{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:39:16Z","timestamp":1784770756530,"version":"3.55.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY019320"],"award-info":[{"award-number":["R01EY019320"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY024581"],"award-info":[{"award-number":["R01EY024581"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX003050"],"award-info":[{"award-number":["BX003050"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX004256"],"award-info":[{"award-number":["BX004256"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IK6BX004858"],"award-info":[{"award-number":["IK6BX004858"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IK6BX005235"],"award-info":[{"award-number":["IK6BX005235"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["RX000444"],"award-info":[{"award-number":["RX000444"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["RX001141"],"award-info":[{"award-number":["RX001141"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007747","name":"University of Utah","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.exer.2021.108583","type":"journal-article","created":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T16:17:45Z","timestamp":1618762665000},"page":"108583","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Natural immunoglobulin M-based delivery of a complement alternative pathway inhibitor in mouse models of retinal degeneration"],"prefix":"10.1016","volume":"207","author":[{"given":"Balasubramaniam","family":"Annamalai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Parsons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kusumam","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4031-4595","authenticated-orcid":false,"given":"Beth","family":"Coughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5527-6643","authenticated-orcid":false,"given":"Bryan W.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e4rbel","family":"Rohrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2021.108583_bib1","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.exer.2007.08.010","article-title":"VEGF modulation of retinal pigment epithelium resistance","volume":"85","author":"Ablonczy","year":"2007","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2021.108583_bib2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s12974-015-0464-8","article-title":"Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement","volume":"12","author":"Alawieh","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.exer.2021.108583_bib3","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aao6459","article-title":"Targeted complement inhibition salvages stressed neurons and inhibits neuroinflammation after stroke in mice","volume":"10","author":"Alawieh","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.exer.2021.108583_bib4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.preteyeres.2009.11.003","article-title":"The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited","volume":"29","author":"Anderson","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2021.108583_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000074","article-title":"A computational framework for ultrastructural mapping of neural circuitry","volume":"7","author":"Anderson","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1016\/j.exer.2021.108583_bib6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1167\/iovs.61.3.45","article-title":"Immunization against oxidized elastin exacerbates structural and functional damage in mouse model of smoke-induced ocular injury","volume":"61","author":"Annamalai","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108583_bib7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1167\/tvst.7.2.3","article-title":"Encapsulated cell technology-based delivery of a complement inhibitor reduces choroidal neovascularization in a mouse model","volume":"7","author":"Annamalai","year":"2018","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.exer.2021.108583_bib8","article-title":"The use of matrigel combined with encapsulated cell technology to deliver a complement inhibitor in a mouse model of choroidal neovascularization","author":"Annamalai","year":"2020","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2021.108583_bib9","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1161\/CIRCULATIONAHA.114.010482","article-title":"Targeting pathogenic postischemic self-recognition by natural IgM to protect against posttransplantation cardiac reperfusion injury","volume":"131","author":"Atkinson","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.exer.2021.108583_bib10","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1172\/JCI25208","article-title":"Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection","volume":"115","author":"Atkinson","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exer.2021.108583_bib11","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/358505a0","article-title":"CD21 is a ligand for CD23 and regulates IgE production","volume":"358","author":"Aubry","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.exer.2021.108583_bib12","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1167\/iovs.11-8638","article-title":"Matrix metalloproteinase activity creates pro-angiogenic environment in primary human retinal pigment epithelial cells exposed to complement","volume":"53","author":"Bandyopadhyay","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108583_bib13","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00281-004-0182-2","article-title":"Inherent specificities in natural antibodies: a key to immune defense against pathogen invasion","volume":"26","author":"Baumgarth","year":"2005","journal-title":"Springer Semin. Immunopathol."},{"key":"10.1016\/j.exer.2021.108583_bib14","article-title":"Encapsulated cell technology for the delivery of biologics to the mouse eye","volume":"157","author":"Belhaj","year":"2020","journal-title":"JoVE"},{"key":"10.1016\/j.exer.2021.108583_bib15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0008-4182(05)80070-5","article-title":"Age-related macular degeneration: economic burden and value-based medicine analysis","volume":"40","author":"Brown","year":"2005","journal-title":"Can. J. Ophthalmol."},{"key":"10.1016\/j.exer.2021.108583_bib16","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1167\/iovs.07-1194","article-title":"Effects of an anti-VEGF-A monoclonal antibody on laser-induced choroidal neovascularization in mice: optimizing methods to quantify vascular changes","volume":"49","author":"Campa","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108583_bib17","doi-asserted-by":"crossref","first-page":"6031","DOI":"10.4049\/jimmunol.0804191","article-title":"IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells","volume":"182","author":"Chen","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2021.108583_bib18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00281-017-0649-6","article-title":"The eye as a complement dysregulation hotspot","volume":"40","author":"Clark","year":"2018","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.exer.2021.108583_bib19","doi-asserted-by":"crossref","first-page":"23794","DOI":"10.1038\/srep23794","article-title":"Connecting the innate and adaptive immune responses in mouse choroidal neovascularization via the anaphylatoxin C5a and gammadeltaT-cells","volume":"6","author":"Coughlin","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2021.108583_bib20","doi-asserted-by":"crossref","first-page":"14682","DOI":"10.1073\/pnas.222551899","article-title":"Drusen proteome analysis: an approach to the etiology of age-related macular degeneration","volume":"99","author":"Crabb","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2021.108583_bib21","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/j.1460-2075.1991.tb08025.x","article-title":"Epstein Barr virus\/complement C3d receptor is an interferon alpha receptor","volume":"10","author":"Delcayre","year":"1991","journal-title":"EMBO J."},{"key":"10.1016\/j.exer.2021.108583_bib22","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1001\/jama.296.3.301","article-title":"Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration","volume":"296","author":"Despriet","year":"2006","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.exer.2021.108583_bib23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4049\/jimmunol.180.1.261","article-title":"Hyperacute rejection by anti-Gal IgG1, IgG2a, and IgG2b is dependent on complement and Fc-gamma receptors","volume":"180","author":"Ding","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2021.108583_bib24","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ncprheum0895","article-title":"Nature and functions of autoantibodies","volume":"4","author":"Elkon","year":"2008","journal-title":"Nat. Clin. Pract. Rheumatol."},{"key":"10.1016\/j.exer.2021.108583_bib25","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.4049\/jimmunol.1102132","article-title":"Pathogenic natural antibodies propagate cerebral injury following ischemic stroke in mice","volume":"188","author":"Elvington","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2021.108583_bib26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/smim.1998.0137","article-title":"The complement system and adaptive immunity","volume":"10","author":"Fearon","year":"1998","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.exer.2021.108583_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000101046","article-title":"Bispecific antibodies: molecules that enable novel therapeutic strategies","volume":"74","author":"Fischer","year":"2007","journal-title":"Pathobiology"},{"key":"10.1016\/j.exer.2021.108583_bib28","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1167\/iovs.10-6266","article-title":"In vivo evaluation of laser-induced choroidal neovascularization using spectral-domain optical coherence tomography","volume":"52","author":"Giani","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108583_bib29","doi-asserted-by":"crossref","first-page":"42027","DOI":"10.1074\/jbc.M305460200","article-title":"Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration","volume":"278","author":"Gu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2021.108583_bib30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0162-3109(00)80298-2","article-title":"Phenotypes of complement knockouts","volume":"49","author":"Holers","year":"2000","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.exer.2021.108583_bib31","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S1521-6616(03)00034-2","article-title":"The complement system as a therapeutic target in autoimmunity","volume":"107","author":"Holers","year":"2003","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.exer.2021.108583_bib32","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.molimm.2006.07.003","article-title":"Complement receptor 2, natural antibodies and innate immunity: inter-relationships in B cell selection and activation","volume":"44","author":"Holers","year":"2007","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.exer.2021.108583_bib33","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/978-1-4614-4118-2_9","article-title":"CR2-mediated targeting of complement inhibitors: bench-to-bedside using a novel strategy for site-specific complement modulation","volume":"735","author":"Holers","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2021.108583_bib34","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s12035-010-8110-z","article-title":"A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration","volume":"41","author":"Hollyfield","year":"2010","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.exer.2021.108583_bib35","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s40259-018-0299-9","article-title":"Expanding the boundaries of biotherapeutics with bispecific antibodies","volume":"32","author":"Husain","year":"2018","journal-title":"BioDrugs"},{"key":"10.1016\/j.exer.2021.108583_bib36","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00417-006-0429-9","article-title":"Analysis of IgG antibody patterns against retinal antigens and antibodies to alpha-crystallin, GFAP, and alpha-enolase in sera of patients with \"wet\" age-related macular degeneration","volume":"245","author":"Joachim","year":"2007","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2021.108583_bib37","doi-asserted-by":"crossref","first-page":"12753","DOI":"10.1074\/jbc.M112.421891","article-title":"Oxidative stress sensitizes RPE cells to complement-mediated injury in a natural antibody-, lectin pathway- and phospholipid epitope-dependent manner","volume":"288","author":"Joseph","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2021.108583_bib38","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.4049\/jimmunol.0803980","article-title":"Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury","volume":"182","author":"Kulik","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2021.108583_bib39","doi-asserted-by":"crossref","first-page":"14534","DOI":"10.1074\/jbc.M114.564674","article-title":"Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation","volume":"289","author":"Kunchithapautham","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2021.108583_bib40","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1167\/iovs.08-2589","article-title":"Mutation survey of known LCA genes and loci in the Saudi Arabian population","volume":"50","author":"Li","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108583_bib41","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1084\/jem.170.6.1931","article-title":"Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2","volume":"170","author":"Lowell","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.exer.2021.108583_bib42","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/hep.29512","article-title":"Natural immunoglobulin M initiates an inflammatory response important for both hepatic ischemia reperfusion injury and regeneration in mice","volume":"67","author":"Marshall","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.exer.2021.108583_bib43","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.0300-9475.2004.01362.x","article-title":"The four mouse IgG isotypes differ extensively in bactericidal and opsonophagocytic activity when reacting with the P1.16 epitope on the outer membrane PorA protein of Neisseria meningitidis","volume":"59","author":"Michaelsen","year":"2004","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.exer.2021.108583_bib44","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.yexmp.2011.09.017","article-title":"Serum autoantibody biomarkers for age-related macular degeneration and possible regulators of neovascularization","volume":"92","author":"Morohoshi","year":"2012","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.exer.2021.108583_bib45","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.bi.57.070188.001541","article-title":"Molecular organization and function of the complement system","volume":"57","author":"Muller-Eberhard","year":"1988","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.exer.2021.108583_bib46","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1016\/j.ajpath.2014.07.017","article-title":"The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning","volume":"184","author":"Mullins","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2021.108583_bib47","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1073\/pnas.0408835103","article-title":"Drusen complement components C3a and C5a promote choroidal neovascularization","volume":"103","author":"Nozaki","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2021.108583_bib48","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1073\/pnas.0408835103","article-title":"Drusen complement components C3a and C5a promote choroidal neovascularization","volume":"103","author":"Nozaki","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2021.108583_bib49","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jcjo.2012.03.016","article-title":"Plasma antiphospholipid antibody levels in age-related macular degeneration","volume":"47","author":"Ozkan","year":"2012","journal-title":"Can. J. Ophthalmol."},{"key":"10.1016\/j.exer.2021.108583_bib50","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1365-2567.2005.02173.x","article-title":"Circulating anti-retinal antibodies as immune markers in age-related macular degeneration","volume":"115","author":"Patel","year":"2005","journal-title":"Immunology"},{"key":"10.1016\/j.exer.2021.108583_bib51","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/0-387-32442-9_12","article-title":"Annexins in Bruch's membrane and drusen","volume":"572","author":"Rayborn","year":"2006","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2021.108583_bib52","first-page":"e166","article-title":"Subcutaneous injection of tumor cells","volume":"101","author":"Reuter","year":"2011","journal-title":"Bio"},{"key":"10.1016\/j.exer.2021.108583_bib53","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.1923","article-title":"Complement: a key system for immune surveillance and homeostasis","volume":"11","author":"Ricklin","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.exer.2021.108583_bib54","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1089\/jop.2011.0212","article-title":"Systemic human CR2-targeted complement alternative pathway inhibitor ameliorates mouse laser-induced choroidal neovascularization","volume":"28","author":"Rohrer","year":"2012","journal-title":"J. Ocul. Pharmacol. Therapeut."},{"key":"10.1016\/j.exer.2021.108583_bib55","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.molimm.2010.12.016","article-title":"The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization","volume":"48","author":"Rohrer","year":"2011","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.exer.2021.108583_bib56","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1167\/iovs.08-2222","article-title":"A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration","volume":"50","author":"Rohrer","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108583_bib57","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3389\/fmicb.2017.00495","article-title":"Antibody engineering for pursuing a healthier future","volume":"8","author":"Saeed","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.exer.2021.108583_bib58","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1167\/iovs.14-15910","article-title":"Local production of the alternative pathway component, Factor B, is sufficient to promote laser-induced choroidal neovascularization","volume":"56","author":"Schnabolk","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108583_bib59","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.exer.2014.10.005","article-title":"A comparative analysis of C57BL\/6J and 6N substrains; chemokine\/cytokine expression and susceptibility to laser-induced choroidal neovascularization","volume":"129","author":"Schnabolk","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2021.108583_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/32b9bc31-ed6d-4d31-9ce0-480407017bad","article-title":"Systemic complement activation in age-related macular degeneration","volume":"3","author":"Scholl","year":"2008","journal-title":"PloS One"},{"key":"10.1016\/j.exer.2021.108583_bib61","article-title":"NEI symposium: age-related macular degeneration (AMD) and complement factor H","volume":"14","author":"Sieving","year":"2005","journal-title":"NIH Videocast June"},{"key":"10.1016\/j.exer.2021.108583_bib62","first-page":"151","article-title":"Natural autoantibodies to apoptotic cell membranes regulate fundamental innate immune functions and suppress inflammation","volume":"8","author":"Silverman","year":"2009","journal-title":"Discov. Med."},{"key":"10.1016\/j.exer.2021.108583_bib63","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jneumeth.2010.10.008","article-title":"Culturing conditions determine neuronal and glial excitability","volume":"194","author":"Stoppelkamp","year":"2010","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.exer.2021.108583_bib64","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40246-016-0079-x","article-title":"AMD and the alternative complement pathway: genetics and functional implications","volume":"10","author":"Tan","year":"2016","journal-title":"Hum. Genom."},{"key":"10.1016\/j.exer.2021.108583_bib65","first-page":"3292","article-title":"Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa","volume":"43","author":"Tao","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108583_bib66","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1172\/JCI65861","article-title":"Detection of complement activation using monoclonal antibodies against C3d","volume":"123","author":"Thurman","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exer.2021.108583_bib67","doi-asserted-by":"crossref","first-page":"16939","DOI":"10.1074\/jbc.M808166200","article-title":"Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury","volume":"284","author":"Thurman","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2021.108583_bib68","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1096\/fj.04-3525fje","article-title":"Molecular composition of drusen and possible involvement of anti-retinal autoimmunity in two different forms of macular degeneration in cynomolgus monkey (Macaca fascicularis)","volume":"19","author":"Umeda","year":"2005","journal-title":"Faseb. J."},{"key":"10.1016\/j.exer.2021.108583_bib69","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nature10449","article-title":"Complement factor H binds malondialdehyde epitopes and protects from oxidative stress","volume":"478","author":"Weismann","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.exer.2021.108583_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067894","article-title":"Alternative complement pathway deficiency ameliorates chronic smoke-induced functional and morphological ocular injury","volume":"8","author":"Woodell","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.exer.2021.108583_bib71","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1167\/iovs.15-18471","article-title":"A targeted inhibitor of the alternative complement pathway accelerates recovery from smoke-induced ocular injury","volume":"57","author":"Woodell","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483521001482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483521001482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:32:53Z","timestamp":1762147973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483521001482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":71,"alternative-id":["S0014483521001482"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2021.108583","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural immunoglobulin M-based delivery of a complement alternative pathway inhibitor in mouse models of retinal degeneration","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2021.108583","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108583"}}