{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:51:30Z","timestamp":1761709890927,"version":"3.44.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.exer.2021.108641","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T02:25:55Z","timestamp":1622255155000},"page":"108641","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["N-retinylidene-N-retinylethanolamine adduct induces expression of chronic inflammation cytokines in retinal pigment epithelium cells"],"prefix":"10.1016","volume":"209","author":[{"given":"Concetta","family":"Scimone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5292-426X","authenticated-orcid":false,"given":"Luigi","family":"Donato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Alibrandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Vadal\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Giglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonina","family":"Sidoti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalia","family":"D'Angelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2021.108641_bib1","series-title":"Database (Oxford)","article-title":"The Ensembl gene annotation System","author":"Aken","year":"2016"},{"key":"10.1016\/j.exer.2021.108641_bib2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00204-019-02637-w","article-title":"Toxic effects of A2E in human ARPE-19 cells were prevented by resveratrol: a potential nutritional bioactive for age-related macular degeneration treatment","volume":"94","author":"Alaimo","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.exer.2021.108641_bib3","article-title":"A2E induces IL-1\u00df production in retinal pigment epithelial cells via the NLRP3 inflammasome","volume":"8","author":"Anderson","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.exer.2021.108641_bib4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/978-3-030-27378-1_47","article-title":"Lipid signaling in retinal pigment epithelium cells exposed to inflammatory and oxidative stress conditions molecular mechanisms underlying degenerative retinal diseases","volume":"1185","author":"Berm\u00fadez","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2021.108641_bib5","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","article-title":"ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks","volume":"25","author":"Bindea","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.exer.2021.108641_bib6","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tibs.2015.11.012","article-title":"Regulators of iron homeostasis: new players in metabolism, cell death, and disease","volume":"41","author":"Bogdan","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.exer.2021.108641_bib7","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.exer.2021.108641_bib8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cellimm.2017.02.005","article-title":"Enhancement of macrophage inflammatory responses by CCL2 is correlated with increased miR-9 expression and downregulation of the ERK1\/2 phosphatase","volume":"314","author":"Carson","year":"2017","journal-title":"Dusp6. Cell. Immunol."},{"key":"10.1016\/j.exer.2021.108641_bib9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/CS20080058","article-title":"Human tribbles homologue 2 is expressed in unstable regions of carotid plaques and regulates macrophage IL-10 in vitro","volume":"116","author":"Deng","year":"2009","journal-title":"Clin. Sci. (Lond)"},{"key":"10.1016\/j.exer.2021.108641_bib10","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3390\/antiox9040307","article-title":"Effects of A2E-induced oxidative stress on retinal epithelial cells: new insights on differential gene response and retinal dystrophies","volume":"9","author":"Donato","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.exer.2021.108641_bib11","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3390\/antiox9050416","article-title":"Discovery of GLO1 new related genes and pathways by RNA-seq on A2E-stressed retinal epithelial cells could improve knowledge on retinitis pigmentosa","volume":"9","author":"Donato","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.exer.2021.108641_bib12","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3389\/fgene.2019.00462","article-title":"LncRRIsearch: a web server for lncRNA-RNA interaction prediction integrated with tissue-specific expression and subcellular localization data","volume":"10","author":"Fukunaga","year":"2019","journal-title":"Front. Genet."},{"issue":"D1","key":"10.1016\/j.exer.2021.108641_bib13","doi-asserted-by":"crossref","first-page":"D559","DOI":"10.1093\/nar\/gky973","article-title":"CORUM: the comprehensive resource of mammalian protein complexes-2019","volume":"47","author":"Giurgiu","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2021.108641_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12859-015-0611-3","article-title":"InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams","volume":"16","author":"Heberle","year":"2015","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.exer.2021.108641_bib15","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1111\/febs.14425","article-title":"Dual specificity phosphatase DUSP6 promotes endothelial inflammation through inducible expression of ICAM-1","volume":"285","author":"Hsu","year":"2018","journal-title":"FEBS J."},{"issue":"D1","key":"10.1016\/j.exer.2021.108641_bib16","first-page":"D498","article-title":"The reactome pathway knowledgebase","volume":"48","author":"Jassal","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.exer.2021.108641_bib17","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2021.108641_bib18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF00918862","article-title":"Differential permeance of retina and retinal pigment epithelium to water: implications for retinal adhesion","volume":"17","author":"Kirchhof","year":"1993","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.exer.2021.108641_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.586578","article-title":"Oxidative damage and antioxidant defense in ferroptosis","volume":"8","author":"Kuang","year":"2020","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.exer.2021.108641_bib20","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bbrc.2019.10.138","article-title":"Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells","volume":"521","author":"Lee","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2021.108641_bib21","doi-asserted-by":"crossref","first-page":"e1214","DOI":"10.1038\/cddis.2014.178","article-title":"Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium","volume":"5","author":"Leontieva","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2021.108641_bib22","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/bioinformatics\/btp692","article-title":"RNA-Seq gene expression estimation with read mapping uncertainty","volume":"26","author":"Li","year":"2010","journal-title":"Bioinformatics"},{"issue":"D1","key":"10.1016\/j.exer.2021.108641_bib23","doi-asserted-by":"crossref","first-page":"D351","DOI":"10.1093\/nar\/gky1100","article-title":"InterPro in 2019: improving coverage, classification and access to protein sequence annotations","volume":"47","author":"Mitchell","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2021.108641_bib24","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1002\/eji.201646809","article-title":"Ablation of the C\u03b22 subunit of PKA in immune cells leads to increased susceptibility to systemic inflammation in mice","volume":"47","author":"Moen","year":"2017","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.exer.2021.108641_bib25","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1167\/iovs.13-11740","article-title":"Retinoid uptake, processing, and secretion in human iPS-RPE support the visual cycle","volume":"55","author":"Mu\u00f1iz","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108641_bib26","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bbrc.2009.11.051","article-title":"IL-11 expression in retinal and corneal cells is regulated by interferon-gamma","volume":"391","author":"Nagineni","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2021.108641_bib27","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.exer.2015.01.003","article-title":"Blue light-induced inflammatory marker expression in the retinal pigment epithelium-choroid of mice and the protective effect of a yellow intraocular lens material in vivo","volume":"132","author":"Narimatsu","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2021.108641_bib28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40035-020-00211-4","article-title":"Inflammation-induced PINCH expression leads to actin depolymerization and mitochondrial mislocalization in neurons","volume":"9","author":"Natarajaseenivasan","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.exer.2021.108641_bib29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1074-7613(00)80013-8","article-title":"Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response","volume":"10","author":"Novick","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.exer.2021.108641_bib30","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/bioinformatics\/btv566","article-title":"Qualimap 2: advanced multi-sample quality control for high-throughput sequencing data","volume":"32","author":"Okonechnikov","year":"2016","journal-title":"Bioinformatics"},{"issue":"Database issue","key":"10.1016\/j.exer.2021.108641_bib31","doi-asserted-by":"crossref","first-page":"D358","DOI":"10.1093\/nar\/gkt1115","article-title":"The MIntAct project--IntAct as a common curation platform for 11 molecular interaction databases","volume":"42","author":"Orchard","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2021.108641_bib32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.scr.2018.01.014","article-title":"A2E-associated cell death and inflammation in retinal pigmented epithelial cells from human induced pluripotent stem cells","volume":"27","author":"Parmar","year":"2018","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.exer.2021.108641_bib33","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2021.108641_bib34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12974-014-0224-1","article-title":"Chemokine-mediated inflammation in the degenerating retina is coordinated by M\u00fcller cells, activated microglia, and retinal pigment epithelium","volume":"12","author":"Rutar","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.exer.2021.108641_bib35","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.4049\/jimmunol.159.3.1107","article-title":"Differential association of phosphatidylinositol 3-kinase with insulin receptor substrate (IRS)-1 and IRS-2 in human thymocytes in response to IL-7","volume":"159","author":"Sharfe","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2021.108641_bib36","doi-asserted-by":"crossref","DOI":"10.1111\/ceo.13834","article-title":"Retinal pigment epithelium and age-related macular degeneration: a review of major disease mechanisms","author":"Somasundaran","year":"2020","journal-title":"Clin. Exp. Ophthalmol. Online ahead of print"},{"key":"10.1016\/j.exer.2021.108641_bib37","first-page":"1","article-title":"Inherited retinal degeneration current genetics practices - a needs assessment","author":"Strait","year":"2020","journal-title":"Ophthalmic Genet."},{"key":"10.1016\/j.exer.2021.108641_bib38","article-title":"Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells","volume":"753","author":"Sun","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2021.108641_bib39","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.exer.2018.11.020","article-title":"Endogenous insulin signaling in the RPE contributes to the maintenance of rod photoreceptor function in diabetes","volume":"180","author":"Tarchick","year":"2019","journal-title":"Exp. Eye Res."},{"issue":"D1","key":"10.1016\/j.exer.2021.108641_bib40","doi-asserted-by":"crossref","first-page":"D331","DOI":"10.1093\/nar\/gkw1108","article-title":"Expansion of the gene ontology knowledgebase and resources","volume":"45","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2021.108641_bib41","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1093\/nar\/gky092","article-title":"UniProt: the universal protein knowledgebase","volume":"46","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2021.108641_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan2507","article-title":"A pathology Atlas of the human cancer transcriptome","volume":"357","author":"Uhlen","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.exer.2021.108641_bib43","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1006\/geno.2002.6748","article-title":"Guidelines for human gene nomenclature","volume":"79","author":"Wain","year":"2002","journal-title":"Genomics"},{"key":"10.1016\/j.exer.2021.108641_bib44","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/s41419-017-0200-7","article-title":"Photosensitization of A2E triggers telomere dysfunction and accelerates retinal pigment epithelium senescence","volume":"9","author":"Wang","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2021.108641_bib45","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1038\/s41598-020-58849-z","article-title":"Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration","volume":"10","author":"Wooff","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2021.108641_bib46","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12867-019-0125-z","article-title":"MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells","volume":"20","author":"Xiong","year":"2019","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.exer.2021.108641_bib47","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.bbrc.2018.09.193","article-title":"Interleukin-18 binding protein attenuates lipopolysaccharide-induced acute lung injury in mice via suppression NF-\u03baB and activation Nrf2 pathway","volume":"505","author":"Zhang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2021.108641_bib48","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1159\/000488166","article-title":"Upregulation of IL-11, an IL-6 family cytokine, promotes tumor progression and correlates with poor prognosis in non-small cell lung cancer","volume":"45","author":"Zhao","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.exer.2021.108641_bib49","first-page":"7301","article-title":"IL-10 inhibits retinal pigment epithelium cell proliferation and migration through regulation of VEGF in rhegmatogenous retinal detachment","volume":"17","author":"Zhao","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.exer.2021.108641_bib50","first-page":"7218","article-title":"The effect of interleukin-6 (IL-6), interleukin-11 (IL-11), signal transducer and activator of transcription 3 (STAT3), and AKT signaling on adipocyte proliferation in a rat model of polycystic ovary syndrome","volume":"25","author":"Zhuang","year":"2019","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483521002074?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483521002074?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:11:08Z","timestamp":1757999468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483521002074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":50,"alternative-id":["S0014483521002074"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2021.108641","relation":{},"ISSN":["0014-4835"],"issn-type":[{"type":"print","value":"0014-4835"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N-retinylidene-N-retinylethanolamine adduct induces expression of chronic inflammation cytokines in retinal pigment epithelium cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2021.108641","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108641"}}