{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:50:52Z","timestamp":1786989052156,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770904"],"award-info":[{"award-number":["81770904"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070927"],"award-info":[{"award-number":["82070927"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["20161059"],"award-info":[{"award-number":["20161059"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["201909188"],"award-info":[{"award-number":["201909188"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.exer.2021.108668","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T05:39:15Z","timestamp":1623821955000},"page":"108668","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Topical calcitriol application promotes diabetic corneal wound healing and reinnervation through inhibiting NLRP3 inflammasome activation"],"prefix":"10.1016","volume":"209","author":[{"given":"Yidi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luqin","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingli","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7770-9275","authenticated-orcid":false,"given":"Qingjun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2021.108668_bib1","doi-asserted-by":"crossref","first-page":"100762","DOI":"10.1016\/j.preteyeres.2019.05.003","article-title":"Corneal nerves in health and disease","volume":"73","author":"Al-Aqaba","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2021.108668_bib2","doi-asserted-by":"crossref","first-page":"4352470","DOI":"10.1155\/2019\/4352470","article-title":"Molecular changes in diabetic wound healing following administration of vitamin D and ginger supplements: biochemical and molecular experimental study","volume":"2019","author":"Al-Rawaf","year":"2019","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.exer.2021.108668_bib3","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1167\/iovs.06-1210","article-title":"Calcitriol is a potent inhibitor of retinal neovascularization","volume":"48","author":"Albert","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108668_bib4","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.coph.2010.04.001","article-title":"Vitamin D: modulator of the immune system","volume":"10","author":"Baeke","year":"2010","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.exer.2021.108668_bib5","doi-asserted-by":"crossref","first-page":"294","DOI":"10.2174\/157339912800840479","article-title":"Corneal changes in diabetes mellitus","volume":"8","author":"Bikbova","year":"2012","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.exer.2021.108668_bib6","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1111\/bph.12557","article-title":"Inhibition of inflammasome activation improves the impaired pattern of healing in genetically diabetic mice","volume":"171","author":"Bitto","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.exer.2021.108668_bib7","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1016\/j.ajpath.2014.06.016","article-title":"The impact of type 1 diabetes mellitus on corneal epithelial nerve morphology and the corneal epithelium","volume":"184","author":"Cai","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2021.108668_bib8","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/JLB.3MA0320-406RR","article-title":"1,25(OH)2 D3 alleviates DSS-induced ulcerative colitis via inhibiting NLRP3 inflammasome activation","volume":"108","author":"Cao","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.exer.2021.108668_bib9","doi-asserted-by":"crossref","first-page":"101093","DOI":"10.1016\/j.redox.2018.101093","article-title":"Calcitriol inhibits ROS-NLRP3-IL-1beta signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells","volume":"21","author":"Dai","year":"2019","journal-title":"Redox Biol"},{"key":"10.1016\/j.exer.2021.108668_bib10","doi-asserted-by":"crossref","first-page":"5155","DOI":"10.1167\/iovs.09-3384","article-title":"Corneal subbasal nerves changes in patients with diabetic retinopathy: an in vivo confocal study","volume":"50","author":"De Cilla","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108668_bib11","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1167\/iovs.13-13553","article-title":"Effect of vitamin D receptor knockout on cornea epithelium wound healing and tight junctions","volume":"55","author":"Elizondo","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108668_bib12","doi-asserted-by":"crossref","first-page":"e111355","DOI":"10.1371\/journal.pone.0111355","article-title":"1,25-dihydroxyvitamin D3 induces LL-37 and HBD-2 production in keratinocytes from diabetic foot ulcers promoting wound healing: an in vitro model","volume":"9","author":"Gonzalez-Curiel","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.exer.2021.108668_bib13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s11154-016-9403-y","article-title":"Vitamin D and diabetes mellitus: causal or casual association?","volume":"18","author":"Grammatiki","year":"2017","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.exer.2021.108668_bib14","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1042\/CS20180600","article-title":"NLRP3 activation induced by neutrophil extracellular traps sustains inflammatory response in the diabetic wound","volume":"133","author":"Liu","year":"2019","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.exer.2021.108668_bib15","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1177\/002215549804600907","article-title":"Human corneal epithelial basement membrane and integrin alterations in diabetes and diabetic retinopathy","volume":"46","author":"Ljubimov","year":"1998","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.exer.2021.108668_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8193523","article-title":"Vitamin D3 protects against diabetic retinopathy by inhibiting high-glucose-induced activation of the ROS\/TXNIP\/NLRP3 inflammasome pathway","volume":"2018","author":"Lu","year":"2018","journal-title":"J Diabetes Res"},{"key":"10.1016\/j.exer.2021.108668_bib17","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.2337\/db19-1051","article-title":"Effects of vitamin D receptor knockout and vitamin D deficiency on corneal epithelial wound healing and nerve density in diabetic mice","volume":"69","author":"Lu","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.exer.2021.108668_bib18","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1167\/iovs.13-13788","article-title":"Effects of vitamin D receptor knockout on cornea epithelium gap junctions","volume":"55","author":"Lu","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108668_bib19","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1167\/iovs.19-27796","article-title":"Influence of vitamin D on corneal epithelial cell desmosomes and hemidesmosomes","volume":"60","author":"Lu","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108668_bib20","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3389\/fphys.2017.00519","article-title":"NLRP3 inflammasome as a molecular marker in diabetic cardiomyopathy","volume":"8","author":"Luo","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.exer.2021.108668_bib21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000486083","article-title":"Vitamin D and diabetes mellitus","volume":"50","author":"Maddaloni","year":"2018","journal-title":"Front. Horm. Res."},{"key":"10.1016\/j.exer.2021.108668_bib22","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/10408398.2014.893504","article-title":"Modulatory effects of 1,25-dihydroxyvitamin D3 on eye disorders: a critical review","volume":"57","author":"Nebbioso","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.exer.2021.108668_bib23","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.survophthal.2020.02.005","article-title":"Diabetic keratopathy: insights and challenges","volume":"65","author":"Priyadarsini","year":"2020","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2021.108668_bib24","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.phrs.2016.11.004","article-title":"Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy","volume":"114","author":"Qiu","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.exer.2021.108668_bib25","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jdiacomp.2016.06.017","article-title":"The effects of vitamin D supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double-blind, placebo-controlled trial","volume":"31","author":"Razzaghi","year":"2017","journal-title":"J. Diabet. Complicat."},{"key":"10.1016\/j.exer.2021.108668_bib26","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/00003226-200007000-00026","article-title":"Ultrastructural changes in corneas of diabetic patients: an electron-microscopy study","volume":"19","author":"Rehany","year":"2000","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2021.108668_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152889","article-title":"Effects of topically applied vitamin D during corneal wound healing","volume":"11","author":"Reins","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.exer.2021.108668_bib28","doi-asserted-by":"crossref","first-page":"107843","DOI":"10.1016\/j.diabres.2019.107843","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9(th) edition","volume":"157","author":"Saeedi","year":"2019","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.exer.2021.108668_bib29","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.1184003","article-title":"The NLRP3 inflammasome: a sensor for metabolic danger?","volume":"327","author":"Schroder","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.exer.2021.108668_bib30","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s00417-016-3267-4","article-title":"1,25-dihydroxyvitamin D3 inhibits corneal wound healing in an ex-vivo mouse model","volume":"254","author":"Sel","year":"2016","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2021.108668_bib31","doi-asserted-by":"crossref","first-page":"e251","DOI":"10.1038\/nutd.2017.4","article-title":"A systematic review on the impact of diabetes mellitus on the ocular surface","volume":"7","author":"Shih","year":"2017","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.exer.2021.108668_bib32","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jsbmb.2017.10.013","article-title":"Calcitriol promotes proangiogenic molecules in keratinocytes in a diabetic foot ulcer model","volume":"174","author":"Trujillo","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.exer.2021.108668_bib33","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fphar.2020.00200","article-title":"Calcipotriol inhibits NLRP3 signal through YAP1 activation to alleviate cholestatic liver injury and fibrosis","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.exer.2021.108668_bib34","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1128\/IAI.00353-08","article-title":"Vitamin D signaling, infectious diseases, and regulation of innate immunity","volume":"76","author":"White","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.exer.2021.108668_bib35","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.ajpath.2016.01.019","article-title":"Targeting imbalance between IL-1beta and IL-1 receptor antagonist ameliorates delayed epithelium wound healing in diabetic mouse corneas","volume":"186","author":"Yan","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2021.108668_bib36","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.2337\/db14-0163","article-title":"Substance P promotes diabetic corneal epithelial wound healing through molecular mechanisms mediated via the neurokinin-1 receptor","volume":"63","author":"Yang","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.exer.2021.108668_bib37","doi-asserted-by":"crossref","first-page":"7359","DOI":"10.1167\/iovs.11-7605","article-title":"Vitamin D enhances corneal epithelial barrier function","volume":"52","author":"Yin","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108668_bib38","doi-asserted-by":"crossref","first-page":"117138","DOI":"10.1016\/j.lfs.2019.117138","article-title":"A new research hot spot: the role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications","volume":"240","author":"Yu","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.exer.2021.108668_bib39","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20171294","article-title":"Vitamin D ameliorates impaired wound healing in streptozotocin-induced diabetic mice by suppressing NF-\u03baB-mediated inflammatory genes","volume":"38","author":"Yuan","year":"2018","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.exer.2021.108668_bib40","doi-asserted-by":"crossref","first-page":"1757925","DOI":"10.1155\/2018\/1757925","article-title":"Vitamin D ameliorates impaired wound healing in streptozotocin-induced diabetic mice by suppressing endoplasmic reticulum stress","volume":"2018","author":"Yuan","year":"2018","journal-title":"J Diabetes Res"},{"key":"10.1016\/j.exer.2021.108668_bib41","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/09273948.2017.1372486","article-title":"Calcitriol, the active metabolite of vitamin D3, inhibits dry eye related corneal inflammation in vivo and in vitro","volume":"27","author":"Zhang","year":"2019","journal-title":"Ocul. Immunol. Inflamm."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483521002347?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483521002347?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:31:23Z","timestamp":1762147883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483521002347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":41,"alternative-id":["S0014483521002347"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2021.108668","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Topical calcitriol application promotes diabetic corneal wound healing and reinnervation through inhibiting NLRP3 inflammasome activation","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2021.108668","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108668"}}