{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:41:07Z","timestamp":1782866467524,"version":"3.54.5"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100001116","name":"Foundation Fighting Blindness","doi-asserted-by":"publisher","award":["TA-NMT-0617-0721-AUG"],"award-info":[{"award-number":["TA-NMT-0617-0721-AUG"]}],"id":[{"id":"10.13039\/100001116","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY028103"],"award-info":[{"award-number":["R01EY028103"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30 EY031631"],"award-info":[{"award-number":["P30 EY031631"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.exer.2020.108397","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T12:45:24Z","timestamp":1607517924000},"page":"108397","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Optimal timing for activation of sigma 1 receptor in the Pde6b\/J (rd10) mouse model of retinitis pigmentosa"],"prefix":"10.1016","volume":"202","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6889-2346","authenticated-orcid":false,"given":"Shannon","family":"Barwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2870-4504","authenticated-orcid":false,"given":"Yutao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia B.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2020.108397_bib1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1167\/iovs.61.3.5","article-title":"Comparison of neuroprotective effects of monomethylfumarate to the sigma 1 receptor ligand (+)-Pentazocine in a murine model of retinitis pigmentosa","volume":"61","author":"Xiao","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108397_bib2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ejphar.2006.02.026","article-title":"A novel adamantane derivative attenuates retinal ischemia-reperfusion damage in the rat retina through sigma1 receptors","volume":"536","author":"Bucolo","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.exer.2020.108397_bib3","first-page":"142","article-title":"New nrf2-inducer compound ITH12674 slows the progression of retinitis pigmentosa in the mouse model rd10","volume":"54","author":"Campello","year":"2020","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.exer.2020.108397_bib4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.preteyeres.2017.08.004","article-title":"The mechanism of cone cell death in Retinitis Pigmentosa","volume":"62","author":"Campochiaro","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2020.108397_bib5","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1021\/acschemneuro.0c00358","article-title":"Retinitis pigmentosa and retinal degenerations: deciphering pathways and targets for drug discovery and development","volume":"11","author":"Carullo","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.exer.2020.108397_bib6","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0042-6989(01)00146-8","article-title":"Retinal degeneration mutants in the mouse","volume":"42","author":"Chang","year":"2002","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2020.108397_bib7","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.visres.2006.11.020","article-title":"Two mouse retinal degenerations caused by missense mutations in the beta-subunit of rod cGMP phosphodiesterase gene","volume":"47","author":"Chang","year":"2007","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2020.108397_bib8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1080\/15569527.2019.1685535","article-title":"(Z)-7,4'-Dimethoxy-6-hydroxy-aurone-4-O-\u03b2-glucopyranoside mitigates retinal degeneration in Rd10 mouse model through inhibiting oxidative stress and inflammatory responses","volume":"39","author":"Chen","year":"2020","journal-title":"Cutan. Ocul. Toxicol."},{"key":"10.1016\/j.exer.2020.108397_bib9","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/j.1471-4159.2011.07354.x","article-title":"Enhancing survival of photoreceptor cells in vivo using the synthetic progestin Norgestrel","volume":"118","author":"Doonan","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.exer.2020.108397_bib10","doi-asserted-by":"crossref","first-page":"4785","DOI":"10.1167\/iovs.07-0343","article-title":"Prevention of excitotoxicity in primary retinal ganglion cells by (+)-pentazocine, a sigma receptor-1 specific ligand","volume":"48","author":"Dun","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108397_bib11","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1007\/s12031-020-01503-0","article-title":"Increased neuroprotective microglia and photoreceptor survival in the retina from a peptide inhibitor of myeloid differentiation factor 88 (MyD88)","volume":"70","author":"Garces","year":"2020","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.exer.2020.108397_bib12","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/cne.21144","article-title":"Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study","volume":"500","author":"Gargini","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.exer.2020.108397_bib13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.preteyeres.2015.06.005","article-title":"Pharmacological approaches to retinitis pigmentosa: a laboratory perspective","volume":"48","author":"Guadagni","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2020.108397_bib14","doi-asserted-by":"crossref","first-page":"5576","DOI":"10.1167\/iovs.06-0608","article-title":"Expression, subcellular localization, and regulation of sigma receptor in retinal muller cells","volume":"47","author":"Jiang","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108397_bib15","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/jnc.14613","article-title":"Metipranolol promotes structure and function of retinal photoreceptors in the rd10 mouse model of human retinitis pigmentosa","volume":"148","author":"Kanan","year":"2019","journal-title":"J. Neurochem."},{"key":"10.1016\/j.exer.2020.108397_bib16","doi-asserted-by":"crossref","first-page":"10689","DOI":"10.1038\/srep10689","article-title":"Subcellular localization of the sigma-1 receptor in retinal neurons - an electron microscopy study","volume":"5","author":"Mavlyutov","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2020.108397_bib17","article-title":"Care delay the most common error in ophthalmic health care","volume":"116","author":"Merkland","year":"2019","journal-title":"Lakartidningen"},{"key":"10.1016\/j.exer.2020.108397_bib18","first-page":"9620876","article-title":"Simultaneous fluorescein angiography and spectral domain optical coherence tomography correlate retinal thickness changes to vascular abnormalities in an in vivo mouse model of retinopathy of prematurity","author":"Mezu-Ndubuisi","year":"2017","journal-title":"J Ophthalmol"},{"key":"10.1016\/j.exer.2020.108397_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.exer.2012.11.002","article-title":"Sigma-1 receptor stimulation attenuates calcium influx through activated L-type Voltage Gated Calcium Channels in purified retinal ganglion cells","volume":"107","author":"Mueller","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2020.108397_bib20","doi-asserted-by":"crossref","first-page":"101199","DOI":"10.1016\/j.redox.2019.101199","article-title":"Hyperhomocysteinemia-induced death of retinal ganglion cells: the role of M\u00fcller glial cells and NRF2","volume":"24","author":"Navneet","year":"2019","journal-title":"Redox Biol"},{"key":"10.1016\/j.exer.2020.108397_bib21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jphs.2014.12.005","article-title":"Role of sigma-1 receptors in neurodegenerative diseases","volume":"127","author":"Nguyen","year":"2015","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.exer.2020.108397_bib22","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0169-328X(01)00249-2","article-title":"Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina","volume":"95","author":"Ola","year":"2001","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.exer.2020.108397_bib23","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1111\/ejn.12196","article-title":"Cone survival and preservation of visual acuity in an animal model of retinal degeneration","volume":"37","author":"Piano","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.exer.2020.108397_bib24","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1167\/iovs.04-0541","article-title":"Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system","volume":"45","author":"Prusky","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108397_bib25","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1167\/iovs.19-27246","article-title":"Norgestrel, a progesterone analogue, promotes significant long-term neuroprotection of cone photoreceptors in a mouse model of retinal disease","volume":"60","author":"Roche","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108397_bib26","doi-asserted-by":"crossref","first-page":"10551","DOI":"10.1074\/jbc.M110.209759","article-title":"Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations","volume":"286","author":"Sakami","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2020.108397_bib27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.exer.2015.01.017","article-title":"Effect of a sigma-1 receptor agonist, cutamesine dihydrochloride (SA4503), on photoreceptor cell death against light-induced damage","volume":"132","author":"Shimazawa","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2020.108397_bib28","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1167\/iovs.08-1824","article-title":"In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine","volume":"49","author":"Smith","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108397_bib29","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.preteyeres.2018.07.003","article-title":"Sigma 1 receptor: a novel therapeutic target in retinal disease","volume":"67","author":"Smith","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2020.108397_bib30","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.tips.2016.01.003","article-title":"The sigma-1 receptor as a pluripotent modulator in living systems","volume":"37","author":"Su","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.exer.2020.108397_bib31","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/978-3-030-27378-1_75","article-title":"The resveratrol prodrug JC19 delays retinal degeneration in rd10 mice","volume":"1185","author":"Vald\u00e9s-S\u00e1nchez","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2020.108397_bib32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.freeradbiomed.2015.04.009","article-title":"Sigma 1 receptor regulates the oxidative stress response in primary retinal M\u00fcller glial cells via NRF2 signaling and system xc(-), the Na(+)-independent glutamate-cystine exchanger","volume":"86","author":"Wang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exer.2020.108397_bib33","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1167\/iovs.15-18995","article-title":"Role of sigma 1 receptor in retinal degeneration of the Ins2Akita\/+ murine model of diabetic retinopathy","volume":"57","author":"Wang","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108397_bib34","first-page":"E3764","article-title":"Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration","volume":"113","author":"Wang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2020.108397_bib35","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.1167\/iovs.17-21947","article-title":"Absence of sigma 1 receptor accelerates photoreceptor cell death in a murine model of retinitis pigmentosa","volume":"58","author":"Wang","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108397_bib36","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.freeradbiomed.2019.02.001","article-title":"The molecular chaperone sigma 1 receptor mediates rescue of retinal cone photoreceptor cells via modulation of NRF2","volume":"134","author":"Wang","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exer.2020.108397_bib37","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1167\/iovs.19-27709","article-title":"Activation of sigma 1 receptor extends survival of cones and improves visual acuity in a murine model of retinitis pigmentosa","volume":"60","author":"Wang","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2020.108397_bib38","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13287-020-01608-8","article-title":"Protective effects of human iPS-derived retinal pigmented epithelial cells on retinal degenerative disease","volume":"11","author":"Zhu","year":"2020","journal-title":"Stem Cell Res. Ther."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483520306552?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483520306552?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:07:00Z","timestamp":1757999220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483520306552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":38,"alternative-id":["S0014483520306552"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2020.108397","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimal timing for activation of sigma 1 receptor in the Pde6brd10\/J (rd10) mouse model of retinitis pigmentosa","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2020.108397","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108397"}}