/100015728","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30EY014801"],"award-info":[{"award-number":["P30EY014801"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY026174"],"award-info":[{"award-number":["R01EY026174"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R61EY032468"],"award-info":[{"award-number":["R61EY032468"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.exer.2020.108284","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T01:15:39Z","timestamp":1602292539000},"page":"108284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"C","title":["Corneal Nerve Abnormalities in Ocular and Systemic Diseases"],"prefix":"10.1016","volume":"202","author":[{"given":"Sneh","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9507-6635","authenticated-orcid":false,"given":"Divy","family":"Mehra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3026-6155","authenticated-orcid":false,"given":"Anat","family":"Galor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2020.108284_bib1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0008-4182(04)80071-1","article-title":"Correlation between corneal sensitivity, subjective dry eye symptoms and corneal staining in Sj\u00f6gren's syndrome","volume":"39","author":"Adatia","year":"2005","journal-title":"Can. J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.exer.2020.108284_bib2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jtos.2015.01.005","article-title":"Autologous serum tears for treatment of photoallodynia in patients with corneal neuropathy: efficacy and evaluation with in vivo confocal microscopy","volume":"13","author":"Aggarwal","year":"2015","journal-title":"Ocul. Surf."},{"issue":"10","key":"10.1016\/j.exer.2020.108284_bib3","first-page":"25","article-title":"Effects of autologous serum eye drops on corneal wound healing after superficial keratectomy in rabbits","author":"Akyol-Salman","year":"2006","journal-title":"Cornea"},{"issue":"5\u20136","key":"10.1016\/j.exer.2020.108284_bib4","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3109\/08820538.2012.711416","article-title":"Vivo confocal microscopy in dry eye disease and related conditions","volume":"27","author":"Alhatem","year":"2012","journal-title":"Semin. Ophthalmol."},{"key":"10.1016\/j.exer.2020.108284_bib5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ajo.2018.02.009","article-title":"Use of autologous serum tears for the treatment of ocular surface disease from patients with systemic autoimmune diseases","volume":"189","author":"Ali","year":"2018","journal-title":"Am. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2020.108284_bib6","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0304-3959(94)90083-3","article-title":"Behavioural pain-related disorders and contribution of the saphenous nerve in crush and chronic constriction injury of the rat sciatic nerve","volume":"59","author":"Attal","year":"1994","journal-title":"Pain"},{"key":"10.1016\/j.exer.2020.108284_bib7","first-page":"44","article-title":"Savran elibol E, oguz H. Patterns of altered corneal sensation in patients with chronic migraine","author":"Aykut","year":"2018","journal-title":"Eye Contact Lens"},{"issue":"4","key":"10.1016\/j.exer.2020.108284_bib8","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/eye.2017.275","article-title":"Corneal sensitivity and subjective complaints of ocular pain in patients with fibromyalgia","volume":"32","author":"Aykut","year":"2018","journal-title":"Eye"},{"issue":"4","key":"10.1016\/j.exer.2020.108284_bib9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1136\/bjo.83.4.399","article-title":"Amniotic membrane transplantation for ocular surface reconstruction","volume":"83","author":"Azuara-Blanco","year":"1999","journal-title":"Br. J. Ophthalmol."},{"issue":"5","key":"10.1016\/j.exer.2020.108284_bib10","first-page":"39","article-title":"Finger-prick autologous blood in the treatment of persistent corneal epithelial defects","author":"Balal","year":"2020","journal-title":"Cornea"},{"issue":"9","key":"10.1016\/j.exer.2020.108284_bib11","first-page":"25","article-title":"Effects of glaucoma medications on corneal endothelium, keratocytes, and subbasal nerves among participants in the ocular hypertension treatment study","author":"Baratz","year":"2006","journal-title":"Cornea"},{"issue":"3","key":"10.1016\/j.exer.2020.108284_bib12","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.pain.2010.03.024","article-title":"Prolonged analgesic response of cornea to topical resiniferatoxin, a potent TRPV1 agonist","volume":"149","author":"Bates","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.exer.2020.108284_bib13","series-title":"Cellular Mechanisms of Sensory Processing","first-page":"87","article-title":"Polymodality in Nociceptive Neurons: Experimental Models of Chemotransduction","author":"Belmonte","year":"1994"},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1167\/iovs.06-0127","article-title":"Relation between corneal innervation with confocal microscopy and corneal sensitivity with noncontact esthesiometry in patients with dry eye","volume":"48","author":"Ben\u00edtez-del-Castillo","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"8","key":"10.1016\/j.exer.2020.108284_bib15","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1167\/iovs.18-24304","article-title":"TRPV1 and TRPM8 channels and nocifensive behavior in a rat model for dry eye","volume":"59","author":"Bereiter","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.exer.2020.108284_bib16","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/jn.1969.32.6.1025","article-title":"Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli","volume":"32","author":"Bessou","year":"1969","journal-title":"J. Neurophysiol."},{"issue":"9","key":"10.1016\/j.exer.2020.108284_bib17","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.ophtha.2018.02.022","article-title":"Phase II randomized, double-masked, vehicle-controlled trial of recombinant human nerve growth factor for neurotrophic keratitis","volume":"125","author":"Bonini","year":"2018","journal-title":"Ophthalmology."},{"issue":"7","key":"10.1016\/j.exer.2020.108284_bib18","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1167\/iovs.04-1426","article-title":"Decreased corneal sensitivity in patients with dry eye","volume":"46","author":"Bourcier","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.exer.2020.108284_bib19","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1097\/ICO.0b013e31827e2a5e","article-title":"Tear osmolarity in Sj\u00f6gren syndrome","volume":"32","author":"Bunya","year":"2013","journal-title":"Cornea"},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jtos.2017.09.004","article-title":"In vivo confocal microscopy detects bilateral changes of corneal immune cells and nerves in unilateral herpes zoster ophthalmicus","volume":"16","author":"Cavalcanti","year":"2018","journal-title":"Ocul. Surf."},{"issue":"2","key":"10.1016\/j.exer.2020.108284_bib21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.clae.2009.12.010","article-title":"Validation of the 5-Item Dry Eye Questionnaire (DEQ-5): discrimination across self-assessed severity and aqueous tear deficient dry eye diagnoses","volume":"33","author":"Chalmers","year":"2010","journal-title":"Contact Lens Anterior Eye"},{"issue":"2","key":"10.1016\/j.exer.2020.108284_bib22","first-page":"92","article-title":"Ocular surface sensitivity repeatability with cochet-bonnet esthesiometer","author":"Chao","year":"2015","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108284_bib23","first-page":"32","article-title":"Changes in rabbit corneal innervation induced by the topical application of benzalkonium chloride","author":"Chen","year":"2013","journal-title":"Cornea"},{"issue":"14","key":"10.1016\/j.exer.2020.108284_bib24","doi-asserted-by":"crossref","first-page":"9600","DOI":"10.1074\/jbc.M113.536862","article-title":"Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel","volume":"289","author":"Chen","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2020.108284_bib25","first-page":"680","article-title":"Kim T-i, seo KY, kim EK, lee HKJJoTKOS","volume":"56","author":"Choi","year":"2015","journal-title":"Corneal Microstructural Changes in Non-Sj^gren Dry Eye Using Confocal Microscopy: Clinical Correlation"},{"key":"10.1016\/j.exer.2020.108284_bib26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1001\/archophthalmol.2011.287","article-title":"Recovery of corneal sensitivity, calcitonin gene-related peptide-positive nerves, and increased wound healing induced by pigment epithelial-derived factor plus docosahexaenoic acid after experimental surgery","volume":"130","author":"Cortina","year":"2011","journal-title":"Arch. Ophthalmol."},{"issue":"8","key":"10.1016\/j.exer.2020.108284_bib27","first-page":"20","article-title":"Tarsorrhaphy: clinical experience from a cornea practice","author":"Cosar","year":"2001","journal-title":"Cornea"},{"issue":"3","key":"10.1016\/j.exer.2020.108284_bib28","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"issue":"6","key":"10.1016\/j.exer.2020.108284_bib29","first-page":"58","article-title":"Cibinetide improves corneal nerve fiber abundance in patients with sarcoidosis-associated small nerve fiber loss and neuropathic pain","author":"Culver","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.exer.2020.108284_bib30","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s40265-020-01289-w","article-title":"Cenegermin: a review in neurotrophic keratitis","volume":"80","author":"Deeks","year":"2020","journal-title":"Drugs"},{"issue":"9","key":"10.1016\/j.exer.2020.108284_bib31","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1167\/iovs.04-0251","article-title":"An in vivo confocal masked study on corneal epithelium and subbasal nerves in patients with dry eye","volume":"45","author":"del Castillo JMBt","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.exer.2020.108284_bib32","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bjophthalmol-2015-307369","article-title":"Ocular surface disease in patients with diabetic peripheral neuropathy","volume":"100","author":"DeMill","year":"2016","journal-title":"Br. J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.exer.2020.108284_bib33","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ophtha.2014.10.004","article-title":"Dry eye disease after refractive surgery: comparative outcomes of small incision lenticule extraction versus LASIK","volume":"122","author":"Denoyer","year":"2015","journal-title":"Ophthalmology."},{"issue":"5","key":"10.1016\/j.exer.2020.108284_bib34","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s10792-014-9901-4","article-title":"The efficacy of topical 0.05 % cyclosporine A in patients with dry eye disease associated with Sj\u00f6gren's syndrome","volume":"34","author":"Devec\u0131","year":"2014","journal-title":"Int. Ophthalmol."},{"issue":"8","key":"10.1016\/j.exer.2020.108284_bib35","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/bjophthalmol-2018-312649","article-title":"Photophobia and sensations of dryness in patients with migraine occur independent of baseline tear volume and improve following botulinum toxin A injections","volume":"103","author":"Diel","year":"2019","journal-title":"Br. J. Ophthalmol."},{"issue":"8","key":"10.1016\/j.exer.2020.108284_bib36","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/bjophthalmol-2018-312649","article-title":"Photophobia and sensations of dryness in patients with migraine occur independent of baseline tear volume and improve following botulinum toxin A injections","volume":"103","author":"Diel","year":"2019","journal-title":"Br. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib37","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/WNO.0b013e3182474548","article-title":"Shedding light on photophobia","volume":"32","author":"Digre","year":"2012","journal-title":"J. Neuro Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2020.108284_bib38","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1385\/ENDO:27:2:101","article-title":"Functional MT1 and MT2 melatonin receptors in mammals","volume":"27","author":"Dubocovich","year":"2005","journal-title":"Endocrine"},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib39","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0002-9394(01)00913-8","article-title":"Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids","volume":"132","author":"Dursun","year":"2001","journal-title":"Am. J. Ophthalmol."},{"issue":"6","key":"10.1016\/j.exer.2020.108284_bib40","first-page":"24","article-title":"The effect of age on the corneal subbasal nerve plexus","author":"Erie","year":"2005","journal-title":"Cornea"},{"issue":"5","key":"10.1016\/j.exer.2020.108284_bib41","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.ajo.2009.06.022","article-title":"Confocal microscopy in ophthalmology","volume":"148","author":"Erie","year":"2009","journal-title":"Am. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2020.108284_bib42","first-page":"37","article-title":"Ocular surface alterations in the context of corneal in vivo confocal microscopic characteristics in patients with fibromyalgia","author":"Erkan Turan","year":"2018","journal-title":"Cornea"},{"issue":"7","key":"10.1016\/j.exer.2020.108284_bib43","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1097\/j.pain.0000000000001552","article-title":"Modification of the neuropathic pain symptom inventory for use in eye pain (NPSI-eye)","volume":"160","author":"Farhangi","year":"2019","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.exer.2020.108284_bib44","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1136\/bjophthalmol-2018-313471","article-title":"Individuals with migraine have a different dry eye symptom profile than individuals without migraine","volume":"104","author":"Farhangi","year":"2020","journal-title":"Br. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib45","first-page":"37","article-title":"Vivo confocal microscopy reveals corneal reinnervation after treatment of neurotrophic keratopathy with corneal neurotization","author":"Fung","year":"2018","journal-title":"Cornea"},{"issue":"10","key":"10.1016\/j.exer.2020.108284_bib46","first-page":"1968","article-title":"Effects of capsaicin on corneal wound healing","volume":"31","author":"Gallar","year":"1990","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"9","key":"10.1016\/j.exer.2020.108284_bib47","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1167\/iovs.08-3083","article-title":"In fibromyalgia","volume":"50","author":"Gallar","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.exer.2020.108284_bib48","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1167\/iovs.12-10819","article-title":"Ocular surface parameters in older male veterans","volume":"54","author":"Galor","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.exer.2020.108284_bib49","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1136\/bjophthalmol-2014-306057","article-title":"Dry eye symptom severity and persistence are associated with symptoms of neuropathic pain","volume":"99","author":"Galor","year":"2015","journal-title":"Br. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib50","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jtos.2017.10.001","article-title":"Neuropathic pain and dry eye","volume":"16","author":"Galor","year":"2018","journal-title":"Ocul. Surf."},{"issue":"4","key":"10.1016\/j.exer.2020.108284_bib51","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/eye.2014.4","article-title":"Corneal sensitivity and morphology of the corneal subbasal nerve plexus in primary congenital glaucoma","volume":"28","author":"Gatzioufas","year":"2014","journal-title":"Eye"},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib52","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1124\/jpet.104.079855","article-title":"AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties","volume":"313","author":"Gavva","year":"2005","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"3","key":"10.1016\/j.exer.2020.108284_bib53","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00417-018-04225-7","article-title":"In vivo confocal microscopy morphometric analysis of corneal subbasal nerve plexus in dry eye disease using newly developed fully automated system","volume":"257","author":"Giannaccare","year":"2019","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"issue":"5","key":"10.1016\/j.exer.2020.108284_bib54","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.exer.2011.02.016","article-title":"Assessing the sensory function of the ocular surface: implications of use of a non-contact air jet aesthesiometer versus the Cochet\u2013Bonnet aesthesiometer","volume":"92","author":"Golebiowski","year":"2011","journal-title":"Exp. Eye Res."},{"issue":"10","key":"10.1016\/j.exer.2020.108284_bib55","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/j.ophtha.2010.07.010","article-title":"Corneal sensation and subbasal nerve alterations in patients with herpes simplex keratitis: an in vivo confocal microscopy study","volume":"117","author":"Hamrah","year":"2010","journal-title":"Ophthalmology."},{"issue":"9","key":"10.1016\/j.exer.2020.108284_bib56","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.ophtha.2012.03.005","article-title":"Cellular changes of the corneal epithelium and stroma in herpes simplex keratitis: an in vivo confocal microscopy study","volume":"119","author":"Hamrah","year":"2012","journal-title":"Ophthalmology."},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib57","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ophtha.2012.07.036","article-title":"Unilateral herpes zoster ophthalmicus results in bilateral corneal nerve alteration: an in vivo confocal microscopy study","volume":"120","author":"Hamrah","year":"2013","journal-title":"Ophthalmology."},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib58","doi-asserted-by":"crossref","first-page":"10720","DOI":"10.1038\/s41598-017-10237-w","article-title":"Vivo confocal microscopy evaluation of ocular surface with graft-versus-host disease-related dry eye disease","volume":"7","author":"He","year":"2017","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.exer.2020.108284_bib59","first-page":"1969","article-title":"Improvement of HSV-1 necrotizing keratitis with amniotic membrane transplantation","volume":"42","author":"Heiligenhaus","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib60","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0306-4522(86)90024-2","article-title":"Capsaicin induced release of multiple tachykinins (substance P, neurokinin A and eledoisin-like material) from Guinea-pig spinal cord and ureter","volume":"19","author":"Hua","year":"1986","journal-title":"Neuroscience"},{"issue":"14","key":"10.1016\/j.exer.2020.108284_bib61","first-page":"85","article-title":"Vivo corneal confocal microscopy and clinical correlations in fibromyalgia","volume":"53","author":"Hussain","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108284_bib62","author":"IASP terminology"},{"issue":"4","key":"10.1016\/j.exer.2020.108284_bib63","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s40135-017-0152-1","article-title":"Diagnosis and treatment of ocular pain: the ophthalmologist's perspective","volume":"5","author":"Jacobs","year":"2017","journal-title":"Current Ophthalmology Reports."},{"issue":"2","key":"10.1016\/j.exer.2020.108284_bib64","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/bjo.87.2.225","article-title":"In vivo confocal microscopy of the human cornea","volume":"87","author":"Jalbert","year":"2003","journal-title":"Br. J. Ophthalmol."},{"issue":"10","key":"10.1016\/j.exer.2020.108284_bib65","first-page":"28","article-title":"Autologous serum 50% eyedrops in the treatment of persistent corneal epithelial defects","author":"Jeng","year":"2009","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2020.108284_bib66","first-page":"12","author":"Julian","year":"2020","journal-title":"B12 as a Treatment for Peripheral Neuropathic Pain: Syst. Rev."},{"issue":"3","key":"10.1016\/j.exer.2020.108284_bib67","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/ICL.0000000000000249","article-title":"Characteristics of ocular pain complaints in patients with idiopathic dry eye symptoms","volume":"43","author":"Kalangara","year":"2017","journal-title":"Eye Contact Lens"},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib68","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1038\/s41598-018-21643-z","article-title":"Greater corneal nerve loss at the inferior whorl is related to the presence of diabetic neuropathy and painful diabetic neuropathy","volume":"8","author":"Kalteniece","year":"2018","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.exer.2020.108284_bib69","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1167\/iovs.19-26914","article-title":"Dysregulated tear fluid nociception-associated factors, corneal dendritic cell density, and vitamin D levels in evaporative dry eye","volume":"60","author":"Khamar","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.exer.2020.108284_bib70","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.ophtha.2014.11.006","article-title":"Effects of corneal nerve density on the response to treatment in dry eye disease","volume":"122","author":"Kheirkhah","year":"2015","journal-title":"Ophthalmology."},{"issue":"4","key":"10.1016\/j.exer.2020.108284_bib72","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/head.12547","article-title":"Chronic migraine is associated with reduced corneal nerve fiber density and symptoms of dry eye","volume":"55","author":"Kinard","year":"2015","journal-title":"Headache J. Head Face Pain"},{"issue":"4\u20135","key":"10.1016\/j.exer.2020.108284_bib73","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/17469899.2019.1657833","article-title":"Diagnostic tests in dry eye","volume":"14","author":"Kloosterboer","year":"2019","journal-title":"Expet Rev. Ophthalmol."},{"issue":"7","key":"10.1016\/j.exer.2020.108284_bib74","first-page":"34","article-title":"Microscopic features of corneas in patients with newly diagnosed graves' disease","author":"Kocabeyoglu","year":"2015","journal-title":"Cornea"},{"issue":"2","key":"10.1016\/j.exer.2020.108284_bib75","first-page":"40","article-title":"Corneal neurotization: a surgical treatment for neurotrophic keratopathy","author":"Kolseth","year":"2020","journal-title":"J. Neuro Ophthalmol."},{"issue":"8","key":"10.1016\/j.exer.2020.108284_bib76","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1016\/S0161-6420(99)90444-X","article-title":"Multilayer amniotic membrane transplantation for reconstruction of deep corneal ulcers","volume":"106","author":"Kruse","year":"1999","journal-title":"Ophthalmology."},{"issue":"8","key":"10.1016\/j.exer.2020.108284_bib77","doi-asserted-by":"crossref","first-page":"4926","DOI":"10.1167\/iovs.11-8708","article-title":"The relationship between subbasal nerve morphology and corneal sensation in ocular surface disease","volume":"53","author":"Labb\u00e9","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"8","key":"10.1016\/j.exer.2020.108284_bib78","doi-asserted-by":"crossref","first-page":"5144","DOI":"10.1167\/iovs.13-12370","article-title":"Corneal nerve structure and function in patients with non-sj\u00f6gren dry eye: clinical correlations","volume":"54","author":"Labb\u00e9","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"9718","key":"10.1016\/j.exer.2020.108284_bib79","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0140-6736(09)62164-4","article-title":"Group cognitive behavioural treatment for low-back pain in primary care: a randomised controlled trial and cost-effectiveness analysis","volume":"375","author":"Lamb","year":"2010","journal-title":"The Lancet."},{"issue":"12","key":"10.1016\/j.exer.2020.108284_bib80","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1001\/jamaophthalmol.2013.5064","article-title":"Corneal changes in neurosurgically induced neurotrophic keratitis","volume":"131","author":"Lambiase","year":"2013","journal-title":"JAMA Ophthalmology."},{"issue":"12","key":"10.1016\/j.exer.2020.108284_bib81","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1097\/ICO.0000000000002081","article-title":"Comprehensive clinical, diagnostic, and advanced imaging characterization of the ocular surface in spontaneous aqueous deficient dry eye disease in dogs","volume":"38","author":"Leonard","year":"2019","journal-title":"Cornea"},{"issue":"5","key":"10.1016\/j.exer.2020.108284_bib82","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/ceo.12898","article-title":"Increased corneal sub-basal nerve density in patients with Sj\u00f6gren syndrome treated with topical cyclosporine A","volume":"45","author":"Levy","year":"2017","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2020.108284_bib83","doi-asserted-by":"crossref","first-page":"1628469","DOI":"10.1155\/2016\/1628469","article-title":"Ocular surface epithelial thickness evaluation in dry eye patients: clinical correlations","volume":"2016","author":"Liang","year":"2016","journal-title":"Journal of Ophthalmology."},{"issue":"10","key":"10.1016\/j.exer.2020.108284_bib84","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/s41433-018-0150-z","article-title":"Effects of ambient humidity on the Cochet\u2013Bonnet aesthesiometer","volume":"32","author":"Lum","year":"2018","journal-title":"Eye"},{"issue":"3","key":"10.1016\/j.exer.2020.108284_bib85","first-page":"461","article-title":"Sensory and sympathetic innervation of the mammalian cornea. A retrograde tracing study","volume":"30","author":"Marfurt","year":"1989","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.exer.2020.108284_bib86","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ajo.2008.10.019","article-title":"An in vivo confocal microscopy analysis of effects of topical antiglaucoma therapy with preservative on corneal innervation and morphology","volume":"147","author":"Martone","year":"2009","journal-title":"Am. J. Ophthalmol."},{"issue":"5","key":"10.1016\/j.exer.2020.108284_bib87","doi-asserted-by":"crossref","first-page":"6108","DOI":"10.1002\/jcp.27345","article-title":"In vivo microscopic and optical coherence tomography classification of neurotrophic keratopathy","volume":"234","author":"Mastropasqua","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.exer.2020.108284_bib88","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1364\/BOE.9.000557","article-title":"In vivo high resolution human corneal imaging using full-field optical coherence tomography","volume":"9","author":"Mazlin","year":"2018","journal-title":"Biomed. Optic Express"},{"issue":"6429","key":"10.1016\/j.exer.2020.108284_bib89","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/363543a0","article-title":"Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia","volume":"363","author":"McLachlan","year":"1993","journal-title":"Nature."},{"issue":"3","key":"10.1016\/j.exer.2020.108284_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40123-020-00263-9","article-title":"Ocular surface pain: a narrative review","volume":"9","author":"Mehra","year":"2020","journal-title":"Ophthalmol Ther."},{"issue":"7","key":"10.1016\/j.exer.2020.108284_bib91","first-page":"25","article-title":"Morphologic alterations of both the stromal and subbasal nerves in the corneas of patients with diabetes","author":"Mocan","year":"2006","journal-title":"Cornea"},{"issue":"2","key":"10.1016\/j.exer.2020.108284_bib92","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jtos.2017.12.001","article-title":"Corneal nerve regeneration after herpes simplex keratitis: a longitudinal in vivo confocal microscopy study","volume":"16","author":"Moein","year":"2018","journal-title":"Ocul. Surf."},{"issue":"4","key":"10.1016\/j.exer.2020.108284_bib93","first-page":"476","article-title":"Ultrastructural organization of human corneal nerves","volume":"37","author":"M\u00fcller","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.exer.2020.108284_bib94","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0014-4835(03)00050-2","article-title":"Corneal nerves: structure, contents and function","volume":"76","author":"M\u00fcller","year":"2003","journal-title":"Exp. Eye Res."},{"issue":"11","key":"10.1016\/j.exer.2020.108284_bib95","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1016\/j.ophtha.2015.06.047","article-title":"Degeneration and regeneration of subbasal corneal nerves after infectious keratitis: a longitudinal in vivo confocal microscopy study","volume":"122","author":"M\u00fcller","year":"2015","journal-title":"Ophthalmology."},{"issue":"8","key":"10.1016\/j.exer.2020.108284_bib96","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1167\/iovs.15-16527","article-title":"Vivo confocal microscopy demonstrates bilateral loss of endothelial cells in unilateral herpes simplex keratitis","volume":"56","author":"M\u00fcller","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.exer.2020.108284_bib97","first-page":"532","article-title":"Reliability of the non-contact corneal aesthesiometer and its comparison with the cochet\u2013bonnet aesthesiometer","volume":"18","author":"Murphy","year":"1998","journal-title":"Ophthalmic Physiol. Optic."},{"issue":"9","key":"10.1016\/j.exer.2020.108284_bib98","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1136\/bjo.2006.112656","article-title":"Age-related differences in the normal human cornea: a laser scanning in vivo confocal microscopy study","volume":"91","author":"Niederer","year":"2007","journal-title":"Br. J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.exer.2020.108284_bib99","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/WCO.0b013e3283466c8e","article-title":"Advances in understanding the mechanisms of migraine-type photophobia","volume":"24","author":"Noseda","year":"2011","journal-title":"Curr. Opin. Neurol."},{"issue":"4","key":"10.1016\/j.exer.2020.108284_bib100","first-page":"20","article-title":"Morphology of corneal nerves using confocal microscopy","author":"Oliveira-Soto","year":"2001","journal-title":"Cornea"},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib101","doi-asserted-by":"crossref","first-page":"23573","DOI":"10.1038\/srep23573","article-title":"Cornea nerve fiber quantification and construction of phenotypes in patients with fibromyalgia","volume":"6","author":"Oudejans","year":"2016","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.exer.2020.108284_bib102","first-page":"4732","article-title":"Nortriptyline is effective in ameliorating symptoms of neuropathic corneal pain","volume":"60","author":"Ozmen","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.exer.2020.108284_bib103","article-title":"Autologous serum eye drops for dry eye","author":"Pan","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"issue":"3","key":"10.1016\/j.exer.2020.108284_bib104","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00003226-199905000-00010","article-title":"Lateral tarsorrhaphy: is it preferable to patching?","volume":"18","author":"Panda","year":"1999","journal-title":"Cornea"},{"issue":"10","key":"10.1016\/j.exer.2020.108284_bib105","doi-asserted-by":"crossref","first-page":"7091","DOI":"10.1167\/iovs.13-12999","article-title":"Standardized baseline human corneal subbasal nerve density for clinical investigations with laser-scanning in vivo confocal microscopy","volume":"54","author":"Parissi","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.exer.2020.108284_bib106","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1136\/bjo.2008.150615","article-title":"In vivo confocal microscopy of human corneal nerves in health, in ocular and systemic disease, and following corneal surgery: a review","volume":"93","author":"Patel","year":"2009","journal-title":"Br. J. Ophthalmol."},{"issue":"7","key":"10.1016\/j.exer.2020.108284_bib107","first-page":"28","article-title":"Corneal Sensitivity and Slit Scanning In Vivo Confocal Microscopy of the Subbasal Nerve Plexus of the Normal Central and Peripheral Human Cornea","author":"Patel","year":"2009","journal-title":"Cornea"},{"issue":"6","key":"10.1016\/j.exer.2020.108284_bib108","first-page":"8","article-title":"Dysfunctional coping mechanisms contribute to dry eye symptoms","author":"Patel","year":"2019","journal-title":"J. Clin. Med."},{"issue":"5","key":"10.1016\/j.exer.2020.108284_bib109","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00003226-199309000-00002","article-title":"Effect of doxycycline hyclate on corneal epithelial wound healing in the rabbit alkali-burn model. Preliminary observations","volume":"12","author":"Perry","year":"1993","journal-title":"Cornea"},{"issue":"3","key":"10.1016\/j.exer.2020.108284_bib110","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jtos.2015.05.002","article-title":"Vivo confocal microscopy of the cornea: new developments in image acquisition, reconstruction, and analysis using the HRT-rostock corneal Module","volume":"13","author":"Petroll","year":"2015","journal-title":"Ocul. Surf."},{"issue":"11","key":"10.1016\/j.exer.2020.108284_bib111","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.2337\/dc13-0193","article-title":"Corneal nerve loss detected with corneal confocal microscopy is symmetrical and related to the severity of diabetic polyneuropathy","volume":"36","author":"Petropoulos","year":"2013","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib112","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ophtha.2019.08.020","article-title":"Topical recombinant human nerve growth factor (cenegermin) for neurotrophic keratopathy: a multicenter randomized vehicle-controlled pivotal trial","volume":"127","author":"Pflugfelder","year":"2020","journal-title":"Ophthalmology."},{"issue":"4","key":"10.1016\/j.exer.2020.108284_bib113","first-page":"1023","volume":"20","author":"Prasad","year":"2014","journal-title":"Diagnostic Neuroimaging in Neuro-ophthalmic Disorders"},{"issue":"5","key":"10.1016\/j.exer.2020.108284_bib114","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.ajo.2015.08.005","article-title":"Corneal sensitivity in tear dysfunction and its correlation with clinical parameters and blink rate","volume":"160","author":"Rahman","year":"2015","journal-title":"Am. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2020.108284_bib115","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.semarthrit.2015.03.003","article-title":"Small fiber neuropathy in women with fibromyalgia. An in vivo assessment using corneal confocal bio-microscopy","volume":"45","author":"Ram\u00edrez","year":"2015","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.exer.2020.108284_bib116","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.2147\/OPTH.S22874","article-title":"Changes in corneal parameters at confocal microscopy in treated glaucoma patients","volume":"5","author":"Ranno","year":"2011","journal-title":"Clin. Ophthalmol."},{"issue":"5","key":"10.1016\/j.exer.2020.108284_bib117","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1526-4637.2005.00061.x","article-title":"A double-blind, randomized multicenter trial comparing duloxetine with placebo in the management of diabetic peripheral neuropathic pain","volume":"6","author":"Raskin","year":"2005","journal-title":"Pain Med."},{"issue":"3","key":"10.1016\/j.exer.2020.108284_bib118","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0161-6420(80)35257-3","article-title":"Corneal hypesthesia and retinopathy in diabetes mellitus","volume":"87","author":"Rogell","year":"1980","journal-title":"Ophthalmology."},{"issue":"10","key":"10.1016\/j.exer.2020.108284_bib119","first-page":"2915","article-title":"M\u00fcller LJ, gr\u00f6nhagen\u2013riska C, vesaluoma MH. Corneal structure and sensitivity in type 1 diabetes mellitus","volume":"41","author":"Rosenberg","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108284_bib120","first-page":"571","article-title":"Diagnosis and management of neurotrophic keratitis","volume":"8","author":"Sacchetti","year":"2014","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.exer.2020.108284_bib121","first-page":"571","article-title":"Diagnosis and management of neurotrophic keratitis","volume":"8","author":"Sacchetti","year":"2014","journal-title":"Clin. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib122","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0002-9394(03)00897-3","article-title":"Corneal epitheliopathy of dry eye induces hyperesthesia to mechanical air jet stimulation","volume":"137","author":"Sade De Paiva","year":"2004","journal-title":"Am. J. Ophthalmol."},{"issue":"6","key":"10.1016\/j.exer.2020.108284_bib123","first-page":"931","article-title":"Ocular surface evaluation in eyes with chronic glaucoma on long term topical antiglaucoma therapy","volume":"10","author":"Saini","year":"2017","journal-title":"Int. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib124","first-page":"22","article-title":"Chikama T-i, nishida T. Correlation of corneal sensation, but not of basal or reflex tear secretion, with the stage of diabetic retinopathy","author":"Saito","year":"2003","journal-title":"Cornea"},{"issue":"4","key":"10.1016\/j.exer.2020.108284_bib125","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0161-6420(99)00176-1","article-title":"Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease11Reprint requests to: linda Lewis, 575 Anton Blvd","volume":"107","author":"Sall","year":"2000","journal-title":"Ophthalmology."},{"issue":"4","key":"10.1016\/j.exer.2020.108284_bib126","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1167\/iovs.11-8775","article-title":"Corneal neurotoxicity due to topical benzalkonium chloride","volume":"53","author":"Sarkar","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.exer.2020.108284_bib127","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1001\/archopht.118.5.615","article-title":"Reliability and validity of the ocular surface disease Index","volume":"118","author":"Schiffman","year":"2000","journal-title":"Arch. Ophthalmol."},{"issue":"3","key":"10.1016\/j.exer.2020.108284_bib128","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.survophthal.2013.09.002","article-title":"Corneal nerves in health and disease","volume":"59","author":"Shaheen","year":"2014","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2020.108284_bib129","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.2147\/OPTH.S185184","article-title":"Update on cenegermin eye drops in the treatment of neurotrophic keratitis","volume":"13","author":"Sheha","year":"2019","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.exer.2020.108284_bib130","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.2147\/JPR.S196705","article-title":"Corneal subbasal nerve plexus changes in patients with episodic migraine: an in vivo confocal microscopy study","volume":"12","author":"Shen","year":"2019","journal-title":"J. Pain Res."},{"key":"10.1016\/j.exer.2020.108284_bib131","doi-asserted-by":"crossref","first-page":"4369750","DOI":"10.1155\/2016\/4369750","article-title":"Corneal dendritic cell density is associated with subbasal nerve plexus features, ocular surface disease Index, and serum vitamin D in evaporative dry eye disease","volume":"2016","author":"Shetty","year":"2016","journal-title":"BioMed Res. Int."},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib132","first-page":"37","article-title":"Subbasal nerve plexus changes in chronic migraine","author":"Shetty","year":"2018","journal-title":"Cornea"},{"issue":"5","key":"10.1016\/j.exer.2020.108284_bib133","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1167\/iovs.17-23743","article-title":"Alterations of murine subbasal corneal nerves after environmental dry eye stress","volume":"59","author":"Simsek","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.exer.2020.108284_bib134","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1167\/iovs.18-26318","article-title":"Changes in murine subbasal corneal nerves after scopolamine-induced dry eye stress exposure","volume":"60","author":"Simsek","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"8","key":"10.1016\/j.exer.2020.108284_bib135","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/ner.12742","article-title":"Noninvasive electrical stimulation for the treatment of chronic ocular pain and photophobia","volume":"21","author":"Sivanesan","year":"2018","journal-title":"Neuromodulation: Technology at the Neural Interface."},{"issue":"3","key":"10.1016\/j.exer.2020.108284_bib136","first-page":"46","article-title":"Blocks for the treatment of chronic ocular pain","author":"Small","year":"2020","journal-title":"Eye Contact Lens"},{"issue":"2","key":"10.1016\/j.exer.2020.108284_bib137","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1167\/iovs.15-18133","article-title":"Corneal mechanical thresholds negatively associate with dry eye and ocular pain symptoms","volume":"57","author":"Spierer","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"12","key":"10.1016\/j.exer.2020.108284_bib138","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1136\/bjo.2004.044024","article-title":"Corneal and conjunctival sensitivity to air stimuli","volume":"88","author":"Stapleton","year":"2004","journal-title":"Br. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2020.108284_bib139","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1136\/bjophthalmol-2014-305072","article-title":"In vivo confocal microscopic characterisation of the cornea in chronic graft-versus-host disease related severe dry eye disease","volume":"99","author":"Steger","year":"2015","journal-title":"Br. J. Ophthalmol."},{"issue":"6","key":"10.1016\/j.exer.2020.108284_bib140","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/glia.23102","article-title":"Corneal epithelial cells function as surrogate Schwann cells for their sensory nerves","volume":"65","author":"Stepp","year":"2017","journal-title":"Glia"},{"issue":"9","key":"10.1016\/j.exer.2020.108284_bib141","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0167-5699(97)01114-6","article-title":"Immunity causing blindness: five different paths to herpes stromal keratitis","volume":"18","author":"Streilein","year":"1997","journal-title":"Immunol. Today"},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib142","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.clae.2010.08.007","article-title":"Increased Langerhan cell density and corneal nerve damage in diabetic patients: role of immune mechanisms in human diabetic neuropathy","volume":"34","author":"Tavakoli","year":"2011","journal-title":"Contact Lens Anterior Eye"},{"issue":"12","key":"10.1016\/j.exer.2020.108284_bib143","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1007\/s00417-017-3759-x","article-title":"Corneal features in ocular graft-versus-host disease by in vivo confocal microscopy","volume":"255","author":"Tepelus","year":"2017","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"issue":"9","key":"10.1016\/j.exer.2020.108284_bib144","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1007\/s00417-017-3680-3","article-title":"Correlation between corneal innervation and inflammation evaluated with confocal microscopy and symptomatology in patients with dry eye syndromes: a preliminary study","volume":"255","author":"Tepelus","year":"2017","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib145","first-page":"123","article-title":"Corneal neurotization: a novel solution to neurotrophic keratopathy","author":"Terzis","year":"2009","journal-title":"Plast. Reconstr. Surg."},{"issue":"2","key":"10.1016\/j.exer.2020.108284_bib146","first-page":"25","article-title":"Ligands reduce ocular pain and inflammation. Molecules (basel, Switzerland)","volume":"1","author":"Thapa","year":"2020","journal-title":"Allosteric Cannabinoid Receptor"},{"issue":"10","key":"10.1016\/j.exer.2020.108284_bib147","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1016\/S0161-6420(99)90412-8","article-title":"Treatment of persistent corneal epithelial defect by autologous serum application","volume":"106","author":"Tsubota","year":"1999","journal-title":"Ophthalmology."},{"issue":"6","key":"10.1016\/j.exer.2020.108284_bib148","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.exer.2008.03.002","article-title":"Alterations in corneal sensitivity and nerve morphology in patients with primary Sj\u00f6gren's syndrome","volume":"86","author":"Tuisku","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2020.108284_bib149","doi-asserted-by":"crossref","first-page":"312401","DOI":"10.1155\/2014\/312401","article-title":"Alterations in the corneal nerve and stem\/progenitor cells in diabetes: preventive effects of insulin-like growth factor-1 treatment","volume":"2014","author":"Ueno","year":"2014","journal-title":"International Journal of Endocrinology."},{"issue":"10","key":"10.1016\/j.exer.2020.108284_bib150","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.jfo.2011.07.011","article-title":"[Corneal sensitivity in patients treated medically for glaucoma or ocular hypertension]","volume":"34","author":"Van Went","year":"2011","journal-title":"J. Fr. Ophtalmol."},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib151","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.biochem.75.103004.142819","article-title":"TRP channels","volume":"76","author":"Venkatachalam","year":"2007","journal-title":"Annu. Rev. Biochem."},{"issue":"9","key":"10.1016\/j.exer.2020.108284_bib152","first-page":"6757","article-title":"Onabotulinum toxin A improves photophobia and sensations of dryness independent of ocular surface parameters","volume":"60","author":"Venkateswaran","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108284_bib153","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2147\/EB.S117261","article-title":"Neurotrophic keratitis: current challenges and future prospects","volume":"10","author":"Versura","year":"2018","journal-title":"Eye Brain"},{"issue":"5","key":"10.1016\/j.exer.2020.108284_bib154","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1167\/iovs.06-1129","article-title":"The cornea in Sj\u00f6gren's syndrome: an in vivo confocal study","volume":"48","author":"Villani","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"9","key":"10.1016\/j.exer.2020.108284_bib155","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.1167\/iovs.10-5380","article-title":"Corneal involvement in graves' orbitopathy: an in vivo confocal study","volume":"51","author":"Villani","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.exer.2020.108284_bib156","first-page":"90","article-title":"Vivo confocal evaluation of the ocular surface morpho-functional unit in dry eye","author":"Villani","year":"2013","journal-title":"Optom. Vis. Sci."},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib157","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.berh.2015.05.002","article-title":"Pain in primary Sjogren's syndrome","volume":"29","author":"Vitali","year":"2015","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"issue":"6","key":"10.1016\/j.exer.2020.108284_bib158","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/bmt.2009.312","article-title":"Baseline profiles of ocular surface and tear dynamics after allogeneic hematopoietic stem cell transplantation in patients with or without chronic GVHD-related dry eye","volume":"45","author":"Wang","year":"2010","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.exer.2020.108284_bib159","first-page":"1024","article-title":"Altered corneal nerves in Chinese thyroid-associated ophthalmopathy patients observed by in vivo confocal microscopy","volume":"25","author":"Wu","year":"2019","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"issue":"3","key":"10.1016\/j.exer.2020.108284_bib160","first-page":"15","article-title":"Decrease in corneal sensitivity and change in tear function in dry eye","author":"Xu","year":"1996","journal-title":"Cornea"},{"issue":"8","key":"10.1016\/j.exer.2020.108284_bib161","doi-asserted-by":"crossref","first-page":"e70908","DOI":"10.1371\/journal.pone.0070908","article-title":"Bilateral nerve alterations in a unilateral experimental neurotrophic keratopathy model: a lateral conjunctival approach for trigeminal axotomy","volume":"8","author":"Yamaguchi","year":"2013","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.exer.2020.108284_bib162","first-page":"13","article-title":"Sensation: the eye and beyond","volume":"91","author":"Yang","year":"2018","journal-title":"Yale J. Biol. Med."},{"issue":"6","key":"10.1016\/j.exer.2020.108284_bib163","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/ner.13146","article-title":"Transcutaneous electrical nerve stimulation for the long-term treatment of ocular pain","volume":"23","author":"Zayan","year":"2020","journal-title":"Neuromodulation"},{"issue":"7","key":"10.1016\/j.exer.2020.108284_bib164","first-page":"24","article-title":"Altered corneal nerves in aqueous tear deficiency viewed by in vivo confocal microscopy","author":"Zhang","year":"2005","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2020.108284_bib71","doi-asserted-by":"crossref","unstructured":"Kim JS, Rafailov L, Leyngold IM, 2020. Corneal neurotization for postherpetic neurotrophic keratopathy: initial experience and clinical outcomes. Ophthalmic Plastic and Reconstructive Surgery. Publish Ahead of Print (April 23, 2020). Doi: 10.1097\/IOP.0000000000001676.","DOI":"10.1097\/IOP.0000000000001676"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448352030542X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448352030542X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:32:56Z","timestamp":1762147976000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448352030542X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":164,"alternative-id":["S001448352030542X"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2020.108284","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Corneal Nerve Abnormalities in Ocular and Systemic Diseases","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2020.108284","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108284"}}