{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T01:11:34Z","timestamp":1780881094902,"version":"3.54.1"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.exer.2021.108471","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T18:14:55Z","timestamp":1611857695000},"page":"108471","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Complement-mediated release of fibroblast growth factor 2 from human RPE cells"],"prefix":"10.1016","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5815-6986","authenticated-orcid":false,"given":"Ping","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0173-6752","authenticated-orcid":false,"given":"Samantha E.","family":"Neal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen L.","family":"Buehne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7519-7731","authenticated-orcid":false,"given":"Grace M.","family":"Tewkesbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Klingeborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yae-Young","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Baciu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn J.","family":"Jaffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2021.108471_bib1","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/BF03401659","article-title":"The transient pore formed by homologous terminal complement complexes functions as a bidirectional route for the transport of autocrine and paracrine signals across human cell membranes","volume":"2","author":"Acosta","year":"1996","journal-title":"Mol. Med."},{"key":"10.1016\/j.exer.2021.108471_bib2","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1111\/j.1582-4934.2008.00415.x","article-title":"A pro-inflammatory signature mediates FGF2-induced angiogenesis","volume":"13","author":"Andres","year":"2009","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.exer.2021.108471_bib3","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1084\/jem.179.3.985","article-title":"Terminal complement proteins C5b-9 release basic fibroblast growth factor and platelet-derived growth factor from endothelial cells","volume":"179","author":"Benzaquen","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.exer.2021.108471_bib4","doi-asserted-by":"crossref","first-page":"31189","DOI":"10.1074\/jbc.M115.671180","article-title":"Complement component C5a primes retinal pigment epithelial cells for inflammasome activation by lipofuscin-mediated photooxidative damage","volume":"290","author":"Brandstetter","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2021.108471_bib5","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1111\/j.1755-3768.2010.02040.x","article-title":"Genetic association study of age-related macular degeneration in the Spanish population","volume":"89","author":"Brion","year":"2011","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.exer.2021.108471_bib6","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1136\/bjo.2007.127670","article-title":"The effects of growth factors on the proliferation and in vitro angiogenesis of human macular inner choroidal endothelial cells","volume":"92","author":"Browning","year":"2008","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2021.108471_bib7","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.crvi.2013.12.003","article-title":"Complement factor H and related proteins in age-related macular degeneration","volume":"337","author":"Calippe","year":"2014","journal-title":"C R Biol"},{"key":"10.1016\/j.exer.2021.108471_bib8","article-title":"Inflammatory mediators and angiogenic factors in choroidal neovascularization: pathogenetic interactions and therapeutic implications","volume":"2010","author":"Campa","year":"2010","journal-title":"Mediators Inflamm 2010"},{"key":"10.1016\/j.exer.2021.108471_bib9","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.4049\/jimmunol.134.3.1804","article-title":"Elimination of terminal complement intermediates from the plasma membrane of nucleated cells: the rate of disappearance differs for cells carrying C5b-7 or C5b-8 or a mixture of C5b-8 with a limited number of C5b-9","volume":"134","author":"Carney","year":"1985","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2021.108471_bib10","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1002\/ijc.22844","article-title":"Epstein-Barr virus latent membrane protein 1 promotes concentration in multivesicular bodies of fibroblast growth factor 2 and its release through exosomes","volume":"121","author":"Ceccarelli","year":"2007","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.exer.2021.108471_bib11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-3-030-27378-1_2","article-title":"A review of pathogenic drivers of age-related macular degeneration, beyond complement, with a focus on potential endpoints for testing therapeutic interventions in preclinical studies","volume":"1185","author":"Choudhary","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2021.108471_bib12","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/S0002-9440(10)65485-5","article-title":"Complement C5b-9 induces receptor tyrosine kinase transactivation in glomerular epithelial cells","volume":"155","author":"Cybulsky","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2021.108471_bib13","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0014-5793(00)01189-3","article-title":"The high molecular weight isoforms of basic fibroblast growth factor (FGF-2): an insight into an intracrine mechanism","volume":"468","author":"Delrieu","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.exer.2021.108471_bib14","doi-asserted-by":"crossref","first-page":"107775","DOI":"10.1016\/j.exer.2019.107775","article-title":"FGF2-induced STAT3 activation regulates pathologic neovascularization","volume":"187","author":"Dong","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2021.108471_bib15","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1600-0854.2010.01059.x","article-title":"Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion","volume":"11","author":"Ebert","year":"2010","journal-title":"Traffic"},{"key":"10.1016\/j.exer.2021.108471_bib16","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.exer.2008.06.017","article-title":"Growth-related effects of oxidant-induced stress on cultured RPE and choroidal endothelial cells","volume":"87","author":"Eichler","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2021.108471_bib17","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1242\/jcs.00036","article-title":"Biosynthetic FGF-2 is targeted to non-lipid raft microdomains following translocation to the extracellular surface of CHO cells","volume":"115","author":"Engling","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.exer.2021.108471_bib18","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/jcp.1041620311","article-title":"Quantitative export of FGF-2 occurs through an alternative, energy-dependent, non-ER\/Golgi pathway","volume":"162","author":"Florkiewicz","year":"1995","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exer.2021.108471_bib19","first-page":"393","article-title":"A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane","volume":"130","author":"Folkman","year":"1988","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2021.108471_bib20","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0002-9394(14)72066-5","article-title":"Basic fibroblast growth factor and vascular endothelial growth factor are present in epiretinal and choroidal neovascular membranes","volume":"122","author":"Frank","year":"1996","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2021.108471_bib21","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1046\/j.1365-2249.2003.02087.x","article-title":"Differential cytokine expression of human retinal pigment epithelial cells in response to stimulation by C5a","volume":"131","author":"Fukuoka","year":"2003","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.exer.2021.108471_bib22","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.4049\/jimmunol.1500937","article-title":"Retinal pigment epithelial cells mitigate the effects of complement attack by endocytosis of C5b-9","volume":"195","author":"Georgiannakis","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2021.108471_bib23","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.preteyeres.2017.06.002","article-title":"On phagocytes and macular degeneration","volume":"61","author":"Guillonneau","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2021.108471_bib24","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s00417-004-0879-x","article-title":"Characterization of the basic fibroblast growth factor-evoked proliferation of the human Muller cell line, MIO-M1","volume":"242","author":"Hollborn","year":"2004","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2021.108471_bib25","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/(SICI)1521-4141(199901)29:01<215::AID-IMMU215>3.0.CO;2-#","article-title":"Expression of multiple forms of IL-1 receptor antagonist (IL-1ra) by human retinal pigment epithelial cells: identification of a new IL-1ra exon","volume":"29","author":"Holtkamp","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.exer.2021.108471_bib26","doi-asserted-by":"crossref","first-page":"5430","DOI":"10.1167\/iovs.03-0609","article-title":"RPE cells modulate subretinal neovascularization, but do not cause regression in mice with sustained expression of VEGF","volume":"44","author":"Ida","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108471_bib27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0014-4835(92)90197-Z","article-title":"Expression of interleukin-1 alpha, interleukin-1 beta, and an interleukin-1 receptor antagonist in human retinal pigment epithelial cells","volume":"55","author":"Jaffe","year":"1992","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2021.108471_bib28","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/0092-8674(91)90033-U","article-title":"Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma","volume":"66","author":"Kandel","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.exer.2021.108471_bib29","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s00018-016-2147-8","article-title":"Inflammation and its role in age-related macular degeneration","volume":"73","author":"Kauppinen","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.exer.2021.108471_bib30","doi-asserted-by":"crossref","first-page":"434010","DOI":"10.1155\/2013\/434010","article-title":"Cytokine levels in the serum of healthy subjects","volume":"2013","author":"Kleiner","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.exer.2021.108471_bib31","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.exer.2019.05.006","article-title":"The role of complement membrane attack complex in dry and wet AMD - from hypothesis to clinical trials","volume":"184","author":"Kumar-Singh","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2021.108471_bib32","doi-asserted-by":"crossref","first-page":"17787","DOI":"10.1074\/jbc.M116.729384","article-title":"Small molecule inhibitors targeting tec kinase block unconventional secretion of fibroblast growth factor 2","volume":"291","author":"La Venuta","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2021.108471_bib33","doi-asserted-by":"crossref","first-page":"27015","DOI":"10.1074\/jbc.R115.689257","article-title":"The startling properties of fibroblast growth factor 2: how to exit mammalian cells without a signal peptide at hand","volume":"290","author":"La Venuta","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2021.108471_bib34","first-page":"1024","article-title":"Human apolipoprotein E2 transgenic mice show lipid accumulation in retinal pigment epithelium and altered expression of VEGF and bFGF in the eyes","volume":"17","author":"Lee","year":"2007","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.exer.2021.108471_bib35","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000439596","article-title":"Complement stimulates retinal pigment epithelial cells to undergo pro-inflammatory changes","volume":"54","author":"Lueck","year":"2015","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.exer.2021.108471_bib36","first-page":"1588","article-title":"Complement gene expression and regulation in mouse retina and retinal pigment epithelium\/choroid","volume":"17","author":"Luo","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2021.108471_bib37","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1038\/emboj.2013.104","article-title":"Unconventional protein secretion: an evolving mechanism","volume":"32","author":"Malhotra","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.exer.2021.108471_bib38","first-page":"1781","article-title":"A novel protein-tyrosine kinase, tec, is preferentially expressed in liver","volume":"5","author":"Mano","year":"1990","journal-title":"Oncogene"},{"key":"10.1016\/j.exer.2021.108471_bib39","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.omtn.2019.07.018","article-title":"Anti-angiogenic and anti-scarring dual action of an anti-fibroblast growth factor 2 aptamer in animal models of retinal disease","volume":"17","author":"Matsuda","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.exer.2021.108471_bib40","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/jcp.1041510113","article-title":"Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum-Golgi complex","volume":"151","author":"Mignatti","year":"1992","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exer.2021.108471_bib41","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1096\/fj.02-0737com","article-title":"Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells","volume":"17","author":"Monsinjon","year":"2003","journal-title":"Faseb. J."},{"key":"10.1016\/j.exer.2021.108471_bib42","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.yjmcc.2013.07.006","article-title":"PKCepsilon activation promotes FGF-2 exocytosis and induces endothelial cell proliferation and sprouting","volume":"63","author":"Monti","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.exer.2021.108471_bib43","doi-asserted-by":"crossref","first-page":"29977","DOI":"10.1074\/jbc.M703742200","article-title":"Live cell imaging of outward and inward vesiculation induced by the complement c5b-9 complex","volume":"282","author":"Moskovich","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.exer.2021.108471_bib44","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/aos.14402","article-title":"Systemic levels of interleukin-6 in patients with age-related macular degeneration: a systematic review and meta-analysis","volume":"98","author":"Nahavandipour","year":"2020","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.exer.2021.108471_bib45","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/jnci\/85.3.241","article-title":"Elevated levels of the angiogenic peptide basic fibroblast growth factor in urine of bladder cancer patients","volume":"85","author":"Nguyen","year":"1993","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.exer.2021.108471_bib46","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1600-0854.2005.00302.x","article-title":"Unconventional secretory routes: direct protein export across the plasma membrane of mammalian cells","volume":"6","author":"Nickel","year":"2005","journal-title":"Traffic"},{"key":"10.1016\/j.exer.2021.108471_bib47","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0002-9440(10)65619-2","article-title":"Basic fibroblast growth factor is neither necessary nor sufficient for the development of retinal neovascularization","volume":"153","author":"Ozaki","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2021.108471_bib48","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.3389\/fimmu.2019.01007","article-title":"The challenges and promise of complement therapeutics for ocular diseases","volume":"10","author":"Park","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exer.2021.108471_bib49","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00281-005-0004-1","article-title":"Emission of membrane vesicles: roles in complement resistance, immunity and cancer","volume":"27","author":"Pilzer","year":"2005","journal-title":"Springer Semin. Immunopathol."},{"key":"10.1016\/j.exer.2021.108471_bib50","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cytogfr.2005.01.004","article-title":"Fibroblast growth factor\/fibroblast growth factor receptor system in angiogenesis","volume":"16","author":"Presta","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.exer.2021.108471_bib51","first-page":"63","article-title":"Astrocytes shed extracellular vesicles that contain fibroblast growth factor-2 and vascular endothelial growth factor","volume":"21","author":"Proia","year":"2008","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.exer.2021.108471_bib52","doi-asserted-by":"crossref","first-page":"6244","DOI":"10.1074\/jbc.M310500200","article-title":"Unconventional secretion of fibroblast growth factor 2 is mediated by direct translocation across the plasma membrane of mammalian cells","volume":"279","author":"Schafer","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2021.108471_bib53","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1111\/j.1582-4934.2007.00100.x","article-title":"Neurons produce FGF2 and VEGF and secrete them at least in part by shedding extracellular vesicles","volume":"11","author":"Schiera","year":"2007","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.exer.2021.108471_bib54","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-3-030-27378-1_6","article-title":"Adaptive and maladaptive complement activation in the retina","volume":"1185","author":"Silverman","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2021.108471_bib55","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s00417-009-1058-x","article-title":"Combinatory inhibition of VEGF and FGF2 is superior to solitary VEGF inhibition in an in vitro model of RPE-induced angiogenesis","volume":"247","author":"Stahl","year":"2009","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2021.108471_bib56","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.jmb.2014.07.012","article-title":"Unconventional secretion of fibroblast growth factor 2--a novel type of protein translocation across membranes?","volume":"427","author":"Steringer","year":"2015","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.exer.2021.108471_bib57","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcdb.2018.02.010","article-title":"A direct gateway into the extracellular space: unconventional secretion of FGF2 through self-sustained plasma membrane pores","volume":"8","author":"Steringer","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.exer.2021.108471_bib58","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/iub.1358","article-title":"Cellular and molecular mechanisms of inflammation-induced angiogenesis","volume":"67","author":"Szade","year":"2015","journal-title":"IUBMB Life"},{"key":"10.1016\/j.exer.2021.108471_bib59","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1242\/jcs.115.15.3039","article-title":"Beyond calcium: new signaling pathways for Tec family kinases","volume":"115","author":"Takesono","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.exer.2021.108471_bib60","doi-asserted-by":"crossref","first-page":"51911","DOI":"10.1074\/jbc.M304192200","article-title":"Shedding of membrane vesicles mediates fibroblast growth factor-2 release from cells","volume":"278","author":"Taverna","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2021.108471_bib61","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s12026-011-8239-5","article-title":"Membrane attack by complement: the assembly and biology of terminal complement complexes","volume":"51","author":"Tegla","year":"2011","journal-title":"Immunol. Res."},{"key":"10.1016\/j.exer.2021.108471_bib62","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/1097-4652(200011)185:2<260::AID-JCP11>3.0.CO;2-X","article-title":"Translocation of FGF2 to the cell surface without release into conditioned media","volume":"185","author":"Trudel","year":"2000","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exer.2021.108471_bib63","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/1097-4652(200010)185:1<135::AID-JCP13>3.0.CO;2-Y","article-title":"Cell injury unmasks a latent proangiogenic phenotype in mice with increased expression of FGF2 in the retina","volume":"185","author":"Yamada","year":"2000","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exer.2021.108471_bib64","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1167\/iovs.13-13554","article-title":"Retinal pigment epithelial cell death by the alternative complement cascade: role of membrane regulatory proteins, calcium, PKC, and oxidative stress","volume":"55","author":"Yang","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108471_bib65","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1167\/iovs.06-0140","article-title":"Oxidant-mediated Akt activation in human RPE cells","volume":"47","author":"Yang","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108471_bib66","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1167\/iovs.16-20083","article-title":"Complement-mediated regulation of apolipoprotein E in cultured human RPE cells","volume":"58","author":"Yang","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108471_bib67","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1167\/iovs.04-1039","article-title":"Human RPE expression of cell survival factors","volume":"46","author":"Yang","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108471_bib68","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1126\/science.1234740","article-title":"Cell biology. Unconventional secretion, unconventional solutions","volume":"340","author":"Zhang","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.exer.2021.108471_bib69","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2353\/ajpath.2006.050479","article-title":"Basic fibroblast growth factor (bFGF, FGF-2) potentiates leukocyte recruitment to inflammation by enhancing endothelial adhesion molecule expression","volume":"168","author":"Zittermann","year":"2006","journal-title":"Am. J. Pathol."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483521000361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483521000361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:12:19Z","timestamp":1757999539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483521000361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":69,"alternative-id":["S0014483521000361"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2021.108471","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complement-mediated release of fibroblast growth factor 2 from human RPE cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2021.108471","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108471"}}