{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:32:56Z","timestamp":1774463576937,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009415","name":"Renaissance Society of America","doi-asserted-by":"publisher","award":["RX002928"],"award-info":[{"award-number":["RX002928"]}],"id":[{"id":"10.13039\/100009415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30EY006360"],"award-info":[{"award-number":["P30EY006360"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.exer.2020.108333","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T12:15:34Z","timestamp":1603887334000},"page":"108333","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Ovariectomy worsens visual function after mild optic nerve crush in rodents"],"prefix":"10.1016","volume":"202","author":[{"given":"Rachael S.","family":"Allen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber","family":"Douglass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harrison","family":"Vo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7914-989X","authenticated-orcid":false,"given":"Andrew J.","family":"Feola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2020.108333_bib1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1167\/iovs.18-25110","article-title":"Retinal deficits precede cognitive and motor deficits in a rat model of type II diabetes","volume":"60","author":"Allen","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108333_bib2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/BF00229323","article-title":"Pattern ERG in rats following section of the optic nerve","volume":"79","author":"Berardi","year":"1990","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.exer.2020.108333_bib3","first-page":"692609","article-title":"Animal models of glaucoma","author":"Bouhenni","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.exer.2020.108333_bib4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1113\/jphysiol.2003.052738","article-title":"Ganglion cell contributions to the rat full-field electroretinogram","volume":"555","author":"Bui","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.exer.2020.108333_bib5","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1167\/iovs.04-0421","article-title":"The gradient of retinal functional changes during acute intraocular pressure elevation","volume":"46","author":"Bui","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108333_bib6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.preteyeres.2004.06.001","article-title":"The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage","volume":"24","author":"Burgoyne","year":"2005","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2020.108333_bib7","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1038\/s41598-018-21475-x","article-title":"Impact of aromatase absence on murine intraocular pressure and retinal ganglion cells","volume":"8","author":"Chen","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2020.108333_bib8","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1001\/archopht.126.1.110","article-title":"Estrogen receptors alpha and beta and the risk of open-angle glaucoma: the Rotterdam Study","volume":"126","author":"de Voogd","year":"2008","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2020.108333_bib9","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3109\/08820538.2015.1114845","article-title":"Is estrogen a therapeutic target for glaucoma?","volume":"31","author":"Dewundara","year":"2016","journal-title":"Semin. Ophthalmol."},{"key":"10.1016\/j.exer.2020.108333_bib10","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1017\/S0952523805225166","article-title":"Independent visual threshold measurements in the two eyes of freely moving rats and mice using a virtual-reality optokinetic system","volume":"22","author":"Douglas","year":"2005","journal-title":"Vis. Neurosci."},{"key":"10.1016\/j.exer.2020.108333_bib11","first-page":"31","article-title":"Graded crush of the rat optic nerve as a brain injury model: combining electrophysiological and behavioral outcome","volume":"2","author":"Duvdevani","year":"1990","journal-title":"Restor. Neurol. Neurosci."},{"key":"10.1016\/j.exer.2020.108333_bib12","doi-asserted-by":"crossref","first-page":"107706","DOI":"10.1016\/j.exer.2019.107706","article-title":"Menopause exacerbates visual dysfunction in experimental glaucoma","volume":"186","author":"Feola","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2020.108333_bib13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1167\/iovs.61.5.16","article-title":"Age and menopause effects on ocular compliance and aqueous outflow","volume":"61","author":"Feola","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108333_bib14","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.1167\/iovs.08-2255","article-title":"Relative course of retinal nerve fiber layer birefringence and thickness and retinal function changes after optic nerve transection","volume":"49","author":"Fortune","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108333_bib15","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.ajpath.2012.12.032","article-title":"VEGF-A is necessary and sufficient for retinal neuroprotection in models of experimental glaucoma","volume":"182","author":"Foxton","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2020.108333_bib16","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1167\/iovs.10-6311","article-title":"Optic nerve crush mice followed longitudinally with spectral domain optical coherence tomography","volume":"52","author":"Gabriele","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108333_bib17","doi-asserted-by":"crossref","first-page":"R169","DOI":"10.1186\/ar1152","article-title":"Ovariectomized rats as a model of postmenopausal osteoarthritis: validation and application","volume":"6","author":"Hoegh-Andersen","year":"2004","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.exer.2020.108333_bib18","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.brainresbull.2009.04.004","article-title":"Rodent models of glaucoma","volume":"81","author":"Johnson","year":"2010","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.exer.2020.108333_bib19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.maturitas.2016.01.015","article-title":"Modeling menopause: the utility of rodents in translational behavioral endocrinology research","volume":"87","author":"Koebele","year":"2016","journal-title":"Maturitas"},{"key":"10.1016\/j.exer.2020.108333_bib20","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/sj.eye.6701576","article-title":"Animal models of optic nerve diseases","volume":"18","author":"Levkovitch-Verbin","year":"2004","journal-title":"Eye"},{"key":"10.1016\/j.exer.2020.108333_bib21","first-page":"4169","article-title":"RGC death in mice after optic nerve crush injury: oxidative stress and neuroprotection","volume":"41","author":"Levkovitch-Verbin","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108333_bib22","article-title":"Association between 17-beta-estradiol and IL-8 and visual field progression in postmenopausal women with primary angle closure glaucoma","author":"Li","year":"2020","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2020.108333_bib23","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.ajo.2009.12.030","article-title":"Estrogen receptor beta gene polymorphism and intraocular pressure elevation in female patients with primary open-angle glaucoma","volume":"149","author":"Mabuchi","year":"2010","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2020.108333_bib24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ajog.2008.01.042","article-title":"Hormones restore biomechanical properties of the vagina and supportive tissues after surgical menopause in young rats","volume":"199","author":"Moalli","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.exer.2020.108333_bib25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.exer.2015.06.020","article-title":"Microbead models in glaucoma","volume":"141","author":"Morgan","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2020.108333_bib26","series-title":"Glaucoma Science and Practice","author":"Morrison","year":"2003"},{"key":"10.1016\/j.exer.2020.108333_bib27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/exer.1996.0184","article-title":"A rat model of chronic pressure-induced optic nerve damage","volume":"64","author":"Morrison","year":"1997","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2020.108333_bib28","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0079-6123(08)01121-7","article-title":"Rat models for glaucoma research","volume":"173","author":"Morrison","year":"2008","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.exer.2020.108333_bib29","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.exer.2010.08.005","article-title":"Pathophysiology of human glaucomatous optic nerve damage: insights from rodent models of glaucoma","volume":"93","author":"Morrison","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2020.108333_bib30","doi-asserted-by":"crossref","first-page":"6505","DOI":"10.1167\/iovs.14-14525","article-title":"Nerve fiber layer thinning lags retinal ganglion cell density following crush axonopathy","volume":"55","author":"Munguba","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108333_bib31","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1097\/IJG.0b013e318064c82d","article-title":"Attributes of female reproductive aging and their relation to primary open-angle glaucoma: a prospective study","volume":"16","author":"Pasquale","year":"2007","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.exer.2020.108333_bib32","first-page":"1471","article-title":"Estrogen pathway polymorphisms in relation to primary open angle glaucoma: an analysis accounting for gender from the United States","volume":"19","author":"Pasquale","year":"2013","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2020.108333_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2015.05.008","article-title":"Electrophysiological assessment of retinal ganglion cell function","author":"Porciatti","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2020.108333_bib34","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1021\/mp400313u","article-title":"17beta-estradiol eye drops protect the retinal ganglion cell layer and preserve visual function in an in vivo model of glaucoma","volume":"10","author":"Prokai-Tatrai","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.exer.2020.108333_bib35","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1167\/iovs.04-0541","article-title":"Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system","volume":"45","author":"Prusky","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108333_bib36","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2020.108333_bib37","doi-asserted-by":"crossref","first-page":"4487","DOI":"10.1167\/iovs.15-17145","article-title":"Comparison of retinal nerve fiber layer thinning and retinal ganglion cell loss after optic nerve transection in adult albino rats","volume":"56","author":"Rovere","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108333_bib38","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0079-6123(08)01144-8","article-title":"17Beta-estradiol prevents retinal ganglion cell loss induced by acute rise of intraocular pressure in rat","volume":"173","author":"Russo","year":"2008","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.exer.2020.108333_bib39","first-page":"624","article-title":"The laboratory rat: relating its age with human's","volume":"4","author":"Sengupta","year":"2013","journal-title":"Int. J. Prev. Med."},{"key":"10.1016\/j.exer.2020.108333_bib40","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0014-4835(05)80131-9","article-title":"Chronic ocular hypertension following episcleral venous occlusion in rats","volume":"61","author":"Shareef","year":"1995","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2020.108333_bib41","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3892\/etm.2012.619","article-title":"Evaluation of a partial optic nerve crush model in rats","volume":"4","author":"Tan","year":"2012","journal-title":"Experimental and therapeutic medicine"},{"key":"10.1016\/j.exer.2020.108333_bib42","article-title":"First delivery and ovariectomy affect biomechanical and structural properties of the vagina in the ovine model","author":"Urbankova","year":"2018","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.exer.2020.108333_bib43","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.exer.2006.01.025","article-title":"Three experimental glaucoma models in rats: comparison of the effects of intraocular pressure elevation on retinal ganglion cell size and death","volume":"83","author":"Urcola","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2020.108333_bib44","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1097\/gme.0b013e3182443137","article-title":"Estrogen deficiency accelerates aging of the optic nerve","volume":"19","author":"Vajaranant","year":"2012","journal-title":"Menopause"},{"key":"10.1016\/j.exer.2020.108333_bib45","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.mehy.2012.05.041","article-title":"Is low dose of estrogen beneficial for prevention of glaucoma?","volume":"79","author":"Wei","year":"2012","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.exer.2020.108333_bib46","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1136\/bjo.2010.196907","article-title":"Retinal nerve fibre layer and visual function loss in glaucoma: the tipping point","volume":"96","author":"Wollstein","year":"2012","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2020.108333_bib47","doi-asserted-by":"crossref","first-page":"4597","DOI":"10.1167\/iovs.07-0349","article-title":"3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: lamina cribrosa and peripapillary scleral position and thickness","volume":"48","author":"Yang","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108333_bib48","first-page":"65","article-title":"Alpha2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration","volume":"40","author":"Yoles","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108333_bib49","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/dneu.20373","article-title":"Retinal ganglion cell protection by 17-beta-estradiol in a mouse model of inherited glaucoma","volume":"67","author":"Zhou","year":"2007","journal-title":"Developmental neurobiology"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483520305911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483520305911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:33:20Z","timestamp":1762148000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483520305911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":49,"alternative-id":["S0014483520305911"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2020.108333","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ovariectomy worsens visual function after mild optic nerve crush in rodents","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2020.108333","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108333"}}