{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:50:49Z","timestamp":1786989049161,"version":"build-2736575974"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100001608","name":"EyeSight Foundation of Alabama","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY030096"],"award-info":[{"award-number":["R01EY030096"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30EY003039"],"award-info":[{"award-number":["P30EY003039"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY027759"],"award-info":[{"award-number":["R01EY027759"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01 EY028284"],"award-info":[{"award-number":["R01 EY028284"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY026574"],"award-info":[{"award-number":["R01EY026574"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["R01 EY028284"],"award-info":[{"award-number":["R01 EY028284"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.exer.2021.108475","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T18:15:14Z","timestamp":1611857714000},"page":"108475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Histologic validation of optical coherence tomography-based three-dimensional morphometric measurements of the human optic nerve head: Methodology and preliminary results"],"prefix":"10.1016","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7489-089X","authenticated-orcid":false,"given":"Massimo A.","family":"Fazio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart K.","family":"Gardiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6745-0466","authenticated-orcid":false,"given":"Luigi","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8976-1134","authenticated-orcid":false,"given":"Meredith","family":"Hubbard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Bianco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udayakumar","family":"Karuppanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4084-8199","authenticated-orcid":false,"given":"Mustapha","family":"El Hamdaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9539-4070","authenticated-orcid":false,"given":"Rafael","family":"Grytz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Crawford","family":"Downs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Girkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2021.108475_bib1","first-page":"4015","article-title":"The African Descent and Glaucoma Evaluation Study (ADAGES): racial differences in the posterior displacement of the anterior laminar cribrosa surface depth","volume":"58","author":"Belghith","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib2","first-page":"2991","article-title":"The optic nerve head as a biomechanical structure: initial finite element modeling","volume":"41","author":"Bellezza","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib3","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1167\/iovs.01-1282","article-title":"Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma","volume":"44","author":"Bellezza","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib4","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/10543400701329422","article-title":"Agreement between methods of measurement with multiple observations per individual","volume":"17","author":"Bland","year":"2007","journal-title":"J. Biopharm. Stat."},{"key":"10.1016\/j.exer.2021.108475_bib5","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.exer.2010.09.005","article-title":"A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma","volume":"93","author":"Burgoyne","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2021.108475_bib6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.exer.2015.06.005","article-title":"The non-human primate experimental glaucoma model","volume":"141","author":"Burgoyne","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2021.108475_bib7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/IJG.0b013e31815a343b","article-title":"Premise and prediction-how optic nerve head biomechanics underlies the susceptibility and clinical behavior of the aged optic nerve head","volume":"17","author":"Burgoyne","year":"2008","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.exer.2021.108475_bib8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.preteyeres.2004.06.001","article-title":"The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage","volume":"24","author":"Burgoyne","year":"2005","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2021.108475_bib9","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/S0161-6420(95)30791-9","article-title":"Early changes in optic disc compliance and surface position in experimental glaucoma","volume":"102","author":"Burgoyne","year":"1995","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2021.108475_bib10","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1167\/iovs.10-6377","article-title":"Human chorioretinal layer thicknesses measured in macula-wide, high-resolution histologic sections","volume":"52","author":"Curcio","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib11","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/OPX.0b013e31817841cb","article-title":"Mechanical environment of the optic nerve head in glaucoma","volume":"85","author":"Downs","year":"2008","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib12","doi-asserted-by":"crossref","first-page":"12639","DOI":"10.1038\/s41598-018-31052-x","article-title":"In vivo optic nerve head mechanical response to intraocular and cerebrospinal fluid pressure: imaging protocol and quantification method","volume":"8","author":"Fazio","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2021.108475_bib13","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1167\/iovs.19-27060","article-title":"The relationship between scleral strain change and differential cumulative intraocular pressure exposure in the nonhuman primate chronic ocular hypertension model","volume":"60","author":"Fazio","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib14","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s10237-013-0517-9","article-title":"Age-related changes in human peripapillary scleral strain","volume":"13","author":"Fazio","year":"2014","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.exer.2021.108475_bib15","doi-asserted-by":"crossref","first-page":"7189","DOI":"10.1167\/iovs.14-14894","article-title":"Human scleral structural stiffness increases more rapidly with age in donors of African descent compared to donors of European descent","volume":"55","author":"Fazio","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib16","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1167\/iovs.15-17940","article-title":"Displacement of the lamina cribrosa in response to acute intraocular pressure elevation in normal individuals of african and European descent","volume":"57","author":"Fazio","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077831","article-title":"Does optic nerve head surface topography change prior to loss of retinal nerve fiber layer thickness: a test of the site of injury hypothesis in experimental glaucoma","volume":"8","author":"Fortune","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.exer.2021.108475_bib18","doi-asserted-by":"crossref","first-page":"7738","DOI":"10.1167\/iovs.10-6925","article-title":"Shadow removal and contrast enhancement in optical coherence tomography images of the human optic nerve head","volume":"52","author":"Girard","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib19","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1167\/iovs.14-14903","article-title":"Lamina cribrosa visibility using optical coherence tomography: comparison of devices and effects of image enhancement techniques","volume":"56","author":"Girard","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib20","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1167\/iovs.14-14903","article-title":"Lamina cribrosa visibility using optical coherence tomography: comparison of devices and effects of image enhancement techniques","volume":"56","author":"Girard","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib21","doi-asserted-by":"crossref","first-page":"4496","DOI":"10.1167\/iovs.19-26645","article-title":"Racial differences in the association of anterior lamina cribrosa surface depth and glaucoma severity in the african descent and glaucoma evaluation study (ADAGES)","volume":"60","author":"Girkin","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib22","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1167\/iovs.17-21842","article-title":"Variation in the three-dimensional histomorphometry of the normal human optic nerve head with age and race: lamina cribrosa and peripapillary scleral thickness and position","volume":"58","author":"Girkin","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib23","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1167\/iovs.17-21842","article-title":"Variation in the three-dimensional histomorphometry of the normal human optic nerve head with age and race: lamina cribrosa and peripapillary scleral thickness and position","volume":"58","author":"Girkin","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib24","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1167\/iovs.17-21842","article-title":"Variation in the three-dimensional histomorphometry of the normal human optic nerve head with age and race: lamina cribrosa and peripapillary scleral thickness and PositionAge-and race-related differences in normal human ONH","volume":"58","author":"Girkin","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib25","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jmbbm.2013.03.027","article-title":"Material properties of the posterior human sclera","volume":"29","author":"Grytz","year":"2014","journal-title":"Journal of the mechanical behavior of biomedical materials"},{"key":"10.1016\/j.exer.2021.108475_bib26","doi-asserted-by":"crossref","first-page":"8163","DOI":"10.1167\/iovs.14-14029","article-title":"Age-and race-related differences in human scleral material properties","volume":"55","author":"Grytz","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib27","first-page":"4778","article-title":"Empirical distortion correction for posterior segment SD-OCT images in small animals","volume":"61","author":"Grytz","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cobme.2020.01.001","article-title":"Connective tissue remodeling in myopia and its potential role in increasing risk of glaucoma","volume":"15","author":"Grytz","year":"2020","journal-title":"Current Opinion in Biomedical Engineering"},{"key":"10.1016\/j.exer.2021.108475_bib29","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1167\/iovs.13-12937","article-title":"Variation of the axial location of Bruch's membrane opening with age, choroidal thickness, and race","volume":"55","author":"Johnstone","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib30","doi-asserted-by":"crossref","DOI":"10.1097\/IJG.0000000000000728","article-title":"Clinical implications of in vivo lamina cribrosa imaging in glaucoma","volume":"26","author":"Kim","year":"2017","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.exer.2021.108475_bib31","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1167\/iovs.16-20802","article-title":"Diagnostic power of lamina cribrosa depth and curvature in glaucoma","volume":"58","author":"Lee","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib32","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1167\/iovs.12-11327","article-title":"Enhancement of lamina cribrosa visibility in optical coherence tomography images using adaptive compensation","volume":"54","author":"Mari","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib33","doi-asserted-by":"crossref","first-page":"8123","DOI":"10.1167\/iovs.14-15251","article-title":"Variation of laminar depth in normal eyes with age and race","volume":"55","author":"Rhodes","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib34","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1167\/iovs.14-16179","article-title":"Peripapillary choroidal thickness variation with age and race in normal eyes","volume":"56","author":"Rhodes","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/bdrc.20023","article-title":"Rapid high resolution three dimensional reconstruction of embryos with episcopic fluorescence image capture","volume":"72","author":"Rosenthal","year":"2004","journal-title":"Birth Defects Res C Embryo Today"},{"key":"10.1016\/j.exer.2021.108475_bib36","first-page":"f1630","article-title":"Limits of agreement (Bland-Altman method)","volume":"346","author":"Sedgwick","year":"2013","journal-title":"BMJ Br. Med. J. (Clin. Res. Ed.)"},{"key":"10.1016\/j.exer.2021.108475_bib37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1136\/bjophthalmol-2017-310232","article-title":"Effect of acute intraocular pressure elevation on the minimum rim width in normal, ocular hypertensive and glaucoma eyes","volume":"102","author":"Sharma","year":"2018","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2021.108475_bib38","first-page":"4189","article-title":"Factors influencing optic nerve head biomechanics","author":"Sigal","year":"2005","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2021.108475_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/iovs.13-12724","article-title":"Eye-specific IOP-induced displacements and deformations of human lamina cribrosa","volume":"55","author":"Sigal","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib40","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1097\/IAE.0b013e3182247535","article-title":"Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: literature review and model","volume":"31","author":"Spaide","year":"2011","journal-title":"Retina"},{"key":"10.1016\/j.exer.2021.108475_bib41","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ajo.2008.05.032","article-title":"Enhanced depth imaging spectral-domain optical coherence tomography","volume":"146","author":"Spaide","year":"2008","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2021.108475_bib42","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.ophtha.2014.02.023","article-title":"Proposed lexicon for anatomic landmarks in normal posterior segment spectral-domain optical coherence tomography: the IN*OCT consensus","volume":"121","author":"Staurenghi","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2021.108475_bib43","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1167\/iovs.15-16707","article-title":"A global shape index to characterize anterior lamina cribrosa morphology and its determinants in healthy Indian eyes","volume":"56","author":"Thakku","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib44","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1167\/iovs.17-23356","article-title":"Seeing the hidden lamina: effects of exsanguination on the optic nerve head","volume":"59","author":"Tran","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib45","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1364\/BOE.5.000322","article-title":"Depth-resolved model-based reconstruction of attenuation coefficients in optical coherence tomography","volume":"5","author":"Vermeer","year":"2013","journal-title":"Biomed. Optic Express"},{"key":"10.1016\/j.exer.2021.108475_bib46","first-page":"5516","article-title":"Optical coherence tomography (OCT) anterior scleral canal opening (ASCO) tilt and rotation relative to Bruch's membrane opening (BMO) and peripapillary scleral bowing (PSB) in healthy eyes","volume":"60","author":"Wang","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/ng785","article-title":"Phenotyping transgenic embryos: a rapid 3-D screening method based on episcopic fluorescence image capturing","volume":"30","author":"Weninger","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2021.108475_bib48","doi-asserted-by":"crossref","first-page":"4597","DOI":"10.1167\/iovs.07-0349","article-title":"3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: lamina cribrosa and peripapillary scleral position and thickness","volume":"48","author":"Yang","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib49","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1167\/iovs.18-25407","article-title":"Factors influencing optical coherence tomography peripapillary choroidal thickness: a multicenter study","volume":"60","author":"Yang","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108475_bib50","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1080\/00031305.2016.1256839","article-title":"A coefficient of determination for generalized linear models","volume":"71","author":"Zhang","year":"2017","journal-title":"Am. Statistician"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483521000403?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483521000403?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:24:56Z","timestamp":1777404296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483521000403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":50,"alternative-id":["S0014483521000403"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2021.108475","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histologic validation of optical coherence tomography-based three-dimensional morphometric measurements of the human optic nerve head: Methodology and preliminary results","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2021.108475","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108475"}}