{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:04:37Z","timestamp":1790449477780,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Government of Russian Federation","award":["14.Z50.31.0046"],"award-info":[{"award-number":["14.Z50.31.0046"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.exer.2020.108394","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T04:50:05Z","timestamp":1607575805000},"page":"108394","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Visualization of different anatomical parts of the enucleated human eye using X-ray micro-CT imaging"],"prefix":"10.1016","volume":"203","author":[{"given":"Sergey Y.","family":"Tkachev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris I.","family":"Mitrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0889-2720","authenticated-orcid":false,"given":"Nikolay S.","family":"Karnaukhov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7770-1601","authenticated-orcid":false,"given":"Evgeniy V.","family":"Sadyrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark V.","family":"Voloshin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey Y.","family":"Maksimov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0676-0871","authenticated-orcid":false,"given":"Anna S.","family":"Goncharova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina A.","family":"Lukbanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina V.","family":"Zaikina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiya V.","family":"Volkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darya V.","family":"Khodakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria V.","family":"Mindar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina A.","family":"Yengibarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana P.","family":"Protasova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey O.","family":"Kit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey M.","family":"Ermakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8172-8666","authenticated-orcid":false,"given":"Sergey V.","family":"Chapek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina S.","family":"Tkacheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2020.108394_bib1","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2014.0717","article-title":"Transverse depth-dependent changes in corneal collagen lamellar orientation and distribution","author":"Abass","year":"2015","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.exer.2020.108394_bib2","doi-asserted-by":"crossref","DOI":"10.1007\/s11307-018-1246-3","article-title":"X-ray-Based 3D virtual histology\u2014adding the next dimension to histological analysis","author":"Albers","year":"2018","journal-title":"Mol. Imag. Biol."},{"key":"10.1016\/j.exer.2020.108394_bib3","doi-asserted-by":"crossref","DOI":"10.1159\/000499186","article-title":"Microcomputed tomography calibration using polymers and minerals for enamel mineral content quantitation","author":"Alyahya","year":"2019","journal-title":"Med. Princ. Pract."},{"key":"10.1016\/j.exer.2020.108394_bib4","series-title":"Emerging Imaging Technologies in Medicine, Emerging Imaging Technologies in Medicine","author":"Anastasio","year":"2012"},{"key":"10.1016\/j.exer.2020.108394_bib5","first-page":"193","article-title":"Collagen fiber changes related to keratoconus with secondary corneal amyloidosis","volume":"11","author":"Araki-Sasaki","year":"2018","journal-title":"Int. Med. Case Rep. J."},{"key":"10.1016\/j.exer.2020.108394_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2020.108394_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-37394-w","article-title":"A step towards valid detection and quantification of lung cancer volume in experimental mice with contrast agent-based X-ray microtomography","author":"Bidola","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2020.108394_bib8","doi-asserted-by":"crossref","DOI":"10.2113\/gselements.2.1.9","article-title":"User facilities around the world","author":"Brown","year":"2006","journal-title":"Elements"},{"key":"10.1016\/j.exer.2020.108394_bib9","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1720862115","article-title":"Three-dimensional virtual histology enabled through cytoplasm-specific X-ray stain for microscopic and nanoscopic computed tomography","author":"Busse","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2020.108394_bib10","series-title":"The Vertebrate Retina","article-title":"La retine des vertebres","author":"Cajal","year":"1893"},{"key":"10.1016\/j.exer.2020.108394_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8617406","article-title":"Contrast-enhanced microCT for virtual 3D anatomical pathology of biological tissues: a literature review","author":"De Bournonville","year":"2019","journal-title":"Contrast Media Mol. Imaging"},{"key":"10.1016\/j.exer.2020.108394_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresrev.2007.03.010","article-title":"A historical reflection of the contributions of Cajal and Golgi to the foundations of neuroscience","author":"De Carlos","year":"2007","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.exer.2020.108394_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/jmor.20392","article-title":"Details of human middle ear morphology based on micro-CT imaging of phosphotungstic acid stained samples","author":"De Greef","year":"2015","journal-title":"J. Morphol."},{"key":"10.1016\/j.exer.2020.108394_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcrs.2010.12.037","article-title":"Anatomy and physiology of the cornea","author":"DelMonte","year":"2011","journal-title":"J. Cataract Refract. Surg."},{"key":"10.1016\/j.exer.2020.108394_bib15","doi-asserted-by":"crossref","DOI":"10.1097\/ICO.0b013e31818225c3","article-title":"Corneal collagen cross-linking: a confocal, electron, and light microscopy study of eye bank corneas","author":"Dhaliwal","year":"2009","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2020.108394_bib16","series-title":"Ophthalmology","article-title":"Human corneal anatomy redefined: a novel pre-descemet\u2019s layer (Dua's Layer)","author":"Dua","year":"2013"},{"key":"10.1016\/j.exer.2020.108394_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0170633","article-title":"Advanced non-destructive ocular visualization methods by improved X-ray imaging techniques","author":"Enders","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.exer.2020.108394_bib18","doi-asserted-by":"crossref","DOI":"10.1039\/C6CP04251A","article-title":"Investigating lithium-ion battery materials during overcharge-induced thermal runaway: an operando and multi-scale X-ray CT study","author":"Finegan","year":"2016","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.exer.2020.108394_bib19","doi-asserted-by":"crossref","DOI":"10.4172\/2155-9570.1000652","article-title":"Comparing anterior segment ocular coherence tomography (AS-OCT), ultrasound biomicroscopy (UBM) and pentacam in evaluating the changes of the anterior segment parameters after phacoemulsification","author":"Ghoneim","year":"2017","journal-title":"J. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2020.108394_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2010.12.010","article-title":"Imaging the aqueous humor outflow pathway in human eyes by three-dimensional micro-computed tomography (3D micro-CT)","author":"Hann","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2020.108394_bib21","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.14-14128","article-title":"Anatomic changes in Schlemm's canal and collector channels in normal and primary open-angle glaucoma eyes using low and high perfusion pressures","author":"Hann","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108394_bib22","article-title":"Feasibility study of the 3D visualization at high resolution of intra-cranial rabbit eyes with X-ray CT phase-contrast imaging","volume":"58","author":"Ivanishko","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108394_bib23","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/192582","article-title":"Inflammatory mechanisms of idiopathic epiretinal membrane formation","author":"Joshi","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.exer.2020.108394_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/srep35202","article-title":"Study of corneal epithelial progenitor origin and the Yap1 requirement using keratin 12 lineage tracing transgenic mice","author":"Kasetti","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2020.108394_bib25","doi-asserted-by":"crossref","DOI":"10.1007\/s11666-017-0532-y","article-title":"3D analysis of porosity in a ceramic coating using X-ray microscopy","author":"Klement","year":"2017","journal-title":"J. Therm. Spray Technol."},{"key":"10.1016\/j.exer.2020.108394_bib26","article-title":"The three-dimensional organization of collagen fibrils in the human cornea and sclera","author":"Komai","year":"1991","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108394_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/(SICI)1099-0518(199706)35:8<1409::AID-POLA9>3.0.CO;2-U","article-title":"Iodine binding capacity and iodine binding energy of glycogen","author":"Lecker","year":"1997","journal-title":"J. Polym. Sci. Part A Polym. Chem."},{"key":"10.1016\/j.exer.2020.108394_bib28","series-title":"Clinical Anatomy and Physiology of the Visual System, Clinical Anatomy and Physiology of the Visual System","author":"Lee Ann","year":"2012"},{"key":"10.1016\/j.exer.2020.108394_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/j.1755-3768.2017.03344","article-title":"Micro-CT study of Bomirski melanoma growing in hamster eye","author":"Leszczy\u0144ski","year":"2017","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.exer.2020.108394_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2017.11.004","article-title":"Visualization of porcine eye anatomy by X-ray microtomography","author":"Leszczy\u0144ski","year":"2018","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2020.108394_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/jemt.23020","article-title":"Three-dimensional visualization of rat retina by X-ray differential phase contrast tomographic microscopy","author":"Liu","year":"2018","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.exer.2020.108394_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17064-z","article-title":"Dual-energy micro-CT for quantifying the time-course and staining characteristics of ex-vivo animal organs treated with iodine-and gadolinium-based contrast agents","author":"Martins de Souza e Silva","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2020.108394_bib33","doi-asserted-by":"crossref","DOI":"10.1364\/BOE.9.000557","article-title":"In vivo high resolution human corneal imaging using full-field optical coherence tomography","author":"Mazlin","year":"2018","journal-title":"Biomed. Optic Express"},{"key":"10.1016\/j.exer.2020.108394_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2015.07.001","article-title":"Corneal structure and transparency","author":"Meek","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2020.108394_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmp.2018.06.004","article-title":"High resolution hard X-ray 3D mapping of a Macaca fascicularis eye: a feasibility study without contrast agents","volume":"51","author":"Mittone","year":"2018","journal-title":"Phys. Med."},{"key":"10.1016\/j.exer.2020.108394_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2008.01.029","article-title":"Three-dimensional microtomographic imaging of human brain cortex","author":"Mizutani","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.exer.2020.108394_bib37","doi-asserted-by":"crossref","DOI":"10.1093\/cercor\/bhp237","article-title":"Microtomographic analysis of neuronal circuits of human brain","author":"Mizutani","year":"2010","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.exer.2020.108394_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-36067-y","article-title":"Nucleus-specific X-ray stain for 3D virtual histology","author":"M\u00fcller","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2020.108394_bib39","series-title":"Micro-Computed Tomography (Micro-CT) in Medicine and Engineering","article-title":"Fundamentals of micro-CT imaging","author":"Orhan","year":"2020"},{"key":"10.1016\/j.exer.2020.108394_bib40","doi-asserted-by":"crossref","DOI":"10.1146\/annurev-bioeng-071910-124717","article-title":"Current status of developments and applications of micro-CT","author":"Ritman","year":"2011","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.exer.2020.108394_bib41","doi-asserted-by":"crossref","DOI":"10.1001\/archopht.124.10.1487","article-title":"Histopathology and ultrastructure of human corneas after amniotic membrane transplantation","author":"Seitz","year":"2006","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2020.108394_bib42","doi-asserted-by":"crossref","DOI":"10.1007\/s12348-012-0074-x","article-title":"Immunohistochemical study of epiretinal membranes in patients with uveitis","author":"Sheybani","year":"2012","journal-title":"J. Ophthalmic Inflamm. Infect."},{"key":"10.1016\/j.exer.2020.108394_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/srep14088","article-title":"Three-dimensional non-destructive soft-tissue visualization with X-ray staining micro-tomography","volume":"5","author":"Silva","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2020.108394_bib44","doi-asserted-by":"crossref","DOI":"10.2147\/OPTH.S97722","article-title":"Epiretinal membrane: optical coherence tomography-based diagnosis and classification","author":"Stevenson","year":"2016","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.exer.2020.108394_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2018.00041","article-title":"Optimization of 3D-visualization of micro-anatomical structures of the human inner ear in osmium tetroxide contrast enhanced micro-CT scans","volume":"12","author":"van den Boogert","year":"2018","journal-title":"Front. Neuroanat."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483520306527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483520306527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:09:08Z","timestamp":1757999348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483520306527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":45,"alternative-id":["S0014483520306527"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2020.108394","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Visualization of different anatomical parts of the enucleated human eye using X-ray micro-CT imaging","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2020.108394","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108394"}}